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Periprocedural Bivalirudin Versus Unfractionated Heparin During Percutaneous Coronary Intervention Following Fibrinolysis for ST-Segment Elevation Myocardial Infarction.

Rashid MK, Singh K, Bernick J, Wells GA, Hibbert B, Russo J, So DY, Le May MR; CAPITAL PCI Group.

J Invasive Cardiol. 2019 Dec;31(12):E387-E391.


A Bayesian Approach for Inferring the Impact of a Discrete Character on Rates of Continuous-Character Evolution in the Presence of Background-Rate Variation.

May MR, Moore BR.

Syst Biol. 2019 Oct 29. pii: syz069. doi: 10.1093/sysbio/syz069. [Epub ahead of print]


Optimal mean arterial pressure in comatose survivors of out-of-hospital cardiac arrest: An analysis of area below blood pressure thresholds.

Russo JJ, Di Santo P, Simard T, James TE, Hibbert B, Couture E, Marbach J, Osborne C, Ramirez FD, Wells GA, Labinaz M, Le May MR; from the CAPITAL study group.

Resuscitation. 2018 Jul;128:175-180. doi: 10.1016/j.resuscitation.2018.04.028. Epub 2018 Apr 22.


Immediate non-culprit vessel percutaneous coronary intervention (PCI) in patients with acute myocardial infarction and cardiogenic shock: a swinging pendulum.

Russo JJ, Bagai A, Le May MR, Yan AT.

J Thorac Dis. 2018 Feb;10(2):661-666. doi: 10.21037/jtd.2018.01.106. No abstract available.


Marital status and outcomes after myocardial infarction: Observations from the Canadian Observational Antiplatelet Study (COAPT).

Ghosh-Swaby OR, Tan M, Bagai A, Yan AT, Goodman SG, Mehta SR, Fisher HN, Cohen EA, Huynh T, Cantor WJ, Le May MR, Déry JP, Welsh RC, Udell JA.

Clin Cardiol. 2018 Mar;41(3):285-292. doi: 10.1002/clc.22901. Epub 2018 Mar 25.


Rapid Global Spread of wRi-like Wolbachia across Multiple Drosophila.

Turelli M, Cooper BS, Richardson KM, Ginsberg PS, Peckenpaugh B, Antelope CX, Kim KJ, May MR, Abrieux A, Wilson DA, Bronski MJ, Moore BR, Gao JJ, Eisen MB, Chiu JC, Conner WR, Hoffmann AA.

Curr Biol. 2018 Mar 19;28(6):963-971.e8. doi: 10.1016/j.cub.2018.02.015. Epub 2018 Mar 8.


Improved maize reference genome with single-molecule technologies.

Jiao Y, Peluso P, Shi J, Liang T, Stitzer MC, Wang B, Campbell MS, Stein JC, Wei X, Chin CS, Guill K, Regulski M, Kumari S, Olson A, Gent J, Schneider KL, Wolfgruber TK, May MR, Springer NM, Antoniou E, McCombie WR, Presting GG, McMullen M, Ross-Ibarra J, Dawe RK, Hastie A, Rank DR, Ware D.

Nature. 2017 Jun 22;546(7659):524-527. doi: 10.1038/nature22971. Epub 2017 Jun 12.


Time to Treatment: Focus on Transfer in ST-Elevation Myocardial Infarction.

Russo J, Le May MR.

Interv Cardiol Clin. 2016 Oct;5(4):427-437. doi: 10.1016/j.iccl.2016.06.003. Epub 2016 Sep 8. Review.


Unraveling the Radial Paradox.

Le May MR, Wells GA.

Circ Cardiovasc Interv. 2017 Feb;10(2):e004865. doi: 10.1161/CIRCINTERVENTIONS.117.004865. No abstract available.


Impact of mean arterial pressure on clinical outcomes in comatose survivors of out-of-hospital cardiac arrest: Insights from the University of Ottawa Heart Institute Regional Cardiac Arrest Registry (CAPITAL-CARe).

Russo JJ, James TE, Hibbert B, Yousef A, Osborne C, Wells GA, Froeschl MP, So DY, Chong AY, Labinaz M, Glover CA, Marquis JF, Dick A, Bernick J, Le May MR.

Resuscitation. 2017 Apr;113:27-32. doi: 10.1016/j.resuscitation.2017.01.007. Epub 2017 Jan 18.


