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HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation.

Efimova EV, Ricco N, Labay E, Mauceri HJ, Flor AC, Ramamurthy A, Sutton HG, Weichselbaum RR, Kron SJ.

Mol Cancer Ther. 2018 Feb;17(2):407-418. doi: 10.1158/1535-7163.MCT-17-0288. Epub 2017 Oct 13.


Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers.

Labay E, Mauceri HJ, Efimova EV, Flor AC, Sutton HG, Kron SJ, Weichselbaum RR.

Oncotarget. 2016 Jun 7;7(23):33919-33. doi: 10.18632/oncotarget.8984.


A survivin-associated adaptive response in radiation therapy.

Grdina DJ, Murley JS, Miller RC, Mauceri HJ, Sutton HG, Li JJ, Woloschak GE, Weichselbaum RR.

Cancer Res. 2013 Jul 15;73(14):4418-28. doi: 10.1158/0008-5472.CAN-12-4640. Epub 2013 May 7.


A manganese superoxide dismutase (SOD2)-mediated adaptive response.

Grdina DJ, Murley JS, Miller RC, Mauceri HJ, Sutton HG, Thirman MJ, Li JJ, Woloschak GE, Weichselbaum RR.

Radiat Res. 2013 Feb;179(2):115-24. doi: 10.1667/RR3126.2. Epub 2012 Dec 13.


Tumor endothelial inflammation predicts clinical outcome in diverse human cancers.

Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR.

PLoS One. 2012;7(10):e46104. doi: 10.1371/journal.pone.0046104. Epub 2012 Oct 4.


Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.

Meng Y, Efimova EV, Hamzeh KW, Darga TE, Mauceri HJ, Fu YX, Kron SJ, Weichselbaum RR.

Mol Ther. 2012 May;20(5):1046-55. doi: 10.1038/mt.2012.19. Epub 2012 Feb 14.


Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer.

Mauceri HJ, Sutton HG, Darga TE, Kocherginsky M, Kochanski J, Weichselbaum RR, Vokes EE.

Oncol Rep. 2012 May;27(5):1625-9. doi: 10.3892/or.2012.1666. Epub 2012 Jan 27.


Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.

Barreto-Andrade JC, Efimova EV, Mauceri HJ, Beckett MA, Sutton HG, Darga TE, Vokes EE, Posner MC, Kron SJ, Weichselbaum RR.

Mol Cancer Ther. 2011 Jul;10(7):1185-93. doi: 10.1158/1535-7163.MCT-11-0061. Epub 2011 May 13.


Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.

Efimova EV, Mauceri HJ, Golden DW, Labay E, Bindokas VP, Darga TE, Chakraborty C, Barreto-Andrade JC, Crawley C, Sutton HG, Kron SJ, Weichselbaum RR.

Cancer Res. 2010 Aug 1;70(15):6277-82. doi: 10.1158/0008-5472.CAN-09-4224. Epub 2010 Jul 7.


Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells.

Meng Y, Mauceri HJ, Khodarev NN, Darga TE, Pitroda SP, Beckett MA, Kufe DW, Weichselbaum RR.

Mol Ther. 2010 May;18(5):912-20. doi: 10.1038/mt.2010.18. Epub 2010 Mar 2.


Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy.

Meng Y, Beckett MA, Liang H, Mauceri HJ, van Rooijen N, Cohen KS, Weichselbaum RR.

Cancer Res. 2010 Feb 15;70(4):1534-43. doi: 10.1158/0008-5472.CAN-09-2995. Epub 2010 Feb 9.


STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.

Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, Beckett MA, Mauceri HJ, Posner MC, Weichselbaum RR.

PLoS One. 2009 Jun 8;4(6):e5821. doi: 10.1371/journal.pone.0005821.


Characterization of response to radiation mediated gene therapy by means of multimodality imaging.

Haney CR, Parasca AD, Fan X, Bell RM, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ, Weichselbaum RR, Pelizzari CA.

Magn Reson Med. 2009 Aug;62(2):348-56. doi: 10.1002/mrm.22008.


Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy.

Mauceri HJ, Beckett MA, Liang H, Sutton HG, Pitroda S, Galka E, Efimova E, Darga T, Khodarev NN, King CR, Posner MC, Hellman S, Kufe DW, Weichselbaum RR.

Cancer Gene Ther. 2009 Apr;16(4):373-81. doi: 10.1038/cgt.2008.86. Epub 2008 Oct 31.


Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy.

Bickenbach KA, Veerapong J, Shao MY, Mauceri HJ, Posner MC, Kron SJ, Weichselbaum RR.

