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Green Spaces, Land Cover, Street Trees and Hypertension in the Megacity of São Paulo.

Moreira TCL, Polizel JL, Santos IS, Filho DFS, Bensenor I, Lotufo PA, Mauad T.

Int J Environ Res Public Health. 2020 Jan 22;17(3). pii: E725. doi: 10.3390/ijerph17030725.


Edible weeds: Are urban environments fit for foraging?

Amato-Lourenco LF, Ranieri GR, de Oliveira Souza VC, Junior FB, Saldiva PHN, Mauad T.

Sci Total Environ. 2020 Jan 1;698:133967. doi: 10.1016/j.scitotenv.2019.133967. Epub 2019 Sep 3.


Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma.

Rossi RC, Anonni R, Ferreira DS, da Silva LFF, Mauad T.

Allergy Asthma Clin Immunol. 2019 Aug 28;15:50. doi: 10.1186/s13223-019-0363-0. eCollection 2019.


Inflammatory and functional responses after (bio)diesel exhaust exposure in allergic sensitized mice. A comparison between diesel and biodiesel.

Timmerman T, de Brito JM, de Almeida NM, de Almeida FM, Arantes-Costa FM, Guimaraes ET, Lichtenfels AJFC, Rivero DHRF, de Oliveira RC, de Lacerda JPA, Moraes JM, Pimental DA, Saraiva-Romanholo BM, Saldiva PHN, Vieira RP, Mauad T.

Environ Pollut. 2019 Oct;253:667-679. doi: 10.1016/j.envpol.2019.06.085. Epub 2019 Jul 5.


Ultrasound-guided minimally invasive autopsy as a tool for rapid post-mortem diagnosis in the 2018 Sao Paulo yellow fever epidemic: Correlation with conventional autopsy.

Duarte-Neto AN, Monteiro RAA, Johnsson J, Cunha MDP, Pour SZ, Saraiva AC, Ho YL, da Silva LFF, Mauad T, Zanotto PMA, Saldiva PHN, de Oliveira IRS, Dolhnikoff M.

PLoS Negl Trop Dis. 2019 Jul 22;13(7):e0007625. doi: 10.1371/journal.pntd.0007625. eCollection 2019 Jul.


Severe pulmonary disease in an adult primary ciliary dyskinesia population in Brazil.

Olm MAK, Marson FAL, Athanazio RA, Nakagawa NK, Macchione M, Loges NT, Omran H, Rached SZ, Bertuzzo CS, Stelmach R, Saldiva PHN, Ribeiro JD, Jones MH, Mauad T.

Sci Rep. 2019 Jun 18;9(1):8693. doi: 10.1038/s41598-019-45017-1.


iNOS Inhibition Reduces Lung Mechanical Alterations and Remodeling Induced by Particulate Matter in Mice.

Prado CM, Righetti RF, Lopes FDTQDS, Leick EA, Arantes-Costa FM, de Almeida FM, Saldiva PHN, Mauad T, Tibério IFLC, Martins MA.

Pulm Med. 2019 Mar 11;2019:4781528. doi: 10.1155/2019/4781528. eCollection 2019.


Effects of diode laser setting for laryngeal surgery in a rabbit model.

Arroyo-Ramos HH, Neri L, Mancini MW, Neto AND, Mauad T, Imamura R.

Eur Arch Otorhinolaryngol. 2019 May;276(5):1431-1438. doi: 10.1007/s00405-019-05344-5. Epub 2019 Mar 16.


The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association.

Cervilha DAB, Ito JT, Lourenço JD, Olivo CR, Saraiva-Romanholo BM, Volpini RA, Oliveira-Junior MC, Mauad T, Martins MA, Tibério IFLC, Vieira RP, Lopes FDTQS.

Sci Rep. 2019 Feb 13;9(1):1921. doi: 10.1038/s41598-019-38600-z.


Clinical relevance of pulmonary vasculature involvement in sickle cell disease.

Carstens GR, Paulino BBA, Katayama EH, Amato-Lourenço LF, Fonseca GH, Souza R, Aiello VD, Mauad T.

Br J Haematol. 2019 Apr;185(2):317-326. doi: 10.1111/bjh.15795. Epub 2019 Feb 10.


