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Items: 1 to 50 of 91

1.

Serum Metabolites Associated with Computed Tomography Findings after Traumatic Brain Injury.

Dickens AM, Posti JP, Takala RSK, Ala-Seppälä H, Mattila I, Coles JP, Frantzén J, Hutchinson PJ, Katila AJ, Kyllönen A, Maanpää HR, Newcombe V, Outtrim J, Tallus J, Carpenter KLH, Menon DK, Hyötyläinen T, Tenovuo O, Orešic M.

J Neurotrauma. 2018 Aug 21. doi: 10.1089/neu.2017.5272. [Epub ahead of print]

PMID:
29947291
2.

Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor.

Orešič M, Anderson G, Mattila I, Manoucheri M, Soininen H, Hyötyläinen T, Basignani C.

Front Neurosci. 2018 Jan 9;11:747. doi: 10.3389/fnins.2017.00747. eCollection 2017.

3.

Congenital diaphragmatic hernia with heart defect has a high risk for hypoplastic left heart syndrome and major extra-cardiac malformations: 10-year national cohort from Finland.

Hautala J, Karstunen E, Ritvanen A, Rintala R, Mattila IP, Räsänen J, Suominen PK, Ojala T.

Acta Obstet Gynecol Scand. 2018 Feb;97(2):204-211. doi: 10.1111/aogs.13274. Epub 2017 Dec 27.

PMID:
29215158
4.

Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort.

O'Gorman A, Suvitaival T, Ahonen L, Cannon M, Zammit S, Lewis G, Roche HM, Mattila I, Hyotylainen T, Oresic M, Brennan L, Cotter DR.

Transl Psychiatry. 2017 Sep 26;7(9):e1240. doi: 10.1038/tp.2017.211.

5.

Congenital aortic stenosis: treatment outcomes in a nationwide survey.

Kallio M, Rahkonen O, Mattila I, Pihkala J.

Scand Cardiovasc J. 2017 Oct;51(5):277-283. doi: 10.1080/14017431.2017.1355069. Epub 2017 Aug 4.

PMID:
28776389
6.

Left-Sided Reoperations After Arterial Switch Operation: A European Multicenter Study.

Vida VL, Zanotto L, Zanotto L, Stellin G; European Congenital Heart Surgeons Association (ECHSA) Study Group, Padalino M, Sarris G, Protopapas E, Prospero C, Pizarro C, Woodford E, Tlaskal T, Berggren H, Kostolny M, Omeje I, Asfour B, Kadner A, Carrel T, Schoof PH, Nosal M, Fragata J, Kozłowski M, Maruszewski B, Vricella LA, Cameron DE, Sojak V, Hazekamp M, Salminen J, Mattila IP, Cleuziou J, Myers PO, Hraska V.

Ann Thorac Surg. 2017 Sep;104(3):899-906. doi: 10.1016/j.athoracsur.2017.04.026. Epub 2017 Jul 12.

PMID:
28709661
7.

Interactions of Insoluble Residue from Enzymatic Hydrolysis of Brewer's Spent Grain with Intestinal Microbiota in Mice.

Maukonen J, Aura AM, Niemi P, Raza GS, Niemelä K, Walkowiak J, Mattila I, Poutanen K, Buchert J, Herzig KH.

J Agric Food Chem. 2017 May 10;65(18):3748-3756. doi: 10.1021/acs.jafc.6b05552. Epub 2017 May 1.

PMID:
28441866
8.

Effect of Bioprocessing on the In Vitro Colonic Microbial Metabolism of Phenolic Acids from Rye Bran Fortified Breads.

Koistinen VM, Nordlund E, Katina K, Mattila I, Poutanen K, Hanhineva K, Aura AM.

J Agric Food Chem. 2017 Mar 8;65(9):1854-1864. doi: 10.1021/acs.jafc.6b05110. Epub 2017 Feb 28.

PMID:
28206756
9.

Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis.

Suvitaival T, Mantere O, Kieseppä T, Mattila I, Pöhö P, Hyötyläinen T, Suvisaari J, Orešič M.

Transl Psychiatry. 2016 Nov 15;6(11):e951. doi: 10.1038/tp.2016.222.

10.

Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury.

