Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 200


Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss.

Bonnevie ED, Gullbrand SE, Ashinsky BG, Tsinman TK, Elliott DM, Chao PG, Smith HE, Mauck RL.

Nat Biomed Eng. 2019 Oct 14. doi: 10.1038/s41551-019-0458-4. [Epub ahead of print]


Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix.

Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS, Lu XL, Enomoto-Iwamoto M, Qin L, Mauck RL, Iozzo RV, Birk DE, Han L.

ACS Nano. 2019 Oct 22;13(10):11320-11333. doi: 10.1021/acsnano.9b04477. Epub 2019 Oct 1.


A common language for evaluating disc degeneration and regeneration: A JOR Spine/ORS Spine Section initiative.

Mauck RL, Alini M, Sakai D.

JOR Spine. 2019 May 31;2(2):e1056. doi: 10.1002/jsp2.1056. eCollection 2019 Jun. No abstract available.


Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model.

Ashinsky BG, Gullbrand SE, Bonnevie ED, Mandalapu SA, Wang C, Elliott DM, Han L, Mauck RL, Smith HE.

Osteoarthritis Cartilage. 2019 Aug 13. pii: S1063-4584(19)31169-0. doi: 10.1016/j.joca.2019.07.016. [Epub ahead of print]


Recombinant human FGF18 preserves depth-dependent mechanical inhomogeneity in articular cartilage.

Meloni GR, Farran A, Mohanraj B, Guehring H, Cocca R, Rabut E, Mauck RL, Dodge GR.

Eur Cell Mater. 2019 Aug 8;38:23-34. doi: 10.22203/eCM.v038a03.


A Systematic Review and Guide to Mechanical Testing for Articular Cartilage Tissue Engineering.

Patel JM, Wise BC, Bonnevie ED, Mauck RL.

Tissue Eng Part C Methods. 2019 Oct;25(10):593-608. doi: 10.1089/ten.TEC.2019.0116. Epub 2019 Sep 30.


Emerging therapies for cartilage regeneration in currently excluded 'red knee' populations.

Martín AR, Patel JM, Zlotnick HM, Carey JL, Mauck RL.

NPJ Regen Med. 2019 May 30;4:12. doi: 10.1038/s41536-019-0074-7. eCollection 2019. Review.


Elevated BMP and Mechanical Signaling Through YAP1/RhoA Poises FOP Mesenchymal Progenitors for Osteogenesis.

Stanley A, Heo SJ, Mauck RL, Mourkioti F, Shore EM.

J Bone Miner Res. 2019 Oct;34(10):1894-1909. doi: 10.1002/jbmr.3760. Epub 2019 Aug 19.


Measuring clinically relevant knee motion with a self-calibrated wearable sensor.

Hullfish TJ, Qu F, Stoeckl BD, Gebhard PM, Mauck RL, Baxter JR.

J Biomech. 2019 May 24;89:105-109. doi: 10.1016/j.jbiomech.2019.04.003. Epub 2019 Apr 5.


Hypoxic Preconditioning Enhances Bone Marrow-Derived Mesenchymal Stem Cell Survival in a Low Oxygen and Nutrient-Limited 3D Microenvironment.

Peck SH, Bendigo JR, Tobias JW, Dodge GR, Malhotra NR, Mauck RL, Smith LJ.

Cartilage. 2019 Apr 11:1947603519841675. doi: 10.1177/1947603519841675. [Epub ahead of print]


Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section.

Smith LJ, Silverman L, Sakai D, Le Maitre CL, Mauck RL, Malhotra NR, Lotz JC, Buckley CT.

JOR Spine. 2018 Dec;1(4):e1036. doi: 10.1002/jsp2.1036. Epub 2018 Oct 8. Review.


Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels.

Loebel C, Mauck RL, Burdick JA.

Nat Mater. 2019 Aug;18(8):883-891. doi: 10.1038/s41563-019-0307-6. Epub 2019 Mar 18.


Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity.

Patel JM, Saleh KS, Burdick JA, Mauck RL.

