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In IgG4 related disease, elevated IgG2 is an artifact not a biomarker.

Mattman A, Chen LYC, van der Gugten G, Chin A, Carruthers M, DeMarco ML, Holmes DT.

Semin Arthritis Rheum. 2019 Aug 12. pii: S0049-0172(19)30510-4. doi: 10.1016/j.semarthrit.2019.08.002. [Epub ahead of print] No abstract available.


Conditions associated with polyclonal hypergammaglobulinemia in the IgG4-related disease era: a retrospective study from a hematology tertiary care center.

Zhao EJ, Carruthers MN, Li CH, Mattman A, Chen LYC.

Haematologica. 2019 Jun 27. pii: haematol.2019.219725. doi: 10.3324/haematol.2019.219725. [Epub ahead of print]


Reference intervals for serum total vitamin B12 and holotranscobalamin concentrations and their change points with methylmalonic acid concentration to assess vitamin B12 status during early and mid-pregnancy.

Schroder TH, Tan A, Mattman A, Sinclair G, Barr SI, Vallance HD, Lamers Y.

Clin Chem Lab Med. 2019 Oct 25;57(11):1790-1798. doi: 10.1515/cclm-2018-1337.


Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing.

Bouquet J, Li T, Gardy JL, Kang X, Stevens S, Stevens J, VanNess M, Snell C, Potts J, Miller RR, Morshed M, McCabe M, Parker S, Uyaguari M, Tang P, Steiner T, Chan WS, De Souza AM, Mattman A, Patrick DM, Chiu CY.

PLoS One. 2019 Mar 21;14(3):e0212193. doi: 10.1371/journal.pone.0212193. eCollection 2019.


IgG4-related disease: what a hematologist needs to know.

Chen LYC, Mattman A, Seidman MA, Carruthers MN.

Haematologica. 2019 Mar;104(3):444-455. doi: 10.3324/haematol.2018.205526. Epub 2019 Jan 31. Review.


Nonfasting lipid testing: the new standard for cardiovascular risk assessment.

Darras P, Mattman A, Francis GA.

CMAJ. 2018 Nov 12;190(45):E1317-E1318. doi: 10.1503/cmaj.180804. No abstract available.


Extreme hyperferritinaemia, soluble interleukin-2 receptor, and haemophagocytic lymphohistiocytosis.

Chen LYC, Hayden A, Mattman A.

Br J Haematol. 2019 May;185(3):605-606. doi: 10.1111/bjh.15579. Epub 2018 Sep 11. No abstract available.


A mitochondrial DNA D loop insertion detected almost exclusively in non-replicating tissues with maternal inheritance across three generations.

Sharma MA, Lee JYJ, Tam A, Sattha B, Mackenzie IR, Vallance HD, Sirrs S, Hannah-Shmouni F, Côté HCF, Mattman A.

Mitochondrion. 2019 May;46:298-301. doi: 10.1016/j.mito.2018.08.002. Epub 2018 Aug 13.


Approach to the interpretation of unexpected laboratory results arising in the care of patients with inborn errors of metabolism (IEM).

Mattman A, Potter M.

Rev Endocr Metab Disord. 2018 Mar;19(1):5-12. doi: 10.1007/s11154-018-9453-4. Review.


Sex Differences in Cardiac Troponin Testing in Patients Presenting to the Emergency Department with Chest Pain.

Humphries KH, Gao M, Lee MK, Izadnegahdar M, Holmes DT, Scheuermeyer FX, Mackay M, Mattman A, Grafstein E.

J Womens Health (Larchmt). 2018 Nov;27(11):1327-1334. doi: 10.1089/jwh.2017.6812. Epub 2018 Jul 16.


Comment on: IgG4-related disease presenting with raised serum IgG2-real timeline of IgG4-RD?

Mattman A, Chen LYC, van der Gugten G, Chin A, Carruthers M, DeMarco ML, Holmes DT.

