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Application of Cytokines of the Bone Morphogenetic Protein (BMP) Family in Spinal Fusion - Effects on the Bone, Intervertebral Discs, and Mesenchymal Stromal Cells.

May RD, Frauchiger DA, Albers CE, Tekari A, Benneker LM, Klenke FM, Hofstetter W, Gantenbein B.

Curr Stem Cell Res Ther. 2019 Jun 27. doi: 10.2174/1574888X14666190628103528. [Epub ahead of print]


Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum.

Ghebre MA, Pang PH, Desai D, Hargadon B, Newby C, Woods J, Rapley L, Cohen SE, Herath A, Gaillard EA, May RD, Brightling CE.

BMC Pulm Med. 2019 Aug 8;19(1):144. doi: 10.1186/s12890-019-0906-7.


Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods.

Frauchiger DA, Tekari A, May RD, Džafo E, Chan SCW, Stoyanov J, Bertolo A, Zhang X, Guerrero J, Sakai D, Schol J, Grad S, Tryfonidou M, Benneker LM, Gantenbein B.

Tissue Eng Part C Methods. 2019 Sep 9. doi: 10.1089/ten.TEC.2018.0375. [Epub ahead of print]


Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species.

Sakai D, Schol J, Bach FC, Tekari A, Sagawa N, Nakamura Y, Chan SCW, Nakai T, Creemers LB, Frauchiger DA, May RD, Grad S, Watanabe M, Tryfonidou MA, Gantenbein B.

JOR Spine. 2018 Jun 27;1(2):e1018. doi: 10.1002/jsp2.1018. eCollection 2018 Jun.


Genipin-Enhanced Fibrin Hydrogel and Novel Silk for Intervertebral Disc Repair in a Loaded Bovine Organ Culture Model.

Frauchiger DA, May RD, Bakirci E, Tekari A, Chan SCW, Wöltje M, Benneker LM, Gantenbein B.

J Funct Biomater. 2018 Jun 24;9(3). pii: E40. doi: 10.3390/jfb9030040.


Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles.

Ghebre MA, Pang PH, Diver S, Desai D, Bafadhel M, Haldar K, Kebadze T, Cohen S, Newbold P, Rapley L, Woods J, Rugman P, Pavord ID, Johnston SL, Barer M, May RD, Brightling CE.

J Allergy Clin Immunol. 2018 Jun;141(6):2027-2036.e12. doi: 10.1016/j.jaci.2018.04.013. Epub 2018 Apr 28.


Inhibitory Effects of Human Primary Intervertebral Disc Cells on Human Primary Osteoblasts in a Co-Culture System.

May RD, Frauchiger DA, Albers CE, Benneker LM, Kohl S, Gantenbein B.

Int J Mol Sci. 2018 Apr 13;19(4). pii: E1195. doi: 10.3390/ijms19041195.


Serum biomarker profiles suggest that atopic dermatitis is a systemic disease.

Thijs JL, Strickland I, Bruijnzeel-Koomen CAFM, Nierkens S, Giovannone B, Knol EF, Csomor E, Sellman BR, Mustelin T, Sleeman MA, de Bruin-Weller MS, Herath A, Drylewicz J, May RD, Hijnen D.

J Allergy Clin Immunol. 2018 Apr;141(4):1523-1526. doi: 10.1016/j.jaci.2017.12.991. Epub 2018 Feb 2. No abstract available.


IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells.

Camelo A, Rosignoli G, Ohne Y, Stewart RA, Overed-Sayer C, Sleeman MA, May RD.

Blood Adv. 2017 Mar 30;1(10):577-589. doi: 10.1182/bloodadvances.2016002352. eCollection 2017 Apr 11.


Differentiation of MSC and annulus fibrosus cells on genetically engineered silk fleece-membrane-composites enriched for GDF-6 or TGF-β3.

Frauchiger DA, Heeb SR, May RD, Wöltje M, Benneker LM, Gantenbein B.

J Orthop Res. 2018 May;36(5):1324-1333. doi: 10.1002/jor.23778. Epub 2017 Nov 22.


EASI p-EASI: Utilizing a combination of serum biomarkers offers an objective measurement tool for disease severity in atopic dermatitis patients.

