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HK97 gp74 possesses an α-helical insertion in the ββα fold that affects its metal binding, cos site digestion, and in vivo activities.

Weiditch SA, Bickers SC, Bona D, Maxwell KL, Kanelis V.

J Bacteriol. 2020 Jan 27. pii: JB.00644-19. doi: 10.1128/JB.00644-19. [Epub ahead of print]


Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing.

Garcia B, Lee J, Edraki A, Hidalgo-Reyes Y, Erwood S, Mir A, Trost CN, Seroussi U, Stanley SY, Cohn RD, Claycomb JM, Sontheimer EJ, Maxwell KL, Davidson AR.

Cell Rep. 2019 Nov 12;29(7):1739-1746.e5. doi: 10.1016/j.celrep.2019.10.017.


Bacterial twist to an antiviral defence.

Maxwell KL.

Nature. 2019 Oct;574(7780):638-639. doi: 10.1038/d41586-019-02974-x. No abstract available.


Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.

Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, Maxwell KL.

Nat Commun. 2019 Jun 26;10(1):2806. doi: 10.1038/s41467-019-10577-3.


A Unified Resource for Tracking Anti-CRISPR Names.

Bondy-Denomy J, Davidson AR, Doudna JA, Fineran PC, Maxwell KL, Moineau S, Peng X, Sontheimer EJ, Wiedenheft B.

CRISPR J. 2018 Oct;1:304-305. doi: 10.1089/crispr.2018.0043. No abstract available.


Meet the Anti-CRISPRs: Widespread Protein Inhibitors of CRISPR-Cas Systems.

Hwang S, Maxwell KL.

CRISPR J. 2019 Feb;2(1):23-30. doi: 10.1089/crispr.2018.0052. Review.


The Diverse Impacts of Phage Morons on Bacterial Fitness and Virulence.

Taylor VL, Fitzpatrick AD, Islam Z, Maxwell KL.

Adv Virus Res. 2019;103:1-31. doi: 10.1016/bs.aivir.2018.08.001. Epub 2018 Oct 3. Review.


Phages Tune in to Host Cell Quorum Sensing.

Maxwell KL.

Cell. 2019 Jan 10;176(1-2):7-8. doi: 10.1016/j.cell.2018.12.007.


A chemical defence against phage infection.

Kronheim S, Daniel-Ivad M, Duan Z, Hwang S, Wong AI, Mantel I, Nodwell JR, Maxwell KL.

Nature. 2018 Dec;564(7735):283-286. doi: 10.1038/s41586-018-0767-x. Epub 2018 Dec 5.


Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.

Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ.

mBio. 2018 Dec 4;9(6). pii: e02321-18. doi: 10.1128/mBio.02321-18.


Type VI secretion system baseplate.

Davidson AR, Maxwell KL.

Nat Microbiol. 2018 Dec;3(12):1330-1331. doi: 10.1038/s41564-018-0311-7. No abstract available.


Phage-Encoded Anti-CRISPR Defenses.

Stanley SY, Maxwell KL.

Annu Rev Genet. 2018 Nov 23;52:445-464. doi: 10.1146/annurev-genet-120417-031321. Epub 2018 Sep 12. Review.


Phage Morons Play an Important Role in Pseudomonas aeruginosa Phenotypes.

Tsao YF, Taylor VL, Kala S, Bondy-Denomy J, Khan AN, Bona D, Cattoir V, Lory S, Davidson AR, Maxwell KL.

J Bacteriol. 2018 Oct 23;200(22). pii: e00189-18. doi: 10.1128/JB.00189-18. Print 2018 Nov 15.


Extrachromosomal circular elements targeted by CRISPR-Cas in Dehalococcoides mccartyi are linked to mobilization of reductive dehalogenase genes.

Molenda O, Tang S, Lomheim L, Gautam VK, Lemak S, Yakunin AF, Maxwell KL, Edwards EA.

ISME J. 2019 Jan;13(1):24-38. doi: 10.1038/s41396-018-0254-2. Epub 2018 Aug 13.


Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein.

Pawluk A, Shah M, Mejdani M, Calmettes C, Moraes TF, Davidson AR, Maxwell KL.

mBio. 2017 Dec 12;8(6). pii: e01751-17. doi: 10.1128/mBio.01751-17.


Looking at the past through a telescope: adults postdated their earliest childhood memories.

Wang Q, Peterson C, Khuu A, Reid CP, Maxwell KL, Vincent JM.

Memory. 2019 Jan;27(1):19-27. doi: 10.1080/09658211.2017.1414268. Epub 2017 Dec 13.


Anti-CRISPR: discovery, mechanism and function.

Pawluk A, Davidson AR, Maxwell KL.

Nat Rev Microbiol. 2018 Jan;16(1):12-17. doi: 10.1038/nrmicro.2017.120. Epub 2017 Oct 24. Review.


The Anti-CRISPR Story: A Battle for Survival.

Maxwell KL.

Mol Cell. 2017 Oct 5;68(1):8-14. doi: 10.1016/j.molcel.2017.09.002. Review.


A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.


Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.

Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B.

Cell. 2017 Mar 23;169(1):47-57.e11. doi: 10.1016/j.cell.2017.03.012.


Naturally Occurring Off-Switches for CRISPR-Cas9.

Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR.

Cell. 2016 Dec 15;167(7):1829-1838.e9. doi: 10.1016/j.cell.2016.11.017. Epub 2016 Dec 8.


The solution structure of an anti-CRISPR protein.

Maxwell KL, Garcia B, Bondy-Denomy J, Bona D, Hidalgo-Reyes Y, Davidson AR.

Nat Commun. 2016 Oct 11;7:13134. doi: 10.1038/ncomms13134.


Rapid Bacterial Detection via an All-Electronic CMOS Biosensor.

Nikkhoo N, Cumby N, Gulak PG, Maxwell KL.

PLoS One. 2016 Sep 12;11(9):e0162438. doi: 10.1371/journal.pone.0162438. eCollection 2016.


Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species.

Pawluk A, Staals RH, Taylor C, Watson BN, Saha S, Fineran PC, Maxwell KL, Davidson AR.

Nat Microbiol. 2016 Jun 13;1(8):16085. doi: 10.1038/nmicrobiol.2016.85.


Baseplate assembly of phage Mu: Defining the conserved core components of contractile-tailed phages and related bacterial systems.

Büttner CR, Wu Y, Maxwell KL, Davidson AR.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10174-9. doi: 10.1073/pnas.1607966113. Epub 2016 Aug 23.


Prophages mediate defense against phage infection through diverse mechanisms.

Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR, Maxwell KL.

ISME J. 2016 Dec;10(12):2854-2866. doi: 10.1038/ismej.2016.79. Epub 2016 Jun 3.


Phages Fight Back: Inactivation of the CRISPR-Cas Bacterial Immune System by Anti-CRISPR Proteins.

Maxwell KL.

PLoS Pathog. 2016 Jan 7;12(1):e1005282. doi: 10.1371/journal.ppat.1005282. eCollection 2016 Jan. Review. No abstract available.


Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins.

Bondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, Wiedenheft B, Maxwell KL, Davidson AR.

Nature. 2015 Oct 1;526(7571):136-9. doi: 10.1038/nature15254. Epub 2015 Sep 23.


The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97.

Cumby N, Reimer K, Mengin-Lecreulx D, Davidson AR, Maxwell KL.

Mol Microbiol. 2015 May;96(3):437-47. doi: 10.1111/mmi.12918. Epub 2015 Jan 30.


A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa.

Pawluk A, Bondy-Denomy J, Cheung VH, Maxwell KL, Davidson AR.

mBio. 2014 Apr 15;5(2):e00896. doi: 10.1128/mBio.00896-14.


HNH proteins are a widespread component of phage DNA packaging machines.

Kala S, Cumby N, Sadowski PD, Hyder BZ, Kanelis V, Davidson AR, Maxwell KL.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6022-7. doi: 10.1073/pnas.1320952111. Epub 2014 Apr 7.


Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages.

Maxwell KL, Fatehi Hassanabad M, Chang T, Paul VD, Pirani N, Bona D, Edwards AM, Davidson AR.

J Bacteriol. 2013 Dec;195(24):5461-8. doi: 10.1128/JB.00805-13. Epub 2013 Oct 4. Erratum in: J Bacteriol. 2014 Jun;196(11):2122. Paul, Vivek D [added].


A shifty chaperone for phage tail assembly.

Maxwell KL, Davidson AR.

J Mol Biol. 2014 Mar 6;426(5):1001-3. doi: 10.1016/j.jmb.2013.08.004. Epub 2013 Aug 9. No abstract available.


The moron comes of age.

Cumby N, Davidson AR, Maxwell KL.

Bacteriophage. 2012 Oct 1;2(4):225-228.


The solution structures of two prophage homologues of the bacteriophage λ Ea8.5 protein reveal a newly discovered hybrid homeodomain/zinc-finger fold.

