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Items: 1 to 50 of 167

1.

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage.

van Gastel J, Leysen H, Santos-Otte P, Hendrickx JO, Azmi A, Martin B, Maudsley S.

Aging (Albany NY). 2019 Dec 3;11. doi: 10.18632/aging.102528. [Epub ahead of print]

2.

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.

van Gastel J, Cai H, Cong WN, Chadwick W, Daimon C, Leysen H, Hendrickx JO, De Schepper R, Vangenechten L, Van Turnhout J, Verswyvel J, Becker KG, Zhang Y, Lehrmann E, Wood WH 3rd, Martin B, Maudsley S.

Mech Ageing Dev. 2019 Dec;184:111150. doi: 10.1016/j.mad.2019.111150. Epub 2019 Sep 28.

PMID:
31574270
3.

Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone-Vascular Axis.

De Maré A, Maudsley S, Azmi A, Hendrickx JO, Opdebeeck B, Neven E, D'Haese PC, Verhulst A.

Toxins (Basel). 2019 Jul 21;11(7). pii: E428. doi: 10.3390/toxins11070428.

4.

Enhanced Molecular Appreciation of Psychiatric Disorders Through High-Dimensionality Data Acquisition and Analytics.

van Gastel J, Hendrickx JO, Leysen H, Martin B, Veenker L, Beuning S, Coppens V, Morrens M, Maudsley S.

Methods Mol Biol. 2019;2011:671-723. doi: 10.1007/978-1-4939-9554-7_39.

PMID:
31273728
5.

Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance.

Opdebeeck B, Maudsley S, Azmi A, De Maré A, De Leger W, Meijers B, Verhulst A, Evenepoel P, D'Haese PC, Neven E.

J Am Soc Nephrol. 2019 May;30(5):751-766. doi: 10.1681/ASN.2018060609. Epub 2019 Apr 2.

PMID:
30940651
6.

GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders.

Hendrickx JO, van Gastel J, Leysen H, Santos-Otte P, Premont RT, Martin B, Maudsley S.

Front Pharmacol. 2018 Dec 17;9:1484. doi: 10.3389/fphar.2018.01484. eCollection 2018. Review.

7.

β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders.

van Gastel J, Hendrickx JO, Leysen H, Santos-Otte P, Luttrell LM, Martin B, Maudsley S.

Front Pharmacol. 2018 Nov 28;9:1369. doi: 10.3389/fphar.2018.01369. eCollection 2018. Review.

8.

Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality.

Anckaerts C, van Gastel J, Leysen V, Hinz R, Azmi A, Simoens P, Shah D, Kara F, Langbeen A, Bols P, Laloux C, Prevot V, Verhoye M, Maudsley S, Van der Linden A.

Neurobiol Aging. 2019 Feb;74:77-89. doi: 10.1016/j.neurobiolaging.2018.10.012. Epub 2018 Oct 17.

PMID:
30439596
9.

Aging and drug discovery.

Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2018 Nov 13;10(11):3079-3088. doi: 10.18632/aging.101646.

10.

G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes.

Leysen H, van Gastel J, Hendrickx JO, Santos-Otte P, Martin B, Maudsley S.

Int J Mol Sci. 2018 Sep 26;19(10). pii: E2919. doi: 10.3390/ijms19102919. Review.

11.

Intelligent and effective informatic deconvolution of "Big Data" and its future impact on the quantitative nature of neurodegenerative disease therapy.

Maudsley S, Devanarayan V, Martin B, Geerts H; Brain Health Modeling Initiative (BHMI).

Alzheimers Dement. 2018 Jul;14(7):961-975. doi: 10.1016/j.jalz.2018.01.014. Epub 2018 Mar 15. Review.

PMID:
29551332
12.

GIT2-A keystone in ageing and age-related disease.

van Gastel J, Boddaert J, Jushaj A, Premont RT, Luttrell LM, Janssens J, Martin B, Maudsley S.

Ageing Res Rev. 2018 May;43:46-63. doi: 10.1016/j.arr.2018.02.002. Epub 2018 Feb 13. Review.

PMID:
29452267
13.

PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease.

Juneja M, Azmi A, Baets J, Roos A, Jennings MJ, Saveri P, Pisciotta C, Bernard-Marissal N, Schneider BL, Verfaillie C, Chrast R, Seeman P, Hahn AF, de Jonghe P, Maudsley S, Horvath R, Pareyson D, Timmerman V.

J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):870-878. doi: 10.1136/jnnp-2017-317562. Epub 2018 Feb 15.

PMID:
29449460
14.

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions.