Orešič M, Posti JP, Kamstrup-Nielsen MH, Takala RSK, Lingsma HF, Mattila I, Jäntti S, Katila AJ, Carpenter KLH, Ala-Seppälä H, Kyllönen A, Maanpää HR, Tallus J, Coles JP, Heino I, Frantzén J, Hutchinson PJ, Menon DK, Tenovuo O, Hyötyläinen T.

EBioMedicine. 2016 Oct;12:118-126. doi: 10.1016/j.ebiom.2016.07.015. Epub 2016 Jul 15.

11.

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI).

Kurko J, Tringham M, Tanner L, Näntö-Salonen K, Vähä-Mäkilä M, Nygren H, Pöhö P, Lietzen N, Mattila I, Olkku A, Hyötyläinen T, Orešič M, Simell O, Niinikoski H, Mykkänen J.

Metabolism. 2016 Sep;65(9):1361-75. doi: 10.1016/j.metabol.2016.05.012. Epub 2016 May 27.

PMID:
27506743
12.

Human gut microbes impact host serum metabolome and insulin sensitivity.

Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Doré J, Mattila I, Plichta DR, Pöhö P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, Jørgensen T, Holm JB, Trošt K; MetaHIT Consortium, Kristiansen K, Brix S, Raes J, Wang J, Hansen T, Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O.

Nature. 2016 Jul 21;535(7612):376-81. Epub 2016 Jul 13.

PMID:
27409811
13.

The effect of continuous wound infusion of ropivacaine on postoperative pain after median sternotomy and mediastinal drain in children.

Mattila I, Pätilä T, Rautiainen P, Korpela R, Nikander S, Puntila J, Salminen J, Suominen PK, Tynkkynen P, Hiller A.

Paediatr Anaesth. 2016 Jul;26(7):727-33. doi: 10.1111/pan.12919. Epub 2016 May 17.

PMID:
27184591
14.

Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites.

Vetrani C, Rivellese AA, Annuzzi G, Adiels M, Borén J, Mattila I, Orešič M, Aura AM.

J Nutr Biochem. 2016 Jul;33:111-8. doi: 10.1016/j.jnutbio.2016.03.007. Epub 2016 Mar 29.

PMID:
27155917
15.

Surgical options after Fontan failure.

van Melle JP, Wolff D, Hörer J, Belli E, Meyns B, Padalino M, Lindberg H, Jacobs JP, Mattila IP, Berggren H, Berger RM, Prêtre R, Hazekamp MG, Helvind M, Nosál M, Tlaskal T, Rubay J, Lazarov S, Kadner A, Hraska V, Fragata J, Pozzi M, Sarris G, Michielon G, di Carlo D, Ebels T.

Heart. 2016 Jul 15;102(14):1127-33. doi: 10.1136/heartjnl-2015-309235. Epub 2016 Apr 13.

PMID:
27076374
16.

Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease.

Hyötyläinen T, Jerby L, Petäjä EM, Mattila I, Jäntti S, Auvinen P, Gastaldelli A, Yki-Järvinen H, Ruppin E, Orešič M.

Nat Commun. 2016 Feb 3;7:8994. doi: 10.1038/ncomms9994.

17.

Long-term outcome after treatment of pulmonary atresia with ventricular septal defect: nationwide study of 109 patients born in 1970-2007.

Kaskinen AK, Happonen JM, Mattila IP, Pitkänen OM.

Eur J Cardiothorac Surg. 2016 May;49(5):1411-8. doi: 10.1093/ejcts/ezv404. Epub 2015 Nov 29.

PMID:
26620210
18.

Fate of fenestration in children treated with fontan operation.

Pihkala JI, Järvelä M, Boldt T, Jokinen E, Liikanen I, Mattila I, Eerola A.

Catheter Cardiovasc Interv. 2016 May;87(6):E233-9. doi: 10.1002/ccd.26324. Epub 2015 Nov 3.

PMID:
26525305
19.

The Effect of Methylprednisolone on Plasma Concentrations of Neutrophil Gelatinase-Associated Lipocalin in Pediatric Heart Surgery.

Pesonen EJ, Suominen PK, Keski-Nisula J, Mattila IP, Rautiainen P, Jahnukainen T.