Kwan JJ, Smirnova E, Khazai S, Evanics F, Maxwell KL, Donaldson LW.

Biochemistry. 2013 May 28;52(21):3612-4. doi: 10.1021/bi400543w. Epub 2013 May 14.


A conserved spiral structure for highly diverged phage tail assembly chaperones.

Pell LG, Cumby N, Clark TE, Tuite A, Battaile KP, Edwards AM, Chirgadze NY, Davidson AR, Maxwell KL.

J Mol Biol. 2013 Jul 24;425(14):2436-49. doi: 10.1016/j.jmb.2013.03.035. Epub 2013 Mar 28.


Tail tip proteins related to bacteriophage λ gpL coordinate an iron-sulfur cluster.

Tam W, Pell LG, Bona D, Tsai A, Dai XX, Edwards AM, Hendrix RW, Maxwell KL, Davidson AR.

J Mol Biol. 2013 Jul 24;425(14):2450-62. doi: 10.1016/j.jmb.2013.03.032. Epub 2013 Mar 28.


Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system.

Bondy-Denomy J, Pawluk A, Maxwell KL, Davidson AR.

Nature. 2013 Jan 17;493(7432):429-32. doi: 10.1038/nature11723. Epub 2012 Dec 16.


Structural and biochemical characterization of phage λ FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity.

Popovic A, Wu B, Arrowsmith CH, Edwards AM, Davidson AR, Maxwell KL.

J Biol Chem. 2012 Sep 14;287(38):32085-95. doi: 10.1074/jbc.M112.378349. Epub 2012 Jul 16.


The bacteriophage HK97 gp15 moron element encodes a novel superinfection exclusion protein.

Cumby N, Edwards AM, Davidson AR, Maxwell KL.

J Bacteriol. 2012 Sep;194(18):5012-9. doi: 10.1128/JB.00843-12. Epub 2012 Jul 13.


The protein gp74 from the bacteriophage HK97 functions as a HNH endonuclease.

Moodley S, Maxwell KL, Kanelis V.

Protein Sci. 2012 Jun;21(6):809-18. doi: 10.1002/pro.2064. Epub 2012 Apr 23.


Metals and the liver.

Maxwell KL, Kowdley KV.

Curr Opin Gastroenterol. 2012 May;28(3):217-22. doi: 10.1097/MOG.0b013e3283521d82. Review.


Long noncontractile tail machines of bacteriophages.

Davidson AR, Cardarelli L, Pell LG, Radford DR, Maxwell KL.

Adv Exp Med Biol. 2012;726:115-42. doi: 10.1007/978-1-4614-0980-9_6. Review.


Transcriptional analysis of a Dehalococcoides-containing microbial consortium reveals prophage activation.

Waller AS, Hug LA, Mo K, Radford DR, Maxwell KL, Edwards EA.

Appl Environ Microbiol. 2012 Feb;78(4):1178-86. doi: 10.1128/AEM.06416-11. Epub 2011 Dec 16.


Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels.

Wylie RG, Ahsan S, Aizawa Y, Maxwell KL, Morshead CM, Shoichet MS.

Nat Mater. 2011 Oct;10(10):799-806. doi: 10.1038/nmat3101.


Assembly mechanism is the key determinant of the dosage sensitivity of a phage structural protein.

Cardarelli L, Maxwell KL, Davidson AR.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10168-73. doi: 10.1073/pnas.1100759108. Epub 2011 Jun 6.


The implementation of the UHC/AACN new graduate nurse residency program in a community hospital.

Maxwell KL.

Nurs Clin North Am. 2011 Mar;46(1):27-33. doi: 10.1016/j.cnur.2010.10.013. Epub 2010 Dec 3. Erratum in: Nurs Clin North Am. 2011 Jun;46(2):ix.


The solution structure of the C-terminal Ig-like domain of the bacteriophage λ tail tube protein.

Pell LG, Gasmi-Seabrook GM, Morais M, Neudecker P, Kanelis V, Bona D, Donaldson LW, Edwards AM, Howell PL, Davidson AR, Maxwell KL.

J Mol Biol. 2010 Oct 29;403(3):468-79. doi: 10.1016/j.jmb.2010.08.044. Epub 2010 Sep 6.


Phages have adapted the same protein fold to fulfill multiple functions in virion assembly.

Cardarelli L, Pell LG, Neudecker P, Pirani N, Liu A, Baker LA, Rubinstein JL, Maxwell KL, Davidson AR.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14384-9. doi: 10.1073/pnas.1005822107. Epub 2010 Jul 26.

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