Rheumatology (Oxford). 2018 Jun 1;57(6):1125-1126. doi: 10.1093/rheumatology/key044. No abstract available.


Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD.

Leitao Filho FS, Ra SW, Mattman A, Schellenberg RS, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Paul Man SF, Aaron SD, Reed RM, Sin DD; Canadian Respiratory Research Network (CRRN).

Respir Res. 2018 Feb 14;19(1):30. doi: 10.1186/s12931-018-0733-z.


Resolution of Spurious Immunonephelometric IgG Subclass Measurement Discrepancies by LC-MS/MS.

van der Gugten G, DeMarco ML, Chen LYC, Chin A, Carruthers M, Holmes DT, Mattman A.

Clin Chem. 2018 Apr;64(4):735-742. doi: 10.1373/clinchem.2017.282319. Epub 2018 Jan 19.


Biochemical signatures mimicking multiple carboxylase deficiency in children with mutations in MT-ATP6.

Larson AA, Balasubramaniam S, Christodoulou J, Burrage LC, Marom R, Graham BH, Diaz GA, Glamuzina E, Hauser N, Heese B, Horvath G, Mattman A, van Karnebeek C, Lane Rutledge S, Williamson A, Estrella L, Van Hove JKL, Weisfeld-Adams JD.

Mitochondrion. 2019 Jan;44:58-64. doi: 10.1016/j.mito.2018.01.001. Epub 2018 Jan 4.


Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.

Hayden A, Lin M, Park S, Pudek M, Schneider M, Jordan MB, Mattman A, Chen LYC.

Blood Adv. 2017 Dec 6;1(26):2529-2534. doi: 10.1182/bloodadvances.2017012310. eCollection 2017 Dec 12.


Utility of Serum IgG4 Levels in a Multiethnic Population.

Qi R, Chen LYC, Park S, Irvine R, Seidman MA, Kelsall JT, Collins D, Yin V, Slack GW, Mattman A, Lam E, Carruthers MN.

Am J Med Sci. 2018 Jan;355(1):61-66. doi: 10.1016/j.amjms.2017.08.014. Epub 2017 Aug 24.


Sex Differences in Diagnoses, Treatment, and Outcomes for Emergency Department Patients With Chest Pain and Elevated Cardiac Troponin.

Humphries KH, Lee MK, Izadnegahdar M, Gao M, Holmes DT, Scheuermeyer FX, Mackay M, Mattman A, Grafstein E.

Acad Emerg Med. 2018 Apr;25(4):413-424. doi: 10.1111/acem.13371. Epub 2018 Feb 8.



Leitao Filho FS, Ra SW, Mattman A, Schellenberg RS, Sin DD.

J Allergy Clin Immunol. 2018 Feb;141(2):831. doi: 10.1016/j.jaci.2017.10.013. Epub 2017 Dec 6. No abstract available.


Erratum: Leigh-Like Syndrome Due to Homoplasmic m.8993T>G Variant with Hypocitrullinemia and Unusual Biochemical Features Suggestive of Multiple Carboxylase Deficiency (MCD).

Balasubramaniam S, Lewis B, Mock DM, Said HM, Tarailo-Graovac M, Mattman A, van Karnebeek CD, Thorburn DR, Rodenburg RJ, Christodoulou J.

JIMD Rep. 2017;33:111. doi: 10.1007/8904_2017_588. No abstract available.


Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12 status compared with pregnant women of European ethnicity.

Schroder TH, Sinclair G, Mattman A, Jung B, Barr SI, Vallance HD, Lamers Y.

Br J Nutr. 2017 Sep;118(6):454-462. doi: 10.1017/S0007114517002331. Epub 2017 Sep 18.


Comparison of hypoalbuminemia-corrected serum calcium using BCP albumin assay to ionized calcium and impact on prescribing in hemodialysis patients

Pan WC, Lau W, Mattman A, Kiaii M, Jung B.