A Woman in Her 80s With Anterior ST-Elevation Myocardial Infarction and Shock.

Motazedian P, Le May MR, Glover C, Hibbert B.

Chest. 2017 Jan;151(1):e5-e8. doi: 10.1016/j.chest.2016.05.040. No abstract available.


Hyperglycaemia in comatose survivors of out-of-hospital cardiac arrest.

Russo JJ, James TE, Hibbert B, Ramirez FD, Simard T, Osborne C, Bernick J, Wells GA, Le May MR; CAPITAL Investigators.

Eur Heart J Acute Cardiovasc Care. 2018 Aug;7(5):442-449. doi: 10.1177/2048872616684685. Epub 2017 Jan 3.


Sealing Intermediate Nonobstructive Coronary Saphenous Vein Graft Lesions With Drug-Eluting Stents as a New Approach to Reducing Cardiac Events: A Randomized Controlled Trial.

Rodés-Cabau J, Jolly SS, Cairns J, Mansour S, L'Allier PL, Teefy PJ, Graham JJ, Le May MR, Cantor WJ, Wood D, Balasubramanian K, DeLarochellière R, Dzavik V; VELETI II Investigators (Sealing Moderate Coronary Saphenous Vein Graft Lesions With Paclitaxel-Eluting Stents).

Circ Cardiovasc Interv. 2016 Nov;9(11). pii: e004336.


A randomised study for optimising crossover from ticagrelor to clopidogrel in patients with acute coronary syndrome. The CAPITAL OPTI-CROSS Study.

Pourdjabbar A, Hibbert B, Chong AY, Le May MR, Labinaz M, Simard T, Ramirez FD, Lugomirski P, Maze R, Froeschl M, Glover C, Dick A, Marquis JF, Bernick J, Wells G, So DY; CAPITAL Investigators.

Thromb Haemost. 2017 Jan 26;117(2):303-310. doi: 10.1160/TH16-04-0340. Epub 2016 Oct 20.


Safety and Efficacy of a Pharmacoinvasive Strategy in ST-Segment Elevation Myocardial Infarction: A Patient Population Study Comparing a Pharmacoinvasive Strategy With a Primary Percutaneous Coronary Intervention Strategy Within a Regional System.

Rashid MK, Guron N, Bernick J, Wells GA, Blondeau M, Chong AY, Dick A, Froeschl MP, Glover CA, Hibbert B, Labinaz M, Marquis JF, Osborne C, So DY, Le May MR.

JACC Cardiovasc Interv. 2016 Oct 10;9(19):2014-2020. doi: 10.1016/j.jcin.2016.07.004.


Critically evaluating the theory and performance of Bayesian analysis of macroevolutionary mixtures.

Moore BR, Höhna S, May MR, Rannala B, Huelsenbeck JP.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9569-74. doi: 10.1073/pnas.1518659113. Epub 2016 Aug 10.


Impact of Center Experience on Patient Radiation Exposure During Transradial Coronary Angiography and Percutaneous Intervention: A Patient-Level, International, Collaborative, Multi-Center Analysis.

Simard T, Hibbert B, Natarajan MK, Mercuri M, Hetherington SL, Wright R, Delewi R, Piek JJ, Lehmann R, Ruzsa Z, Lange HW, Geijer H, Sandborg M, Kansal V, Bernick J, Di Santo P, Pourdjabbar A, Ramirez FD, Chow BJ, Chong AY, Labinaz M, Le May MR, O'Brien ER, Wells GA, So D.

J Am Heart Assoc. 2016 May 31;5(6). pii: e003333. doi: 10.1161/JAHA.116.003333.


Reply: Radial Versus Femoral: Issues Remain and Questions Need Answers.

Le May MR, Singh K, Wells GA.

JACC Cardiovasc Interv. 2016 May 9;9(9):979-80. doi: 10.1016/j.jcin.2016.03.001. No abstract available.


Radial versus femoral access for percutaneous coronary intervention in ST-elevation myocardial infarction patients treated with fibrinolysis: Results from the randomized routine early invasive clinical trials.

Graham JJ, Yan AT, Tan MK, Cantor WJ, DiMario C, Jolly SS, Halvorsen S, Fernandez-Aviles F, Le May MR, Scheller B, Borgia F, Piscione F, Madan M, Goodman SG.

