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Items: 1 to 50 of 95

1.

Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.

Li M, Kandror O, Akopian T, Dharkar P, Wlodawer A, Maurizi MR, Goldberg AL.

J Biol Chem. 2016 Apr 1;291(14):7465-76. doi: 10.1074/jbc.M115.700344. Epub 2016 Feb 8.

2.

Mitochondrial ClpP activity is required for cisplatin resistance in human cells.

Zhang Y, Maurizi MR.

Biochim Biophys Acta. 2016 Feb;1862(2):252-64. doi: 10.1016/j.bbadis.2015.12.005. Epub 2015 Dec 7.

3.

The proteasome gets a grip on protein complexity.

Humbard MA, Maurizi MR.

Nat Struct Mol Biol. 2015 Mar;22(3):181-3. doi: 10.1038/nsmb.2977. No abstract available.

PMID:
25736088
4.

ClpX shifts into high gear to unfold stable proteins.

Maurizi MR, Stan G.

Cell. 2013 Oct 24;155(3):502-4. doi: 10.1016/j.cell.2013.10.007. Epub 2013 Oct 24.

5.

The N-degradome of Escherichia coli: limited proteolysis in vivo generates a large pool of proteins bearing N-degrons.

Humbard MA, Surkov S, De Donatis GM, Jenkins LM, Maurizi MR.

J Biol Chem. 2013 Oct 4;288(40):28913-24. doi: 10.1074/jbc.M113.492108. Epub 2013 Aug 19.

6.

The purification of the Chlamydomonas reinhardtii chloroplast ClpP complex: additional subunits and structural features.

Derrien B, Majeran W, Effantin G, Ebenezer J, Friso G, van Wijk KJ, Steven AC, Maurizi MR, Vallon O.

Plant Mol Biol. 2012 Sep;80(2):189-202. doi: 10.1007/s11103-012-9939-5. Epub 2012 Jul 8.

7.

4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells.

Kang JH, Chang YC, Maurizi MR.

J Biol Chem. 2012 May 4;287(19):15661-71. doi: 10.1074/jbc.M112.358473. Epub 2012 Mar 20.

8.

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

Li DH, Chung YS, Gloyd M, Joseph E, Ghirlando R, Wright GD, Cheng YQ, Maurizi MR, Guarné A, Ortega J.

Chem Biol. 2010 Sep 24;17(9):959-69. doi: 10.1016/j.chembiol.2010.07.008.

9.

Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber.

Cha SS, An YJ, Lee CR, Lee HS, Kim YG, Kim SJ, Kwon KK, De Donatis GM, Lee JH, Maurizi MR, Kang SG.

EMBO J. 2010 Oct 20;29(20):3520-30. doi: 10.1038/emboj.2010.226. Epub 2010 Sep 10.

10.

Structure of the N-terminal fragment of Escherichia coli Lon protease.

Li M, Gustchina A, Rasulova FS, Melnikov EE, Maurizi MR, Rotanova TV, Dauter Z, Wlodawer A.

Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):865-73. doi: 10.1107/S0907444910019554. Epub 2010 Jul 9.

11.

Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotations.

Effantin G, Ishikawa T, De Donatis GM, Maurizi MR, Steven AC.

Structure. 2010 May 12;18(5):553-62. doi: 10.1016/j.str.2010.02.016.

12.

Binding of the ClpA unfoldase opens the axial gate of ClpP peptidase.

Effantin G, Maurizi MR, Steven AC.

J Biol Chem. 2010 May 7;285(19):14834-40. doi: 10.1074/jbc.M109.090498. Epub 2010 Mar 16.

13.

A single ClpS monomer is sufficient to direct the activity of the ClpA hexamer.

De Donatis GM, Singh SK, Viswanathan S, Maurizi MR.

J Biol Chem. 2010 Mar 19;285(12):8771-81. doi: 10.1074/jbc.M109.053736. Epub 2010 Jan 12.

14.

Turnover of endogenous SsrA-tagged proteins mediated by ATP-dependent proteases in Escherichia coli.

Lies M, Maurizi MR.

J Biol Chem. 2008 Aug 22;283(34):22918-29. doi: 10.1074/jbc.M801692200. Epub 2008 Jun 12.

15.

Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors.

Granot Z, Kobiler O, Melamed-Book N, Eimerl S, Bahat A, Lu B, Braun S, Maurizi MR, Suzuki CK, Oppenheim AB, Orly J.

Mol Endocrinol. 2007 Sep;21(9):2164-77. Epub 2007 Jun 19.

PMID:
17579211
16.

Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains.

Rotanova TV, Botos I, Melnikov EE, Rasulova F, Gustchina A, Maurizi MR, Wlodawer A.

Protein Sci. 2006 Aug;15(8):1815-28. Review.

17.

Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site.

Szyk A, Maurizi MR.

J Struct Biol. 2006 Oct;156(1):165-74. Epub 2006 Apr 21.

PMID:
16682229
18.

Crystal structure of the N-terminal domain of E. coli Lon protease.

Li M, Rasulova F, Melnikov EE, Rotanova TV, Gustchina A, Maurizi MR, Wlodawer A.

Protein Sci. 2005 Nov;14(11):2895-900. Epub 2005 Sep 30.

19.

Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX.

Kang SG, Dimitrova MN, Ortega J, Ginsburg A, Maurizi MR.

J Biol Chem. 2005 Oct 21;280(42):35424-32. Epub 2005 Aug 22.

20.

The molecular chaperone, ClpA, has a single high affinity peptide binding site per hexamer.

Piszczek G, Rozycki J, Singh SK, Ginsburg A, Maurizi MR.

J Biol Chem. 2005 Apr 1;280(13):12221-30. Epub 2005 Jan 18.