Airway smooth muscle reduction after bronchial thermoplasty in severe asthma correlates with FEV1.

d'Hooghe JNS, Goorsenberg AWM, Ten Hacken NHT, Weersink EJM, Roelofs JJTH, Mauad T, Shah PL, Annema JT, Bonta PI; TASMA research group.

Clin Exp Allergy. 2019 Apr;49(4):541-544. doi: 10.1111/cea.13365. Epub 2019 Feb 20. No abstract available.


Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model.

Ito JT, Cervilha DAB, Lourenço JD, Gonçalves NG, Volpini RA, Caldini EG, Landman G, Lin CJ, Velosa APP, Teodoro WPR, Tibério IFLC, Mauad T, Martins MA, Macchione M, Lopes FDTQDS.

PLoS One. 2019 Jan 10;14(1):e0209351. doi: 10.1371/journal.pone.0209351. eCollection 2019.


Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice.

Ribeiro Júnior G, de Souza Xavier Costa N, Belotti L, Dos Santos Alemany AA, Amato-Lourenço LF, da Cunha PG, de Oliveira Duro S, Ribeiro SP, Veras MM, Quirino Dos Santos Lopes FDT, Marcourakis T, Nascimento Saldiva PH, Poliselli Farsky SH, Mauad T.

Ecotoxicol Environ Saf. 2019 Apr 15;170:314-323. doi: 10.1016/j.ecoenv.2018.11.139. Epub 2018 Dec 7.


Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells.

Andersson CK, Shikhagaie M, Mori M, Al-Garawi A, Reed JL, Humbles AA, Welliver R, Mauad T, Bjermer L, Jordana M, Erjefält JS.

ERJ Open Res. 2018 Nov 23;4(4). pii: 00038-2018. doi: 10.1183/23120541.00038-2018. eCollection 2018 Oct.


Acute exposure to diesel and sewage biodiesel exhaust causes pulmonary and systemic inflammation in mice.

de Brito JM, Mauad T, Cavalheiro GF, Yoshizaki K, de André PA, Lichtenfels AJFC, Guimarães ET, Rivero DHRF, Antonangelo L, Oliveira LB, Pedroso LRM, Macchione M, Saldiva PHN.

Sci Total Environ. 2018 Jul 1;628-629:1223-1233. doi: 10.1016/j.scitotenv.2018.02.019. Epub 2018 Feb 20.


Airway smooth muscle proliferation and inflammation in asthma.

James AL, Noble PB, Drew SA, Mauad T, Bai TR, Abramson MJ, McKay KO, Green FHY, Elliot JG.

J Appl Physiol (1985). 2018 Oct 1;125(4):1090-1096. doi: 10.1152/japplphysiol.00342.2018. Epub 2018 Jul 19.


Inflammation-dependent and independent airway remodelling in asthma.

Elliot JG, Noble PB, Mauad T, Bai TR, Abramson MJ, McKay KO, Green FHY, James AL.

Respirology. 2018 Dec;23(12):1138-1145. doi: 10.1111/resp.13360. Epub 2018 Jun 26.


Respiratory Condition of Family Farmers Exposed to Pesticides in the State of Rio de Janeiro, Brazil.

Buralli RJ, Ribeiro H, Mauad T, Amato-Lourenço LF, Salge JM, Diaz-Quijano FA, Leão RS, Marques RC, Silva DS, Guimarães JRD.

Int J Environ Res Public Health. 2018 Jun 8;15(6). pii: E1203. doi: 10.3390/ijerph15061203.


Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.

de Barros Mendes Lopes T, Groth EE, Veras M, Furuya TK, de Souza Xavier Costa N, Ribeiro Júnior G, Lopes FD, de Almeida FM, Cardoso WV, Saldiva PHN, Chammas R, Mauad T.

Environ Pollut. 2018 Oct;241:511-520. doi: 10.1016/j.envpol.2018.05.055. Epub 2018 Jun 5.


Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review.

Mauad T, Nascimento FBPD, Dolhnikoff M, Picka MCM, Saldiva PHN; BIAS.

BMC Pulm Med. 2018 Mar 20;18(1):50. doi: 10.1186/s12890-018-0615-7. Review.


