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Items: 1 to 50 of 235

1.

High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation.

Singh RK, Lund FW, Haka AS, Maxfield FR.

J Cell Sci. 2019 Dec 2;132(23). pii: jcs237271. doi: 10.1242/jcs.237271.

PMID:
31719160
2.

Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis.

Maxfield FR, Barbosa-Lorenzi VC, Singh RK.

Traffic. 2019 Oct 30. doi: 10.1111/tra.12712. [Epub ahead of print] Review.

PMID:
31664749
3.

TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates.

Singh RK, Haka AS, Asmal A, Barbosa-Lorenzi VC, Grosheva I, Chin HF, Xiong Y, Hla T, Maxfield FR.

Arterioscler Thromb Vasc Biol. 2019 Oct 10:ATVBAHA119313200. doi: 10.1161/ATVBAHA.119.313200. [Epub ahead of print]

PMID:
31597445
4.

2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.

Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, Salahi F, Wiest O, Xu X, Porter FD, Pipalia NH, Cruz DL, Holson EB, Schaffer JE, Walkley SU, Maxfield FR, Ory DS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1545-1561. doi: 10.1016/j.bbalip.2019.04.011. Epub 2019 Apr 30.

PMID:
31051283
5.

Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism.

Singh RK, Haka AS, Bhardwaj P, Zha X, Maxfield FR.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):137-149. doi: 10.1161/ATVBAHA.118.312087.

PMID:
30580573
6.

Comment on 'Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol'.

Courtney KC, Fung KY, Maxfield FR, Fairn GD, Zha X.

Elife. 2018 Nov 13;7. pii: e38493. doi: 10.7554/eLife.38493.

7.

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV Jr.

Atherosclerosis. 2018 Oct;277:145-154. doi: 10.1016/j.atherosclerosis.2018.08.042. Epub 2018 Aug 30.

8.

Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

Crespo M, Vilar E, Tsai SY, Chang K, Amin S, Srinivasan T, Zhang T, Pipalia NH, Chen HJ, Witherspoon M, Gordillo M, Xiang JZ, Maxfield FR, Lipkin S, Evans T, Chen S.

Nat Med. 2018 Apr 10;24(4):526. doi: 10.1038/nm0418-526a.

PMID:
29634683
9.

Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain.

Solé-Domènech S, Rojas AV, Maisuradze GG, Scheraga HA, Lobel P, Maxfield FR.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1493-1498. doi: 10.1073/pnas.1719808115. Epub 2018 Jan 29.

10.

Membrane order in the plasma membrane and endocytic recycling compartment.

Iaea DB, Maxfield FR.

PLoS One. 2017 Nov 10;12(11):e0188041. doi: 10.1371/journal.pone.0188041. eCollection 2017.

11.

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.

Stefan CJ, Trimble WS, Grinstein S, Drin G, Reinisch K, De Camilli P, Cohen S, Valm AM, Lippincott-Schwartz J, Levine TP, Iaea DB, Maxfield FR, Futter CE, Eden ER, Judith D, van Vliet AR, Agostinis P, Tooze SA, Sugiura A, McBride HM.

BMC Biol. 2017 Oct 31;15(1):102. doi: 10.1186/s12915-017-0432-0.

12.

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity.

Coats BR, Schoenfelt KQ, Barbosa-Lorenzi VC, Peris E, Cui C, Hoffman A, Zhou G, Fernandez S, Zhai L, Hall BA, Haka AS, Shah AM, Reardon CA, Brady MJ, Rhodes CJ, Maxfield FR, Becker L.

Cell Rep. 2017 Sep 26;20(13):3149-3161. doi: 10.1016/j.celrep.2017.08.096.

13.

Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.

Wang Y, Subramanian M, Yurdagul A Jr, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M, Maxfield FR, Tabas I.

Cell. 2017 Oct 5;171(2):331-345.e22. doi: 10.1016/j.cell.2017.08.041. Epub 2017 Sep 21.

14.

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.

Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA.

ACS Nano. 2017 Nov 28;11(11):10689-10703. doi: 10.1021/acsnano.7b04743. Epub 2017 Sep 12.

15.

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism.

Singh RK, Haka AS, Brumfield A, Grosheva I, Bhardwaj P, Chin HF, Xiong Y, Hla T, Maxfield FR.

J Lipid Res. 2017 Oct;58(10):1977-1987. doi: 10.1194/jlr.M076398. Epub 2017 Aug 16.

16.

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

Crespo M, Vilar E, Tsai SY, Chang K, Amin S, Srinivasan T, Zhang T, Pipalia NH, Chen HJ, Witherspoon M, Gordillo M, Xiang JZ, Maxfield FR, Lipkin S, Evans T, Chen S.

