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Items: 37

1.

Identification of somatic alterations in lipoma using whole exome sequencing.

Kanojia D, Dakle P, Mayakonda A, Parameswaran R, Puhaindran ME, Min VLK, Madan V, Koeffler P.

Sci Rep. 2019 Oct 7;9(1):14370. doi: 10.1038/s41598-019-50805-w.

2.

RNA-binding protein ZFP36L1 suppresses hypoxia and cell cycle signaling.

Loh XY, Sun QY, Ding LW, Mayakonda A, Venkatachalam N, Yeo MS, Silva TC, Xiao JF, B Doan N, W Said J, Ran XB, Zhou SQ, Dakle P, Shyamsunder P, Koh AP, Huang RY, P Berman B, Tan SY, Yang H, Lin DC, Koeffler HP.

Cancer Res. 2019 Sep 24. pii: canres.2796.2018. doi: 10.1158/0008-5472.CAN-18-2796. [Epub ahead of print]

PMID:
31551365
3.

Identification of a novel enhancer of CEBPE essential for granulocytic differentiation.

Shyamsunder P, Shanmugasundaram M, Mayakonda A, Dakle P, Teoh WW, Han L, Kanojia D, Lim MC, Fullwood M, An O, Yang H, Shi J, Hossain MZ, Madan V, Koeffler HP.

Blood. 2019 Jun 6;133(23):2507-2517. doi: 10.1182/blood.2018886077. Epub 2019 Apr 5.

PMID:
30952671
4.

Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma.

Chen Y, Xu L, Mayakonda A, Huang ML, Kanojia D, Tan TZ, Dakle P, Lin RY, Ke XY, Said JW, Chen J, Gery S, Ding LW, Jiang YY, Pang A, Puhaindran ME, Goh BC, Koeffler HP.

Nat Commun. 2019 Mar 22;10(1):1353. doi: 10.1038/s41467-019-09257-z.

5.

Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice.

Han L, Madan V, Mayakonda A, Dakle P, Woon TW, Shyamsunder P, Nordin HBM, Cao Z, Sundaresan J, Lei I, Wang Z, Koeffler HP.

Leukemia. 2019 Sep;33(9):2291-2305. doi: 10.1038/s41375-019-0438-4. Epub 2019 Mar 11.

6.

Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias.

Lao ZT, Ding LW, An O, Hattori N, Sun QY, Tan KT, Mayakonda A, Chuan WG, Madan V, Lin DC, Yang H, Koeffler HP.

Haematologica. 2019 May;104(5):e200-e203. doi: 10.3324/haematol.2018.202911. Epub 2018 Dec 4. No abstract available.

7.

Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1.

Lin L, Huang M, Shi X, Mayakonda A, Hu K, Jiang YY, Guo X, Chen L, Pang B, Doan N, Said JW, Xie J, Gery S, Cheng X, Lin Z, Li J, Berman BP, Yin D, Lin DC, Koeffler HP.

Nucleic Acids Res. 2019 Feb 20;47(3):1255-1267. doi: 10.1093/nar/gky1207.

8.

Maftools: efficient and comprehensive analysis of somatic variants in cancer.

Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP.

Genome Res. 2018 Nov;28(11):1747-1756. doi: 10.1101/gr.239244.118. Epub 2018 Oct 19.

9.

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Tan KT, Ding LW, Sun QY, Lao ZT, Chien W, Ren X, Xiao JF, Loh XY, Xu L, Lill M, Mayakonda A, Lin DC, Yang H, Koeffler HP.

BMC Cancer. 2018 Oct 1;18(1):940. doi: 10.1186/s12885-018-4840-5.

10.

Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression.

Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC, Koeffler HP.

Nat Commun. 2018 Sep 6;9(1):3619. doi: 10.1038/s41467-018-06081-9.

11.

ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion.

Madan V, Han L, Hattori N, Teoh WW, Mayakonda A, Sun QY, Ding LW, Nordin HBM, Lim SL, Shyamsunder P, Dakle P, Sundaresan J, Doan NB, Sanada M, Sato-Otsubo A, Meggendorfer M, Yang H, Said JW, Ogawa S, Haferlach T, Liang DC, Shih LY, Nakamaki T, Wang QT, Koeffler HP.