Exercise Performed Concomitantly with Particulate Matter Exposure Inhibits Lung Injury.

Silva-Renno A, Baldivia GC, Oliveira-Junior MC, Brandao-Rangel MAR, El-Mafarjeh E, Dolhnikoff M, Mauad T, Britto JM, Saldiva PHN, Oliveira LVF, Ligeiro-Oliveira AP, Graudenz GS, Vieira RP.

Int J Sports Med. 2018 Feb;39(2):133-140. doi: 10.1055/s-0043-121147. Epub 2017 Nov 21.


A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages.

Boorsma CE, van der Veen TA, Putri KSS, de Almeida A, Draijer C, Mauad T, Fejer G, Brandsma CA, van den Berge M, Bossé Y, Sin D, Hao K, Reithmeier A, Andersson G, Olinga P, Timens W, Casini A, Melgert BN.

Sci Rep. 2017 Oct 3;7(1):12570. doi: 10.1038/s41598-017-12623-w.


Airway pathology in severe asthma is related to airflow obstruction but not symptom control.

Ferreira DS, Carvalho-Pinto RM, Gregório MG, Annoni R, Teles AM, Buttignol M, Araújo-Paulino BB, Katayama EH, Oliveira BL, Del Frari HS, Cukier A, Dolhnikoff M, Stelmach R, Rabe KF, Mauad T.

Allergy. 2018 Mar;73(3):635-643. doi: 10.1111/all.13323. Epub 2017 Oct 23.


Myofibroblasts are increased in the lung parenchyma in asthma.

Boser SR, Mauad T, Araújo-Paulino BB, Mitchell I, Shrestha G, Chiu A, Butt J, Kelly MM, Caldini E, James A, Green FHY.

PLoS One. 2017 Aug 7;12(8):e0182378. doi: 10.1371/journal.pone.0182378. eCollection 2017.


Airway and parenchyma immune cells in influenza A(H1N1)pdm09 viral and non-viral diffuse alveolar damage.

Buttignol M, Pires-Neto RC, Rossi E Silva RC, Albino MB, Dolhnikoff M, Mauad T.

Respir Res. 2017 Aug 3;18(1):147. doi: 10.1186/s12931-017-0630-x.


Compensatory lung growth after bilobectomy in emphysematous rats.

Almeida FM, Saraiva-Romanholo BM, Vieira RP, Moriya HT, Ligeiro-de-Oliveira AP, Lopes FD, Castro-Faria-Neto HC, Mauad T, Martins MA, Pazetti R.

PLoS One. 2017 Jul 27;12(7):e0181819. doi: 10.1371/journal.pone.0181819. eCollection 2017.


Regulatory T-Cell Distribution within Lung Compartments in COPD.

Sales DS, Ito JT, Zanchetta IA, Annoni R, Aun MV, Ferraz LFS, Cervilha DAB, Negri E, Mauad T, Martins MA, Lopes FDTQS.

COPD. 2017 Oct;14(5):533-542. doi: 10.1080/15412555.2017.1346069. Epub 2017 Jul 26.


The effects of particulate matter on inflammation of respiratory system: Differences between male and female.

Yoshizaki K, Brito JM, Silva LF, Lino-Dos-Santos-Franco A, Frias DP, E Silva RCR, Amato-Lourenço LF, Saldiva PHN, de Fátima Lopes Calvo Tibério I, Mauad T, Macchione M.

Sci Total Environ. 2017 May 15;586:284-295. doi: 10.1016/j.scitotenv.2017.01.221. Epub 2017 Feb 4.


Identification of IL-17F/frequent exacerbator endotype in asthma.

Ricciardolo FLM, Sorbello V, Folino A, Gallo F, Massaglia GM, Favatà G, Conticello S, Vallese D, Gani F, Malerba M, Folkerts G, Rolla G, Profita M, Mauad T, Di Stefano A, Ciprandi G.

J Allergy Clin Immunol. 2017 Aug;140(2):395-406. doi: 10.1016/j.jaci.2016.10.034. Epub 2016 Dec 5.


Effectiveness of traffic-related elements in tree bark and pollen abortion rates for assessing air pollution exposure on respiratory mortality rates.