Cardiovasc Revasc Med. 2016 Jul-Aug;17(5):295-301. doi: 10.1016/j.carrev.2016.03.008. Epub 2016 Mar 28.


A pharmacodynamic analysis for the co-administration of inducers of CYP3A with ticagrelor: A cautionary tale in managing patients with acute coronary syndromes.

Pourdjabbar A, Hibbert B, Chong AY, Abunassar J, Malhotra N, Whitten TA, Le May MR, So DY; CAPITAL investigators.

Int J Cardiol. 2016 Jul 1;214:423-5. doi: 10.1016/j.ijcard.2016.03.153. Epub 2016 Mar 24. No abstract available.


Does stent strut design impact clinical outcomes: comparative safety and efficacy of Endeavor Resolute versus Resolute Integrity zotarolimus-eluting stents.

Di Santo P, Simard T, Ramirez FD, Pourdjabbar A, Harnett DT, Singh K, Moreland R, Chong AY, Dick A, Labinaz M, Froeschl M, Froeschl M, Le May MR, So DY, Hibbert B.

Clin Invest Med. 2015 Oct 7;38(5):E296-304.


TESS: an R package for efficiently simulating phylogenetic trees and performing Bayesian inference of lineage diversification rates.

Höhna S, May MR, Moore BR.

Bioinformatics. 2016 Mar 1;32(5):789-91. doi: 10.1093/bioinformatics/btv651. Epub 2015 Nov 4.


Efficacy of Radial Versus Femoral Access in the Acute Coronary Syndrome: Is it the Operator or the Operation That Matters?

Le May MR, Singh K, Wells GA.

JACC Cardiovasc Interv. 2015 Sep;8(11):1405-9. doi: 10.1016/j.jcin.2015.06.016. Review.


Percutaneous coronary intervention with RACER renal stents in very large diameter coronary arteries.

Harnett DT, Maze R, Pourdjabbar A, Ramirez FD, Simard T, Di Santo P, Gallagher S, Singh K, So D, Le May MR, Labinaz M, Hibbert B, Chong AY, Glover C; CAPITAL investigators.

Int J Cardiol. 2015 Dec 15;201:342-4. doi: 10.1016/j.ijcard.2015.03.007. Epub 2015 Mar 3. No abstract available.


Safety and Efficacy of Staged Percutaneous Coronary Intervention During Index Admission for ST-Elevation Myocardial Infarction With Multivessel Coronary Disease (Insights from the University of Ottawa Heart Institute STEMI Registry).

Russo JJ, Wells GA, Chong AY, So DY, Glover CA, Froeschl MP, Hibbert B, Marquis JF, Dick A, Blondeau M, Bernick J, Labinaz M, Le May MR; CAPITAL Investigators.

Am J Cardiol. 2015 Oct 15;116(8):1157-62. doi: 10.1016/j.amjcard.2015.07.029. Epub 2015 Jul 29.


Consistency of benefit from an early invasive strategy after fibrinolysis: a patient-level meta-analysis.

Abdel-Qadir H, Yan AT, Tan M, Borgia F, Piscione F, Di Mario C, Halvorsen S, Cantor WJ, Westerhout CM, Scheller B, Le May MR, Fernandez-Aviles F, Sánchez PL, Lee DS, Goodman SG.

Heart. 2015 Oct;101(19):1554-61. doi: 10.1136/heartjnl-2015-307815. Epub 2015 Jul 14.


Reperfusion Times for Radial Versus Femoral Access in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Observations From the Cardiac Care Network Provincial Primary PCI Registry.

Cantor WJ, Ko DT, Natarajan MK, Džavík V, Wijeysundera HC, Wang JT, Kingsbury KJ, Velianou JL, Cohen EA, Le May MR, Tu JV.

Circ Cardiovasc Interv. 2015 May;8(5). pii: e002097. doi: 10.1161/CIRCINTERVENTIONS.114.002097.


A prospective randomized evaluation of a pharmacogenomic approach to antiplatelet therapy among patients with ST-elevation myocardial infarction: the RAPID STEMI study.

So DY, Wells GA, McPherson R, Labinaz M, Le May MR, Glover C, Dick AJ, Froeschl M, Marquis JF, Gollob MH, Tran L, Bernick J, Hibbert B, Roberts JD.

Pharmacogenomics J. 2016 Feb;16(1):71-8. doi: 10.1038/tpj.2015.17. Epub 2015 Apr 7.