Clin Nephrol. 2018 Jan;89 (2018)(1):34-40. doi: 10.5414/CN109070.


Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review.

Lin M, Park S, Hayden A, Giustini D, Trinkaus M, Pudek M, Mattman A, Schneider M, Chen LYC.

Ann Hematol. 2017 Aug;96(8):1241-1251. doi: 10.1007/s00277-017-2993-y. Epub 2017 May 12. Review.


Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease.

Leitao Filho FS, Won Ra S, Mattman A, Schellenberg RS, Fishbane N, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Man SFP, Aaron SD, Reed RM, Sin DD.

J Allergy Clin Immunol. 2017 Oct;140(4):1164-1167.e6. doi: 10.1016/j.jaci.2017.01.046. Epub 2017 Apr 27. No abstract available.


IgG4-related disease and lymphocyte-variant hypereosinophilic syndrome: A comparative case series.

Carruthers MN, Park S, Slack GW, Dalal BI, Skinnider BF, Schaeffer DF, Dutz JP, Law JK, Donnellan F, Marquez V, Seidman M, Wong PC, Mattman A, Chen LY.

Eur J Haematol. 2017 Apr;98(4):378-387. doi: 10.1111/ejh.12842. Epub 2017 Jan 20.


Leigh-Like Syndrome Due to Homoplasmic m.8993T>G Variant with Hypocitrullinemia and Unusual Biochemical Features Suggestive of Multiple Carboxylase Deficiency (MCD).

Balasubramaniam S, Lewis B, Mock DM, Said HM, Tarailo-Graovac M, Mattman A, van Karnebeek CD, Thorburn DR, Rodenburg RJ, Christodoulou J.

JIMD Rep. 2017;33:99-107. doi: 10.1007/8904_2016_559. Epub 2016 Jul 22. Erratum in: JIMD Rep. 2017;33:111.


Exome Sequencing and the Management of Neurometabolic Disorders.

Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Ye XC, Zhang LH, Bhavsar AP, Lee JJ, Drögemöller BI, Abdelsayed M, Alfadhel M, Armstrong L, Baumgartner MR, Burda P, Connolly MB, Cameron J, Demos M, Dewan T, Dionne J, Evans AM, Friedman JM, Garber I, Lewis S, Ling J, Mandal R, Mattman A, McKinnon M, Michoulas A, Metzger D, Ogunbayo OA, Rakic B, Rozmus J, Ruben P, Sayson B, Santra S, Schultz KR, Selby K, Shekel P, Sirrs S, Skrypnyk C, Superti-Furga A, Turvey SE, Van Allen MI, Wishart D, Wu J, Wu J, Zafeiriou D, Kluijtmans L, Wevers RA, Eydoux P, Lehman AM, Vallance H, Stockler-Ipsiroglu S, Sinclair G, Wasserman WW, van Karnebeek CD.

N Engl J Med. 2016 Jun 9;374(23):2246-55. doi: 10.1056/NEJMoa1515792. Epub 2016 May 25.


Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency.

Schroder TH, Mattman A, Sinclair G, Vallance HD, Lamers Y.

Clin Biochem. 2016 Sep;49(13-14):973-8. doi: 10.1016/j.clinbiochem.2016.03.007. Epub 2016 Apr 15.


Cross-Sectional Associations of Serum Perfluoroalkyl Acids and Thyroid Hormones in U.S. Adults: Variation According to TPOAb and Iodine Status (NHANES 2007-2008).

Webster GM, Rauch SA, Marie NS, Mattman A, Lanphear BP, Venners SA.

Environ Health Perspect. 2016 Jul;124(7):935-42. doi: 10.1289/ehp.1409589. Epub 2015 Oct 30.


Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case-control study.

Miller RR, Reid WD, Mattman A, Yamabayashi C, Steiner T, Parker S, Gardy J, Tang P, Patrick DM.

J Transl Med. 2015 May 20;13:159. doi: 10.1186/s12967-015-0527-8.


