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Items: 1 to 50 of 185

1.

The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells.

Buck T, Hack CT, Berg D, Berg U, Kunz L, Mayerhofer A.

Sci Rep. 2019 Mar 5;9(1):3585. doi: 10.1038/s41598-019-40329-8.

2.

Necroptosis in primate luteolysis: a role for ceramide.

Bagnjuk K, Stöckl JB, Fröhlich T, Arnold GJ, Behr R, Berg U, Berg D, Kunz L, Bishop C, Xu J, Mayerhofer A.

Cell Death Discov. 2019 Feb 11;5:67. doi: 10.1038/s41420-019-0149-7. eCollection 2019.

3.

Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins.

Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R.

EMBO Rep. 2019 Mar;20(3). pii: e46451. doi: 10.15252/embr.201846451. Epub 2019 Feb 7.

PMID:
30733281
4.

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.

Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, Mayerhofer A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B.

EMBO Rep. 2019 Mar;20(3). pii: e46449. doi: 10.15252/embr.201846449. Epub 2019 Feb 7.

PMID:
30733280
5.

Human testicular peritubular cells, mast cells and testicular inflammation.

Mayerhofer A, Walenta L, Mayer C, Eubler K, Welter H.

Andrologia. 2018 Dec;50(11):e13055. doi: 10.1111/and.13055. Review.

PMID:
30569646
6.

Ca2+ Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2.

Eubler K, Herrmann C, Tiefenbacher A, Köhn FM, Schwarzer JU, Kunz L, Mayerhofer A.

Int J Mol Sci. 2018 Sep 19;19(9). pii: E2829. doi: 10.3390/ijms19092829.

7.

NLRP3 in somatic non-immune cells of rodent and primate testes.

Walenta L, Schmid N, Schwarzer JU, Köhn FM, Urbanski HF, Behr R, Strauss L, Poutanen M, Mayerhofer A.

Reproduction. 2018 Sep;156(3):231-238. doi: 10.1530/REP-18-0111. Epub 2018 Jun 15.

PMID:
29907661
8.

Insights into the role of androgen receptor in human testicular peritubular cells.

Mayer C, Adam M, Walenta L, Schmid N, Heikelä H, Schubert K, Flenkenthaler F, Dietrich KG, Gruschka S, Arnold GJ, Fröhlich T, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A.

Andrology. 2018 Sep;6(5):756-765. doi: 10.1111/andr.12509. Epub 2018 Jun 5.

PMID:
29869453
9.

Characterization of a non-human primate model for the study of testicular peritubular cells-comparison with human testicular peritubular cells.

Schmid N, Stöckl JB, Flenkenthaler F, Dietrich KG, Schwarzer JU, Köhn FM, Drummer C, Fröhlich T, Arnold GJ, Behr R, Mayerhofer A.

Mol Hum Reprod. 2018 Aug 1;24(8):401-410. doi: 10.1093/molehr/gay025.

PMID:
29846669
10.

Acetylcholine and necroptosis are players in follicular development in primates.

Du Y, Bagnjuk K, Lawson MS, Xu J, Mayerhofer A.

Sci Rep. 2018 Apr 18;8(1):6166. doi: 10.1038/s41598-018-24661-z.

11.

Neuropeptide and steroid hormone mediators of neuroendocrine regulation.

Heck AL, Crestani CC, Fernández-Guasti A, Larco DO, Mayerhofer A, Roselli CE.

J Neuroendocrinol. 2018 Oct;30(10):e12599. doi: 10.1111/jne.12599. Epub 2018 Aug 7. Review.

PMID:
29645316
12.

Prostaglandin E2 (PGE2) is a testicular peritubular cell-derived factor involved in human testicular homeostasis.

Rey-Ares V, Rossi SP, Dietrich KG, Köhn FM, Schwarzer JU, Welter H, Frungieri MB, Mayerhofer A.

Mol Cell Endocrinol. 2018 Sep 15;473:217-224. doi: 10.1016/j.mce.2018.01.022. Epub 2018 Feb 2.

PMID:
29408603
13.

Alpha 1 adrenergic receptor-mediated inflammatory responses in human testicular peritubular cells.

Rossi SP, Walenta L, Rey-Ares V, Köhn FM, Schwarzer JU, Welter H, Calandra RS, Frungieri MB, Mayerhofer A.

