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Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction.

Hu Q, Zhang H, Gutierrez Cortes N, Wu D, Wang P, Zhang J, Mattison JA, Smith E, Bettcher LF, Wang M, Lakatta EG, Sheu SS, Wang W.

Circ Res. 2020 Jan 3. doi: 10.1161/CIRCRESAHA.119.315252. [Epub ahead of print]


Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates.

Ushakumary MG, Wang M, V H, Titus AS, Zhang J, Liu L, Monticone R, Wang Y, Mattison JA, Cabo R, Lakatta EG, Kailasam S.

PLoS One. 2019 Dec 5;14(12):e0225911. doi: 10.1371/journal.pone.0225911. eCollection 2019.


Pharmacokinetics of Exenatide in nonhuman primates following its administration in the form of sustained-release PT320 and Bydureon.

Li Y, Vaughan KL, Tweedie D, Jung J, Kim HK, Choi HI, Kim DS, Mattison JA, Greig NH.

Sci Rep. 2019 Nov 20;9(1):17208. doi: 10.1038/s41598-019-53356-2.


Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys.

Natarajan N, Vujic A, Das J, Wang AC, Phu KK, Kiehm SH, Ricci-Blair EM, Zhu AY, Vaughan KL, Colman RJ, Mattison JA, Lee RT.

JCI Insight. 2019 Sep 19;4(18). pii: 128685. doi: 10.1172/jci.insight.128685.


Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.

Demarest TG, Truong GTD, Lovett J, Mohanty JG, Mattison JA, Mattson MP, Ferrucci L, Bohr VA, Moaddel R.

Anal Biochem. 2019 May 1;572:1-8. doi: 10.1016/j.ab.2019.02.019. Epub 2019 Feb 27.


Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta).

Duffy KB, Ray B, Lahiri DK, Tilmont EM, Tinkler GP, Herbert RL, Greig NH, Ingram DK, Ottinger MA, Mattison JA.

J Alzheimers Dis. 2019;68(1):115-126. doi: 10.3233/JAD-180487.


Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells.

Khayrullin A, Krishnan P, Martinez-Nater L, Mendhe B, Fulzele S, Liu Y, Mattison JA, Hamrick MW.

Cells. 2019 Jan 10;8(1). pii: E37. doi: 10.3390/cells8010037.


Design and in Vivo Characterization of A1 Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.

Tosh DK, Rao H, Bitant A, Salmaso V, Mannes P, Lieberman DI, Vaughan KL, Mattison JA, Rothwell AC, Auchampach JA, Ciancetta A, Liu N, Cui Z, Gao ZG, Reitman ML, Gavrilova O, Jacobson KA.

J Med Chem. 2019 Feb 14;62(3):1502-1522. doi: 10.1021/acs.jmedchem.8b01662. Epub 2019 Jan 3.


Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells.

Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A.

Sci Transl Med. 2018 Nov 14;10(467). pii: eaat4271. doi: 10.1126/scitranslmed.aat4271.


Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.

Mitchell SJ, Bernier M, Mattison JA, Aon MA, Kaiser TA, Anson RM, Ikeno Y, Anderson RM, Ingram DK, de Cabo R.

Cell Metab. 2019 Jan 8;29(1):221-228.e3. doi: 10.1016/j.cmet.2018.08.011. Epub 2018 Sep 6.


Watch the Clock, Not the Scale.

Vaughan KL, Mattison JA.

Cell Metab. 2018 Jun 5;27(6):1159-1160. doi: 10.1016/j.cmet.2018.05.016.


The Ultrastructure, Spatial Distribution, and Osmium Tetroxide Binding of Lipofuscin and Melanosomes in Aging Monkey Retinal Epithelium.

Gouras P, Brown KR, Mattison JA, Neuringer M, Nagasaki T, Ivert L.

Curr Eye Res. 2018 Aug;43(8):1019-1023. doi: 10.1080/02713683.2018.1464194. Epub 2018 May 14.


α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice.

Maxwell N, Castro RW, Sutherland NM, Vaughan KL, Szarowicz MD, de Cabo R, Mattison JA, Valdez G.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12726. Epub 2018 Feb 4.


Response to Le Bourg.

Mattison JA, Colman RJ.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):310. doi: 10.1093/gerona/glx173. No abstract available.


Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies.

Vaughan KL, Kaiser T, Peaden R, Anson RM, de Cabo R, Mattison JA.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):48-53. doi: 10.1093/gerona/glx088. Erratum in: J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1207.


Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.


Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.

Aghazadeh-Sanai N, Downs JL, Mattison JA, Ingram DK, Kohama SG, Urbanski HF.

Neurobiol Aging. 2017 Jul;55:213-216. doi: 10.1016/j.neurobiolaging.2017.03.032. Epub 2017 Apr 8.


Nutrition, metabolism, and targeting aging in nonhuman primates.

Balasubramanian P, Mattison JA, Anderson RM.

Ageing Res Rev. 2017 Oct;39:29-35. doi: 10.1016/j.arr.2017.02.002. Epub 2017 Feb 20. Review.