Miquel S, Champ C, Day J, Aarts E, Bahr BA, Bakker M, Bánáti D, Calabrese V, Cederholm T, Cryan J, Dye L, Farrimond JA, Korosi A, Layé S, Maudsley S, Milenkovic D, Mohajeri MH, Sijben J, Solomon A, Spencer JPE, Thuret S, Vanden Berghe W, Vauzour D, Vellas B, Wesnes K, Willatts P, Wittenberg R, Geurts L.

Ageing Res Rev. 2018 Mar;42:40-55. doi: 10.1016/j.arr.2017.12.004. Epub 2017 Dec 15. Review.

15.

Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung.

Vermeulen Z, Hervent AS, Dugaucquier L, Vandekerckhove L, Rombouts M, Beyens M, Schrijvers DM, De Meyer GRY, Maudsley S, De Keulenaer GW, Segers VFM.

Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H934-H945. doi: 10.1152/ajpheart.00206.2017. Epub 2017 Aug 19.

16.

Correction for Lu et al., "Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair".

Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S.

Mol Cell Biol. 2017 Aug 11;37(17). pii: e00310-17. doi: 10.1128/MCB.00310-17. Print 2017 Sep 1. No abstract available.

17.

Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction.

Martin B, Wang R, Cong WN, Daimon CM, Wu WW, Ni B, Becker KG, Lehrmann E, Wood WH 3rd, Zhang Y, Etienne H, van Gastel J, Azmi A, Janssens J, Maudsley S.

J Biol Chem. 2017 Jul 7;292(27):11508-11530. doi: 10.1074/jbc.M116.773820. Epub 2017 May 18.

18.

Translating in vitro ligand bias into in vivo efficacy.

Luttrell LM, Maudsley S, Gesty-Palmer D.

Cell Signal. 2018 Jan;41:46-55. doi: 10.1016/j.cellsig.2017.05.002. Epub 2017 May 7. Review.

19.

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.

Siddiqui S, Lustig A, Carter A, Sankar M, Daimon CM, Premont RT, Etienne H, van Gastel J, Azmi A, Janssens J, Becker KG, Zhang Y, Wood W, Lehrmann E, Martin JG, Martin B, Taub DD, Maudsley S.

Aging (Albany NY). 2017 Mar 4;9(3):706-740. doi: 10.18632/aging.101185.

20.

Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases.

Janssens J, Lu D, Ni B, Chadwick W, Siddiqui S, Azmi A, Etienne H, Jushaj A, van Gastel J, Martin B, Maudsley S.

Vitam Horm. 2017;104:263-311. doi: 10.1016/bs.vh.2016.10.006. Epub 2016 Nov 29. Review.

PMID:
28215298
21.

Big data to smart data in Alzheimer's disease: The brain health modeling initiative to foster actionable knowledge.

Geerts H, Dacks PA, Devanarayan V, Haas M, Khachaturian ZS, Gordon MF, Maudsley S, Romero K, Stephenson D; Brain Health Modeling Initiative (BHMI).

Alzheimers Dement. 2016 Sep;12(9):1014-1021. doi: 10.1016/j.jalz.2016.04.008. Epub 2016 May 26. Review.

22.

Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2.

Grammatikakis I, Zhang P, Panda AC, Kim J, Maudsley S, Abdelmohsen K, Yang X, Martindale JL, Motiño O, Hutchison ER, Mattson MP, Gorospe M.

Cell Rep. 2016 May 3;15(5):926-934. doi: 10.1016/j.celrep.2016.03.080. Epub 2016 Apr 21.

23.

GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.

Martin B, Chadwick W, Janssens J, Premont RT, Schmalzigaug R, Becker KG, Lehrmann E, Wood WH, Zhang Y, Siddiqui S, Park SS, Cong WN, Daimon CM, Maudsley S.

Front Endocrinol (Lausanne). 2016 Jan 18;6:191. doi: 10.3389/fendo.2015.00191. eCollection 2015.

24.

Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder.

Daimon CM, Jasien JM, Wood WH 3rd, Zhang Y, Becker KG, Silverman JL, Crawley JN, Martin B, Maudsley S.

Front Physiol. 2015 Nov 24;6:324. doi: 10.3389/fphys.2015.00324. eCollection 2015.

25.

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains.

Janssens J, Philtjens S, Kleinberger G, Van Mossevelde S, van der Zee J, Cacace R, Engelborghs S, Sieben A, Banzhaf-Strathmann J, Dillen L, Merlin C, Cuijt I, Robberecht C, Schmid B, Santens P, Ivanoiu A, Vandenbulcke M, Vandenberghe R, Cras P, De Deyn PP, Martin JJ, Maudsley S, Haass C, Cruts M, Van Broeckhoven C; Belgian Neurology (BELNEU) consortium.