Mol Cell Endocrinol. 2018 Oct 15;474:1-9. doi: 10.1016/j.mce.2018.01.027. Epub 2018 Jan 31.

PMID:
29407194
14.

Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility.

Hakkarainen J, Zhang FP, Jokela H, Mayerhofer A, Behr R, Cisneros-Montalvo S, Nurmio M, Toppari J, Ohlsson C, Kotaja N, Sipilä P, Poutanen M.

FASEB J. 2018 Jun;32(6):3229-3241. doi: 10.1096/fj.201700921R. Epub 2018 Jan 24.

PMID:
29401623
15.

ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation.

Walenta L, Fleck D, Fröhlich T, von Eysmondt H, Arnold GJ, Spehr J, Schwarzer JU, Köhn FM, Spehr M, Mayerhofer A.

Sci Rep. 2018 Jan 23;8(1):1431. doi: 10.1038/s41598-018-19624-3.

16.

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells.

Mayer C, Adam M, Glashauser L, Dietrich K, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A.

Sci Rep. 2016 Nov 16;6:37128. doi: 10.1038/srep37128.

17.

L-DOPA in the hu man ovarian follicular fluid acts as an antioxidant factor on granulosa cells.

Blohberger J, Buck T, Berg D, Berg U, Kunz L, Mayerhofer A.

J Ovarian Res. 2016 Sep 29;9(1):62.

18.

In vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat.

Urra J, Blohberger J, Tiszavari M, Mayerhofer A, Lara HE.

Sci Rep. 2016 Jul 21;6:30129. doi: 10.1038/srep30129.

19.

Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells.

Rossi SP, Windschüttl S, Matzkin ME, Rey-Ares V, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Mayerhofer A, Frungieri MB.

Mol Cell Endocrinol. 2016 Oct 15;434:154-65. doi: 10.1016/j.mce.2016.06.021. Epub 2016 Jun 18.

PMID:
27329155
20.

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.

Schell C, Kretz O, Liang W, Kiefer B, Schneider S, Sellung D, Bork T, Leiber C, Rüegg MA, Mallidis C, Schlatt S, Mayerhofer A, Huber TB, Grahammer F.

Am J Pathol. 2016 Feb;186(2):324-36. doi: 10.1016/j.ajpath.2015.10.012. Epub 2015 Dec 10.

PMID:
26683665
21.

Pro-nerve growth factor in the ovary and human granulosa cells.

Meinel S, Blohberger J, Berg D, Berg U, Dissen GA, Ojeda SR, Mayerhofer A.

Horm Mol Biol Clin Investig. 2015 Nov;24(2):91-9. doi: 10.1515/hmbci-2015-0028.

22.

Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules.

Windschüttl S, Kampfer C, Mayer C, Flenkenthaler F, Fröhlich T, Schwarzer JU, Köhn FM, Urbanski H, Arnold GJ, Mayerhofer A.

Sci Rep. 2015 Sep 3;5:12820. doi: 10.1038/srep12820.

23.

Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles: a marker of growing follicles?

Merz C, Saller S, Kunz L, Xu J, Yeoman RR, Ting AY, Lawson MS, Stouffer RL, Hennebold JD, Pau F, Dissen GA, Ojeda SR, Zelinski MB, Mayerhofer A.

J Ovarian Res. 2015 Mar 7;8:8. doi: 10.1186/s13048-015-0136-4.

24.

Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?

Blohberger J, Kunz L, Einwang D, Berg U, Berg D, Ojeda SR, Dissen GA, Fröhlich T, Arnold GJ, Soreq H, Lara H, Mayerhofer A.

Cell Death Dis. 2015 Mar 12;6:e1685. doi: 10.1038/cddis.2015.51.

25.

Cyclooxygenase and prostaglandins in somatic cell populations of the testis.

Frungieri MB, Calandra RS, Mayerhofer A, Matzkin ME.

Reproduction. 2015 Apr;149(4):R169-80. doi: 10.1530/REP-14-0392. Epub 2014 Dec 12. Review.

PMID:
25504871
26.

The G-protein-coupled estrogen receptor (GPER/GPR30) in ovarian granulosa cell tumors.

Heublein S, Mayr D, Friese K, Jarrin-Franco MC, Lenhard M, Mayerhofer A, Jeschke U.

Int J Mol Sci. 2014 Aug 27;15(9):15161-72. doi: 10.3390/ijms150915161.

27.

Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility.

Sandner F, Welter H, Schwarzer JU, Köhn FM, Urbanski HF, Mayerhofer A.

Andrology. 2014 Sep;2(5):695-701. doi: 10.1111/j.2047-2927.2014.00243.x. Epub 2014 Jul 23.

28.

Angiotensin II regulates testicular peritubular cell function via AT1 receptor: a specific situation in male infertility.

Welter H, Huber A, Lauf S, Einwang D, Mayer C, Schwarzer JU, Köhn FM, Mayerhofer A.

Mol Cell Endocrinol. 2014 Aug 5;393(1-2):171-8. doi: 10.1016/j.mce.2014.06.011. Epub 2014 Jun 24.

PMID:
24970685
29.

Are testicular mast cells involved in the regulation of germ cells in man?

Windschüttl S, Nettersheim D, Schlatt S, Huber A, Welter H, Schwarzer JU, Köhn FM, Schorle H, Mayerhofer A.

Andrology. 2014 Jul;2(4):615-22. doi: 10.1111/j.2047-2927.2014.00227.x. Epub 2014 Jun 12.

30.

Maternal sympathetic stress impairs follicular development and puberty of the offspring.

Barra R, Cruz G, Mayerhofer A, Paredes A, Lara HE.

Reproduction. 2014 Aug;148(2):137-45. doi: 10.1530/REP-14-0150. Epub 2014 May 7.

PMID:
24811779
31.

Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity.

Landreh L, Spinnler K, Schubert K, Häkkinen MR, Auriola S, Poutanen M, Söder O, Svechnikov K, Mayerhofer A.

J Clin Endocrinol Metab. 2014 Jul;99(7):E1227-35. doi: 10.1210/jc.2013-4199. Epub 2014 Mar 31.

PMID:
24684461
32.

Melatonin in testes of infertile men: evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations.

Rossi SP, Windschuettl S, Matzkin ME, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Mayerhofer A, Frungieri MB.

Andrology. 2014 May;2(3):436-49. doi: 10.1111/j.2047-2927.2014.00207.x. Epub 2014 Mar 21.

33.

Secretome analysis of testicular peritubular cells: a window into the human testicular microenvironment and the spermatogonial stem cell niche in man.

Flenkenthaler F, Windschüttl S, Fröhlich T, Schwarzer JU, Mayerhofer A, Arnold GJ.

J Proteome Res. 2014 Mar 7;13(3):1259-69. doi: 10.1021/pr400769z. Epub 2014 Jan 30.

PMID:
24422521
34.

Pigment-Epithelium Derived Factor (PEDF) and the human ovary: a role in the generation of ROS in granulosa cells.

Kampfer C, Saller S, Windschüttl S, Berg D, Berg U, Mayerhofer A.

Life Sci. 2014 Mar 3;97(2):129-36. doi: 10.1016/j.lfs.2013.12.007. Epub 2013 Dec 17.

PMID:
24361362
35.

Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cells: implications for physiology and pathology.

Saller S, Kunz L, Berg D, Berg U, Lara H, Urra J, Hecht S, Pavlik R, Thaler CJ, Mayerhofer A.

Hum Reprod. 2014 Mar;29(3):555-67. doi: 10.1093/humrep/det422. Epub 2013 Nov 27.

PMID:
24287819
36.

Effects of acoustic stimuli used for vestibular evoked myogenic potential studies on the cochlear function.

Krause E, Mayerhofer A, Gürkov R, Drexl M, Braun T, Olzowy B, Boetzel K.

Otol Neurotol. 2013 Sep;34(7):1186-92. doi: 10.1097/MAO.0b013e31829ce7b4.

PMID:
23921920
37.

Is technology assisted guided self-help successful in treating female adolescents with bulimia nervosa?

Wagner G, Wagner G, Penelo E, Nobis G, Mayerhofer A, Schau J, Spitzer M, Imgart H, Karwautz A.

Neuropsychiatr. 2013;27(2):66-73. doi: 10.1007/s40211-013-0062-x. Epub 2013 Apr 23.

PMID:
23609487
38.

Human testicular peritubular cells: more than meets the eye.

Mayerhofer A.

Reproduction. 2013 Apr 29;145(5):R107-16. doi: 10.1530/REP-12-0497. Print 2013 May. Review.

PMID:
23431272
39.

Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients.

Welter H, Kampfer C, Lauf S, Feil R, Schwarzer JU, Köhn FM, Mayerhofer A.

Andrology. 2013 Mar;1(2):318-24. doi: 10.1111/j.2047-2927.2012.00030.x. Epub 2012 Nov 29.

40.

The Ca2+-activated, large conductance K+-channel (BKCa) is a player in the LH/hCG signaling cascade in testicular Leydig cells.

Matzkin ME, Lauf S, Spinnler K, Rossi SP, Köhn FM, Kunz L, Calandra RS, Frungieri MB, Mayerhofer A.

Mol Cell Endocrinol. 2013 Mar 10;367(1-2):41-9. doi: 10.1016/j.mce.2012.12.015. Epub 2012 Dec 23.

PMID:
23267835
41.

Decorin is a part of the ovarian extracellular matrix in primates and may act as a signaling molecule.

Adam M, Saller S, Ströbl S, Hennebold JD, Dissen GA, Ojeda SR, Stouffer RL, Berg D, Berg U, Mayerhofer A.

Hum Reprod. 2012 Nov;27(11):3249-58. doi: 10.1093/humrep/des297. Epub 2012 Aug 11.

42.

Peritubular myoid cells have a role in postnatal testicular growth.

Nurmio M, Kallio J, Adam M, Mayerhofer A, Toppari J, Jahnukainen K.

Spermatogenesis. 2012 Apr 1;2(2):79-87.

43.

Evidence for an adaptation in ROS scavenging systems in human testicular peritubular cells from infertility patients.

Kampfer C, Spillner S, Spinnler K, Schwarzer JU, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Köhn FM, Matzkin ME, Calandra RS, Frungieri MB, Mayerhofer A.

Int J Androl. 2012 Dec;35(6):793-801. doi: 10.1111/j.1365-2605.2012.01281.x. Epub 2012 May 29.

PMID:
22640168
44.

High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function.

Adam M, Urbanski HF, Garyfallou VT, Welsch U, Köhn FM, Ullrich Schwarzer J, Strauss L, Poutanen M, Mayerhofer A.

Int J Androl. 2012 Aug;35(4):550-61. doi: 10.1111/j.1365-2605.2011.01225.x. Epub 2011 Nov 15.

45.

Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells.

Saller S, Merz-Lange J, Raffael S, Hecht S, Pavlik R, Thaler C, Berg D, Berg U, Kunz L, Mayerhofer A.

Endocrinology. 2012 Mar;153(3):1472-83. doi: 10.1210/en.2011-1769. Epub 2012 Jan 10.

PMID:
22234472
46.

Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling.

Adam M, Schwarzer JU, Köhn FM, Strauss L, Poutanen M, Mayerhofer A.

Hum Reprod. 2011 Oct;26(10):2613-25. doi: 10.1093/humrep/der245. Epub 2011 Jul 25.

PMID:
21791437
47.

Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF action.

Spinnler K, Fröhlich T, Arnold GJ, Kunz L, Mayerhofer A.

J Biol Chem. 2011 Sep 9;286(36):31707-13. doi: 10.1074/jbc.M111.233486. Epub 2011 Jul 18.

48.

Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase.

Welter H, Köhn FM, Mayerhofer A.

Fertil Steril. 2011 Aug;96(2):309-13. doi: 10.1016/j.fertnstert.2011.05.035. Epub 2011 Jun 17.

PMID:
21683347
49.

Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man.

Spinnler K, Köhn FM, Schwarzer U, Mayerhofer A.

Hum Reprod. 2010 Sep;25(9):2181-7. doi: 10.1093/humrep/deq170. Epub 2010 Jul 3.

PMID:
20601681
50.

Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1β.

Matzkin ME, Mayerhofer A, Rossi SP, Gonzalez B, Gonzalez CR, Gonzalez-Calvar SI, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Frungieri MB.

Fertil Steril. 2010 Oct;94(5):1933-6. doi: 10.1016/j.fertnstert.2010.01.039. Epub 2010 Feb 26.

PMID:
20188355

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