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Items: 1 to 50 of 71

1.

A novel technique for retrieval of a broken biopsy needle.

Asprey W, Knuttinen G, Long JR, Fox M, Flug J, Mayer JP, Schwartz AJ.

Skeletal Radiol. 2019 Sep 2. doi: 10.1007/s00256-019-03304-y. [Epub ahead of print]

PMID:
31485680
2.

A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity.

Brunel FM, Mayer JP, Gelfanov VM, Zaykov AN, Finan B, Perez-Tilve D, DiMarchi RD.

ACS Chem Biol. 2019 Aug 16;14(8):1829-1835. doi: 10.1021/acschembio.9b00420. Epub 2019 Aug 6.

PMID:
31343157
3.

Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety.

He R, Finan B, Mayer JP, DiMarchi RD.

Molecules. 2019 May 14;24(10). pii: E1855. doi: 10.3390/molecules24101855. Review.

4.

Structurally Constrained Insulin Analogs by Directed Stepwise Crosslinking.

Zhang F, Mayer JP, Gelfanov V, Liu F, DiMarchi RD.

Protein Pept Lett. 2018;25(12):1149-1154. doi: 10.2174/0929866525666181101103500.

PMID:
30381053
5.

Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity.

Brandt SJ, Mayer JP, Ford J, Gelfanov VM, DiMarchi RD.

Peptides. 2018 Feb;100:18-23. doi: 10.1016/j.peptides.2017.11.022.

PMID:
29412818
6.

Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases.

DiMarchi RD, Mayer JP, Gelfanov VM, Tschöp M.

J Pept Sci. 2018 Jan;24(1). doi: 10.1002/psc.3056. Review.

PMID:
29322647
7.

Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-β42.

Adams DJ, Nemkov TG, Mayer JP, Old WM, Stowell MHB.

PLoS One. 2017 Aug 9;12(8):e0182804. doi: 10.1371/journal.pone.0182804. eCollection 2017.

8.

Once Blind, Now We See GLP-1 Molecular Action.

Mayer JP, Tschöp MH, DiMarchi RD.

Cell Metab. 2017 Aug 1;26(2):289-291. doi: 10.1016/j.cmet.2017.07.014.

9.

Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision.

Thalluri K, Kou B, Yang X, Zaykov AN, Mayer JP, Gelfanov VM, Liu F, DiMarchi RD.

J Pept Sci. 2017 Jun;23(6):455-465. doi: 10.1002/psc.3010. Epub 2017 May 3.

PMID:
28466571
10.

Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.

Wu F, Mayer JP, Gelfanov VM, Liu F, DiMarchi RD.

J Org Chem. 2017 Apr 7;82(7):3506-3512. doi: 10.1021/acs.joc.6b03078. Epub 2017 Mar 27.

PMID:
28319665
11.

Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision.

Thalluri K, Kou B, Gelfanov V, Mayer JP, Liu F, DiMarchi RD.

Org Lett. 2017 Feb 3;19(3):706-709. doi: 10.1021/acs.orglett.6b03876. Epub 2017 Jan 26.

PMID:
28124920
12.

Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon.

Mroz PA, Perez-Tilve D, Liu F, Mayer JP, DiMarchi RD.

ACS Chem Biol. 2016 Dec 16;11(12):3412-3420. Epub 2016 Nov 8.

PMID:
27797473
13.

Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.

Mroz PA, Perez-Tilve D, Liu F, Gelfanov V, DiMarchi RD, Mayer JP.

J Med Chem. 2016 Sep 8;59(17):8061-7. doi: 10.1021/acs.jmedchem.6b00840. Epub 2016 Aug 25.

PMID:
27509198
14.

Chemical Synthesis of Human Insulin-Like Peptide-6.

Wu F, Mayer JP, Zaykov AN, Zhang F, Liu F, DiMarchi RD.

Chemistry. 2016 Jul 4;22(28):9777-83. doi: 10.1002/chem.201601410. Epub 2016 Jun 3.

PMID:
27259101
15.

Pursuit of a perfect insulin.

Zaykov AN, Mayer JP, DiMarchi RD.

Nat Rev Drug Discov. 2016 Jun;15(6):425-39. doi: 10.1038/nrd.2015.36. Epub 2016 Mar 18. Review.

PMID:
26988411
16.

Chemical synthesis of peptides within the insulin superfamily.

Liu F, Zaykov AN, Levy JJ, DiMarchi RD, Mayer JP.

J Pept Sci. 2016 May;22(5):260-70. doi: 10.1002/psc.2863. Epub 2016 Feb 22. Review.

