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Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury.

Glotfelty EJ, Delgado T, Tovar-Y-Romo LB, Luo Y, Hoffer B, Olson L, Karlsson T, Mattson MP, Harvey B, Tweedie D, Li Y, Greig NH.

ACS Pharmacol Transl Sci. 2019 Apr 12;2(2):66-91. doi: 10.1021/acsptsci.9b00003. Epub 2019 Feb 11.


Comparing 3D ultrastructure of presynaptic and postsynaptic mitochondria.

Delgado T, Petralia RS, Freeman DW, Sedlacek M, Wang YX, Brenowitz SD, Sheu SH, Gu JW, Kapogiannis D, Mattson MP, Yao PJ.

Biol Open. 2019 Aug 1;8(8). pii: bio044834. doi: 10.1242/bio.044834.


A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition.

Sawmiller D, Habib A, Hou H, Mori T, Fan A, Tian J, Zeng J, Giunta B, Sanberg PR, Mattson MP, Tan J.

Biol Psychiatry. 2019 Aug 1;86(3):208-220. doi: 10.1016/j.biopsych.2019.04.026. Epub 2019 May 2.


Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons.

Rivell A, Petralia RS, Wang YX, Mattson MP, Yao PJ.

Neuromolecular Med. 2019 Sep;21(3):314-321. doi: 10.1007/s12017-019-08553-7. Epub 2019 Jun 8.


NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.

Bahn G, Park JS, Yun UJ, Lee YJ, Choi Y, Park JS, Baek SH, Choi BY, Cho YS, Kim HK, Han J, Sul JH, Baik SH, Lim J, Wakabayashi N, Bae SH, Han JW, Arumugam TV, Mattson MP, Jo DG.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12516-12523. doi: 10.1073/pnas.1819541116. Epub 2019 Jun 4.


Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.

Kishimoto Y, Zhu W, Hosoda W, Sen JM, Mattson MP.

Neuromolecular Med. 2019 Sep;21(3):239-249. doi: 10.1007/s12017-019-08539-5. Epub 2019 May 11.


Curcumin and hormesis with particular emphasis on neural cells.

Calabrese EJ, Dhawan G, Kapoor R, Mattson MP, Rattan SI.

Food Chem Toxicol. 2019 Jul;129:399-404. doi: 10.1016/j.fct.2019.04.053. Epub 2019 Apr 30. Review.


SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.

Liu Y, Cheng A, Li YJ, Yang Y, Kishimoto Y, Zhang S, Wang Y, Wan R, Raefsky SM, Lu D, Saito T, Saido T, Zhu J, Wu LJ, Mattson MP.

Nat Commun. 2019 Apr 23;10(1):1886. doi: 10.1038/s41467-019-09897-1.


Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.

Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP.

Nat Neurosci. 2019 May;22(5):719-728. doi: 10.1038/s41593-019-0372-9. Epub 2019 Apr 1.


Sonic hedgehog expression in the postnatal brain.

Rivell A, Petralia RS, Wang YX, Clawson E, Moehl K, Mattson MP, Yao PJ.

Biol Open. 2019 Mar 26;8(3). pii: bio040592. doi: 10.1242/bio.040592.


Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.

Demarest TG, Truong GTD, Lovett J, Mohanty JG, Mattison JA, Mattson MP, Ferrucci L, Bohr VA, Moaddel R.

Anal Biochem. 2019 May 1;572:1-8. doi: 10.1016/j.ab.2019.02.019. Epub 2019 Feb 27.


Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA.

Nat Neurosci. 2019 Mar;22(3):401-412. doi: 10.1038/s41593-018-0332-9. Epub 2019 Feb 11.


Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury.

Rubovitch V, Pharayra A, Har-Even M, Dvir O, Mattson MP, Pick CG.

J Mol Neurosci. 2019 Apr;67(4):613-621. doi: 10.1007/s12031-019-01271-6. Epub 2019 Feb 8.


An Evolutionary Perspective on Why Food Overconsumption Impairs Cognition.

Mattson MP.

Trends Cogn Sci. 2019 Mar;23(3):200-212. doi: 10.1016/j.tics.2019.01.003. Epub 2019 Jan 19. Review.


Uric acid enhances longevity and endurance and protects the brain against ischemia.

Cutler RG, Camandola S, Feldman NH, Yoon JS, Haran JB, Arguelles S, Mattson MP.

Neurobiol Aging. 2019 Mar;75:159-168. doi: 10.1016/j.neurobiolaging.2018.10.031. Epub 2018 Dec 12.


Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons.

Zhao Q, Lu D, Wang J, Liu B, Cheng H, Mattson MP, Cheng A.

Cell Death Differ. 2019 Sep;26(9):1600-1614. doi: 10.1038/s41418-018-0230-4. Epub 2018 Nov 2.


Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease.

Brose RD, Lehrmann E, Zhang Y, Reeves RH, Smith KD, Mattson MP.

Neurobiol Aging. 2018 Dec;72:121-133. doi: 10.1016/j.neurobiolaging.2018.08.021. Epub 2018 Aug 29.


Enhancing and Extending Biological Performance and Resilience.

Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, Bøtker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME.

Dose Response. 2018 Aug 15;16(3):1559325818784501. doi: 10.1177/1559325818784501. eCollection 2018 Jul-Sep. Review.


Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.

Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson MP.

Neurobiol Aging. 2018 Oct;70:160-169. doi: 10.1016/j.neurobiolaging.2018.06.016. Epub 2018 Jun 21.


Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.

Mattson MP, Arumugam TV.

Cell Metab. 2018 Jun 5;27(6):1176-1199. doi: 10.1016/j.cmet.2018.05.011. Review.


Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis.

Fitzgerald KC, Vizthum D, Henry-Barron B, Schweitzer A, Cassard SD, Kossoff E, Hartman AL, Kapogiannis D, Sullivan P, Baer DJ, Mattson MP, Appel LJ, Mowry EM.

Mult Scler Relat Disord. 2018 Jul;23:33-39. doi: 10.1016/j.msard.2018.05.002. Epub 2018 May 5.


Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes.

Freeman DW, Noren Hooten N, Eitan E, Green J, Mode NA, Bodogai M, Zhang Y, Lehrmann E, Zonderman AB, Biragyn A, Egan J, Becker KG, Mattson MP, Ejiogu N, Evans MK.

Diabetes. 2018 Nov;67(11):2377-2388. doi: 10.2337/db17-1308. Epub 2018 May 2.


Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus.

Hamilton KA, Wang Y, Raefsky SM, Berkowitz S, Spangler R, Suire CN, Camandola S, Lipsky RH, Mattson MP.

PLoS One. 2018 May 1;13(5):e0196223. doi: 10.1371/journal.pone.0196223. eCollection 2018.


Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, Karamyan VT, Vemuganti R, Sobey CG, Mattson MP, Jo DG, Arumugam TV.

Hum Mol Genet. 2018 Jul 1;27(13):2405. doi: 10.1093/hmg/ddy138. No abstract available.


Invaginating Structures in Mammalian Synapses.

Petralia RS, Wang YX, Mattson MP, Yao PJ.

Front Synaptic Neurosci. 2018 Apr 5;10:4. doi: 10.3389/fnsyn.2018.00004. eCollection 2018. Review.


Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease.

Raefsky SM, Furman R, Milne G, Pollock E, Axelsen P, Mattson MP, Shchepinov MS.

Neurobiol Aging. 2018 Jun;66:165-176. doi: 10.1016/j.neurobiolaging.2018.02.024. Epub 2018 Mar 5.


Notch signaling and neuronal death in stroke.

Arumugam TV, Baik SH, Balaganapathy P, Sobey CG, Mattson MP, Jo DG.

Prog Neurobiol. 2018 Jun - Aug;165-167:103-116. doi: 10.1016/j.pneurobio.2018.03.002. Epub 2018 Mar 21. Review.


Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice.

Griffioen K, Mattson MP, Okun E.

Heliyon. 2018 Jan 18;4(1):e00508. doi: 10.1016/j.heliyon.2018.e00508. eCollection 2018 Jan.


Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis.

Mazucanti CH, Kawamoto EM, Mattson MP, Scavone C, Camandola S.

J Cereb Blood Flow Metab. 2019 Aug;39(8):1544-1556. doi: 10.1177/0271678X18762700. Epub 2018 Mar 1.


Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.

Marosi K, Moehl K, Navas-Enamorado I, Mitchell SJ, Zhang Y, Lehrmann E, Aon MA, Cortassa S, Becker KG, Mattson MP.

FASEB J. 2018 Jul;32(7):3844-3858. doi: 10.1096/fj.201701378RR. Epub 2018 Feb 27.


Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, Karamyan VT, Vemuganti R, Sobey CG, Mattson MP, Jo DG, Arumugam TV.

Hum Mol Genet. 2018 May 1;27(9):1497-1513. doi: 10.1093/hmg/ddy057. Erratum in: Hum Mol Genet. 2018 Jul 1;27(13):2405.


NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5.


Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease.

Camandola S, Plick N, Mattson MP.

Neurochem Res. 2019 Jan;44(1):214-227. doi: 10.1007/s11064-018-2492-0. Epub 2018 Feb 8. Review.


Intermittent metabolic switching, neuroplasticity and brain health.

Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A.

Nat Rev Neurosci. 2018 Feb;19(2):63-80. doi: 10.1038/nrn.2017.156. Epub 2018 Jan 11. Review.


Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke.

Chen X, Arumugam TV, Cheng YL, Lee JH, Chigurupati S, Mattson MP, Basta M.

Neuromolecular Med. 2018 Mar;20(1):63-72. doi: 10.1007/s12017-017-8474-6. Epub 2018 Jan 3.


Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.


Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.

Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG 3rd, Leeuwenburgh C, Mattson MP.

Obesity (Silver Spring). 2018 Feb;26(2):254-268. doi: 10.1002/oby.22065. Epub 2017 Oct 31. Review.


Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal.

Zhang S, Eitan E, Wu TY, Mattson MP.

Neurobiol Aging. 2018 Jan;61:52-65. doi: 10.1016/j.neurobiolaging.2017.09.016. Epub 2017 Sep 22.


How does hormesis impact biology, toxicology, and medicine?

Calabrese EJ, Mattson MP.

NPJ Aging Mech Dis. 2017 Sep 15;3:13. doi: 10.1038/s41514-017-0013-z. eCollection 2017. Review.


Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.

Wahl D, Coogan SC, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG.

Clin Interv Aging. 2017 Sep 8;12:1419-1428. doi: 10.2147/CIA.S145247. eCollection 2017. Review.


In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles.

Eitan E, Tosti V, Suire CN, Cava E, Berkowitz S, Bertozzi B, Raefsky SM, Veronese N, Spangler R, Spelta F, Mustapic M, Kapogiannis D, Mattson MP, Fontana L.

Aging Cell. 2017 Dec;16(6):1430-1433. doi: 10.1111/acel.12657. Epub 2017 Sep 17.


NAD+ in Aging: Molecular Mechanisms and Translational Implications.

Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA.

Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Review.


Purine Biosynthesis Enzymes in Hippocampal Neurons.

Williamson J, Petralia RS, Wang YX, Mattson MP, Yao PJ.

Neuromolecular Med. 2017 Dec;19(4):518-524. doi: 10.1007/s12017-017-8466-6. Epub 2017 Sep 2.


Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.

de Mello-Coelho V, Cutler RG, Bunbury A, Tammara A, Mattson MP, Taub DD.

Mech Ageing Dev. 2017 Oct;167:46-55. doi: 10.1016/j.mad.2017.08.015. Epub 2017 Sep 1.


Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles.

Suire CN, Eitan E, Shaffer NC, Tian Q, Studenski S, Mattson MP, Kapogiannis D.

Exp Gerontol. 2017 Nov;98:209-216. doi: 10.1016/j.exger.2017.08.024. Epub 2017 Aug 23.


Invaginating Presynaptic Terminals in Neuromuscular Junctions, Photoreceptor Terminals, and Other Synapses of Animals.

Petralia RS, Wang YX, Mattson MP, Yao PJ.

Neuromolecular Med. 2017 Sep;19(2-3):193-240. doi: 10.1007/s12017-017-8445-y. Epub 2017 Jun 13. Review.


Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation.

Camandola S, Mattson MP.

Obesity (Silver Spring). 2017 Jul;25(7):1237-1245. doi: 10.1002/oby.21871. Epub 2017 May 12.


Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes.

Eitan E, Green J, Bodogai M, Mode NA, Bæk R, Jørgensen MM, Freeman DW, Witwer KW, Zonderman AB, Biragyn A, Mattson MP, Noren Hooten N, Evans MK.

Sci Rep. 2017 May 2;7(1):1342. doi: 10.1038/s41598-017-01386-z.


skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans.

Wilson MA, Iser WB, Son TG, Logie A, Cabral-Costa JV, Mattson MP, Camandola S.

PLoS One. 2017 May 1;12(5):e0176798. doi: 10.1371/journal.pone.0176798. eCollection 2017.


Brain metabolism in health, aging, and neurodegeneration.

Camandola S, Mattson MP.

EMBO J. 2017 Jun 1;36(11):1474-1492. doi: 10.15252/embj.201695810. Epub 2017 Apr 24. Review.

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