Pediatr Crit Care Med. 2016 Feb;17(2):121-7. doi: 10.1097/PCC.0000000000000573.

PMID:
26509817
20.

Chronic Hypoxemia in Children With Congenital Heart Defect Impairs Airway Epithelial Sodium Transport.

Kaskinen AK, Helve O, Andersson S, Kirjavainen T, Martelius L, Mattila IP, Rautiainen P, Pitkänen OM.

Pediatr Crit Care Med. 2016 Jan;17(1):45-52. doi: 10.1097/PCC.0000000000000568.

PMID:
26509813
21.

Renal transplantation in infants.

Jalanko H, Mattila I, Holmberg C.

Pediatr Nephrol. 2016 May;31(5):725-35. doi: 10.1007/s00467-015-3144-0. Epub 2015 Jun 27. Review.

PMID:
26115617
22.

The influence of sample collection methodology and sample preprocessing on the blood metabolic profile.

Jørgenrud B, Jäntti S, Mattila I, Pöhö P, Rønningen KS, Yki-Järvinen H, Orešič M, Hyötyläinen T.

Bioanalysis. 2015;7(8):991-1006. doi: 10.4155/bio.15.16.

PMID:
25966010
23.

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen AM, Peet A, Tillmann V, Pöhö P, Mattila I, Lähdesmäki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Orešič M, Huttenhower C, Knip M; DIABIMMUNE Study Group, Xavier RJ.

Cell Host Microbe. 2015 Feb 11;17(2):260-73. doi: 10.1016/j.chom.2015.01.001. Epub 2015 Feb 5.

24.

Long-term results of the Ross procedure in a population-based follow-up.

Kallio M, Pihkala J, Sairanen H, Mattila I.

Eur J Cardiothorac Surg. 2015 May;47(5):e164-70. doi: 10.1093/ejcts/ezv004. Epub 2015 Feb 7.

PMID:
25661074
25.

Favourable mid-term outcome after heart transplantation for late Fontan failure.

Michielon G, van Melle JP, Wolff D, Di Carlo D, Jacobs JP, Mattila IP, Berggren H, Lindberg H, Padalino MA, Meyns B, Prêtre R, Helvind M, Carrel T, Ebels T.

Eur J Cardiothorac Surg. 2015 Apr;47(4):665-71. doi: 10.1093/ejcts/ezu280. Epub 2014 Jul 17.

PMID:
25035415
26.

Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge.

Bondia-Pons I, Maukonen J, Mattila I, Rissanen A, Saarela M, Kaprio J, Hakkarainen A, Lundbom J, Lundbom N, Hyötyläinen T, Pietiläinen KH, Orešič M.

FASEB J. 2014 Sep;28(9):4169-79. doi: 10.1096/fj.14-250167. Epub 2014 May 20.

27.

Resection of the stenotic segment with individually tailored anastomosis for symptomatic congenital tracheal stenosis in infants.

Aaltonen PL, Puntila JT, Suominen PK, Mattila IP, Sairanen HI, Lindahl H, Salminen JT.

Eur J Cardiothorac Surg. 2014 Jun;45(6):e215-9. doi: 10.1093/ejcts/ezu113. Epub 2014 Mar 28.

PMID:
24682872
28.

Release of small phenolic compounds from brewer's spent grain and its lignin fractions by human intestinal microbiota in vitro.

Aura AM, Niemi P, Mattila I, Niemelä K, Smeds A, Tamminen T, Faulds C, Buchert J, Poutanen K.

J Agric Food Chem. 2013 Oct 9;61(40):9744-53. doi: 10.1021/jf4024195. Epub 2013 Sep 26.

PMID:
24028071
29.

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids.

Orešič M, Hyötyläinen T, Kotronen A, Gopalacharyulu P, Nygren H, Arola J, Castillo S, Mattila I, Hakkarainen A, Borra RJ, Honka MJ, Verrijken A, Francque S, Iozzo P, Leivonen M, Jaser N, Juuti A, Sørensen TI, Nuutila P, Van Gaal L, Yki-Järvinen H.

Diabetologia. 2013 Oct;56(10):2266-74. doi: 10.1007/s00125-013-2981-2. Epub 2013 Jul 4.

30.

Interactions of a lignin-rich fraction from brewer's spent grain with gut microbiota in vitro.