Carvalho-Oliveira R, Amato-Lourenço LF, Moreira TC, Silva DR, Vieira BD, Mauad T, Saiki M, Saldiva PH.

Environ Int. 2017 Feb;99:161-169. doi: 10.1016/j.envint.2016.09.008. Epub 2016 Nov 17.


The Expression of Water and Ion Channels in Diffuse Alveolar Damage Is Not Dependent on DAD Etiology.

Pires-Neto RC, Del Carlo Bernardi F, Alves de Araujo P, Mauad T, Dolhnikoff M.

PLoS One. 2016 Nov 11;11(11):e0166184. doi: 10.1371/journal.pone.0166184. eCollection 2016.


The extracellular matrix - the under-recognized element in lung disease?

Burgess JK, Mauad T, Tjin G, Karlsson JC, Westergren-Thorsson G.

J Pathol. 2016 Dec;240(4):397-409. doi: 10.1002/path.4808. Epub 2016 Oct 28. Review.


Biomonitoring of genotoxic effects and elemental accumulation derived from air pollution in community urban gardens.

Amato-Lourenco LF, Lobo DJA, Guimarães ET, Moreira TCL, Carvalho-Oliveira R, Saiki M, Saldiva PHN, Mauad T.

Sci Total Environ. 2017 Jan 1;575:1438-1444. doi: 10.1016/j.scitotenv.2016.09.221. Epub 2016 Oct 5.


Miliary tuberculosis: a severe opportunistic infection in juvenile systemic lupus erythematosus patients.

Freire PS, Montoni JD, Ribeiro AS, Marques HH, Mauad T, Silva CA.

Rev Bras Reumatol Engl Ed. 2016 May-Jun;56(3):274-9. doi: 10.1016/j.rbre.2014.04.007. Epub 2014 Nov 28. English, Portuguese.


The influence of atmospheric particles on the elemental content of vegetables in urban gardens of Sao Paulo, Brazil.

Amato-Lourenco LF, Moreira TCL, de Oliveira Souza VC, Barbosa F Jr, Saiki M, Saldiva PHN, Mauad T.

Environ Pollut. 2016 Sep;216:125-134. doi: 10.1016/j.envpol.2016.05.036. Epub 2016 May 29.


The effects of urban particulate matter on the nasal epithelium by gender: An experimental study in mice.

Yoshizaki K, Fuziwara CS, Brito JM, Santos TMN, Kimura ET, Correia AT, Amato-Lourenco LF, Vasconcellos P, Silva LF, Brentani MM, Mauad T, Saldiva PHN, Macchione M.

Environ Pollut. 2016 Jun;213:359-369. doi: 10.1016/j.envpol.2016.02.044. Epub 2016 Mar 1.


Human bronchial epithelial cells exposed in vitro to diesel exhaust particles exhibit alterations in cell rheology and cytotoxicity associated with decrease in antioxidant defenses and imbalance in pro- and anti-apoptotic gene expression.

Seriani R, de Souza CE, Krempel PG, Frias DP, Matsuda M, Correia AT, Ferreira MZ, Alencar AM, Negri EM, Saldiva PH, Mauad T, Macchione M.

Environ Sci Pollut Res Int. 2016 May;23(10):9862-70. doi: 10.1007/s11356-016-6228-x. Epub 2016 Feb 9.


A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema.

Stolk J, Broekman W, Mauad T, Zwaginga JJ, Roelofs H, Fibbe WE, Oostendorp J, Bajema I, Versteegh MI, Taube C, Hiemstra PS.

QJM. 2016 May;109(5):331-6. doi: 10.1093/qjmed/hcw001. Epub 2016 Jan 27.


Old dilemma: asthma with irreversible airway obstruction or COPD.

Fattahi F, Vonk JM, Bulkmans N, Fleischeuer R, Gouw A, Grünberg K, Mauad T, Popper H, Felipe-Silva A, Vrugt B, Wright JL, Yang HM, Kocks JW, Hylkema MN, Postma DS, Timens W, Ten Hacken NH.

Virchows Arch. 2015 Nov;467(5):583-93. doi: 10.1007/s00428-015-1824-6. Epub 2015 Sep 14.