21.

Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP.

Kang SG, Maurizi MR, Thompson M, Mueser T, Ahvazi B.

J Struct Biol. 2004 Dec;148(3):338-52.

PMID:
15522782
22.

ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes.

Ortega J, Lee HS, Maurizi MR, Steven AC.

J Struct Biol. 2004 Apr-May;146(1-2):217-26.

PMID:
15037252
23.
24.

Crystallographic investigation of peptide binding sites in the N-domain of the ClpA chaperone.

Xia D, Esser L, Singh SK, Guo F, Maurizi MR.

J Struct Biol. 2004 Apr-May;146(1-2):166-79.

PMID:
15037248
25.

Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution.

Botos I, Melnikov EE, Cherry S, Khalatova AG, Rasulova FS, Tropea JE, Maurizi MR, Rotanova TV, Gustchina A, Wlodawer A.

J Struct Biol. 2004 Apr-May;146(1-2):113-22. Review.

PMID:
15037242
26.

Protein binding and disruption by Clp/Hsp100 chaperones.

Maurizi MR, Xia D.

Structure. 2004 Feb;12(2):175-83. Review.

27.

The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site.

Botos I, Melnikov EE, Cherry S, Tropea JE, Khalatova AG, Rasulova F, Dauter Z, Maurizi MR, Rotanova TV, Wlodawer A, Gustchina A.

J Biol Chem. 2004 Feb 27;279(9):8140-8. Epub 2003 Dec 9.

28.

Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA.

Guo F, Esser L, Singh SK, Maurizi MR, Xia D.

J Biol Chem. 2002 Nov 29;277(48):46753-62. Epub 2002 Sep 15.

29.

Alternating translocation of protein substrates from both ends of ClpXP protease.

Ortega J, Lee HS, Maurizi MR, Steven AC.

EMBO J. 2002 Sep 16;21(18):4938-49.

30.

Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease.

Guo F, Maurizi MR, Esser L, Xia D.

J Biol Chem. 2002 Nov 29;277(48):46743-52. Epub 2002 Aug 29.

31.

Love it or cleave it: tough choices in protein quality control.

Maurizi MR.

Nat Struct Biol. 2002 Jun;9(6):410-2. No abstract available.

PMID:
12032552
32.

Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP.

Kang SG, Ortega J, Singh SK, Wang N, Huang NN, Steven AC, Maurizi MR.

J Biol Chem. 2002 Jun 7;277(23):21095-102. Epub 2002 Mar 28.

33.

Degradation of L-glutamate dehydrogenase from Escherichia coli: allosteric regulation of enzyme stability.

Maurizi MR, Rasulova F.

Arch Biochem Biophys. 2002 Jan 15;397(2):206-16.

PMID:
11795873
34.
35.

Cell biology. Surviving starvation.

Gottesman S, Maurizi MR.

Science. 2001 Jul 27;293(5530):614-5. No abstract available.

PMID:
11474088
36.

Functional domains of the ClpA and ClpX molecular chaperones identified by limited proteolysis and deletion analysis.

Singh SK, Rozycki J, Ortega J, Ishikawa T, Lo J, Steven AC, Maurizi MR.

J Biol Chem. 2001 Aug 3;276(31):29420-9. Epub 2001 May 9.

37.

Translocation pathway of protein substrates in ClpAP protease.

Ishikawa T, Beuron F, Kessel M, Wickner S, Maurizi MR, Steven AC.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4328-33. Epub 2001 Apr 3.

38.

The RssB response regulator directly targets sigma(S) for degradation by ClpXP.

Zhou Y, Gottesman S, Hoskins JR, Maurizi MR, Wickner S.

Genes Dev. 2001 Mar 1;15(5):627-37.

39.

Visualization of substrate binding and translocation by the ATP-dependent protease, ClpXP.

Ortega J, Singh SK, Ishikawa T, Maurizi MR, Steven AC.

Mol Cell. 2000 Dec;6(6):1515-21.

40.

Docking of components in a bacterial complex.

Ishikawa T, Maurizi MR, Belnap D, Steven AC.

Nature. 2000 Dec 7;408(6813):667-8. No abstract available.

PMID:
11130060
41.
42.

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP.

Singh SK, Grimaud R, Hoskins JR, Wickner S, Maurizi MR.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8898-903.

43.

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP.

Hoskins JR, Singh SK, Maurizi MR, Wickner S.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8892-7.

44.

Posttranslational quality control: folding, refolding, and degrading proteins.

Wickner S, Maurizi MR, Gottesman S.

Science. 1999 Dec 3;286(5446):1888-93. Review.

PMID:
10583944
45.

ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease.

Singh SK, Guo F, Maurizi MR.

Biochemistry. 1999 Nov 9;38(45):14906-15.

PMID:
10555973
46.

Nucleotide-dependent oligomerization of ClpB from Escherichia coli.

Zolkiewski M, Kessel M, Ginsburg A, Maurizi MR.

Protein Sci. 1999 Sep;8(9):1899-903.

47.

Here's the hook: similar substrate binding sites in the chaperone domains of Clp and Lon.

Wickner S, Maurizi MR.

Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8318-20. No abstract available.

48.
49.

Importance of heptameric ring integrity for activity of Escherichia coli ClpP.

Thompson MW, Miller J, Maurizi MR, Kempner E.

Eur J Biochem. 1998 Dec 15;258(3):923-8.

50.

At sixes and sevens: characterization of the symmetry mismatch of the ClpAP chaperone-assisted protease.

Beuron F, Maurizi MR, Belnap DM, Kocsis E, Booy FP, Kessel M, Steven AC.

J Struct Biol. 1998 Nov;123(3):248-59.

PMID:
9878579

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