Relationship between time to invasive assessment and clinical outcomes of patients undergoing an early invasive strategy after fibrinolysis for ST-segment elevation myocardial infarction: a patient-level analysis of the randomized early routine invasive clinical trials.

Madan M, Halvorsen S, Di Mario C, Tan M, Westerhout CM, Cantor WJ, Le May MR, Borgia F, Piscione F, Scheller B, Armstrong PW, Fernandez-Aviles F, Sanchez PL, Graham JJ, Yan AT, Goodman SG.

JACC Cardiovasc Interv. 2015 Jan;8(1 Pt B):166-174. doi: 10.1016/j.jcin.2014.09.005. Epub 2014 Oct 31.


Prophylactic warfarin therapy after primary percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction.

Le May MR, Acharya S, Wells GA, Burwash I, Chong AY, So DY, Glover CA, Froeschl MPV, Hibbert B, Marquis JF, Dick A, Blondeau M, Bernick J, Labinaz M.

JACC Cardiovasc Interv. 2015 Jan;8(1 Pt B):155-162. doi: 10.1016/j.jcin.2014.07.018. Epub 2014 Oct 30.


Superiority of ticagrelor over clopidogrel in patients after cardiac arrest undergoing therapeutic hypothermia.

Moudgil R, Al-Turbak H, Osborne C, Hibbert B, So DY, Le May MR; CAPITAL Investigators.

Can J Cardiol. 2014 Nov;30(11):1396-9. doi: 10.1016/j.cjca.2014.07.745. Epub 2014 Aug 15.


Routine invasive management early after fibrinolysis: relationship between baseline risk and treatment effects in a pooled patient-level analysis of 7 randomized controlled trials.

Bagai A, Tan M, Di Mario C, Halvorsen S, Cantor WJ, Le May MR, Fernandez-Aviles F, Scheller B, Armstrong PW, Borgia F, Piscione F, Sánchez PL, Westerhout CM, Goodman SG, Yan AT.

Am Heart J. 2014 Nov;168(5):757-65. doi: 10.1016/j.ahj.2014.07.027. Epub 2014 Aug 7.


The dawn of open access to phylogenetic data.

Magee AF, May MR, Moore BR.

PLoS One. 2014 Oct 24;9(10):e110268. doi: 10.1371/journal.pone.0110268. eCollection 2014.


Endovascular cooling catheter related thrombosis in patients undergoing therapeutic hypothermia for out of hospital cardiac arrest.

Maze R, Le May MR, Froeschl M, Hazra SK, Wells PS, Osborne C, Labinaz M, Hibbert B, So DY; CArdiovascular Percutaneous Intervention TriAL (CAPITAL) investigators.

Resuscitation. 2014 Oct;85(10):1354-8. doi: 10.1016/j.resuscitation.2014.05.029. Epub 2014 Jun 27.


Explaining Darwin's corollary to Haldane's rule: the role of mitonuclear interactions in asymmetric postzygotic isolation among toads.

Brandvain Y, Pauly GB, May MR, Turelli M.

Genetics. 2014 Jun;197(2):743-7. doi: 10.1534/genetics.113.161133. Epub 2014 Apr 1.


A comparative pharmacodynamic study of ticagrelor versus clopidogrel and ticagrelor in patients undergoing primary percutaneous coronary intervention: the CAPITAL RELOAD study.

Hibbert B, Maze R, Pourdjabbar A, Simard T, Ramirez FD, Moudgil R, Blondeau M, Labinaz M, Dick A, Glover C, Froeschl M, Marquis JF, So DY, Le May MR.

PLoS One. 2014 Mar 20;9(3):e92078. doi: 10.1371/journal.pone.0092078. eCollection 2014.


Left atrial myxoma: a rare cause of dyspnea.

Pourdjabbar A, Hibbert B, Maze R, Lai C, Le May MR.

Can J Cardiol. 2014 Apr;30(4):465.e1-2. doi: 10.1016/j.cjca.2013.11.017. Epub 2013 Nov 21. No abstract available.


A pulsatile chest wall mass: pseudoaneurysm of the ascending aorta.

Giles K, Hibbert B, Boodhwani M, Le May MR.

Intensive Care Med. 2014 Apr;40(4):618-9. doi: 10.1007/s00134-014-3211-1. Epub 2014 Jan 30. No abstract available.


Does high-density lipoprotein influence the development of saphenous vein graft disease after coronary bypass surgery?: exploratory analysis from the CASCADE trial.

