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Items: 20


Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus.

Tsetsarkin KA, Maximova OA, Liu G, Kenney H, Teterina NL, Pletnev AG.

MBio. 2019 Apr 23;10(2). pii: e02904-18. doi: 10.1128/mBio.02904-18.


Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice.

Tsetsarkin KA, Maximova OA, Liu G, Kenney H, Teterina N, Bloom ME, Grabowski JM, Mlera L, Nagata BM, Moore I, Martens C, Amaro-Carambot E, Lamirande EW, Whitehead SS, Pletnev AG.

Nat Commun. 2018 Dec 17;9(1):5350. doi: 10.1038/s41467-018-07782-x.


Flaviviruses and the Central Nervous System: Revisiting Neuropathological Concepts.

Maximova OA, Pletnev AG.

Annu Rev Virol. 2018 Sep 29;5(1):255-272. doi: 10.1146/annurev-virology-092917-043439. Review.


West Nile Virus Spreads Transsynaptically within the Pathways of Motor Control: Anatomical and Ultrastructural Mapping of Neuronal Virus Infection in the Primate Central Nervous System.

Maximova OA, Bernbaum JG, Pletnev AG.

PLoS Negl Trop Dis. 2016 Sep 12;10(9):e0004980. doi: 10.1371/journal.pntd.0004980. eCollection 2016 Sep.


MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives.

Teterina NL, Maximova OA, Kenney H, Liu G, Pletnev AG.

Antiviral Res. 2016 Mar;127:57-67. doi: 10.1016/j.antiviral.2016.01.003. Epub 2016 Jan 19.


Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions.

Teterina NL, Liu G, Maximova OA, Pletnev AG.

Virology. 2014 May;456-457:247-58. doi: 10.1016/j.virol.2014.04.001. Epub 2014 Apr 19.


Assurance of neuroattenuation of a live vaccine against West Nile virus: a comprehensive study of neuropathogenesis after infection with chimeric WN/DEN4Δ30 vaccine in comparison to two parental viruses and a surrogate flavivirus reference vaccine.

Maximova OA, Speicher JM, Skinner JR, Murphy BR, St Claire MC, Ragland DR, Herbert RL, Pare DR, Moore RM, Pletnev AG.

Vaccine. 2014 May 30;32(26):3187-97. doi: 10.1016/j.vaccine.2014.04.002. Epub 2014 Apr 13.


The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.

Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan MJ, Maximova OA, Sharma S, Zhu J, Wang H, Morse HC 3rd, Ozato K.

Immunity. 2014 Feb 20;40(2):187-98. doi: 10.1016/j.immuni.2013.11.022. Epub 2014 Jan 30.


Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss.

Gaidamakov S, Maximova OA, Chon H, Blewett NH, Wang H, Crawford AK, Day A, Tulchin N, Crouch RJ, Morse HC 3rd, Blitzer RD, Maraia RJ.

Mol Cell Biol. 2014 Jan;34(1):123-31. doi: 10.1128/MCB.01010-13. Epub 2013 Nov 4.


MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype.

Heiss BL, Maximova OA, Thach DC, Speicher JM, Pletnev AG.

J Virol. 2012 May;86(10):5647-59. doi: 10.1128/JVI.07125-11. Epub 2012 Mar 14.


Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak.

Sheng ZM, Chertow DS, Ambroggio X, McCall S, Przygodzki RM, Cunningham RE, Maximova OA, Kash JC, Morens DM, Taubenberger JK.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16416-21. doi: 10.1073/pnas.1111179108. Epub 2011 Sep 19.


Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype.

Heiss BL, Maximova OA, Pletnev AG.

J Virol. 2011 Feb;85(4):1464-72. doi: 10.1128/JVI.02091-10. Epub 2010 Dec 1.


High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence.

Maximova OA, Murphy BR, Pletnev AG.

Vaccine. 2010 Dec 6;28(52):8315-26. doi: 10.1016/j.vaccine.2010.07.070. Epub 2010 Aug 3.


The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome.

Engel AR, Rumyantsev AA, Maximova OA, Speicher JM, Heiss B, Murphy BR, Pletnev AG.

Virology. 2010 Sep 15;405(1):243-52. doi: 10.1016/j.virol.2010.06.014. Epub 2010 Jul 1.


Cellular inflammatory response to flaviviruses in the central nervous system of a primate host.

Maximova OA, Faucette LJ, Ward JM, Murphy BR, Pletnev AG.

J Histochem Cytochem. 2009 Oct;57(10):973-89. doi: 10.1369/jhc.2009.954180. Epub 2009 Jul 6.


Visceral and neural larva migrans in rhesus macaques.

Gozalo AS, Maximova OA, StClaire MC, Montali RJ, Ward JM, Cheng LI, Elkins WR, Kazacos KR.

J Am Assoc Lab Anim Sci. 2008 Jul;47(4):64-7.


Comparative neuropathogenesis and neurovirulence of attenuated flaviviruses in nonhuman primates.

Maximova OA, Ward JM, Asher DM, St Claire M, Finneyfrock BW, Speicher JM, Murphy BR, Pletnev AG.

J Virol. 2008 Jun;82(11):5255-68. doi: 10.1128/JVI.00172-08. Epub 2008 Mar 19.


Computerized morphometric analysis of pathological prion protein deposition in scrapie-infected hamster brain.

Maximova OA, Taffs RE, Pomeroy KL, Piccardo P, Asher DM.

J Histochem Cytochem. 2006 Jan;54(1):97-107. Epub 2005 Sep 7.


Effect of 5,7-dihydroxytryptamine on the food-aversive conditioning in the snail Helix lucorum L.

Balaban PM, Vehovszky A, Maximova OA, Zakharov IS.

Brain Res. 1987 Feb 24;404(1-2):201-10.


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