Nat Med. 2017 Jul;23(7):878-884. doi: 10.1038/nm.4355. Epub 2017 Jun 19. Erratum in: Nat Med. 2018 Apr 10;24(4):526.

17.

Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane.

Iaea DB, Mao S, Lund FW, Maxfield FR.

Mol Biol Cell. 2017 Apr 15;28(8):1111-1122. doi: 10.1091/mbc.E16-07-0499. Epub 2017 Feb 16.

18.

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.

Pipalia NH, Subramanian K, Mao S, Ralph H, Hutt DM, Scott SM, Balch WE, Maxfield FR.

J Lipid Res. 2017 Apr;58(4):695-708. doi: 10.1194/jlr.M072140. Epub 2017 Feb 13. Erratum in: J Lipid Res. 2017 Sep;58(9):1932.

19.

The endocytic pathway in microglia during health, aging and Alzheimer's disease.

Solé-Domènech S, Cruz DL, Capetillo-Zarate E, Maxfield FR.

Ageing Res Rev. 2016 Dec;32:89-103. doi: 10.1016/j.arr.2016.07.002. Epub 2016 Jul 12. Review.

20.

Role of STARD4 and NPC1 in intracellular sterol transport.

Maxfield FR, Iaea DB, Pipalia NH.

Biochem Cell Biol. 2016 Dec;94(6):499-506. Epub 2016 Jan 28. Review.

PMID:
27421092
21.

Sphingosine kinases are not required for inflammatory responses in macrophages.

Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T.

J Biol Chem. 2016 May 20;291(21):11465. doi: 10.1074/jbc.A113.483750. No abstract available.

22.

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.

Haka AS, Barbosa-Lorenzi VC, Lee HJ, Falcone DJ, Hudis CA, Dannenberg AJ, Maxfield FR.

J Lipid Res. 2016 Jun;57(6):980-92. doi: 10.1194/jlr.M064089. Epub 2016 Apr 4.

23.

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR.

Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008.

24.

Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse.

Singh RK, Barbosa-Lorenzi VC, Lund FW, Grosheva I, Maxfield FR, Haka AS.

J Cell Sci. 2016 Mar 1;129(5):1072-82. doi: 10.1242/jcs.181743. Epub 2016 Jan 22.

25.

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.

Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS.

J Lipid Res. 2015 Dec;56(12):2408-19. doi: 10.1194/jlr.D064287. Epub 2015 Oct 24.

26.

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation.

Haka AS, Singh RK, Grosheva I, Hoffner H, Capetillo-Zarate E, Chin HF, Anandasabapathy N, Maxfield FR.

Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2092-103. doi: 10.1161/ATVBAHA.115.305843. Epub 2015 Aug 20.

27.

STARD4 Membrane Interactions and Sterol Binding.

Iaea DB, Dikiy I, Kiburu I, Eliezer D, Maxfield FR.

Biochemistry. 2015 Aug 4;54(30):4623-36. doi: 10.1021/acs.biochem.5b00618. Epub 2015 Jul 22.

28.

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.

Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Chung C, Lieberman AP, Sikora J, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, Ory DS.

J Neurosci. 2015 May 27;35(21):8091-106. doi: 10.1523/JNEUROSCI.4173-14.2015.

29.

Cholesterol trafficking and distribution.

Iaea DB, Maxfield FR.

Essays Biochem. 2015;57:43-55. doi: 10.1042/bse0570043.

PMID:
25658343
30.

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.

Patel JZ, Nevalainen TJ, Savinainen JR, Adams Y, Laitinen T, Runyon RS, Vaara M, Ahenkorah S, Kaczor AA, Navia-Paldanius D, Gynther M, Aaltonen N, Joharapurkar AA, Jain MR, Haka AS, Maxfield FR, Laitinen JT, Parkkari T.

ChemMedChem. 2015 Feb;10(2):253-65. doi: 10.1002/cmdc.201402453. Epub 2014 Dec 11.

31.

Role of endosomes and lysosomes in human disease.

Maxfield FR.

Cold Spring Harb Perspect Biol. 2014 May 1;6(5):a016931. doi: 10.1101/cshperspect.a016931. Review.

32.

Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.

Nociari MM, Lehmann GL, Perez Bay AE, Radu RA, Jiang Z, Goicochea S, Schreiner R, Warren JD, Shan J, Adam de Beaumais S, Ménand M, Sollogoub M, Maxfield FR, Rodriguez-Boulan E.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1402-8. doi: 10.1073/pnas.1400530111. Epub 2014 Mar 24.

33.

Sphingosine kinases are not required for inflammatory responses in macrophages.

Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T.