Cancer Gene Ther. 2008 Mar;15(3):133-9. Epub 2007 Dec 21.


Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.

Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR.

Cancer Res. 2007 Oct 1;67(19):9214-20.


Local gene delivery of tumor necrosis factor alpha can impact primary tumor growth and metastases through a host-mediated response.

MacGill RS, Davis TA, Macko J, Mauceri HJ, Weichselbaum RR, King CR.

Clin Exp Metastasis. 2007;24(7):521-31. Epub 2007 Jul 25.


Establishment of a syngeneic model of hepatic colorectal oligometastases.

Mezhir JJ, Smith KD, Kimchi ET, Park JO, Lopez CA, Mauceri HJ, Beckett MA, Hellman S, Weichselbaum RR, Posner MC.

J Surg Res. 2006 Dec;136(2):288-93. Epub 2006 Aug 23.


Forphenicinol enhances the antitumor effects of cyclophosphamide in a model of squamous cell carcinoma.

Murphy KT, Wardak A, Beckett MA, Lopez CA, Mehta N, Kimchi E, Salloum RM, Jaskowiak NT, Posner MC, Ohno T, Kufe DW, Weichselbaum RR, Mauceri HJ.

Cancer Chemother Pharmacol. 2005 Sep;56(3):317-21. Epub 2005 May 11.


Chemoinducible gene therapy: a strategy to enhance doxorubicin antitumor activity.

Lopez CA, Kimchi ET, Mauceri HJ, Park JO, Mehta N, Murphy KT, Beckett MA, Hellman S, Posner MC, Kufe DW, Weichselbaum RR.

Mol Cancer Ther. 2004 Sep;3(9):1167-75.


Glioblastoma cells block radiation-induced programmed cell death of endothelial cells.

Brown CK, Khodarev NN, Yu J, Moo-Young T, Labay E, Darga TE, Posner MC, Weichselbaum RR, Mauceri HJ.

FEBS Lett. 2004 May 7;565(1-3):167-70.


Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy (Review).

Lopez CA, Park JO, Mauceri HJ, Beckett MA, Weichselbaum RR, Posner MC.

Int J Oncol. 2004 Mar;24(3):731-6. Review.


Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells.

Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, Yassari R, Gupta N, Weichselbaum RR.

J Cell Sci. 2003 Mar 15;116(Pt 6):1013-22.


Dual induction of the Epo-Egr-TNF-alpha- plasmid in hypoxic human colon adenocarcinoma produces tumor growth delay.

Salloum RM, Saunders MP, Mauceri HJ, Hanna NN, Gorski DH, Posner MC, Stratford IJ, Weichselbaum RR.

Am Surg. 2003 Jan;69(1):24-7. Erratum in: Am Surg. 2003 Apr;69(4):362.


Selective gene expression using a DF3/MUC1 promoter in a human esophageal adenocarcinoma model.

Gupta VK, Park JO, Kurihara T, Koons A, Mauceri HJ, Jaskowiak NT, Kufe DW, Weichselbaum RR, Posner MC.

Gene Ther. 2003 Feb;10(3):206-12.


Prolonged treatment with angiostatin reduces metastatic burden during radiation therapy.

Gorski DH, Mauceri HJ, Salloum RM, Halpern A, Seetharam S, Weichselbaum RR.

Cancer Res. 2003 Jan 15;63(2):308-11.


Angiostatin potentiates cyclophosphamide treatment of metastatic disease.

Mauceri HJ, Seetharam S, Beckett MA, Schumm LP, Koons A, Gupta VK, Park JO, Manan A, Lee JY, Montag AG, Kufe DW, Weichselbaum RR.

Cancer Chemother Pharmacol. 2002 Nov;50(5):412-8. Epub 2002 Sep 18.


Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy.

Weichselbaum RR, Kufe DW, Hellman S, Rasmussen HS, King CR, Fischer PH, Mauceri HJ.

Lancet Oncol. 2002 Nov;3(11):665-71. Review.


Transcriptional control of viral gene therapy by cisplatin.

Park JO, Lopez CA, Gupta VK, Brown CK, Mauceri HJ, Darga TE, Manan A, Hellman S, Posner MC, Kufe DW, Weichselbaum RR.

J Clin Invest. 2002 Aug;110(3):403-10.


Combined gene therapy and ionizing radiation is a novel approach to treat human esophageal adenocarcinoma.

Gupta VK, Park JO, Jaskowiak NT, Mauceri HJ, Seetharam S, Weichselbaum RR, Posner MC.