Exposure of Neonatal Mice to Tobacco Smoke Disturbs Synaptic Proteins and Spatial Learning and Memory from Late Infancy to Early Adulthood.

Torres LH, Garcia RC, Blois AM, Dati LM, Durão AC, Alves AS, Pacheco-Neto M, Mauad T, Britto LR, Xavier GF, Camarini R, Marcourakis T.

PLoS One. 2015 Aug 25;10(8):e0136399. doi: 10.1371/journal.pone.0136399. eCollection 2015.


Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis.

Constantino L, Gonçalves RC, Giombelli VR, Tomasi CD, Vuolo F, Kist LW, de Oliveira GM, Pasquali MA, Bogo MR, Mauad T, Horn A Jr, Melo KV, Fernandes C, Moreira JC, Ritter C, Dal-Pizzol F.

Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.


Detection of the source of hemorrhage using postmortem computerized tomographic angiography in a case of a giant juvenile nasopharyngeal angiofibroma after surgical treatment.

do Nascimento FB, dos Santos GA, Melo NA, Damasceno EB, Mauad T.

Forensic Sci Med Pathol. 2015 Sep;11(3):427-31. doi: 10.1007/s12024-015-9697-1. Epub 2015 Jul 28.


The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.

Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB.

Am J Respir Crit Care Med. 2015 Oct 15;192(8):998-1008. doi: 10.1164/rccm.201410-1820OC.


Diagnosis of primary ciliary dyskinesia.

Olm MA, Caldini EG, Mauad T.

J Bras Pneumol. 2015 May-Jun;41(3):251-63. doi: 10.1590/S1806-37132015000004447. Review. English, Portuguese.


Association of Lung Inflammatory Cells with Small Airways Function and Exhaled Breath Markers in Smokers - Is There a Specific Role for Mast Cells?

Nussbaumer-Ochsner Y, Stolk J, Ferraz da Silva LF, van Schadewijk A, de Jeu RC, Prins FA, Mauad T, Rabe KF, Hiemstra PS.

PLoS One. 2015 Jun 12;10(6):e0129426. doi: 10.1371/journal.pone.0129426. eCollection 2015.


Neuroepithelial structures associated with neurogenous subgemmal plaque of the tongue: an autopsy finding.

Fonseca FP, Latta Moreira JP, Almeida OP, Vargas PA, Mauad T.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jul;120(1):94-6. doi: 10.1016/j.oooo.2015.02.487. Epub 2015 Apr 4. No abstract available.


Chronic exposure of diesel exhaust particles induces alveolar enlargement in mice.

Yoshizaki K, Brito JM, Moriya HT, Toledo AC, Ferzilan S, Ligeiro de Oliveira AP, Machado ID, Farsky SH, Silva LF, Martins MA, Saldiva PH, Mauad T, Macchione M.

Respir Res. 2015 Feb 7;16:18. doi: 10.1186/s12931-015-0172-z.


Enriched inorganic compounds in diesel exhaust particles induce mitogen-activated protein kinase activation, cytoskeleton instability, and cytotoxicity in human bronchial epithelial cells.

Seriani R, Junqueira MS, Carvalho-Sousa CE, Arruda AC, Martinez D, Alencar AM, Garippo AL, Brito JM, Martins MA, Saldiva PH, Negri EM, Mauad T, Macchione M.

Exp Toxicol Pathol. 2015 Apr;67(4):323-9. doi: 10.1016/j.etp.2015.02.004. Epub 2015 Mar 11.


Increased expression of granzymes A and B in fatal asthma.

Annoni R, Silva LF, Nussbaumer-Ochsner Y, van Schadewijk A, Mauad T, Hiemstra PS, Rabe KF.

Eur Respir J. 2015 May;45(5):1485-8. doi: 10.1183/09031936.00213814. Epub 2015 Mar 5. No abstract available.


Organic and inorganic fractions of diesel exhaust particles produce changes in mucin profile of mouse trachea explants.

Seriani R, Junqueira MS, Toledo AC, Corrêa AT, Silva LF, Martins MA, Saldiva PH, Mauad T, Macchione M.

J Toxicol Environ Health A. 2015;78(4):215-25. doi: 10.1080/15287394.2014.947456.


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