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Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease.

Brose RD, Lehrmann E, Zhang Y, Reeves RH, Smith KD, Mattson MP.

Neurobiol Aging. 2018 Aug 29;72:121-133. doi: 10.1016/j.neurobiolaging.2018.08.021. [Epub ahead of print]


Enhancing and Extending Biological Performance and Resilience.

Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, Bøtker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME.

Dose Response. 2018 Aug 15;16(3):1559325818784501. doi: 10.1177/1559325818784501. eCollection 2018 Jul-Sep. Review.


Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.

Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson MP.

Neurobiol Aging. 2018 Oct;70:160-169. doi: 10.1016/j.neurobiolaging.2018.06.016. Epub 2018 Jun 21.


Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.

Mattson MP, Arumugam TV.

Cell Metab. 2018 Jun 5;27(6):1176-1199. doi: 10.1016/j.cmet.2018.05.011. Review.


Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis.

Fitzgerald KC, Vizthum D, Henry-Barron B, Schweitzer A, Cassard SD, Kossoff E, Hartman AL, Kapogiannis D, Sullivan P, Baer DJ, Mattson MP, Appel LJ, Mowry EM.

Mult Scler Relat Disord. 2018 Jul;23:33-39. doi: 10.1016/j.msard.2018.05.002. Epub 2018 May 5.


Altered Extracellular Vesicle Concentration, Cargo and Function in Diabetes Mellitus.

Freeman DW, Noren Hooten N, Eitan E, Green J, Mode NA, Bodogai M, Zhang Y, Lehrmann E, Zonderman AB, Biragyn A, Egan J, Becker KG, Mattson MP, Ejiogu N, Evans MK.

Diabetes. 2018 May 2. pii: db171308. doi: 10.2337/db17-1308. [Epub ahead of print]


Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus.

Hamilton KA, Wang Y, Raefsky SM, Berkowitz S, Spangler R, Suire CN, Camandola S, Lipsky RH, Mattson MP.

PLoS One. 2018 May 1;13(5):e0196223. doi: 10.1371/journal.pone.0196223. eCollection 2018.


Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, Karamyan VT, Vemuganti R, Sobey CG, Mattson MP, Jo DG, Arumugam TV.

Hum Mol Genet. 2018 Jul 1;27(13):2405. doi: 10.1093/hmg/ddy138. No abstract available.


Invaginating Structures in Mammalian Synapses.

Petralia RS, Wang YX, Mattson MP, Yao PJ.

Front Synaptic Neurosci. 2018 Apr 5;10:4. doi: 10.3389/fnsyn.2018.00004. eCollection 2018. Review.


Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease.

Raefsky SM, Furman R, Milne G, Pollock E, Axelsen P, Mattson MP, Shchepinov MS.

Neurobiol Aging. 2018 Jun;66:165-176. doi: 10.1016/j.neurobiolaging.2018.02.024. Epub 2018 Mar 5.


Notch signaling and neuronal death in stroke.

Arumugam TV, Baik SH, Balaganapathy P, Sobey CG, Mattson MP, Jo DG.

Prog Neurobiol. 2018 Jun - Aug;165-167:103-116. doi: 10.1016/j.pneurobio.2018.03.002. Epub 2018 Mar 21. Review.


Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice.

Griffioen K, Mattson MP, Okun E.

Heliyon. 2018 Jan 18;4(1):e00508. doi: 10.1016/j.heliyon.2018.e00508. eCollection 2018 Jan.


Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis.

Mazucanti CH, Kawamoto EM, Mattson MP, Scavone C, Camandola S.

J Cereb Blood Flow Metab. 2018 Mar 1:271678X18762700. doi: 10.1177/0271678X18762700. [Epub ahead of print]


Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.

Marosi K, Moehl K, Navas-Enamorado I, Mitchell SJ, Zhang Y, Lehrmann E, Aon MA, Cortassa S, Becker KG, Mattson MP.

FASEB J. 2018 Jul;32(7):3844-3858. doi: 10.1096/fj.201701378RR. Epub 2018 Feb 27.


Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, Karamyan VT, Vemuganti R, Sobey CG, Mattson MP, Jo DG, Arumugam TV.