Thijs JL, Drylewicz J, Fiechter R, Strickland I, Sleeman MA, Herath A, May RD, Bruijnzeel-Koomen CAFM, Knol EF, Giovannone B, de Bruin-Weller MS, Nierkens S, Hijnen DJ.

J Allergy Clin Immunol. 2017 Dec;140(6):1703-1705. doi: 10.1016/j.jaci.2017.06.046. Epub 2017 Aug 16. No abstract available.


Biologic response of human anterior cruciate ligamentocytes on collagen-patches to platelet-rich plasma formulations with and without leucocytes.

Krismer AM, Cabra RS, May RD, Frauchiger DA, Kohl S, Ahmad SS, Gantenbein B.

J Orthop Res. 2017 Dec;35(12):2733-2739. doi: 10.1002/jor.23599. Epub 2017 May 30.


Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis.

Thijs JL, Strickland I, Bruijnzeel-Koomen CAFM, Nierkens S, Giovannone B, Csomor E, Sellman BR, Mustelin T, Sleeman MA, de Bruin-Weller MS, Herath A, Drylewicz J, May RD, Hijnen D.

J Allergy Clin Immunol. 2017 Sep;140(3):730-737. doi: 10.1016/j.jaci.2017.03.023. Epub 2017 Apr 13. Erratum in: J Allergy Clin Immunol. 2018 Aug;142(2):714.


The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells.

Tekari A, May RD, Frauchiger DA, Chan SC, Benneker LM, Gantenbein B.

Eur Cell Mater. 2017 Feb 23;33:197-210. doi: 10.22203/eCM.v033a15.


Efficient Nonviral Transfection of Primary Intervertebral Disc Cells by Electroporation for Tissue Engineering Application.

May RD, Tekari A, Frauchiger DA, Krismer A, Benneker LM, Gantenbein B.

Tissue Eng Part C Methods. 2017 Jan;23(1):30-37. doi: 10.1089/ten.TEC.2016.0355. Epub 2016 Dec 27.


Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2.

Popovic B, Breed J, Rees DG, Gardener MJ, Vinall LM, Kemp B, Spooner J, Keen J, Minter R, Uddin F, Colice G, Wilkinson T, Vaughan T, May RD.

J Mol Biol. 2017 Jan 20;429(2):208-219. doi: 10.1016/j.jmb.2016.12.005. Epub 2016 Dec 9.


The complex biology and contribution of Staphylococcus aureus in atopic dermatitis, current and future therapies.

Hepburn L, Hijnen DJ, Sellman BR, Mustelin T, Sleeman MA, May RD, Strickland I.

Br J Dermatol. 2017 Jul;177(1):63-71. doi: 10.1111/bjd.15139. Epub 2017 Jun 11. Review.


Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.

Cohen ES, Scott IC, Majithiya JB, Rapley L, Kemp BP, England E, Rees DG, Overed-Sayer CL, Woods J, Bond NJ, Veyssier CS, Embrey KJ, Sims DA, Snaith MR, Vousden KA, Strain MD, Chan DT, Carmen S, Huntington CE, Flavell L, Xu J, Popovic B, Brightling CE, Vaughan TJ, Butler R, Lowe DC, Higazi DR, Corkill DJ, May RD, Sleeman MA, Mustelin T.

Nat Commun. 2015 Sep 14;6:8327. doi: 10.1038/ncomms9327.


Strategies targeting the IL-4/IL-13 axes in disease.

May RD, Fung M.

Cytokine. 2015 Sep;75(1):89-116. Review.


Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial.

Brightling CE, Chanez P, Leigh R, O'Byrne PM, Korn S, She D, May RD, Streicher K, Ranade K, Piper E.

Lancet Respir Med. 2015 Sep;3(9):692-701. doi: 10.1016/S2213-2600(15)00197-6. Epub 2015 Jul 28.


Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease.

Ghebre MA, Bafadhel M, Desai D, Cohen SE, Newbold P, Rapley L, Woods J, Rugman P, Pavord ID, Newby C, Burton PR, May RD, Brightling CE.

J Allergy Clin Immunol. 2015 Jan;135(1):63-72. doi: 10.1016/j.jaci.2014.06.035. Epub 2014 Aug 13.


A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma.