Jerzewski K, Ruel M, Voisine P, Le May MR, Kulik A.

J Cardiothorac Surg. 2013 Jul 10;8:172. doi: 10.1186/1749-8090-8-172.


Response to letter regarding article, "Bivalirudin for primary percutaneous coronary interventions: outcome assessment in the Ottawa STEMI registry".

Hibbert B, MacDougall A, Blondeau M, O'Brien ER, So DY, Labinaz M, Dick A, Glover C, Froeschl M, Marquis JF, Wells GA, Le May MR.

Circ Cardiovasc Interv. 2013 Apr;6(2):e27. doi: 10.1161/CIRCINTERVENTIONS.113.000133. No abstract available.


Three year clinical outcomes with zotarolimus (Endeavor) drug-eluting stents in an unrestricted contemporary practice.

Giles K, Hibbert B, Drzymala L, Armstrong M, So D, Le May MR, Glover C.

Int J Cardiol. 2013 Sep 20;168(1):595-6. doi: 10.1016/j.ijcard.2013.01.234. Epub 2013 Feb 26. No abstract available.


Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution.

Melters DP, Bradnam KR, Young HA, Telis N, May MR, Ruby JG, Sebra R, Peluso P, Eid J, Rank D, Garcia JF, DeRisi JL, Smith T, Tobias C, Ross-Ibarra J, Korf I, Chan SW.

Genome Biol. 2013 Jan 30;14(1):R10. doi: 10.1186/gb-2013-14-1-r10.


Bivalirudin for primary percutaneous coronary interventions: outcome assessment in the Ottawa STEMI registry.

Hibbert B, MacDougall A, Labinaz M, O'Brien ER, So DY, Dick A, Glover C, Froeschl M, Marquis JF, Wells GA, Blondeau M, Le May MR.

Circ Cardiovasc Interv. 2012 Dec;5(6):805-12. doi: 10.1161/CIRCINTERVENTIONS.112.968966. Epub 2012 Nov 13.


Response to letter: "Role of intra-aortic balloon pumping on cerebral perfusion after cardiac arrest".

Maze R, Hibbert B, Le May MR.

Resuscitation. 2013 Jan;84(1):e7. doi: 10.1016/j.resuscitation.2012.10.019. Epub 2012 Oct 30. No abstract available.


Lessons Learned from the Ottawa Regional STEMI Program.

Le May MR, Blondeau MSK.

Interv Cardiol Clin. 2012 Oct;1(4):567-582. doi: 10.1016/j.iccl.2012.06.012. Epub 2012 Aug 20. Review.


Reduction in mortality as a result of direct transport from the field to a receiving center for primary percutaneous coronary intervention.

Le May MR, Wells GA, So DY, Glover CA, Froeschl M, Maloney J, Dionne R, Marquis JF, O'Brien ER, Dick A, Sherrard HL, Trickett J, Poirier P, Blondeau M, Bernick J, Labinaz M.

J Am Coll Cardiol. 2012 Oct 2;60(14):1223-30. doi: 10.1016/j.jacc.2012.07.008.


The impact of therapeutic hypothermia as adjunctive therapy in a regional primary PCI program.

Maze R, Le May MR, Hibbert B, So DY, Froeschl M, Glover CA, Dick A, Marquis JF, Blondeau M, Labinaz M.

Resuscitation. 2013 Apr;84(4):460-4. doi: 10.1016/j.resuscitation.2012.08.002. Epub 2012 Aug 21.


Transradial versus transfemoral artery approach for coronary angiography and percutaneous coronary intervention in the extremely obese.

Hibbert B, Simard T, Wilson KR, Hawken S, Wells GA, Ramirez FD, Le May MR, So DY, Glover CA, Froeschl M, Marquis JF, Labinaz M, Dick A, O'Brien ER.

JACC Cardiovasc Interv. 2012 Aug;5(8):819-26. doi: 10.1016/j.jcin.2012.04.009.


Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial.

Roberts JD, Wells GA, Le May MR, Labinaz M, Glover C, Froeschl M, Dick A, Marquis JF, O'Brien E, Goncalves S, Druce I, Stewart A, Gollob MH, So DY.

Lancet. 2012 May 5;379(9827):1705-11. doi: 10.1016/S0140-6736(12)60161-5. Epub 2012 Mar 29.


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