Nitrous Oxide (N2O)-Induced Acute Psychosis.

Wong SL, Harrison R, Mattman A, Hsiung GY.

Can J Neurol Sci. 2014 Sep;41(5):672-4. doi: 10.1017/cjn.2014.30. No abstract available.


Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: a population-based cohort study.

Webster GM, Venners SA, Mattman A, Martin JW.

Environ Res. 2014 Aug;133:338-47. doi: 10.1016/j.envres.2014.06.012. Epub 2014 Jul 12.


The determinants of poor respiratory health status in adults living with human immunodeficiency virus infection.

Leung JM, Liu JC, Mtambo A, Ngan D, Nashta N, Guillemi S, Harris M, Lima VD, Mattman A, Shaipanich T, Raju R, Hague C, Leipsic JA, Sin DD, Montaner JS, Man SF.

AIDS Patient Care STDS. 2014 May;28(5):240-7. doi: 10.1089/apc.2013.0373. Epub 2014 Apr 17.


Corroboration of the prozone phenomenon in IgG4-related disease: comment on the article by Khosroshahi et al.

Urquhart N, Mattman A.

Arthritis Rheumatol. 2014 Jul;66(7):1963-4. doi: 10.1002/art.38663. No abstract available.


Total IgG method insensitivity to the presence of IgG4 immunoglobulins.

Mattman A, Wong S, Urquhart N, Wong P.

Clin Biochem. 2014 Aug;47(12):1124-7. doi: 10.1016/j.clinbiochem.2014.03.018. Epub 2014 Apr 6.


Second trimester thyroid-stimulating hormone, total and free thyroxine reference intervals for the Beckman Coulter Access® 2 platform.

Wong SL, Webster GM, Venners S, Mattman A.

Clin Chim Acta. 2014 Jan 20;428:96-8. doi: 10.1016/j.cca.2013.11.006. Epub 2013 Nov 16. No abstract available.


Immunoglobulin G4-related lung disease: a disease with many different faces.

Hui P, Mattman A, Wilcox PG, Wright JL, Sin DD.

Can Respir J. 2013 Sep-Oct;20(5):335-8.


Practice patterns of mitochondrial disease physicians in North America. Part 1: diagnostic and clinical challenges.

Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R; Mitochondrial Medicine Society Clinical Directors Working Group; MMS Clinical Director's Work Group, Anselm I, Collins A, Cohen BH, DeBrosse SD, Dimmock D, Falk MJ, Ganesh J, Greene C, Gropman AL, Haas R, Kahler SG, Kamholz J, Kendall F, Korson MS, Mattman A, Milone M, Niyazov D, Pearl PL, Reimschisel T, Salvarinova-Zivkovic R, Sims K, Tarnopolsky M, Tsao CY, van Hove J, Walsh L, Wolfe LA.

Mitochondrion. 2014 Jan;14(1):26-33. doi: 10.1016/j.mito.2013.07.116. Epub 2013 Jul 26.


Increased Prevalence of Hypertension in Young Adults with High Heteroplasmy Levels of the MELAS m.3243A>G Mutation.

Hannah-Shmouni F, Sirrs S, Mezei MM, Waters PJ, Mattman A.

JIMD Rep. 2014;12:17-23. doi: 10.1007/8904_2013_239. Epub 2013 Jul 12.


Antiglycine receptor antibody and encephalomyelitis with rigidity and myoclonus (PERM) related to small cell lung cancer.

Kyskan R, Chapman K, Mattman A, Sin D.

BMJ Case Rep. 2013 Jun 21;2013. pii: bcr2013010027. doi: 10.1136/bcr-2013-010027.


Safety of statin therapy in patients with mitochondrial diseases.

Hannah-Shmouni F, Al-Sarraf A, Frohlich J, Mezei MM, Sirrs S, Mattman A.