Cohen ES, Dobson CL, Käck H, Wang B, Sims DA, Lloyd CO, England E, Rees DG, Guo H, Karagiannis SN, O'Brien S, Persdotter S, Ekdahl H, Butler R, Keyes F, Oakley S, Carlsson M, Briend E, Wilkinson T, Anderson IK, Monk PD, von Wachenfeldt K, Eriksson PO, Gould HJ, Vaughan TJ, May RD.

MAbs. 2014 May-Jun;6(3):756-64. doi: 10.4161/mabs.28394. Epub 2014 Feb 28.


Development of a mouse model mimicking key aspects of a viral asthma exacerbation.

Clarke DL, Davis NH, Majithiya JB, Piper SC, Lewis A, Sleeman MA, Corkill DJ, May RD.

Clin Sci (Lond). 2014 Apr;126(8):567-80. doi: 10.1042/CS20130149.


Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation.

Clarke DL, Davis NH, Campion CL, Foster ML, Heasman SC, Lewis AR, Anderson IK, Corkill DJ, Sleeman MA, May RD, Robinson MJ.

Mucosal Immunol. 2014 May;7(3):558-67. doi: 10.1038/mi.2013.74. Epub 2013 Oct 16.


Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.

Desai D, Newby C, Symon FA, Haldar P, Shah S, Gupta S, Bafadhel M, Singapuri A, Siddiqui S, Woods J, Herath A, Anderson IK, Bradding P, Green R, Kulkarni N, Pavord I, Marshall RP, Sousa AR, May RD, Wardlaw AJ, Brightling CE.

Am J Respir Crit Care Med. 2013 Sep 15;188(6):657-63. doi: 10.1164/rccm.201208-1470OC.


A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma.

Piper E, Brightling C, Niven R, Oh C, Faggioni R, Poon K, She D, Kell C, May RD, Geba GP, Molfino NA.

Eur Respir J. 2013 Feb;41(2):330-8. doi: 10.1183/09031936.00223411. Epub 2012 Jun 27.


Distinct roles for S100a8 in early embryo development and in the maternal deciduum.

Baker JR, Jeffery R, May RD, Mathies M, Spencer-Dene B, Poulsom R, Hogg N.

Dev Dyn. 2011 Sep;240(9):2194-203. doi: 10.1002/dvdy.22709.


Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma.

May RD, Monk PD, Cohen ES, Manuel D, Dempsey F, Davis NH, Dodd AJ, Corkill DJ, Woods J, Joberty-Candotti C, Conroy LA, Koentgen F, Martin EC, Wilson R, Brennan N, Powell J, Anderson IK.

Br J Pharmacol. 2012 May;166(1):177-93. doi: 10.1111/j.1476-5381.2011.01659.x.


Quantum-cascade laser measurements of stratospheric methane and nitrous oxide.

Webster CR, Flesch GJ, Scott DC, Swanson JE, May RD, Woodward WS, Gmachl C, Capasso F, Sivco DL, Baillargeon JN, Hutchinson AL, Cho AY.

Appl Opt. 2001 Jan 20;40(3):321-6.


Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma.

Hadjicharalambous C, Dent G, May RD, Handy RL, Anderson IK, Davies DE, Djukanovic R.

J Allergy Clin Immunol. 2004 Apr;113(4):657-62.


Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100.

Marciani DJ, Reynolds RC, Pathak AK, Finley-Woodman K, May RD.

Vaccine. 2003 Sep 8;21(25-26):3961-71.


Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine.

Marcian DJ, Ptak RG, Voss TG, Reynolds RC, Pathak AK, Chamblin TL, Scholl DR, May RD.

Int Immunopharmacol. 2002 Nov;2(12):1703-11. Erratum in: Int Immunopharmacol. 2005 Oct;5(11):1658.


Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins.

Marciani DJ, Pathak AK, Reynolds RC, Seitz L, May RD.

Int Immunopharmacol. 2001 Apr;1(4):813-8.


Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity.

Marciani DJ, Press JB, Reynolds RC, Pathak AK, Pathak V, Gundy LE, Farmer JT, Koratich MS, May RD.

Vaccine. 2000 Jul 15;18(27):3141-51.