Niemi P, Aura AM, Maukonen J, Smeds AI, Mattila I, Niemelä K, Tamminen T, Faulds CB, Buchert J, Poutanen K.

J Agric Food Chem. 2013 Jul 10;61(27):6754-62. doi: 10.1021/jf401738x. Epub 2013 Jun 26.

PMID:
23768078
31.

Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry.

Hartonen M, Mattila I, Ruskeepää AL, Orešič M, Hyötyläinen T.

J Chromatogr A. 2013 Jun 7;1293:142-9. doi: 10.1016/j.chroma.2013.04.005. Epub 2013 Apr 8.

PMID:
23642768
32.

Outcome of pediatric heart transplantation recipients treated with ventricular assist device.

Jahnukainen T, Rautiainen P, Mattila IP, Puntila J, Haavisto A, Qvist E, Pihkala J, Peräsaari J, Merenmies J, Sairanen H, Jalanko H, Salminen JT.

Pediatr Transplant. 2013 Feb;17(1):73-9. doi: 10.1111/petr.12028. Epub 2012 Nov 28.

PMID:
23190354
33.

Neurodevelopmental burden at age 5 years in patients with univentricular heart.

Sarajuuri A, Jokinen E, Mildh L, Tujulin AM, Mattila I, Valanne L, Lönnqvist T.

Pediatrics. 2012 Dec;130(6):e1636-46. doi: 10.1542/peds.2012-0486. Epub 2012 Nov 19.

PMID:
23166336
34.

Formation of phenolic microbial metabolites and short-chain fatty acids from rye, wheat, and oat bran and their fractions in the metabolical in vitro colon model.

Nordlund E, Aura AM, Mattila I, Kössö T, Rouau X, Poutanen K.

J Agric Food Chem. 2012 Aug 22;60(33):8134-45. doi: 10.1021/jf3008037. Epub 2012 Aug 14.

PMID:
22731123
35.

Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance.

Hyötyläinen T, Mattila I, Wiedmer SK, Koivuniemi A, Taskinen MR, Yki-Järvinen H, Orešič M.

Mol Biosyst. 2012 Oct;8(10):2559-65. doi: 10.1039/c2mb25115a.

PMID:
22722885
36.

Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches.

Aura AM, Mattila I, Hyötyläinen T, Gopalacharyulu P, Cheynier V, Souquet JM, Bes M, Le Bourvellec C, Guyot S, Orešič M.

Eur J Nutr. 2013 Mar;52(2):833-46. doi: 10.1007/s00394-012-0391-8. Epub 2012 Jun 16.

37.

Mesoportal bypass using a constructed saphenous vein graft for extrahepatic portal vein obstruction--technique, feasibility, and outcomes.

Luoto T, Pakarinen M, Mattila I, Rintala R.

J Pediatr Surg. 2012 Apr;47(4):688-93. doi: 10.1016/j.jpedsurg.2011.10.065.

PMID:
22498382
38.

Metabolic regulation in progression to autoimmune diabetes.

Sysi-Aho M, Ermolov A, Gopalacharyulu PV, Tripathi A, Seppänen-Laakso T, Maukonen J, Mattila I, Ruohonen ST, Vähätalo L, Yetukuri L, Härkönen T, Lindfors E, Nikkilä J, Ilonen J, Simell O, Saarela M, Knip M, Kaski S, Savontaus E, Orešič M.

PLoS Comput Biol. 2011 Oct;7(10):e1002257. doi: 10.1371/journal.pcbi.1002257. Epub 2011 Oct 27.

39.

Neurocognitive development and behavioral outcome of 2-year-old children with univentricular heart.

Puosi R, Korkman M, Sarajuuri A, Jokinen E, Mildh L, Mattila I, Lönnqvist T.

J Int Neuropsychol Soc. 2011 Nov;17(6):1094-103. doi: 10.1017/S135561771100110X. Epub 2011 Oct 13.

PMID:
22014005
40.

Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread.

Bondia-Pons I, Nordlund E, Mattila I, Katina K, Aura AM, Kolehmainen M, Orešič M, Mykkänen H, Poutanen K.

Nutr J. 2011 Oct 19;10:116. doi: 10.1186/1475-2891-10-116.