Caloric restriction improves health and survival of rhesus monkeys.

Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, de Cabo R, Anderson RM.

Nat Commun. 2017 Jan 17;8:14063. doi: 10.1038/ncomms14063.


Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.

Cell Metab. 2017 Jan 10;25(1):218. doi: 10.1016/j.cmet.2016.12.003. No abstract available.


An overview of nonhuman primates in aging research.

Mattison JA, Vaughan KL.

Exp Gerontol. 2017 Aug;94:41-45. doi: 10.1016/j.exger.2016.12.005. Epub 2016 Dec 10.


Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function.

Swomley AM, Triplett JC, Keeney JT, Warrier G, Pearson KJ, Mattison JA, de Cabo R, Cai J, Klein JB, Butterfield DA.

J Nutr Biochem. 2017 Jan;39:169-179. doi: 10.1016/j.jnutbio.2016.10.006. Epub 2016 Oct 13.


Obesity and Aging in Humans and Nonhuman Primates: A Mini-Review.

Vaughan KL, Mattison JA.

Gerontology. 2016;62(6):611-617. Epub 2016 Apr 28. Review.


Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.

Moon HY, Becke A, Berron D, Becker B, Sah N, Benoni G, Janke E, Lubejko ST, Greig NH, Mattison JA, Duzel E, van Praag H.

Cell Metab. 2016 Aug 9;24(2):332-40. doi: 10.1016/j.cmet.2016.05.025. Epub 2016 Jun 23.


Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G.

Cell Metab. 2016 Jun 14;23(6):1078-1092. doi: 10.1016/j.cmet.2016.05.004. Erratum in: Cell Metab. 2017 Jan 10;25(1):218.


Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.

Bernier M, Wahl D, Ali A, Allard J, Faulkner S, Wnorowski A, Sanghvi M, Moaddel R, Alfaras I, Mattison JA, Tarantini S, Tucsek Z, Ungvari Z, Csiszar A, Pearson KJ, de Cabo R.

Aging (Albany NY). 2016 May;8(5):899-916. doi: 10.18632/aging.100942.


Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates.

Hyatt JP, Nguyen L, Hall AE, Huber AM, Kocan JC, Mattison JA, de Cabo R, LaRocque JR, Talmadge RJ.

Front Physiol. 2016 Mar 2;7:77. doi: 10.3389/fphys.2016.00077. eCollection 2016.


Circular RNAs in monkey muscle: age-dependent changes.

Abdelmohsen K, Panda AC, De S, Grammatikakis I, Kim J, Ding J, Noh JH, Kim KM, Mattison JA, de Cabo R, Gorospe M.

Aging (Albany NY). 2015 Nov;7(11):903-10.


Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.

Ortega-Molina A, Lopez-Guadamillas E, Mattison JA, Mitchell SJ, Muñoz-Martin M, Iglesias G, Gutierrez VM, Vaughan KL, Szarowicz MD, González-García I, López M, Cebrián D, Martinez S, Pastor J, de Cabo R, Serrano M.

Cell Metab. 2015 Apr 7;21(4):558-70. doi: 10.1016/j.cmet.2015.02.017. Epub 2015 Mar 26.


Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity.

Lee-Chang C, Bodogai M, Moritoh K, Olkhanud PB, Chan AC, Croft M, Mattison JA, Holst PJ, Gress RE, Ferrucci L, Hakim F, Biragyn A.

Blood. 2014 Aug 28;124(9):1450-9. doi: 10.1182/blood-2014-03-563940. Epub 2014 Jul 18.


Natural infection of human adenovirus 36 in rhesus monkeys is associated with a reduction in fasting glucose 36.

Dhurandhar NV, Dhurandhar EJ, Ingram DK, Vaughan K, Mattison JA.

J Diabetes. 2014 Nov;6(6):614-6. doi: 10.1111/1753-0407.12178. Epub 2014 Sep 18. No abstract available.


Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

Mattison JA, Wang M, Bernier M, Zhang J, Park SS, Maudsley S, An SS, Santhanam L, Martin B, Faulkner S, Morrell C, Baur JA, Peshkin L, Sosnowska D, Csiszar A, Herbert RL, Tilmont EM, Ungvari Z, Pearson KJ, Lakatta EG, de Cabo R.

Cell Metab. 2014 Jul 1;20(1):183-90. doi: 10.1016/j.cmet.2014.04.018. Epub 2014 May 29.


Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys.

Bailey JF, Fields AJ, Liebenberg E, Mattison JA, Lotz JC, Kramer PA.

Osteoarthritis Cartilage. 2014 Jul;22(7):980-5. doi: 10.1016/j.joca.2014.04.027. Epub 2014 May 10.


Comparison of anesthesia protocols for intravenous glucose tolerance testing in rhesus monkeys.

Vaughan KL, Szarowicz MD, Herbert RL, Mattison JA.

J Med Primatol. 2014 Jun;43(3):162-8. doi: 10.1111/jmp.12104. Epub 2014 Feb 7.


Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R.

Cell Metab. 2013 Oct 1;18(4):533-45. doi: 10.1016/j.cmet.2013.09.004.


Age-related changes in microRNA levels in serum.

Noren Hooten N, Fitzpatrick M, Wood WH 3rd, De S, Ejiogu N, Zhang Y, Mattison JA, Becker KG, Zonderman AB, Evans MK.

Aging (Albany NY). 2013 Oct;5(10):725-40.


Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.

Fiori JL, Shin YK, Kim W, Krzysik-Walker SM, González-Mariscal I, Carlson OD, Sanghvi M, Moaddel R, Farhang K, Gadkaree SK, Doyle ME, Pearson KJ, Mattison JA, de Cabo R, Egan JM.

Diabetes. 2013 Oct;62(10):3500-13. doi: 10.2337/db13-0266. Epub 2013 Jul 24.


Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta).

Sitzmann BD, Brown DI, Garyfallou VT, Kohama SG, Mattison JA, Ingram DK, Roth GS, Ottinger MA, Urbanski HF.

Age (Dordr). 2014 Feb;36(1):183-97. doi: 10.1007/s11357-013-9563-6. Epub 2013 Jul 24.


MicroRNA 33 regulates glucose metabolism.

Ramírez CM, Goedeke L, Rotllan N, Yoon JH, Cirera-Salinas D, Mattison JA, Suárez Y, de Cabo R, Gorospe M, Fernández-Hernando C.

Mol Cell Biol. 2013 Aug;33(15):2891-902. doi: 10.1128/MCB.00016-13. Epub 2013 May 28.


A regulatory role for microRNA 33* in controlling lipid metabolism gene expression.

Goedeke L, Vales-Lara FM, Fenstermaker M, Cirera-Salinas D, Chamorro-Jorganes A, Ramírez CM, Mattison JA, de Cabo R, Suárez Y, Fernández-Hernando C.

Mol Cell Biol. 2013 Jun;33(11):2339-52. doi: 10.1128/MCB.01714-12. Epub 2013 Apr 1.


Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies.

Urbanski HF, Mattison JA, Roth GS, Ingram DK.

Exp Gerontol. 2013 Oct;48(10):1136-9. doi: 10.1016/j.exger.2013.01.001. Epub 2013 Jan 11. Review.


Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.

Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R.

Nature. 2012 Sep 13;489(7415):318-21. doi: 10.1038/nature11432.


Telomere dynamics in rhesus monkeys: no apparent effect of caloric restriction.

Smith DL Jr, Mattison JA, Desmond RA, Gardner JP, Kimura M, Roth GS, Ingram DK, Allison DB, Aviv A.

J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1163-8. doi: 10.1093/gerona/glr136. Epub 2011 Aug 22.


Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore Longitudinal Study of Aging.

Stenholm S, Metter EJ, Roth GS, Ingram DK, Mattison JA, Taub DD, Ferrucci L.

Aging Clin Exp Res. 2011 Apr;23(2):153-8.


Impact of Moderate Calorie Restriction on the Reproductive Neuroendocrine Axis of Male Rhesus Macaques.

Sitzmann BD, Mattison JA, Ingram DK, Roth GS, Ottinger MA, Urbanski HF.

Open Longev Sci. 2010;3(10):38-47.


Effects of moderate calorie restriction on testosterone production and semen characteristics in young rhesus macaques (Macaca mulatta).

Sitzmann BD, Leone EH, Mattison JA, Ingram DK, Roth GS, Urbanski HF, Zelinski MB, Ottinger MA.

Biol Reprod. 2010 Oct;83(4):635-40. doi: 10.1095/biolreprod.110.084186. Epub 2010 Jul 7.


The incidence of spontaneous neoplasia in two populations of captive rhesus macaques (Macaca mulatta).

Simmons HA, Mattison JA.

Antioxid Redox Signal. 2011 Jan 15;14(2):221-7. doi: 10.1089/ars.2010.3311. Epub 2010 Oct 28.


Ovarian reserve tests and their utility in predicting response to controlled ovarian stimulation in rhesus monkeys.

Wu JM, Takahashi DL, Ingram DK, Mattison JA, Roth G, Ottinger MA, Zelinski MB.

Am J Primatol. 2010 Aug;72(8):672-80. doi: 10.1002/ajp.20823.


Metformin supplementation and life span in Fischer-344 rats.

Smith DL Jr, Elam CF Jr, Mattison JA, Lane MA, Roth GS, Ingram DK, Allison DB.

J Gerontol A Biol Sci Med Sci. 2010 May;65(5):468-74. doi: 10.1093/gerona/glq033. Epub 2010 Mar 19.


Topographic and age-related changes of the retinal epithelium and Bruch's membrane of rhesus monkeys.

Gouras P, Ivert L, Neuringer M, Mattison JA.

Graefes Arch Clin Exp Ophthalmol. 2010 Jul;248(7):973-84. doi: 10.1007/s00417-010-1325-x. Epub 2010 Mar 2.

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