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Items: 1 to 50 of 201

1.

A new approach to treating renal anaemia.

Maxwell PH.

Nat Rev Nephrol. 2019 Dec;15(12):731-732. doi: 10.1038/s41581-019-0207-7. No abstract available.

PMID:
31511661
2.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, Van Looveren R, Loopmans S, Bultynck G, Vinckier S, Meersman F, Maxwell PH, Rai J, Weis M, Eyre DR, Ghesquière B, Fendt SM, Carmeliet P, Carmeliet G.

Nature. 2019 Jan;565(7740):511-515. doi: 10.1038/s41586-019-0874-3. Epub 2019 Jan 16.

PMID:
30651640
3.

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function.

Briston T, Stephen JM, Thomas LW, Esposito C, Chung YL, Syafruddin SE, Turmaine M, Maddalena LA, Greef B, Szabadkai G, Maxwell PH, Vanharanta S, Ashcroft M.

Front Oncol. 2018 Oct 4;8:388. doi: 10.3389/fonc.2018.00388. eCollection 2018.

4.

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ, Ferdinand JR, Collord G, Botting RA, Popescu DM, Loudon KW, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Del Castillo Velasco-Herrera M, Guzzo C, Richoz N, Mamanova L, Aho T, Armitage JN, Riddick ACP, Mushtaq I, Farrell S, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Maxwell PH, Lindsay S, Warren AY, Stewart GD, Sebire N, Coleman N, Haniffa M, Teichmann SA, Clatworthy M, Behjati S.

Science. 2018 Aug 10;361(6402):594-599. doi: 10.1126/science.aat1699.

5.

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.

Stegen S, Stockmans I, Moermans K, Thienpont B, Maxwell PH, Carmeliet P, Carmeliet G.

Nat Commun. 2018 Jul 2;9(1):2557. doi: 10.1038/s41467-018-04679-7.

6.

Low doses of DNA damaging agents extend Saccharomyces cerevisiae chronological lifespan by promoting entry into quiescence.

Ross EM, Maxwell PH.

Exp Gerontol. 2018 Jul 15;108:189-200. doi: 10.1016/j.exger.2018.04.020. Epub 2018 Apr 26.

8.

Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine.

Liu R, Chen C, Xia X, Liao Q, Wang Q, Newcombe PJ, Xu S, Chen M, Ding Y, Li X, Liao Z, Li F, Du M, Huang H, Dong R, Deng W, Wang Y, Zeng B, Pan Q, Jiang D, Zeng H, Sham P, Cao Y, Maxwell PH, Gao ZL, Peng L, Wang Y.

Sci Rep. 2017 Aug 23;7(1):9214. doi: 10.1038/s41598-017-07012-2.

9.

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.

10.

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.

Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PH.

Kidney Int. 2017 Oct;92(4):900-908. doi: 10.1016/j.kint.2017.03.008. Epub 2017 May 12.

11.

Cardiopulmonary phenotype associated with human PHD2 mutation.

Talbot NP, Smith TG, Balanos GM, Dorrington KL, Maxwell PH, Robbins PA.

Physiol Rep. 2017 Apr;5(7). pii: e13224. doi: 10.14814/phy2.13224.

12.

A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population.

Voskarides K, Stefanou C, Pieri M, Demosthenous P, Felekkis K, Arsali M, Athanasiou Y, Xydakis D, Stylianou K, Daphnis E, Goulielmos G, Loizou P, Savige J, Höhne M, Völker LA, Benzing T, Maxwell PH, Gale DP, Gorski M, Böger C, Kollerits B, Kronenberg F, Paulweber B, Zavros M, Pierides A, Deltas C.

PLoS One. 2017 Mar 23;12(3):e0174274. doi: 10.1371/journal.pone.0174274. eCollection 2017.

13.

Hypoxia and B cells.

Burrows N, Maxwell PH.

Exp Cell Res. 2017 Jul 15;356(2):197-203. doi: 10.1016/j.yexcr.2017.03.019. Epub 2017 Mar 12. Review.

PMID:
28300562
14.

Mutations in mitochondrial DNA causing tubulointerstitial kidney disease.

Connor TM, Hoer S, Mallett A, Gale DP, Gomez-Duran A, Posse V, Antrobus R, Moreno P, Sciacovelli M, Frezza C, Duff J, Sheerin NS, Sayer JA, Ashcroft M, Wiesener MS, Hudson G, Gustafsson CM, Chinnery PF, Maxwell PH.

PLoS Genet. 2017 Mar 7;13(3):e1006620. doi: 10.1371/journal.pgen.1006620. eCollection 2017 Mar.

15.

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1.

Li L, Zhang Q, Yang H, Zou Q, Lai C, Jiang F, Zhao P, Luo Z, Yang J, Chen Q, Wang Y, Newsome PN, Frampton J, Maxwell PH, Li W, Chen S, Wang D, Siu TS, Tam S, Tse HF, Qin B, Bao X, Esteban MA, Lai L.