Acta Neuropathol Commun. 2015 Nov 10;3:68. doi: 10.1186/s40478-015-0246-7.

26.

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus.

Mou Z, Hyde TM, Lipska BK, Martinowich K, Wei P, Ong CJ, Hunter LA, Palaguachi GI, Morgun E, Teng R, Lai C, Condarco TA, Demidowich AP, Krause AJ, Marshall LJ, Haack K, Voruganti VS, Cole SA, Butte NF, Comuzzie AG, Nalls MA, Zonderman AB, Singleton AB, Evans MK, Martin B, Maudsley S, Tsao JW, Kleinman JE, Yanovski JA, Han JC.

Cell Rep. 2015 Nov 10;13(6):1073-1080. doi: 10.1016/j.celrep.2015.09.065. Epub 2015 Oct 29.

27.

Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia.

Hardies K, de Kovel CG, Weckhuysen S, Asselbergh B, Geuens T, Deconinck T, Azmi A, May P, Brilstra E, Becker F, Barisic N, Craiu D, Braun KP, Lal D, Thiele H, Schubert J, Weber Y, van 't Slot R, Nürnberg P, Balling R, Timmerman V, Lerche H, Maudsley S, Helbig I, Suls A, Koeleman BP, De Jonghe P; autosomal recessive working group of the EuroEPINOMICS RES Consortium.

Brain. 2015 Nov;138(Pt 11):3238-50. doi: 10.1093/brain/awv263. Epub 2015 Sep 17.

PMID:
26384929
28.

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

Luttrell LM, Maudsley S, Bohn LM.

Mol Pharmacol. 2015 Sep;88(3):579-88. doi: 10.1124/mol.115.099630. Epub 2015 Jul 1. Review.

29.

Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.

Maudsley S, Martin B, Janssens J, Etienne H, Jushaj A, van Gastel J, Willemsen A, Chen H, Gesty-Palmer D, Luttrell LM.

Methods. 2016 Jan 1;92:51-63. doi: 10.1016/j.ymeth.2015.05.013. Epub 2015 May 16.

30.

Delineation of a conserved arrestin-biased signaling repertoire in vivo.

Maudsley S, Martin B, Gesty-Palmer D, Cheung H, Johnson C, Patel S, Becker KG, Wood WH 3rd, Zhang Y, Lehrmann E, Luttrell LM.

Mol Pharmacol. 2015 Apr;87(4):706-17. doi: 10.1124/mol.114.095224. Epub 2015 Jan 30.

31.

Nuclear GIT2 is an ATM substrate and promotes DNA repair.

Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S.

Mol Cell Biol. 2015 Apr;35(7):1081-96. doi: 10.1128/MCB.01432-14. Epub 2015 Jan 20. Erratum in: Mol Cell Biol. 2017 Aug 11;37(17 ):.

32.

Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.

Cong WN, Chadwick W, Wang R, Daimon CM, Cai H, Amma J, Wood WH 3rd, Becker KG, Martin B, Maudsley S.

J Biol Chem. 2015 Jan 30;290(5):2728-43. doi: 10.1074/jbc.M114.588608. Epub 2014 Dec 11.

33.

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.

Mirsoian A, Bouchlaka MN, Sckisel GD, Chen M, Pai CC, Maverakis E, Spencer RG, Fishbein KW, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Taub DD, Murphy WJ.

J Exp Med. 2014 Nov 17;211(12):2373-83. doi: 10.1084/jem.20140116. Epub 2014 Nov 3.

34.

Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor System.

Janssens J, Etienne H, Idriss S, Azmi A, Martin B, Maudsley S.

Front Endocrinol (Lausanne). 2014 Sep 1;5:142. doi: 10.3389/fendo.2014.00142. eCollection 2014. Review.

35.

The effects of aging on the BTBR mouse model of autism spectrum disorder.

Jasien JM, Daimon CM, Wang R, Shapiro BK, Martin B, Maudsley S.

Front Aging Neurosci. 2014 Sep 1;6:225. doi: 10.3389/fnagi.2014.00225. eCollection 2014.

36.

Higher TNF-α, IGF-1, and Leptin Levels are Found in Tasters than Non-Tasters.

Wang R, van Keeken NM, Siddiqui S, Dijksman LM, Maudsley S, Derval D, van Dam PS, Martin B.

Front Endocrinol (Lausanne). 2014 Jul 29;5:125. doi: 10.3389/fendo.2014.00125. eCollection 2014.

37.

Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients.