Acta Biomater. 2019 Jul 15;93:222-238. doi: 10.1016/j.actbio.2019.01.061. Epub 2019 Jan 31. Review.


Extracellular vesicles mediate improved functional outcomes in engineered cartilage produced from MSC/chondrocyte cocultures.

Kim M, Steinberg DR, Burdick JA, Mauck RL.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1569-1578. doi: 10.1073/pnas.1815447116. Epub 2019 Jan 15.


Cell migration: implications for repair and regeneration in joint disease.

Qu F, Guilak F, Mauck RL.

Nat Rev Rheumatol. 2019 Mar;15(3):167-179. doi: 10.1038/s41584-018-0151-0. Review.


Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc.

Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Engiles JB, Smith LJ, Elliott DM, Schaer TP, Smith HE, Mauck RL.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaau0670. doi: 10.1126/scitranslmed.aau0670.


ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification.

Haupt J, Stanley A, McLeod CM, Cosgrove BD, Culbert AL, Wang L, Mourkioti F, Mauck RL, Shore EM.

Mol Biol Cell. 2019 Jan 1;30(1):17-29. doi: 10.1091/mbc.E18-05-0311. Epub 2018 Oct 31.


A Wearable Magnet-Based System to Assess Activity and Joint Flexion in Humans and Large Animals.

Qu F, Stoeckl BD, Gebhard PM, Hullfish TJ, Baxter JR, Mauck RL.

Ann Biomed Eng. 2018 Dec;46(12):2069-2078. doi: 10.1007/s10439-018-2105-8. Epub 2018 Aug 6.


Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission.

Freedman BR, Rodriguez AB, Leiphart RJ, Newton JB, Ban E, Sarver JJ, Mauck RL, Shenoy VB, Soslowsky LJ.

Sci Rep. 2018 Jul 18;8(1):10854. doi: 10.1038/s41598-018-29060-y.


Chondrocyte and mesenchymal stem cell derived engineered cartilage exhibits differential sensitivity to pro-inflammatory cytokines.

Mohanraj B, Huang AH, Yeger-McKeever MJ, Schmidt MJ, Dodge GR, Mauck RL.

J Orthop Res. 2018 Nov;36(11):2901-2910. doi: 10.1002/jor.24061. Epub 2018 Jul 13.


Donor Variation and Optimization of Human Mesenchymal Stem Cell Chondrogenesis in Hyaluronic Acid.

Kim M, Erickson IE, Huang AH, Garrity ST, Mauck RL, Steinberg DR.

Tissue Eng Part A. 2018 Nov;24(21-22):1693-1703. doi: 10.1089/ten.TEA.2017.0520. Epub 2018 Sep 21.


Promise, progress, and problems in whole disc tissue engineering.

Gullbrand SE, Smith LJ, Smith HE, Mauck RL.

JOR Spine. 2018 May 23;1(2):e1015. doi: 10.1002/jsp2.1015. eCollection 2018 Jun. Review.


Sprifermin treatment enhances cartilage integration in an in vitro repair model.

Sennett ML, Meloni GR, Farran AJE, Guehring H, Mauck RL, Dodge GR.

J Orthop Res. 2018 Oct;36(10):2648-2656. doi: 10.1002/jor.24048. Epub 2018 Jul 26.


Physiology and Engineering of the Graded Interfaces of Musculoskeletal Junctions.

Bonnevie ED, Mauck RL.

Annu Rev Biomed Eng. 2018 Jun 4;20:403-429. doi: 10.1146/annurev-bioeng-062117-121113. Epub 2018 Apr 11. Review.


Impacts of maturation on the micromechanics of the meniscus extracellular matrix.

Li Q, Wang C, Han B, Qu F, Qi H, Li CY, Mauck RL, Han L.

J Biomech. 2018 Apr 27;72:252-257. doi: 10.1016/j.jbiomech.2018.02.037. Epub 2018 Mar 9.


Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics.

Szczesny SE, Aeppli C, David A, Mauck RL.

J Biomech. 2018 Apr 11;71:251-256. doi: 10.1016/j.jbiomech.2018.02.014. Epub 2018 Feb 21.


Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates.

Gong Z, Szczesny SE, Caliari SR, Charrier EE, Chaudhuri O, Cao X, Lin Y, Mauck RL, Janmey PA, Burdick JA, Shenoy VB.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2686-E2695. doi: 10.1073/pnas.1716620115. Epub 2018 Mar 5.


Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues.

Qu F, Li Q, Wang X, Cao X, Zgonis MH, Esterhai JL, Shenoy VB, Han L, Mauck RL.

Sci Rep. 2018 Feb 19;8(1):3295. doi: 10.1038/s41598-018-21212-4.


Towards the scale up of tissue engineered intervertebral discs for clinical application.

Gullbrand SE, Kim DH, Bonnevie E, Ashinsky BG, Smith LJ, Elliott DM, Mauck RL, Smith HE.

Acta Biomater. 2018 Apr 1;70:154-164. doi: 10.1016/j.actbio.2018.01.050. Epub 2018 Feb 8.


Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments.

Vega SL, Kwon MY, Song KH, Wang C, Mauck RL, Han L, Burdick JA.

Nat Commun. 2018 Feb 9;9(1):614. doi: 10.1038/s41467-018-03021-5.


Dose and Timing of N-Cadherin Mimetic Peptides Regulate MSC Chondrogenesis within Hydrogels.

Kwon MY, Vega SL, Gramlich WM, Kim M, Mauck RL, Burdick JA.

Adv Healthc Mater. 2018 May;7(9):e1701199. doi: 10.1002/adhm.201701199. Epub 2018 Jan 23.


Role of dexamethasone in the long-term functional maturation of MSC-laden hyaluronic acid hydrogels for cartilage tissue engineering.

Kim M, Garrity ST, Steinberg DR, Dodge GR, Mauck RL.

J Orthop Res. 2018 Jun;36(6):1717-1727. doi: 10.1002/jor.23815. Epub 2017 Dec 29.


Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair.

Qu F, Holloway JL, Esterhai JL, Burdick JA, Mauck RL.

Nat Commun. 2017 Nov 24;8(1):1780. doi: 10.1038/s41467-017-01955-w.


In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty.

Martin JT, Gullbrand SE, Kim DH, Ikuta K, Pfeifer CG, Ashinsky BG, Smith LJ, Elliott DM, Smith HE, Mauck RL.

Sci Rep. 2017 Nov 17;7(1):15765. doi: 10.1038/s41598-017-15887-4.


Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells.

Szczesny SE, Driscoll TP, Tseng HY, Liu PC, Heo SJ, Mauck RL, Chao PG.

ACS Biomater Sci Eng. 2017 Nov 13;3(11):2869-2876. doi: 10.1021/acsbiomaterials.6b00646. Epub 2016 Dec 8.


Mechano-adaptation of the stem cell nucleus.

Heo SJ, Cosgrove BD, Dai EN, Mauck RL.

Nucleus. 2018 Jan 1;9(1):9-19. doi: 10.1080/19491034.2017.1371398. Epub 2017 Nov 13. Review.


On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis.

McLeod CM, Mauck RL.

Eur Cell Mater. 2017 Oct 27;34:217-231. doi: 10.22203/eCM.v034a14. Review.


Expansion of mesenchymal stem cells on electrospun scaffolds maintains stemness, mechano-responsivity, and differentiation potential.

Heo SJ, Szczesny SE, Kim DH, Saleh KS, Mauck RL.

J Orthop Res. 2018 Feb;36(2):808-815. doi: 10.1002/jor.23772. Epub 2017 Dec 5.


Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model.

Tian Z, Ma X, Yasen M, Mauck RL, Qin L, Shofer FS, Smith LJ, Pacifici M, Enomoto-Iwamoto M, Zhang Y.

Am J Phys Med Rehabil. 2018 Mar;97(3):170-177. doi: 10.1097/PHM.0000000000000818.


Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model.

Pfeifer CG, Fisher MB, Saxena V, Kim M, Henning EA, Steinberg DA, Dodge GR, Mauck RL.

