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Items: 1 to 50 of 154

1.

Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.

Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV.

J Biol Chem. 2011 Aug 26;286(34):30034-46. doi: 10.1074/jbc.M111.260133. Epub 2011 Jul 7.

2.

Long-term localized high-frequency electric stimulation within the myocardial infarct: effects on matrix metalloproteinases and regional remodeling.

Mukherjee R, Rivers WT, Ruddy JM, Matthews RG, Koval CN, Plyler RA, Chang EI, Patel RK, Kern CB, Stroud RE, Spinale FG.

Circulation. 2010 Jul 6;122(1):20-32. doi: 10.1161/CIRCULATIONAHA.110.936872. Epub 2010 Jun 21.

3.

Short-term disruption in regional left ventricular electrical conduction patterns increases interstitial matrix metalloproteinase activity.

Mukherjee R, Zavadzkas JA, Rivers WT, McLean JE, Chang EI, Bouges S, Matthews RG, Koval CN, Stroud RE, Spinale FG.

Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H217-24. doi: 10.1152/ajpheart.00065.2010. Epub 2010 May 14.

4.

Insights into the reactivation of cobalamin-dependent methionine synthase.

Koutmos M, Datta S, Pattridge KA, Smith JL, Matthews RG.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18527-32. doi: 10.1073/pnas.0906132106. Epub 2009 Oct 21.

5.

A love affair with vitamins.

Matthews RG.

J Biol Chem. 2009 Sep 25;284(39):26217-28. doi: 10.1074/jbc.X109.041178. Epub 2009 Jul 13. No abstract available.

6.

Spectroscopic and computational characterization of the base-off forms of cob(II)alamin.

Liptak MD, Fleischhacker AS, Matthews RG, Telser J, Brunold TC.

J Phys Chem B. 2009 Apr 16;113(15):5245-54. doi: 10.1021/jp810136d.

7.

Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli.

Hondorp ER, Matthews RG.

J Bacteriol. 2009 May;191(10):3407-10. doi: 10.1128/JB.01722-08. Epub 2009 Mar 13.

8.

Cobalamin- and corrinoid-dependent enzymes.

Matthews RG.

Met Ions Life Sci. 2009;6:53-114. doi: 10.1039/BK9781847559159-00053. Epub 2009 Jan 30.

9.

Cobalamin-dependent and cobamide-dependent methyltransferases.

Matthews RG, Koutmos M, Datta S.

Curr Opin Struct Biol. 2008 Dec;18(6):658-66. doi: 10.1016/j.sbi.2008.11.005. Review.

10.
11.

Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice.

Deng L, Elmore CL, Lawrance AK, Matthews RG, Rozen R.

Mol Genet Metab. 2008 Jul;94(3):336-42. doi: 10.1016/j.ymgme.2008.03.004. Epub 2008 Apr 14.

12.

A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor.

Datta S, Koutmos M, Pattridge KA, Ludwig ML, Matthews RG.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4115-20. doi: 10.1073/pnas.0800329105. Epub 2008 Mar 10.

13.

Metal active site elasticity linked to activation of homocysteine in methionine synthases.

Koutmos M, Pejchal R, Bomer TM, Matthews RG, Smith JL, Ludwig ML.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3286-91. doi: 10.1073/pnas.0709960105. Epub 2008 Feb 22.

14.

Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias.

Matthews RG, Elmore CL.

Clin Chem Lab Med. 2007;45(12):1700-3. Review.

15.

Ligand trans influence governs conformation in cobalamin-dependent methionine synthase.

Fleischhacker AS, Matthews RG.

Biochemistry. 2007 Oct 30;46(43):12382-92. Epub 2007 Oct 9.

16.
17.

Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269.

Huang S, Romanchuk G, Pattridge K, Lesley SA, Wilson IA, Matthews RG, Ludwig M.

Protein Sci. 2007 Aug;16(8):1588-95.

18.

Probing the role of the histidine 759 ligand in cobalamin-dependent methionine synthase.

Liptak MD, Fleischhacker AS, Matthews RG, Brunold TC.

Biochemistry. 2007 Jul 10;46(27):8024-35. Epub 2007 Jun 13.

19.

Folate Biosynthesis, Reduction, and Polyglutamylation and the Interconversion of Folate Derivatives.

Green JM, Matthews RG.

EcoSal Plus. 2007 Apr;2(2). doi: 10.1128/ecosalplus.3.6.3.6.

PMID:
26443588
20.

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.

Elmore CL, