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Items: 1 to 50 of 54

1.

Identification of Bioactive Small Molecule Inhibitors of Separase.

Henschke L, Frese M, Hellmuth S, Marx A, Stemmann O, Mayer TU.

ACS Chem Biol. 2019 Sep 30. doi: 10.1021/acschembio.9b00661. [Epub ahead of print]

PMID:
31553567
2.

Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20.

Heim A, Tischer T, Mayer TU.

EMBO Rep. 2018 Dec;19(12). pii: e46433. doi: 10.15252/embr.201846433. Epub 2018 Oct 29.

PMID:
30373936
3.

Small molecule tools in mitosis research.

Teusel F, Henschke L, Mayer TU.

Methods Cell Biol. 2018;144:137-155. doi: 10.1016/bs.mcb.2018.03.005. Epub 2018 Apr 27.

PMID:
29804666
4.

Structural basis of human kinesin-8 function and inhibition.

Locke J, Joseph AP, Peña A, Möckel MM, Mayer TU, Topf M, Moores CA.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9539-E9548. doi: 10.1073/pnas.1712169114. Epub 2017 Oct 23.

5.

Xenopus laevis Kif18A is a highly processive kinesin required for meiotic spindle integrity.

Möckel MM, Heim A, Tischer T, Mayer TU.

Biol Open. 2017 Apr 15;6(4):463-470. doi: 10.1242/bio.023952.

6.

Regulation of Cell Division.

Heim A, Rymarczyk B, Mayer TU.

Adv Exp Med Biol. 2017;953:83-116. Review. Erratum in: Adv Exp Med Biol. 2017;953:E1. Malhotra, Saurav [removed].

PMID:
27975271
7.

Chemical Genetics Approach to Engineer Kinesins with Sensitivity towards a Small-Molecule Inhibitor of Eg5.

Möckel MM, Hund C, Mayer TU.

Chembiochem. 2016 Nov 3;17(21):2042-2045. doi: 10.1002/cbic.201600451. Epub 2016 Sep 20.

PMID:
27550380
8.

Small Molecule Approach to Study the Function of Mitotic Kinesins.

Al-Obaidi N, Kastl J, Mayer TU.

Methods Mol Biol. 2016;1413:283-99. doi: 10.1007/978-1-4939-3542-0_18.

PMID:
27193856
9.

Retraction Notice to: The Anaphase-Promoting Complex/Cyclosome Is Essential for Entry into Meiotic M-Phase.

Malhotra S, Vinod PK, Mansfeld J, Stemmann O, Mayer TU.

Dev Cell. 2016 May 9;37(3):289. doi: 10.1016/j.devcel.2016.04.013. No abstract available.

10.

Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells.

Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU.

ACS Chem Biol. 2016 Jun 17;11(6):1544-51. doi: 10.1021/acschembio.6b00203. Epub 2016 Apr 28.

11.

RETRACTED: The Anaphase-Promoting Complex/Cyclosome Is Essential for Entry into Meiotic M-Phase.

Malhotra S, Vinod PK, Mansfeld J, Stemmann O, Mayer TU.

Dev Cell. 2016 Jan 11;36(1):94-102. doi: 10.1016/j.devcel.2015.12.009. Retraction in: Dev Cell. 2016 May 9;37(3):289.

12.

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.

Badertscher L, Wild T, Montellese C, Alexander LT, Bammert L, Sarazova M, Stebler M, Csucs G, Mayer TU, Zamboni N, Zemp I, Horvath P, Kutay U.

Cell Rep. 2015 Dec 29;13(12):2879-91. doi: 10.1016/j.celrep.2015.11.061. Epub 2015 Dec 17.

13.

Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit.

Heim A, Konietzny A, Mayer TU.

EMBO Rep. 2015 Nov;16(11):1501-10. doi: 10.15252/embr.201540876. Epub 2015 Sep 22.

14.

Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint.

Kastl J, Braun J, Prestel A, Möller HM, Huhn T, Mayer TU.

ACS Chem Biol. 2015 Jul 17;10(7):1661-6. doi: 10.1021/acschembio.5b00121. Epub 2015 May 15.

PMID:
25978000
15.

Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A.

Braun J, Möckel MM, Strittmatter T, Marx A, Groth U, Mayer TU.

ACS Chem Biol. 2015 Feb 20;10(2):554-60. doi: 10.1021/cb500789h. Epub 2014 Nov 26.

PMID:
25402598
16.

Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels-Alder reactions.

Späte AK, Schart VF, Häfner J, Niederwieser A, Mayer TU, Wittmann V.

Beilstein J Org Chem. 2014 Sep 22;10:2235-42. doi: 10.3762/bjoc.10.232. eCollection 2014.

17.

Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains.

Schneider T, Schneider D, Rösner D, Malhotra S, Mortensen F, Mayer TU, Scheffner M, Marx A.

Angew Chem Int Ed Engl. 2014 Nov 17;53(47):12925-9. doi: 10.1002/anie.201407192. Epub 2014 Sep 4.

PMID:
25196034
18.

Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A.

Häfner J, Mayr MI, Möckel MM, Mayer TU.

Nat Commun. 2014 Jul 22;5:4397. doi: 10.1038/ncomms5397.

PMID:
25048371
19.

Fluorogenic ATP analogues for online monitoring of ATP consumption: observing ubiquitin activation in real time.

Hacker SM, Pagliarini D, Tischer T, Hardt N, Schneider D, Mex M, Mayer TU, Scheffner M, Marx A.

Angew Chem Int Ed Engl. 2013 Nov 4;52(45):11916-9. doi: 10.1002/anie.201304723. Epub 2013 Sep 17. No abstract available.

PMID:
24105922
20.

Modulation of cell cycle control during oocyte-to-embryo transitions.

Hörmanseder E, Tischer T, Mayer TU.

EMBO J. 2013 Aug 14;32(16):2191-203. doi: 10.1038/emboj.2013.164. Epub 2013 Jul 26. Review.

21.

The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles.

Vinod PK, Zhou X, Zhang T, Mayer TU, Novak B.

Biophys Chem. 2013 Jul-Aug;177-178:1-6. doi: 10.1016/j.bpc.2013.03.002. Epub 2013 Mar 19.

PMID:
23562861
22.

The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions.

Tischer T, Hörmanseder E, Mayer TU.

Science. 2012 Oct 26;338(6106):520-4. doi: 10.1126/science.1228394. Epub 2012 Sep 27.

23.

The functional antagonism between Eg5 and dynein in spindle bipolarization is not compatible with a simple push-pull model.

Florian S, Mayer TU.

Cell Rep. 2012 May 31;1(5):408-16. doi: 10.1016/j.celrep.2012.03.006. Epub 2012 Apr 20.

24.

HiTSEE KNIME: a visualization tool for hit selection and analysis in high-throughput screening experiments for the KNIME platform.

Strobelt H, Bertini E, Braun J, Deussen O, Groth U, Mayer TU, Merhof D.

BMC Bioinformatics. 2012;13 Suppl 8:S4. doi: 10.1186/1471-2105-13-S8-S4. Epub 2012 May 18.

25.

A non-motor microtubule binding site is essential for the high processivity and mitotic function of kinesin-8 Kif18A.

Mayr MI, Storch M, Howard J, Mayer TU.

PLoS One. 2011;6(11):e27471. doi: 10.1371/journal.pone.0027471. Epub 2011 Nov 10.

26.

Modulated microtubule dynamics enable Hklp2/Kif15 to assemble bipolar spindles.

Florian S, Mayer TU.

Cell Cycle. 2011 Oct 15;10(20):3533-44. doi: 10.4161/cc.10.20.17817. Epub 2011 Oct 15.

PMID:
22024925
27.

Identification of novel quadruplex ligands from small molecule libraries by FRET-based high-throughput screening.

Benz A, Singh V, Mayer TU, Hartig JS.

Chembiochem. 2011 Jun 14;12(9):1422-6. doi: 10.1002/cbic.201100094. Epub 2011 May 26. No abstract available.

PMID:
21618675
28.

Automatic quantification of microtubule dynamics enables RNAi-screening of new mitotic spindle regulators.

Sironi L, Solon J, Conrad C, Mayer TU, Brunner D, Ellenberg J.

Cytoskeleton (Hoboken). 2011 May;68(5):266-78. doi: 10.1002/cm.20510. Epub 2011 Apr 13.

PMID:
21491614
29.

Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1.

Hörmanseder E, Tischer T, Heubes S, Stemmann O, Mayer TU.

EMBO Rep. 2011 May;12(5):436-43. doi: 10.1038/embor.2011.32. Epub 2011 Mar 11.

30.

Small Molecule Inhibitors of Human DNA Polymerase λ.