Haematologica. 2018 Dec;103(12):1980-1990. doi: 10.3324/haematol.2018.189928. Epub 2018 Aug 9.

12.

ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer.

Guo X, Zhang Y, Mayakonda A, Madan V, Ding LW, Lin LH, Zia S, Gery S, Tyner JW, Zhou W, Yin D, Lin DC, Koeffler HP.

Oncogene. 2018 Nov;37(45):5939-5951. doi: 10.1038/s41388-018-0371-4. Epub 2018 Jul 6.

PMID:
29980791
13.

The c-MYC-BMI1 axis is essential for SETDB1-mediated breast tumourigenesis.

Xiao JF, Sun QY, Ding LW, Chien W, Liu XY, Mayakonda A, Jiang YY, Loh XY, Ran XB, Doan NB, Castor B, Chia D, Said JW, Tan KT, Yang H, Fu XY, Lin DC, Koeffler HP.

J Pathol. 2018 Sep;246(1):89-102. doi: 10.1002/path.5126. Epub 2018 Aug 3.

PMID:
29926931
14.

CARD10, a CEBPE target involved in granulocytic differentiation.

Shyamsunder P, Sankar H, Mayakonda A, Han L, Nordin HBM, Woon TW, Shanmugasundaram M, Dakle P, Madan V, Koeffler HP.

Haematologica. 2018 Aug;103(8):1269-1277. doi: 10.3324/haematol.2018.190280. Epub 2018 May 17.

15.

Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.

Xu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HP.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5086-E5095. doi: 10.1073/pnas.1712363115. Epub 2018 May 15.

16.

Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma.

Xie JJ, Jiang YY, Jiang Y, Li CQ, Lim MC, An O, Mayakonda A, Ding LW, Long L, Sun C, Lin LH, Chen L, Wu JY, Wu ZY, Cao Q, Fang WK, Yang W, Soukiasian H, Meltzer SJ, Yang H, Fullwood M, Xu LY, Li EM, Lin DC, Koeffler HP.

Gastroenterology. 2018 Jun;154(8):2137-2151.e1. doi: 10.1053/j.gastro.2018.02.018. Epub 2018 Feb 15.

PMID:
29454790
17.

Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma.

Yuan J, Jiang YY, Mayakonda A, Huang M, Ding LW, Lin H, Yu F, Lu Y, Loh TKS, Chow M, Savage S, Tyner JW, Lin DC, Koeffler HP.

Cancer Res. 2017 Dec 1;77(23):6614-6626. doi: 10.1158/0008-5472.CAN-17-1143. Epub 2017 Sep 26.

18.

Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.

Takao S, Chien W, Madan V, Lin DC, Ding LW, Sun QY, Mayakonda A, Sudo M, Xu L, Chen Y, Jiang YY, Gery S, Lill M, Park E, Senapedis W, Baloglu E, Müschen M, Koeffler HP.

Leukemia. 2018 Mar;32(3):616-625. doi: 10.1038/leu.2017.281. Epub 2017 Sep 14.

PMID:
28904384
19.

Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas.

Lin DC, Dinh HQ, Xie JJ, Mayakonda A, Silva TC, Jiang YY, Ding LW, He JZ, Xu XE, Hao JJ, Wang MR, Li C, Xu LY, Li EM, Berman BP, Phillip Koeffler H.

Gut. 2018 Oct;67(10):1769-1779. doi: 10.1136/gutjnl-2017-314607. Epub 2017 Aug 31.

20.

Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin.

Garg M, Kanojia D, Mayakonda A, Ganesan TS, Sadhanandhan B, Suresh S, S S, Nagare RP, Said JW, Doan NB, Ding LW, Baloglu E, Shacham S, Kauffman M, Koeffler HP.

Sci Rep. 2017 Aug 29;7(1):9749. doi: 10.1038/s41598-017-10325-x.

21.

BCL6 promotes glioma and serves as a therapeutic target.

Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-3986. doi: 10.1073/pnas.1609758114. Epub 2017 Mar 29. Erratum in: Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4317.

22.

Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma.

Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VKM, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP.

Clin Cancer Res. 2017 Aug 1;23(15):4376-4387. doi: 10.1158/1078-0432.CCR-16-2185. Epub 2017 Mar 23.

23.

Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma.

Lin DC, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman BP, Song EW, Yin D, Koeffler HP.

Cancer Res. 2017 May 1;77(9):2255-2265. doi: 10.1158/0008-5472.CAN-16-2822. Epub 2017 Feb 20.

24.

Mutational profiling of acute lymphoblastic leukemia with testicular relapse.

Ding LW, Sun QY, Mayakonda A, Tan KT, Chien W, Lin DC, Jiang YY, Xu L, Garg M, Lao ZT, Lill M, Yang H, Yeoh AE, Koeffler HP.

J Hematol Oncol. 2017 Mar 2;10(1):65. doi: 10.1186/s13045-017-0434-y.

25.

Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma.

Garg M, Kanojia D, Mayakonda A, Said JW, Doan NB, Chien W, Ganesan TS, Chuang LS, Venkatachalam N, Baloglu E, Shacham S, Kauffman M, Koeffler HP.

Oncotarget. 2017 Jan 31;8(5):7521-7532. doi: 10.18632/oncotarget.13485.

26.

Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD.

Chien W, Sun QY, Ding LW, Mayakonda A, Takao S, Liu L, Lim SL, Tan KT, Garg M, De Sousa Maria Varela A, Xiao J, Jacob N, Behrens K, Stocking C, Lill M, Madan V, Hattori N, Gery S, Ogawa S, Wakita S, Ikezoe T, Shih LY, Alpermann T, Haferlach T, Yang H, Koeffler HP.

Leukemia. 2017 Mar;31(3):762-766. doi: 10.1038/leu.2016.343. Epub 2016 Nov 24. No abstract available.

PMID:
27881871
27.

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.

Ding LW, Sun QY, Tan KT, Chien W, Mayakonda A, Yeoh AEJ, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Jiang YY, Xu L, Lim SL, Liu LZ, Madan V, Sanada M, Fernández LT, Hema Preethi SS, Lill M, Kantarjian HM, Kornblau SM, Miyano S, Liang DC, Ogawa S, Shih LY, Yang H, Koeffler HP.

Cancer Res. 2017 Jan 15;77(2):390-400. doi: 10.1158/0008-5472.CAN-16-1303. Epub 2016 Nov 21. Erratum in: Cancer Res. 2017 Apr 15;77(8):2174.

28.

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.

Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, Koeffler HP.

Oncogene. 2017 Apr 20;36(16):2243-2254. doi: 10.1038/onc.2016.377. Epub 2016 Nov 7.

29.

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma.

Hao JJ, Lin DC, Dinh HQ, Mayakonda A, Jiang YY, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ, Berman BP, Wang MR, Koeffler HP.

Nat Genet. 2016 Dec;48(12):1500-1507. doi: 10.1038/ng.3683. Epub 2016 Oct 17.

30.

Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency.

Ding LW, Ikezoe T, Tan KT, Mori M, Mayakonda A, Chien W, Lin DC, Jiang YY, Lill M, Yang H, Sun QY, Koeffler HP.

Leukemia. 2017 Jan;31(1):244-245. doi: 10.1038/leu.2016.256. Epub 2016 Sep 29. No abstract available.

31.

Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.

Madan V, Shyamsunder P, Han L, Mayakonda A, Nagata Y, Sundaresan J, Kanojia D, Yoshida K, Ganesan S, Hattori N, Fulton N, Tan KT, Alpermann T, Kuo MC, Rostami S, Matthews J, Sanada M, Liu LZ, Shiraishi Y, Miyano S, Chendamarai E, Hou HA, Malnassy G, Ma T, Garg M, Ding LW, Sun QY, Chien W, Ikezoe T, Lill M, Biondi A, Larson RA, Powell BL, Lübbert M, Chng WJ, Tien HF, Heuser M, Ganser A, Koren-Michowitz M, Kornblau SM, Kantarjian HM, Nowak D, Hofmann WK, Yang H, Stock W, Ghavamzadeh A, Alimoghaddam K, Haferlach T, Ogawa S, Shih LY, Mathews V, Koeffler HP.

Leukemia. 2016 Dec;30(12):2430. doi: 10.1038/leu.2016.237. Epub 2016 Oct 7. No abstract available.

PMID:
27713533
32.

Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD).

Sun QY, Ding LW, Tan KT, Chien W, Mayakonda A, Lin DC, Loh XY, Xiao JF, Meggendorfer M, Alpermann T, Garg M, Lim SL, Madan V, Hattori N, Nagata Y, Miyano S, Yeoh AE, Hou HA, Jiang YY, Takao S, Liu LZ, Tan SZ, Lill M, Hayashi M, Kinoshita A, Kantarjian HM, Kornblau SM, Ogawa S, Haferlach T, Yang H, Koeffler HP.

Leukemia. 2017 Jan;31(1):1-10. doi: 10.1038/leu.2016.160. Epub 2016 Jun 8.

33.

Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma.

Jiang YY, Lin DC, Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR, Koeffler HP.

Gut. 2017 Aug;66(8):1358-1368. doi: 10.1136/gutjnl-2016-311818. Epub 2016 May 10.

34.

Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.

Madan V, Shyamsunder P, Han L, Mayakonda A, Nagata Y, Sundaresan J, Kanojia D, Yoshida K, Ganesan S, Hattori N, Fulton N, Tan KT, Alpermann T, Kuo MC, Rostami S, Matthews J, Sanada M, Liu LZ, Shiraishi Y, Miyano S, Chendamarai E, Hou HA, Malnassy G, Ma T, Garg M, Ding LW, Sun QY, Chien W, Ikezoe T, Lill M, Biondi A, Larson RA, Powell BL, Lübbert M, Chng WJ, Tien HF, Heuser M, Ganser A, Koren-Michowitz M, Kornblau SM, Kantarjian HM, Nowak D, Hofmann WK, Yang H, Stock W, Ghavamzadeh A, Alimoghaddam K, Haferlach T, Ogawa S, Shih LY, Mathews V, Koeffler HP.

Leukemia. 2016 Aug;30(8):1672-81. doi: 10.1038/leu.2016.69. Epub 2016 Apr 11. Erratum in: Leukemia. 2016 Dec;30(12 ):2430.

35.

CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling.

Sun H, Lin DC, Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, Mayakonda A, Thomas T, Forscher C, Baloglu E, Shacham S, Rajalingam R, Koeffler HP.

Cancer Res. 2016 May 1;76(9):2687-97. doi: 10.1158/0008-5472.CAN-15-1572. Epub 2016 Mar 8.

36.

Genomic landscape of liposarcoma.

Kanojia D, Nagata Y, Garg M, Lee DH, Sato A, Yoshida K, Sato Y, Sanada M, Mayakonda A, Bartenhagen C, Klein HU, Doan NB, Said JW, Mohith S, Gunasekar S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Myklebost O, Yang H, Dugas M, Meza-Zepeda LA, Silberman AW, Forscher C, Tyner JW, Ogawa S, Koeffler HP.

Oncotarget. 2015 Dec 15;6(40):42429-44. doi: 10.18632/oncotarget.6464.

37.

Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.

Garg M, Nagata Y, Kanojia D, Mayakonda A, Yoshida K, Haridas Keloth S, Zang ZJ, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ding LW, Alpermann T, Sun QY, Lin DC, Chien W, Madan V, Liu LZ, Tan KT, Sampath A, Venkatesan S, Inokuchi K, Wakita S, Yamaguchi H, Chng WJ, Kham SK, Yeoh AE, Sanada M, Schiller J, Kreuzer KA, Kornblau SM, Kantarjian HM, Haferlach T, Lill M, Kuo MC, Shih LY, Blau IW, Blau O, Yang H, Ogawa S, Koeffler HP.

Blood. 2015 Nov 26;126(22):2491-501. doi: 10.1182/blood-2015-05-646240. Epub 2015 Oct 5.

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