J Clin Lipidol. 2013 Mar-Apr;7(2):182. doi: 10.1016/j.jacl.2012.08.003. Epub 2012 Aug 10. No abstract available.


Acylcarnitine profile in thyroid disease.

Wong S, Hannah-Shmouni F, Sinclair G, Sirrs S, Dahl M, Mattman A.

Clin Biochem. 2013 Jan;46(1-2):180-3. doi: 10.1016/j.clinbiochem.2012.10.006. Epub 2012 Oct 23.


Use of once-weekly statin in combination with ezetimibe in a patient with mitochondrial disease.

Li M, Al-Sarraf A, Mattman A, Frohlich J.

BMJ Case Rep. 2012 Apr 23;2012. pii: bcr1220115369. doi: 10.1136/bcr.12.2011.5369.


Investigating maternal risk factors as potential targets of intervention to reduce socioeconomic inequality in small for gestational age: a population-based study.

Hayward I, Malcoe LH, Cleathero LA, Janssen PA, Lanphear BP, Hayes MV, Mattman A, Pampalon R, Venners SA.

BMC Public Health. 2012 Jun 13;12:333. doi: 10.1186/1471-2458-12-333.


Emphysema in an adult with galactosialidosis linked to a defect in primary elastic fiber assembly.

Lehman A, Mattman A, Sin D, Pare P, Zong Z, d'Azzo A, Campos Y, Sirrs S, Hinek A.

Mol Genet Metab. 2012 May;106(1):99-103. doi: 10.1016/j.ymgme.2012.02.004. Epub 2012 Feb 8.


Sanger sequencing solved a cryptic case of severe alpha₁-antitrypsin deficiency.

Zhan SH, Abboud RT, Jung B, Kuchinka B, Ralston D, Casey B, Mattman A.

Clin Biochem. 2012 Apr;45(6):499-501. doi: 10.1016/j.clinbiochem.2012.01.027. Epub 2012 Feb 4.


Cardiac troponin testing in the acute care setting: ordering, reporting, and high sensitivity assays--an update from the Canadian society of clinical chemists (CSCC).

Kavsak PA, Allen LC, Apple FS, Booth RA, Chan PC, Delvin E, Fraser A, Fu L, Gornall D, Collier C, Hill S, Hoffman B, Huang Y, Lavoie J, Lou A, Mattman A, McQueen M, Meng QH, Oleschuk C, Pudek M, Randell E, Sohn KY, Thorlacius L, Yip PM, Dahdah N, Devereaux PJ, Dhesy-Thind S, Hotte SJ, Worster A.

Clin Biochem. 2011 Nov;44(16):1273-7. doi: 10.1016/j.clinbiochem.2011.08.001. Epub 2011 Aug 7. No abstract available.


Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: pitfalls of mutation analyses in patients with low α-galactosidase A activity.

Yoshimitsu M, Higuchi K, Miyata M, Devine S, Mattman A, Sirrs S, Medin JA, Tei C, Takenaka T.

J Cardiol. 2011 May;57(3):345-53. doi: 10.1016/j.jjcc.2010.12.004. Epub 2011 Feb 17.


White and gray matter alterations in adults with Niemann-Pick disease type C: a cross-sectional study.

Scheel M, Abegg M, Lanyon LJ, Mattman A, Barton JJ.

Neurology. 2011 Jan 11;76(2):201; author reply 201-2. doi: 10.1212/WNL.0b013e3181fe7341. No abstract available.


Alpha1-antitrypsin deficiency: a clinical-genetic overview.

Abboud RT, Nelson TN, Jung B, Mattman A.

Appl Clin Genet. 2011 Mar 31;4:55-65. doi: 10.2147/TACG.S10604. Print 2011.


Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients.

Leung S, Mattman A, Snyder F, Kassam R, Meneilly G, Nexo E.

Clin Biochem. 2010 Jun;43(9):759-60. doi: 10.1016/j.clinbiochem.2010.02.011. Epub 2010 Mar 6.


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