J Biol Chem. 2017 Mar 17;292(11):4755-4763. doi: 10.1074/jbc.M116.764787. Epub 2017 Jan 4.

16.

Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.

Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa AS, Gaude E, Drubbel AV, Theobald SJ, Abbo SR, Tran MG, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, Warren A, Gnanapragasam V, Gottlieb E, Franze K, Huntly B, Maher ER, Maxwell PH, Saez-Rodriguez J, Frezza C.

Nature. 2016 Dec 1;540(7631):150. doi: 10.1038/nature20144. Epub 2016 Oct 19. No abstract available.

PMID:
27760119
17.

A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen.

Gale DP, Oygar DD, Lin F, Oygar PD, Khan N, Connor TM, Lapsley M, Maxwell PH, Neild GH.

Nephrol Dial Transplant. 2016 Nov;31(11):1908-1914. Epub 2016 Apr 8.

19.

Manifesto for a healthy and health-creating society.

Crisp N, Stuckler D, Horton R, Adebowale V, Bailey S, Baker M, Bell J, Bird J, Black C, Campbell J, Davies J, Henry H, Lechler R, Mawson A, Maxwell PH, McKee M, Warwick C.

Lancet. 2016 Dec 10;388(10062):e24-e27. doi: 10.1016/S0140-6736(16)31801-3. Epub 2016 Oct 7. Erratum in: Lancet. 2017 Mar 25;389(10075):e4. Lancet. 2017 Mar 25;389(10075):e4.

PMID:
27726950
20.

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.

Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa AS, Gaude E, Drubbel AV, Theobald SJ, Abbo SR, Tran MG, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, Warren A, Gnanapragasam V, Gottlieb E, Franze K, Huntly B, Maher ER, Maxwell PH, Saez-Rodriguez J, Frezza C.

Nature. 2016 Aug 31;537(7621):544-547. doi: 10.1038/nature19353. Erratum in: Nature. 2016 Dec 1;540(7631):150.

21.

Dent Disease in Chinese Children and Findings from Heterozygous Mothers: Phenotypic Heterogeneity, Fetal Growth, and 10 Novel Mutations.

Li F, Yue Z, Xu T, Chen M, Zhong L, Liu T, Jing X, Deng J, Hu B, Liu Y, Wang H, Lai KN, Sun L, Liu J, Maxwell PH, Wang Y.

J Pediatr. 2016 Jul;174:204-210.e1. doi: 10.1016/j.jpeds.2016.04.007. Epub 2016 May 9.

PMID:
27174143
22.

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma.

Al-Lamki RS, Wang J, Yang J, Burrows N, Maxwell PH, Eisen T, Warren AY, Vanharanta S, Pacey S, Vandenabeele P, Pober JS, Bradley JR.

Oncotarget. 2016 Apr 26;7(17):24111-24. doi: 10.18632/oncotarget.8125.

23.

Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).

Burrows N, Cane G, Robson M, Gaude E, Howat WJ, Szlosarek PW, Pedley RB, Frezza C, Ashcroft M, Maxwell PH.

Sci Rep. 2016 Mar 14;6:22950. doi: 10.1038/srep22950.

24.

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.

Stegen S, van Gastel N, Eelen G, Ghesquière B, D'Anna F, Thienpont B, Goveia J, Torrekens S, Van Looveren R, Luyten FP, Maxwell PH, Wielockx B, Lambrechts D, Fendt SM, Carmeliet P, Carmeliet G.

Cell Metab. 2016 Feb 9;23(2):265-79. doi: 10.1016/j.cmet.2016.01.002.

25.

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond.

Maxwell PH, Eckardt KU.

Nat Rev Nephrol. 2016 Mar;12(3):157-68. doi: 10.1038/nrneph.2015.193. Epub 2015 Dec 14. Review.

PMID:
26656456
26.

What might retrotransposons teach us about aging?

Maxwell PH.

Curr Genet. 2016 May;62(2):277-82. doi: 10.1007/s00294-015-0538-2. Epub 2015 Nov 18. Review.

27.

Preferential retrotransposition in aging yeast mother cells is correlated with increased genome instability.

Patterson MN, Scannapieco AE, Au PH, Dorsey S, Royer CA, Maxwell PH.

DNA Repair (Amst). 2015 Oct;34:18-27. doi: 10.1016/j.dnarep.2015.07.004. Epub 2015 Aug 7.

28.

Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.

Levine AP, Connor TM, Oygar DD, Neild GH, Segal AW, Maxwell PH, Gale DP.

BMC Genomics. 2015 Mar 10;16:163. doi: 10.1186/s12864-015-1360-4.

29.

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.

Henze AT, Garvalov BK, Seidel S, Cuesta AM, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A, Acker T.

Nat Commun. 2014 Nov 25;5:5582. doi: 10.1038/ncomms6582.

31.
32.

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.

Ong SG, Lee WH, Theodorou L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson SM, Maxwell PH, Yellon DM, Hausenloy DJ.