41.

Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.

Castillo S, Mattila I, Miettinen J, Orešič M, Hyötyläinen T.

Anal Chem. 2011 Apr 15;83(8):3058-67. doi: 10.1021/ac103308x. Epub 2011 Mar 24.

PMID:
21434611
42.

Metabolome in schizophrenia and other psychotic disorders: a general population-based study.

Orešič M, Tang J, Seppänen-Laakso T, Mattila I, Saarni SE, Saarni SI, Lönnqvist J, Sysi-Aho M, Hyötyläinen T, Perälä J, Suvisaari J.

Genome Med. 2011 Mar 23;3(3):19. doi: 10.1186/gm233.

43.

Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains.

Canelas AB, Harrison N, Fazio A, Zhang J, Pitkänen JP, van den Brink J, Bakker BM, Bogner L, Bouwman J, Castrillo JI, Cankorur A, Chumnanpuen P, Daran-Lapujade P, Dikicioglu D, van Eunen K, Ewald JC, Heijnen JJ, Kirdar B, Mattila I, Mensonides FI, Niebel A, Penttilä M, Pronk JT, Reuss M, Salusjärvi L, Sauer U, Sherman D, Siemann-Herzberg M, Westerhoff H, de Winde J, Petranovic D, Oliver SG, Workman CT, Zamboni N, Nielsen J.

Nat Commun. 2010;1:145. doi: 10.1038/ncomms1150.

PMID:
21266995
44.

Metabolome in progression to Alzheimer's disease.

Orešič M, Hyötyläinen T, Herukka SK, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H.

Transl Psychiatry. 2011 Dec 13;1:e57. doi: 10.1038/tp.2011.55.

45.

Bioprocessing of wheat bran in whole wheat bread increases the bioavailability of phenolic acids in men and exerts antiinflammatory effects ex vivo.

Mateo Anson N, Aura AM, Selinheimo E, Mattila I, Poutanen K, van den Berg R, Havenaar R, Bast A, Haenen GR.

J Nutr. 2011 Jan;141(1):137-43. doi: 10.3945/jn.110.127720. Epub 2010 Nov 24.

PMID:
21106920
46.

Metabolomic analysis of plasma metabolites that may mediate effects of rye bread on satiety and weight maintenance in postmenopausal women.

Lankinen M, Schwab U, Seppänen-Laakso T, Mattila I, Juntunen K, Mykkänen H, Poutanen K, Gylling H, Oresic M.

J Nutr. 2011 Jan;141(1):31-6. doi: 10.3945/jn.110.131656. Epub 2010 Nov 17.

PMID:
21084654
47.

Prevention of postoperative pericardial adhesions in children with hypoplastic left heart syndrome.

Salminen JT, Mattila IP, Puntila JT, Sairanen HI.

Interact Cardiovasc Thorac Surg. 2011 Feb;12(2):270-2. doi: 10.1510/icvts.2010.241448. Epub 2010 Nov 16.

PMID:
21081553
48.

Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro.

Aura AM, Mattila I, Hyötyläinen T, Gopalacharyulu P, Bounsaythip C, Orešič M, Oksman-Caldentey KM.

Mol Biosyst. 2011 Feb;7(2):437-46. doi: 10.1039/c0mb00023j. Epub 2010 Nov 8.

PMID:
21060933
49.

Neurodevelopment in children with hypoplastic left heart syndrome.

Sarajuuri A, Jokinen E, Puosi R, Mildh L, Mattila I, Lano A, Lönnqvist T.

J Pediatr. 2010 Sep;157(3):414-20, 420.e1-4. doi: 10.1016/j.jpeds.2010.04.027. Epub 2010 Jun 8.

PMID:
20570285
50.

Surgery for transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction: European Congenital Heart Surgeons Association multicentre study.

Hazekamp MG, Gomez AA, Koolbergen DR, Hraska V, Metras DR, Mattila IP, Daenen W, Berggren HE, Rubay JE, Stellin G; European Congenital Heart Surgeons Association.

Eur J Cardiothorac Surg. 2010 Dec;38(6):699-706. doi: 10.1016/j.ejcts.2010.03.030. Epub 2010 May 13. Review.

PMID:
20466558

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