Ann Surg Oncol. 2002 Jun;9(5):500-4.


Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance.

Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR.

Cancer J. 2002 Jan-Feb;8(1):47-54.


Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo.

Skelly CL, Curi MA, Meyerson SL, Woo DH, Hari D, Vosicky JE, Advani SJ, Mauceri HJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB.

Gene Ther. 2001 Dec;8(24):1840-6.


Tumor production of angiostatin is enhanced after exposure to TNF-alpha.

Mauceri HJ, Seetharam S, Beckett MA, Lee JY, Gupta VK, Gately S, Stack MS, Brown CK, Swedberg K, Kufe DW, Weichselbaum RR.

Int J Cancer. 2002 Feb 1;97(4):410-5.


Treatment of head and neck and esophageal xenografts employing Alimta and concurrent ionizing radiation.

Mauceri HJ, Seetharam S, Salloum RM, Vokes EE, Weichselbaum RR.

Int J Oncol. 2001 Oct;19(4):833-5.


NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity.

Salloum RM, Jaskowiak NT, Mauceri HJ, Seetharam S, Beckett MA, Koons AM, Hari DM, Gupta VK, Reimer C, Kalluri R, Posner MC, Hellman S, Kufe DW, Weichselbaum RR.

Cancer Res. 2000 Dec 15;60(24):6958-63.


Antitumor interaction of short-course endostatin and ionizing radiation.

Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR.

Cancer J. 2000 Sep-Oct;6(5):287-93.


Angiostatin induces mitotic cell death of proliferating endothelial cells.

Hari D, Beckett MA, Sukhatme VP, Dhanabal M, Nodzenski E, Lu H, Mauceri HJ, Kufe DW, Weichselbaum RR.

Mol Cell Biol Res Commun. 2000 May;3(5):277-82.


Gene therapy enhances the antiproliferative effect of radiation in intimal hyperplasia.

Fortunato JE, Mauceri HJ, Kocharyan H, Song RH, Salloum R, Vosicky J, Swedberg K, Malik S, Abusharif F, Glagov S, Weichselbaum RR, Bassiouny HS.

J Surg Res. 2000 Apr;89(2):155-62.


In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.

Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW, Weichselbaum RR.

Clin Cancer Res. 2000 Feb;6(2):737-42.


Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation.

Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, Weichselbaum RR.

Cancer Res. 1999 Jul 15;59(14):3374-8.


Radiation-inducible gene therapy.

Mauceri HJ, Hanna NN, Staba MJ, Beckett MA, Kufe DW, Weichselbaum RR.

C R Acad Sci III. 1999 Feb-Mar;322(2-3):225-8. Review.


Tumor necrosis factor-alpha-based gene therapy enhances radiation cytotoxicity in human prostate cancer.

Chung TD, Mauceri HJ, Hallahan DE, Yu JJ, Chung S, Grdina WL, Yajnik S, Kufe DW, Weichselbaum RR.

Cancer Gene Ther. 1998 Nov-Dec;5(6):344-9.


Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin.

Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR.

Cancer Res. 1998 Dec 15;58(24):5686-9.


Combined effects of angiostatin and ionizing radiation in antitumour therapy.

Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, Bigelow K, Heimann R, Gately S, Dhanabal M, Soff GA, Sukhatme VP, Kufe DW, Weichselbaum RR.

Nature. 1998 Jul 16;394(6690):287-91.


Adenoviral TNF-alpha gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft.

Staba MJ, Mauceri HJ, Kufe DW, Hallahan DE, Weichselbaum RR.

Gene Ther. 1998 Mar;5(3):293-300.


Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation.

Chmura SJ, Mauceri HJ, Advani S, Heimann R, Beckett MA, Nodzenski E, Quintans J, Kufe DW, Weichselbaum RR.

Cancer Res. 1997 Oct 1;57(19):4340-7.


Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts.

Hanna NN, Mauceri HJ, Wayne JD, Hallahan DE, Kufe DW, Weichselbaum RR.

Cancer Res. 1997 Oct 1;57(19):4205-9.


Increased injection number enhances adenoviral genetic radiotherapy.

Mauceri HJ, Seung LP, Grdina WL, Swedberg KA, Weichselbaum RR.

Radiat Oncol Investig. 1997;5(5):220-6.


Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature.

Mauceri HJ, Hanna NN, Wayne JD, Hallahan DE, Hellman S, Weichselbaum RR.

Cancer Res. 1996 Oct 1;56(19):4311-4.


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