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Items: 19

1.

Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.

Geuijen CAW, De Nardis C, Maussang D, Rovers E, Gallenne T, Hendriks LJA, Visser T, Nijhuis R, Logtenberg T, de Kruif J, Gros P, Throsby M.

Cancer Cell. 2018 May 14;33(5):922-936.e10. doi: 10.1016/j.ccell.2018.04.003.

2.

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose.

de Vries Schultink AHM, Doornbos RP, Bakker ABH, Bol K, Throsby M, Geuijen C, Maussang D, Schellens JHM, Beijnen JH, Huitema ADR.

Invest New Drugs. 2018 Dec;36(6):1006-1015. doi: 10.1007/s10637-018-0593-x. Epub 2018 May 5.

3.

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome.

de Wit RH, Heukers R, Brink HJ, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer HF, Bachelerie F, Smit MJ.

J Pharmacol Exp Ther. 2017 Oct;363(1):35-44. doi: 10.1124/jpet.117.242735. Epub 2017 Aug 2.

PMID:
28768817
4.

Glutathione conjugation dose-dependently increases brain-specific liposomal drug delivery in vitro and in vivo.

Maussang D, Rip J, van Kregten J, van den Heuvel A, van der Pol S, van der Boom B, Reijerkerk A, Chen L, de Boer M, Gaillard P, de Vries H.

Drug Discov Today Technol. 2016 Jun;20:59-69. doi: 10.1016/j.ddtec.2016.09.003. Epub 2016 Oct 13.

PMID:
27986226
5.

Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats.

Rip J, Chen L, Hartman R, van den Heuvel A, Reijerkerk A, van Kregten J, van der Boom B, Appeldoorn C, de Boer M, Maussang D, de Lange EC, Gaillard PJ.

J Drug Target. 2014 Jun;22(5):460-7. doi: 10.3109/1061186X.2014.888070. Epub 2014 Feb 14.

6.

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101).

Gaillard PJ, Appeldoorn CC, Dorland R, van Kregten J, Manca F, Vugts DJ, Windhorst B, van Dongen GA, de Vries HE, Maussang D, van Tellingen O.

PLoS One. 2014 Jan 8;9(1):e82331. doi: 10.1371/journal.pone.0082331. eCollection 2014.

7.

Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.

Maussang D, Mujić-Delić A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen GA, Merchiers P, van Rompaey P, Smit MJ.

J Biol Chem. 2013 Oct 11;288(41):29562-72. doi: 10.1074/jbc.M113.498436. Epub 2013 Aug 26.

8.

Constitutive β-catenin signaling by the viral chemokine receptor US28.

Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ.

PLoS One. 2012;7(11):e48935. doi: 10.1371/journal.pone.0048935. Epub 2012 Nov 8.

9.

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.

Wijtmans M, Maussang D, Sirci F, Scholten DJ, Canals M, Mujić-Delić A, Chong M, Chatalic KL, Custers H, Janssen E, de Graaf C, Smit MJ, de Esch IJ, Leurs R.

Eur J Med Chem. 2012 May;51:184-92. doi: 10.1016/j.ejmech.2012.02.041. Epub 2012 Feb 27.

PMID:
22424612
10.

Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection.

Zoughlami Y, Voermans C, Brussen K, van Dort KA, Kootstra NA, Maussang D, Smit MJ, Hordijk PL, van Hennik PB.

Blood. 2012 Mar 1;119(9):2024-32. doi: 10.1182/blood-2011-06-364828. Epub 2012 Jan 11.

11.

Pharmacological modulation of chemokine receptor function.

Scholten DJ, Canals M, Maussang D, Roumen L, Smit MJ, Wijtmans M, de Graaf C, Vischer HF, Leurs R.

Br J Pharmacol. 2012 Mar;165(6):1617-1643. doi: 10.1111/j.1476-5381.2011.01551.x. Review.

12.

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.

Jähnichen S, Blanchetot C, Maussang D, Gonzalez-Pajuelo M, Chow KY, Bosch L, De Vrieze S, Serruys B, Ulrichts H, Vandevelde W, Saunders M, De Haard HJ, Schols D, Leurs R, Vanlandschoot P, Verrips T, Smit MJ.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20565-70. doi: 10.1073/pnas.1012865107. Epub 2010 Nov 8.

13.

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice.

Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, Tortorella D, Smit MJ, Lira SA.

J Clin Invest. 2010 Nov;120(11):3969-78. doi: 10.1172/JCI42563. Epub 2010 Oct 11.

14.

HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis.

Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, Fraile-Ramos A, Lira SA, Söderberg-Nauclér C, Smit MJ.

Sci Signal. 2010 Aug 3;3(133):ra58. doi: 10.1126/scisignal.2001180.

15.

Herpesvirus-encoded G protein-coupled receptors as modulators of cellular function.

Maussang D, Vischer HF, Leurs R, Smit MJ.

Mol Pharmacol. 2009 Oct;76(4):692-701. doi: 10.1124/mol.109.057091. Epub 2009 Jul 1. Review.

PMID:
19570946
16.

Pharmacological and biochemical characterization of human cytomegalovirus-encoded G protein-coupled receptors.

Maussang D, Vischer HF, Schreiber A, Michel D, Smit MJ.

Methods Enzymol. 2009;460:151-71. doi: 10.1016/S0076-6879(09)05207-0.

PMID:
19446724
17.

The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2.

Maussang D, Langemeijer E, Fitzsimons CP, Stigter-van Walsum M, Dijkman R, Borg MK, Slinger E, Schreiber A, Michel D, Tensen CP, van Dongen GA, Leurs R, Smit MJ.

Cancer Res. 2009 Apr 1;69(7):2861-9. doi: 10.1158/0008-5472.CAN-08-2487. Epub 2009 Mar 24.

18.

Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria.

Shang L, Fukata M, Thirunarayanan N, Martin AP, Arnaboldi P, Maussang D, Berin C, Unkeless JC, Mayer L, Abreu MT, Lira SA.

Gastroenterology. 2008 Aug;135(2):529-38. doi: 10.1053/j.gastro.2008.04.020. Epub 2008 Apr 22.

19.

Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis.

Maussang D, Verzijl D, van Walsum M, Leurs R, Holl J, Pleskoff O, Michel D, van Dongen GA, Smit MJ.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13068-73. Epub 2006 Aug 21.

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