Strittmatter T, Bareth B, Immel TA, Huhn T, Mayer TU, Marx A.

ACS Chem Biol. 2011 Apr 15;6(4):314-9. doi: 10.1021/cb100382m. Epub 2011 Jan 18.

PMID:
21194240
31.

Five molecules we would take to a remote island.

Mayer TU, Marx A.

Chem Biol. 2010 Jun 25;17(6):556-60. doi: 10.1016/j.chembiol.2010.06.002. Review.

32.

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF.

J Neurosci. 2010 Jun 30;30(26):8974-83. doi: 10.1523/JNEUROSCI.1199-10.2010.

33.

Monastrol analogs: a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening.

Svetlik J, Veizerová L, Mayer TU, Catarinella M.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4073-6. doi: 10.1016/j.bmcl.2010.05.085. Epub 2010 May 26.

PMID:
20542426
34.

BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.

Catarinella M, Grüner T, Strittmatter T, Marx A, Mayer TU.

Angew Chem Int Ed Engl. 2009;48(48):9072-6. doi: 10.1002/anie.200904510. No abstract available.

PMID:
19856362
35.

Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex.

Hümmer S, Mayer TU.

Curr Biol. 2009 Apr 14;19(7):607-12. doi: 10.1016/j.cub.2009.02.046. Epub 2009 Mar 19.

36.

Chemical genetics: reshaping biology through chemistry.

Florian S, Hümmer S, Catarinella M, Mayer TU.

HFSP J. 2007 Jul;1(2):104-14. doi: 10.2976/1.2752600. Epub 2007 Jul 12.

37.

Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase.

Lessmann T, Leuenberger MG, Menninger S, Lopez-Canet M, Müller O, Hümmer S, Bormann J, Korn K, Fava E, Zerial M, Mayer TU, Waldmann H.

Chem Biol. 2007 Apr;14(4):443-51.

38.

The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression.

Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU.

Curr Biol. 2007 Mar 20;17(6):488-98. Epub 2007 Mar 8.

39.

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

Schust J, Sperl B, Hollis A, Mayer TU, Berg T.

Chem Biol. 2006 Nov;13(11):1235-42.

40.

Cytostatic factor: an activity that puts the cell cycle on hold.

Schmidt A, Rauh NR, Nigg EA, Mayer TU.

J Cell Sci. 2006 Apr 1;119(Pt 7):1213-8. Review.

41.

Synthesis and biological evaluation of novel EG5 inhibitors.

Sarli V, Huemmer S, Sunder-Plassmann N, Mayer TU, Giannis A.

Chembiochem. 2005 Nov;6(11):2005-13.

PMID:
16216042
42.

Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation.

Rauh NR, Schmidt A, Bormann J, Nigg EA, Mayer TU.

Nature. 2005 Oct 13;437(7061):1048-52. Epub 2005 Aug 28.

PMID:
16127448
43.

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Sunder-Plassmann N, Sarli V, Gartner M, Utz M, Seiler J, Huemmer S, Mayer TU, Surrey T, Giannis A.

Bioorg Med Chem. 2005 Nov 15;13(22):6094-111. Epub 2005 Aug 3.

PMID:
16084101
44.

Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.

Schmidt A, Duncan PI, Rauh NR, Sauer G, Fry AM, Nigg EA, Mayer TU.

Genes Dev. 2005 Feb 15;19(4):502-13.

45.

High-content screening and profiling of drug activity in an automated centrosome-duplication assay.

Perlman ZE, Mitchison TJ, Mayer TU.

Chembiochem. 2005 Jan;6(1):145-51.

PMID:
15568197
46.

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.

Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA.

J Cell Biol. 2003 Sep 1;162(5):863-75. Epub 2003 Aug 25.

47.

HR22C16: a potent small-molecule probe for the dynamics of cell division.

Hotha S, Yarrow JC, Yang JG, Garrett S, Renduchintala KV, Mayer TU, Kapoor TM.

Angew Chem Int Ed Engl. 2003 May 30;42(21):2379-82. No abstract available.

PMID:
12783501
48.

Chemical genetics: tailoring tools for cell biology.

Mayer TU.

Trends Cell Biol. 2003 May;13(5):270-7. Review.

PMID:
12742171
49.

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ.

J Cell Biol. 2000 Sep 4;150(5):975-88.

50.

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis.

Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL.

Chem Biol. 2000 Apr;7(4):275-86. Erratum in: Chem Biol 2001 Dec;8(12):1265.

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