Wang R, Ross CA, Cai H, Cong WN, Daimon CM, Carlson OD, Egan JM, Siddiqui S, Maudsley S, Martin B.

Front Physiol. 2014 Jun 23;5:231. doi: 10.3389/fphys.2014.00231. eCollection 2014.

38.

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

Mattison JA, Wang M, Bernier M, Zhang J, Park SS, Maudsley S, An SS, Santhanam L, Martin B, Faulkner S, Morrell C, Baur JA, Peshkin L, Sosnowska D, Csiszar A, Herbert RL, Tilmont EM, Ungvari Z, Pearson KJ, Lakatta EG, de Cabo R.

Cell Metab. 2014 Jul 1;20(1):183-90. doi: 10.1016/j.cmet.2014.04.018. Epub 2014 May 29.

39.

What is the role of metabolic hormones in taste buds of the tongue.

Cai H, Maudsley S, Martin B.

Front Horm Res. 2014;42:134-46. doi: 10.1159/000358322. Epub 2014 Apr 7. Review.

PMID:
24732931
40.

Pharmacophore model of the quercetin binding site of the SIRT6 protein.

Ravichandran S, Singh N, Donnelly D, Migliore M, Johnson P, Fishwick C, Luke BT, Martin B, Maudsley S, Fugmann SD, Moaddel R.

J Mol Graph Model. 2014 Apr;49:38-46. doi: 10.1016/j.jmgm.2014.01.004. Epub 2014 Jan 20.

41.

The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases.

Daimon CM, Chirdon P, Maudsley S, Martin B.

Am J Alzheimers Dis (Columbia). 2013;1(1). doi: 10.7726/ajad.2013.1003.

42.

Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.

Okun E, Griffioen KJ, Rothman S, Wan R, Cong WN, De Cabo R, Martin-Montalvo A, Levette A, Maudsley S, Martin B, Arumugam TV, Mattson MP.

Brain Behav Immun. 2014 Feb;36:90-100. doi: 10.1016/j.bbi.2013.10.013. Epub 2013 Oct 18.

43.

Altered lipid and salt taste responsivity in ghrelin and GOAT null mice.

Cai H, Cong WN, Daimon CM, Wang R, Tschöp MH, Sévigny J, Martin B, Maudsley S.

PLoS One. 2013 Oct 4;8(10):e76553. doi: 10.1371/journal.pone.0076553. eCollection 2013.

44.

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators.

Cai H, Daimon CM, Cong WN, Wang R, Chirdon P, de Cabo R, Sévigny J, Maudsley S, Martin B.

J Gerontol A Biol Sci Med Sci. 2014 May;69(5):532-44. doi: 10.1093/gerona/glt129. Epub 2013 Sep 28.

45.

Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.

Cong WN, Wang R, Cai H, Daimon CM, Scheibye-Knudsen M, Bohr VA, Turkin R, Wood WH 3rd, Becker KG, Moaddel R, Maudsley S, Martin B.

PLoS One. 2013 Aug 7;8(8):e70257. doi: 10.1371/journal.pone.0070257. eCollection 2013.

46.

Plurigon: three dimensional visualization and classification of high-dimensionality data.

Martin B, Chen H, Daimon CM, Chadwick W, Siddiqui S, Maudsley S.

Front Physiol. 2013 Jul 22;4:190. doi: 10.3389/fphys.2013.00190. eCollection 2013.

47.

Systems analysis of arrestin pathway functions.

Maudsley S, Siddiqui S, Martin B.

Prog Mol Biol Transl Sci. 2013;118:431-67. doi: 10.1016/B978-0-12-394440-5.00017-6. Review.

PMID:
23764064
48.

Textrous!: extracting semantic textual meaning from gene sets.

Chen H, Martin B, Daimon CM, Siddiqui S, Luttrell LM, Maudsley S.

PLoS One. 2013 Apr 30;8(4):e62665. doi: 10.1371/journal.pone.0062665. Print 2013.

49.

The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women.

Harvie M, Wright C, Pegington M, McMullan D, Mitchell E, Martin B, Cutler RG, Evans G, Whiteside S, Maudsley S, Camandola S, Wang R, Carlson OD, Egan JM, Mattson MP, Howell A.

Br J Nutr. 2013 Oct;110(8):1534-47. doi: 10.1017/S0007114513000792. Epub 2013 Apr 16.

50.

BRET Biosensor Analysis of Receptor Tyrosine Kinase Functionality.

Siddiqui S, Cong WN, Daimon CM, Martin B, Maudsley S.

Front Endocrinol (Lausanne). 2013 Apr 9;4:46. doi: 10.3389/fendo.2013.00046. eCollection 2013.

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