Tissue Eng Part C Methods. 2017 Nov;23(11):745-753. doi: 10.1089/ten.TEC.2017.0109. Epub 2017 Oct 27.


Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model.

Gullbrand SE, Schaer TP, Agarwal P, Bendigo JR, Dodge GR, Chen W, Elliott DM, Mauck RL, Malhotra NR, Smith LJ.

Acta Biomater. 2017 Sep 15;60:201-209. doi: 10.1016/j.actbio.2017.07.025. Epub 2017 Jul 19.


Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation.

Riggin CN, Qu F, Kim DH, Huegel J, Steinberg DR, Kuntz AF, Soslowsky LJ, Mauck RL, Bernstein J.

Ann Biomed Eng. 2017 Oct;45(10):2348-2359. doi: 10.1007/s10439-017-1876-7. Epub 2017 Jun 26.


Enhanced nutrient transport improves the depth-dependent properties of tri-layered engineered cartilage constructs with zonal co-culture of chondrocytes and MSCs.

Kim M, Farrell MJ, Steinberg DR, Burdick JA, Mauck RL.

Acta Biomater. 2017 Aug;58:1-11. doi: 10.1016/j.actbio.2017.06.025. Epub 2017 Jun 16.


Large Animal Models of Meniscus Repair and Regeneration: A Systematic Review of the State of the Field.

Bansal S, Keah NM, Neuwirth AL, O'Reilly O, Qu F, Seiber BN, Mandalapu S, Mauck RL, Zgonis MH.

Tissue Eng Part C Methods. 2017 Nov;23(11):661-672. doi: 10.1089/ten.TEC.2017.0080. Epub 2017 Aug 4. Review.


* Optimization of Preculture Conditions to Maximize the In Vivo Performance of Cell-Seeded Engineered Intervertebral Discs.

Martin JT, Gullbrand SE, Mohanraj B, Ashinsky BG, Kim DH, Ikuta K, Elliott DM, Smith LJ, Mauck RL, Smith HE.

Tissue Eng Part A. 2017 Sep;23(17-18):923-934. doi: 10.1089/ten.tea.2016.0491. Epub 2017 Apr 19.


A retinaculum-sparing surgical approach preserves porcine stifle joint cartilage in an experimental animal model of cartilage repair.

Bonadio MB, Friedman JM, Sennett ML, Mauck RL, Dodge GR, Madry H.

J Exp Orthop. 2017 Dec;4(1):11. doi: 10.1186/s40634-017-0083-7. Epub 2017 Apr 17.


Biphasic Finite Element Modeling Reconciles Mechanical Properties of Tissue-Engineered Cartilage Constructs Across Testing Platforms.

Meloni GR, Fisher MB, Stoeckl BD, Dodge GR, Mauck RL.

Tissue Eng Part A. 2017 Jul;23(13-14):663-674. doi: 10.1089/ten.tea.2016.0191. Epub 2017 Apr 14.


Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs.

Yousefi F, Kim M, Nahri SY, Mauck RL, Pleshko N.

Tissue Eng Part A. 2018 Jan;24(1-2):106-116. doi: 10.1089/ten.TEA.2017.0035. Epub 2017 May 15.


Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model.

Friedman JM, Sennett ML, Bonadio MB, Orji KO, Neuwirth AL, Keah N, Carey JL, Moutos FT, Estes BT, Guilak F, Madry H, Mauck RL, Dodge GR.

Cartilage. 2018 Oct;9(4):428-437. doi: 10.1177/1947603517700953. Epub 2017 Apr 11.


* Thermosensitive Poly(N-vinylcaprolactam) Injectable Hydrogels for Cartilage Tissue Engineering.

Sala RL, Kwon MY, Kim M, Gullbrand SE, Henning EA, Mauck RL, Camargo ER, Burdick JA.

Tissue Eng Part A. 2017 Sep;23(17-18):935-945. doi: 10.1089/ten.tea.2016.0464. Epub 2017 Apr 6.

Supplemental Content

Loading ...
Support Center