Hydrogen radicals, nitrogen radicals, and the production of O3 in the upper troposphere

Wennberg PO, Hanisco TF, Jaegle L, Jacob DJ, Hintsa EJ, Lanzendorf EJ, Anderson JG, Gao R, Keim ER, Donnelly SG, Negro LAD, Fahey DW, McKeen SA, Salawitch RJ, Webster CR, May RD, Herman RL, Proffitt MH, Margitan JJ, Atlas EL, Schauffler SM, Flocke F, McElroy CT, Bui TP.

Science. 1998 Jan 2;279(5347):49-53.


Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro.

Erickson-Miller CL, May RD, Tomaszewski J, Osborn B, Murphy MJ, Page JG, Parchment RE.

Cancer Chemother Pharmacol. 1997;39(5):467-72.


Carcinogenicity of 2',3'-dideoxycytidine in mice.

Rao GN, Collins BJ, Giles HD, Heath JE, Foley JF, May RD, Buckley LA.

Cancer Res. 1996 Oct 15;56(20):4666-72.


Removal of Stratospheric O3 by Radicals: In Situ Measurements of OH, HO2, NO, NO2, ClO, and BrO.

Wennberg PO, Cohen RC, Stimpfle RM, Koplow JP, Anderson JG, Salawitch RJ, Fahey DW, Woodbridge EL, Keim ER, Gao RS, Webster CR, May RD, Toohey DW, Avallone LM, Proffitt MH, Loewenstein M, Podolske JR, Chan KR, Wofsy SC.

Science. 1994 Oct 21;266(5184):398-404.


Aircraft (ER-2) laser infrared absorption spectrometer (ALIAS) for in-situ stratospheric measurements of HCI, N(2)O, CH(4), NO(2), and HNO(3).

Webster CR, May RD, Trimble CA, Chave RG, Kendall J.

Appl Opt. 1994 Jan 20;33(3):454-72. doi: 10.1364/AO.33.000454.


Chemical loss of ozone in the arctic polar vortex in the winter of 1991-1992.

Salawitch RJ, Wofsy SC, Gottlieb EW, Lait LR, Newman PA, Schoeberl MR, Loewenstein M, Podolske JR, Strahan SE, Proffitt MH, Webster CR, May RD, Fahey DW, Baumgardner D, Dye JE, Wilson JC, Kelly KK, Elkins JW, Chan KR, Anderson JG.

Science. 1993 Aug 27;261(5125):1146-9.


Chlorine chemistry on polar stratospheric cloud particles in the arctic winter.

Webster CR, May RD, Toohey DW, Avallone LM, Anderson JG, Newman P, Lait L, Schoeberl MR, Elkins JW, Chan KR.

Science. 1993 Aug 27;261(5125):1130-4.


Cancer dormancy: studies of the murine BCL1 lymphoma.

Uhr JW, Tucker T, May RD, Siu H, Vitetta ES.

Cancer Res. 1991 Sep 15;51(18 Suppl):5045s-5053s.


Balloon-borne laser spectrometer measurements of NO(2) with gas absorption sensitivities below 10(-5).

May RD, Webster CR.

Appl Opt. 1990 Dec 1;29(34):5042-5. doi: 10.1364/AO.29.005042. No abstract available.


Tunable diode laser IR spectrometer for in situ measurements of the gas phase composition and particle size distribution of Titan's atmosphere.

Webster CR, Sander SP, Beer R, May RD, Knollenberg RG, Hunten DM, Ballard J.

Appl Opt. 1990 Mar 1;29(7):907-17. doi: 10.1364/AO.29.000907.


Immunoconjugates containing ricin A chain and either human anti-gp41 or CD4 kill H9 cells infected with different isolates of HIV, but do not inhibit normal T or B cell function.

Till MA, Ghetie V, May RD, Auerbach PC, Zolla-Pazner S, Gorny MK, Gregory T, Uhr JW, Vitetta ES.

J Acquir Immune Defic Syndr. 1990;3(6):609-14.


Frequency stability of a tunable diode laser mounted in a compact Stirling cycle cooler.

Durso SS, May RD, Tuchscherer MA, Webster CR.

Appl Opt. 1989 Sep 15;28(18):3791-2. doi: 10.1364/AO.28.003791.


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