Hum Mol Genet. 2018 May 1;27(9):1497-1513. doi: 10.1093/hmg/ddy057.


NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5.


Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease.

Camandola S, Plick N, Mattson MP.

Neurochem Res. 2018 Feb 8. doi: 10.1007/s11064-018-2492-0. [Epub ahead of print]


Intermittent metabolic switching, neuroplasticity and brain health.

Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A.

Nat Rev Neurosci. 2018 Feb;19(2):63-80. doi: 10.1038/nrn.2017.156. Epub 2018 Jan 11. Review.


Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke.

Chen X, Arumugam TV, Cheng YL, Lee JH, Chigurupati S, Mattson MP, Basta M.

Neuromolecular Med. 2018 Mar;20(1):63-72. doi: 10.1007/s12017-017-8474-6. Epub 2018 Jan 3.


Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.


Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.

Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG 3rd, Leeuwenburgh C, Mattson MP.

Obesity (Silver Spring). 2018 Feb;26(2):254-268. doi: 10.1002/oby.22065. Epub 2017 Oct 31. Review.


Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal.

Zhang S, Eitan E, Wu TY, Mattson MP.

Neurobiol Aging. 2018 Jan;61:52-65. doi: 10.1016/j.neurobiolaging.2017.09.016. Epub 2017 Sep 22.


How does hormesis impact biology, toxicology, and medicine?

Calabrese EJ, Mattson MP.

NPJ Aging Mech Dis. 2017 Sep 15;3:13. doi: 10.1038/s41514-017-0013-z. eCollection 2017. Review.


Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.

Wahl D, Coogan SC, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG.

Clin Interv Aging. 2017 Sep 8;12:1419-1428. doi: 10.2147/CIA.S145247. eCollection 2017. Review.


In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles.

Eitan E, Tosti V, Suire CN, Cava E, Berkowitz S, Bertozzi B, Raefsky SM, Veronese N, Spangler R, Spelta F, Mustapic M, Kapogiannis D, Mattson MP, Fontana L.

Aging Cell. 2017 Dec;16(6):1430-1433. doi: 10.1111/acel.12657. Epub 2017 Sep 17.


NAD+ in Aging: Molecular Mechanisms and Translational Implications.

Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA.

Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Review.


Purine Biosynthesis Enzymes in Hippocampal Neurons.

Williamson J, Petralia RS, Wang YX, Mattson MP, Yao PJ.

Neuromolecular Med. 2017 Dec;19(4):518-524. doi: 10.1007/s12017-017-8466-6. Epub 2017 Sep 2.


Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.

de Mello-Coelho V, Cutler RG, Bunbury A, Tammara A, Mattson MP, Taub DD.

Mech Ageing Dev. 2017 Oct;167:46-55. doi: 10.1016/j.mad.2017.08.015. Epub 2017 Sep 1.


Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles.

Suire CN, Eitan E, Shaffer NC, Tian Q, Studenski S, Mattson MP, Kapogiannis D.

Exp Gerontol. 2017 Nov;98:209-216. doi: 10.1016/j.exger.2017.08.024. Epub 2017 Aug 23.


Invaginating Presynaptic Terminals in Neuromuscular Junctions, Photoreceptor Terminals, and Other Synapses of Animals.

Petralia RS, Wang YX, Mattson MP, Yao PJ.

Neuromolecular Med. 2017 Sep;19(2-3):193-240. doi: 10.1007/s12017-017-8445-y. Epub 2017 Jun 13. Review.


Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation.

Camandola S, Mattson MP.

Obesity (Silver Spring). 2017 Jul;25(7):1237-1245. doi: 10.1002/oby.21871. Epub 2017 May 12.


Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes.

Eitan E, Green J, Bodogai M, Mode NA, Bæk R, Jørgensen MM, Freeman DW, Witwer KW, Zonderman AB, Biragyn A, Mattson MP, Noren Hooten N, Evans MK.

Sci Rep. 2017 May 2;7(1):1342. doi: 10.1038/s41598-017-01386-z.


skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans.

Wilson MA, Iser WB, Son TG, Logie A, Cabral-Costa JV, Mattson MP, Camandola S.