PMID:
26910514
17.

Resolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains.

Horness RE, Basom EJ, Mayer JP, Thielges MC.

J Am Chem Soc. 2016 Feb 3;138(4):1130-3. doi: 10.1021/jacs.5b11999. Epub 2016 Jan 25.

18.

Protein chemical synthesis in drug discovery.

Liu F, Mayer JP.

Top Curr Chem. 2015;362:183-228. doi: 10.1007/128_2014_598.

PMID:
25707613
19.

Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity.

Wu F, Chabenne JR, Gelfanov VM, Mayer JP, DiMarchi RD.

J Pept Sci. 2015 Mar;21(3):223-30. doi: 10.1002/psc.2744. Epub 2015 Feb 9.

PMID:
25665061
20.

Chemical synthesis of insulin analogs through a novel precursor.

Zaykov AN, Mayer JP, Gelfanov VM, DiMarchi RD.

ACS Chem Biol. 2014 Mar 21;9(3):683-91. doi: 10.1021/cb400792s. Epub 2014 Jan 2.

PMID:
24328449
21.

An Fmoc compatible, O to S shift-mediated procedure for the preparation of C-terminal thioester peptides.

Liu F, Mayer JP.

J Org Chem. 2013 Oct 4;78(19):9848-56. doi: 10.1021/jo4015112. Epub 2013 Sep 19.

PMID:
24000771
22.

Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.

Kaur ZP, Ochman AR, Mayer JP, Gelfanov VM, DiMarchi RD.

ACS Chem Biol. 2013 Aug 16;8(8):1822-9. doi: 10.1021/cb4002624. Epub 2013 Jun 18.

PMID:
23730814
23.

Concise synthetic routes to human insulin.

Liu F, Luo EY, Flora DB, Mayer JP.

Org Lett. 2013 Feb 15;15(4):960-3. doi: 10.1021/ol400149j. Epub 2013 Feb 7.

PMID:
23391097
24.

Site-specific fluorescein labeling of human insulin.

Liu F, Kohn WD, Mayer JP.

J Pept Sci. 2012 May;18(5):336-41. doi: 10.1002/psc.2405. Epub 2012 Mar 26.

PMID:
22492582
25.

Discovery of potent, cyclic calcitonin gene-related peptide receptor antagonists.

Yan LZ, Johnson KW, Rothstein E, Flora D, Edwards P, Li B, Li J, Lynch R, Vaughn R, Clemens-Smith A, McCarty D, Chow C, McKnight KL, Lu J, Nisenbaum ES, Mayer JP.

J Pept Sci. 2011 May;17(5):383-6. doi: 10.1002/psc.1358. Epub 2011 Mar 15.

PMID:
21412957
26.

Congenital infections with Trypanosoma cruzi or Toxoplasma gondii are associated with decreased serum concentrations of interferon-γ and interleukin-18 but increased concentrations of interleukin-10.

Mayer JP, Biancardi M, Altcheh J, Freilij H, Weinke T, Liesenfeld O.

Ann Trop Med Parasitol. 2010 Sep;104(6):485-92. doi: 10.1179/136485910X12786389891362.

PMID:
20863437
27.

Construct validity of the core competencies for public health professionals.

Edgar M, Mayer JP, Scharff DP.

J Public Health Manag Pract. 2009 Jul-Aug;15(4):E7-16. doi: 10.1097/PHH.0b013e31819c1452.

PMID:
19525770
28.

Modulation of blood pressure by central melanocortinergic pathways.

Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, Lomas DJ, O'Rahilly S, Farooqi IS.

N Engl J Med. 2009 Jan 1;360(1):44-52. doi: 10.1056/NEJMoa0803085. Epub 2008 Dec 17.

29.

Laparoscopic approach to ovarian mass in children and adolescents: already a standard in therapy.

Mayer JP, Bettolli M, Kolberg-Schwerdt A, Lempe M, Schlesinger F, Hayek I, Schaarschmidt K.

J Laparoendosc Adv Surg Tech A. 2009 Apr;19 Suppl 1:S111-5. doi: 10.1089/lap.2008.0191.

PMID:
19021468
30.

Making multiple methods in evaluation work for Catholic hospitals.

Ehrensberger R, Mayer JP.

Health Prog. 2008 Sep-Oct;89(5):40-3. No abstract available.

PMID:
18814793
31.

A new combined flow-cytometry-based assay reveals excellent activity against Toxoplasma gondii and low toxicity of new bisphosphonates in vitro and in vivo.

Shubar HM, Mayer JP, Hopfenmüller W, Liesenfeld O.

J Antimicrob Chemother. 2008 May;61(5):1110-9. doi: 10.1093/jac/dkn047. Epub 2008 Feb 19.

PMID:
18285314
32.

Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents.

Gourcerol G, Coskun T, Craft LS, Mayer JP, Heiman ML, Wang L, Million M, St-Pierre DH, Taché Y.

Obesity (Silver Spring). 2007 Nov;15(11):2643-52.

33.

Melanocortin-4 receptor agonists for the treatment of obesity.

Emmerson PJ, Fisher MJ, Yan LZ, Mayer JP.

Curr Top Med Chem. 2007;7(11):1121-30. Review.

PMID:
17584132
34.

Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.

Yan LZ, Hsiung HM, Heiman ML, Gadski RA, Emmerson PJ, Hertel J, Flora D, Edwards P, Smiley D, Zhang L, Husain S, Kahl SD, DiMarchi RD, Mayer JP.

Curr Top Med Chem. 2007;7(11):1052-67. Review.

PMID:
17584126
35.

All things being equal.

Mayer JP.

Nature. 2007 May 17;447(7142):352. No abstract available.

PMID:
17549809
36.

Insulin structure and function.

Mayer JP, Zhang F, DiMarchi RD.

Biopolymers. 2007;88(5):687-713. Review.

PMID:
17410596
37.

pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity.

Kohn WD, Micanovic R, Myers SL, Vick AM, Kahl SD, Zhang L, Strifler BA, Li S, Shang J, Beals JM, Mayer JP, DiMarchi RD.

Peptides. 2007 Apr;28(4):935-48. Epub 2007 Jan 25.

PMID:
17328992
38.

The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state.

Hua QX, Mayer JP, Jia W, Zhang J, Weiss MA.

J Biol Chem. 2006 Sep 22;281(38):28131-42. Epub 2006 Jul 24.

39.

A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.

Hsiung HM, Hertel J, Zhang XY, Smith DP, Smiley DL, Heiman ML, Yang DD, Husain S, Mayer JP, Zhang L, Mo H, Yan LZ.

Endocrinology. 2005 Dec;146(12):5257-66. Epub 2005 Sep 15.

PMID:
16166226
40.

Drugging the undruggable.

Mayer JP, Dimarchi RD.

Chem Biol. 2005 Aug;12(8):860-1.

41.

Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.

Yan LZ, Flora D, Edwards P, Smiley DL, Emmerson PJ, Hsiung HM, Gadski R, Hertel J, Heiman ML, Husain S, O'Brien TP, Kahl SD, Zhang L, Dimarchi RD, Mayer JP.

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4611-4.

PMID:
16105738
42.

Discovery of a beta-MSH-derived MC-4R selective agonist.

Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ.

J Med Chem. 2005 May 5;48(9):3095-8.

PMID:
15857110
43.

Detection and control of aspartimide formation in the synthesis of cyclic peptides.

Flora D, Mo H, Mayer JP, Khan MA, Yan LZ.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1065-8.

PMID:
15686913
44.

Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.

Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC.

J Neurochem. 2004 Dec;91(6):1249-59.

45.

Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.

Richardson TI, Ornstein PL, Briner K, Fisher MJ, Backer RT, Biggers CK, Clay MP, Emmerson PJ, Hertel LW, Hsiung HM, Husain S, Kahl SD, Lee JA, Lindstrom TD, Martinelli MJ, Mayer JP, Mullaney JT, O'Brien TP, Pawlak JM, Revell KD, Shah J, Zgombick JM, Herr RJ, Melekhov A, Sampson PB, King CH.

J Med Chem. 2004 Jan 29;47(3):744-55.

PMID:
14736255
47.

Use of trichloroacetimidate linker in solid-phase Peptide synthesis.

Yan LZ, Mayer JP.

J Org Chem. 2003 Feb 7;68(3):1161-2.

PMID:
12558452
48.

Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats.

Tschöp M, Flora DB, Mayer JP, Heiman ML.

Obes Res. 2002 Oct;10(10):991-9.

49.

A polymer-bound iminophosphorane approach for the synthesis of quinazolines.

Zhang W, Mayer JP, Hall SE, Weigel JA.

J Comb Chem. 2001 May-Jun;3(3):255-6. No abstract available.

PMID:
11350248
50.

Solid-phase synthesis of C-terminal peptide hydroxamic acids.

Zhang W, Zhang L, Li X, Weigel JA, Hall SE, Mayer JP.

J Comb Chem. 2001 Mar-Apr;3(2):151-3. No abstract available.

PMID:
11300853

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