J Biol Chem. 2013 Nov 8;288(45):32563-73. doi: 10.1074/jbc.M113.483750. Epub 2013 Sep 30. Erratum in: J Biol Chem. 2016 May 20;291(21):11465. Lee, Hyeuk Jong [corrected to Lee, Hyuek Jong].

34.

Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.

Helquist P, Maxfield FR, Wiech NL, Wiest O.

Neurotherapeutics. 2013 Oct;10(4):688-97. doi: 10.1007/s13311-013-0217-2. Review.

35.

Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.

Haka AS, Grosheva I, Singh RK, Maxfield FR.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1768-78. doi: 10.1161/ATVBAHA.112.301109. Epub 2013 May 23.

36.

Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary.

Tortorella LL, Pipalia NH, Mukherjee S, Pastan I, Fitzgerald D, Maxfield FR.

PLoS One. 2012;7(10):e47320. doi: 10.1371/journal.pone.0047320. Epub 2012 Oct 9.

37.

STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC.

Garbarino J, Pan M, Chin HF, Lund FW, Maxfield FR, Breslow JL.

J Lipid Res. 2012 Dec;53(12):2716-25. doi: 10.1194/jlr.M032227. Epub 2012 Oct 2.

38.

Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy.

Haka AS, Potteaux S, Fraser H, Randolph GJ, Maxfield FR.

PLoS One. 2012;7(9):e44823. Epub 2012 Sep 14.

39.

Multiphoton microscopy in the evaluation of human bladder biopsies.

Jain M, Robinson BD, Scherr DS, Sterling J, Lee MM, Wysock J, Rubin MA, Maxfield FR, Zipfel WR, Webb WW, Mukherjee S.

Arch Pathol Lab Med. 2012 May;136(5):517-26. doi: 10.5858/arpa.2011-0147-OA.

40.

Analysis of cholesterol trafficking with fluorescent probes.

Maxfield FR, Wüstner D.

Methods Cell Biol. 2012;108:367-93. doi: 10.1016/B978-0-12-386487-1.00017-1.

41.

STARD4 abundance regulates sterol transport and sensing.

Mesmin B, Pipalia NH, Lund FW, Ramlall TF, Sokolov A, Eliezer D, Maxfield FR.

Mol Biol Cell. 2011 Nov;22(21):4004-15. doi: 10.1091/mbc.E11-04-0372. Epub 2011 Sep 7.

42.

Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery.

Tewari AK, Shevchuk MM, Sterling J, Grover S, Herman M, Yadav R, Mudalair K, Srivastava A, Rubin MA, Zipfel WR, Maxfield FR, Xu C, Webb WW, Mukherjee S.

BJU Int. 2011 Nov;108(9):1421-9. doi: 10.1111/j.1464-410X.2011.10169.x. Epub 2011 Mar 28.

43.

Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.

Majumdar A, Capetillo-Zarate E, Cruz D, Gouras GK, Maxfield FR.

Mol Biol Cell. 2011 May 15;22(10):1664-76. doi: 10.1091/mbc.E10-09-0745. Epub 2011 Mar 25.

44.

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.

Pipalia NH, Cosner CC, Huang A, Chatterjee A, Bourbon P, Farley N, Helquist P, Wiest O, Maxfield FR.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5620-5. doi: 10.1073/pnas.1014890108. Epub 2011 Mar 21.

45.

Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling.

Pagler TA, Wang M, Mondal M, Murphy AJ, Westerterp M, Moore KJ, Maxfield FR, Tall AR.

Circ Res. 2011 Jan 21;108(2):194-200. doi: 10.1161/CIRCRESAHA.110.228619. Epub 2010 Dec 9.

46.

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.

Rujoi M, Pipalia NH, Maxfield FR.

PLoS One. 2010 Sep 21;5(9):e12788. doi: 10.1371/journal.pone.0012788.

47.

Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches.

Rosenbaum AI, Maxfield FR.

J Neurochem. 2011 Mar;116(5):789-95. doi: 10.1111/j.1471-4159.2010.06976.x. Epub 2011 Jan 7. Review.

48.

Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages.

VanderVen BC, Hermetter A, Huang A, Maxfield FR, Russell DG, Yates RM.

Cytometry A. 2010 Aug;77(8):751-60. doi: 10.1002/cyto.a.20911.

49.

Cholesterol, the central lipid of mammalian cells.

Maxfield FR, van Meer G.

Curr Opin Cell Biol. 2010 Aug;22(4):422-9. doi: 10.1016/j.ceb.2010.05.004. Epub 2010 Jun 2. Review.

50.

Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.

Rosenbaum AI, Cosner CC, Mariani CJ, Maxfield FR, Wiest O, Helquist P.

J Med Chem. 2010 Jul 22;53(14):5281-9. doi: 10.1021/jm100499s.

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