PLoS One. 2017 May 1;12(5):e0176798. doi: 10.1371/journal.pone.0176798. eCollection 2017.


Brain metabolism in health, aging, and neurodegeneration.

Camandola S, Mattson MP.

EMBO J. 2017 Jun 1;36(11):1474-1492. doi: 10.15252/embj.201695810. Epub 2017 Apr 24. Review.


Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.

Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG.

Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208.


Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP.

Nigam SM, Xu S, Kritikou JS, Marosi K, Brodin L, Mattson MP.

J Neurochem. 2017 Jul;142(2):286-296. doi: 10.1111/jnc.14034. Epub 2017 May 18.


Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.

McGee-Lawrence ME, Wenger KH, Misra S, Davis CL, Pollock NK, Elsalanty M, Ding K, Isales CM, Hamrick MW, Wosiski-Kuhn M, Arounleut P, Mattson MP, Cutler RG, Yu JC, Stranahan AM.

Endocrinology. 2017 May 1;158(5):1160-1171. doi: 10.1210/en.2016-1250.


Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA, Fang EF.

Trends Neurosci. 2017 Mar;40(3):151-166. doi: 10.1016/j.tins.2017.01.002. Epub 2017 Feb 9. Review.


TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury.

Liu Y, Zhou LJ, Wang J, Li D, Ren WJ, Peng J, Wei X, Xu T, Xin WJ, Pang RP, Li YY, Qin ZH, Murugan M, Mattson MP, Wu LJ, Liu XG.

J Neurosci. 2017 Jan 25;37(4):871-881. doi: 10.1523/JNEUROSCI.2235-16.2016.


Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease.

Pawlosky RJ, Kemper MF, Kashiwaya Y, King MT, Mattson MP, Veech RL.

J Neurochem. 2017 Apr;141(2):195-207. doi: 10.1111/jnc.13958. Epub 2017 Mar 15.


Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal.

Zhang S, Eitan E, Mattson MP.

J Neurochem. 2017 Mar;140(6):941-954. doi: 10.1111/jnc.13957. Epub 2017 Feb 16.


Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons.

Yao PJ, Manor U, Petralia RS, Brose RD, Wu RT, Ott C, Wang YX, Charnoff A, Lippincott-Schwartz J, Mattson MP.

Mol Biol Cell. 2017 Feb 1;28(3):387-395. doi: 10.1091/mbc.E16-07-0553. Epub 2016 Dec 8.


Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models.

Eitan E, Hutchison ER, Marosi K, Comotto J, Mustapic M, Nigam SM, Suire C, Maharana C, Jicha GA, Liu D, Machairaki V, Witwer KW, Kapogiannis D, Mattson MP.

NPJ Aging Mech Dis. 2016;2. pii: 16019. Epub 2016 Sep 22.


Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance.

Raefsky SM, Mattson MP.

Free Radic Biol Med. 2017 Jan;102:203-216. doi: 10.1016/j.freeradbiomed.2016.11.045. Epub 2016 Nov 29. Review.


Sonic Hedgehog Signaling and Hippocampal Neuroplasticity.

Yao PJ, Petralia RS, Mattson MP.

Trends Neurosci. 2016 Dec;39(12):840-850. doi: 10.1016/j.tins.2016.10.001. Epub 2016 Nov 16. Review.


Impact of intermittent fasting on health and disease processes.

Mattson MP, Longo VD, Harvie M.

Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31. Review.


Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM 3rd, Brosh RM Jr, Gorospe M, Bohr VA.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507. Epub 2016 Oct 18.


The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.

Ehmsen JT, Liu Y, Wang Y, Paladugu N, Johnson AE, Rothstein JD, du Lac S, Mattson MP, Höke A.

Sci Rep. 2016 Oct 19;6:35592. doi: 10.1038/srep35592.


3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons.

Marosi K, Kim SW, Moehl K, Scheibye-Knudsen M, Cheng A, Cutler R, Camandola S, Mattson MP.

J Neurochem. 2016 Dec;139(5):769-781. doi: 10.1111/jnc.13868. Epub 2016 Nov 14.


NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.

Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004.

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