Cardiovasc Res. 2014 Oct 1;104(1):24-36. doi: 10.1093/cvr/cvu172. Epub 2014 Jul 25.

PMID:
25063991
33.

The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.

Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, Maxwell PH, Esteban MA.

J Biol Chem. 2014 Feb 7;289(6):3339-51. doi: 10.1074/jbc.M113.538157. Epub 2013 Dec 26.

34.

Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences.

Yang OC, Maxwell PH, Pollard PJ.

Kidney Int. 2013 Oct;84(4):667-81. doi: 10.1038/ki.2013.245. Epub 2013 Jul 3. Review.

35.

The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition.

Barriga EH, Maxwell PH, Reyes AE, Mayor R.

J Cell Biol. 2013 May 27;201(5):759-76. doi: 10.1083/jcb.201212100.

36.

Xenon treatment protects against cold ischemia associated delayed graft function and prolongs graft survival in rats.

Zhao H, Watts HR, Chong M, Huang H, Tralau-Stewart C, Maxwell PH, Maze M, George AJ, Ma D.

Am J Transplant. 2013 Aug;13(8):2006-18. doi: 10.1111/ajt.12293. Epub 2013 May 24.

37.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC.

Circ Res. 2013 Jun 7;112(12):1583-91. doi: 10.1161/CIRCRESAHA.111.300119. Epub 2013 Apr 5.

PMID:
23564640
38.

Epistatic role of the MYH9/APOL1 region on familial hematuria genes.

Voskarides K, Demosthenous P, Papazachariou L, Arsali M, Athanasiou Y, Zavros M, Stylianou K, Xydakis D, Daphnis E, Gale DP, Maxwell PH, Elia A, Pattaro C, Pierides A, Deltas C.

PLoS One. 2013;8(3):e57925. doi: 10.1371/journal.pone.0057925. Epub 2013 Mar 14.

39.

Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study.

Connor TM, Oygar DD, Gale DP, Steenkamp R, Nitsch D, Neild GH, Maxwell PH.

PLoS One. 2013;8(1):e54394. doi: 10.1371/journal.pone.0054394. Epub 2013 Jan 17.

40.

C3 glomerulonephritis and CFHR5 nephropathy.

Gale DP, Maxwell PH.

Nephrol Dial Transplant. 2013 Feb;28(2):282-8. doi: 10.1093/ndt/gfs441. Epub 2012 Nov 2. Review.

PMID:
23125424
41.

What happens to clinical training fellows? A retrospective study of the 20 years outcome of a Medical Research Council UK cohort.

Stewart PM, Bryan S, Dukes P, van Oudheusden HL, Walker R, Maxwell PH.

BMJ Open. 2012 Aug 30;2(4). pii: e001792. doi: 10.1136/bmjopen-2012-001792. Print 2012.

43.

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.

Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW.

Development. 2012 Jul;139(13):2340-50. doi: 10.1242/dev.070813. Epub 2012 May 23.

44.

Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy.

Mowat FM, Gonzalez F, Luhmann UF, Lange CA, Duran Y, Smith AJ, Maxwell PH, Ali RR, Bainbridge JW.

Am J Pathol. 2012 Apr;180(4):1726-39. doi: 10.1016/j.ajpath.2011.12.033. Epub 2012 Feb 17.

45.

The ERA-EDTA Working Group on inherited kidney disorders.

Devuyst O, Antignac C, Bindels RJ, Chauveau D, Emma F, Gansevoort R, Maxwell PH, Ong AC, Remuzzi G, Ronco P, Schaefer F.

Nephrol Dial Transplant. 2012 Jan;27(1):67-9. doi: 10.1093/ndt/gfr764. No abstract available.

46.

Tumor strengths and frailties: Aspiring to prevent colon cancer.

Maxwell PH.

Nat Med. 2012 Jan 6;18(1):32-3. doi: 10.1038/nm.2637. No abstract available.

PMID:
22227665
47.

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.

Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, Ashcroft M.

J Clin Invest. 2012 Feb;122(2):600-11. doi: 10.1172/JCI58780. Epub 2012 Jan 3.

48.

Retrotransposition is associated with genome instability during chronological aging.

Maxwell PH, Burhans WC, Curcio MJ.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20376-81. doi: 10.1073/pnas.1100271108. Epub 2011 Oct 20.

49.

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.

Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, Baban D, Nye E, Stamp GW, Wolhuter K, Stevens M, Fischer R, Carmeliet P, Maxwell PH, Pugh CW, Frizzell N, Soga T, Kessler BM, El-Bahrawy M, Ratcliffe PJ, Pollard PJ.

Cancer Cell. 2011 Oct 18;20(4):524-37. doi: 10.1016/j.ccr.2011.09.006.

50.

Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.

Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K, Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C.

J Am Soc Nephrol. 2011 Nov;22(11):2004-15. doi: 10.1681/ASN.2010121249. Epub 2011 Sep 15.

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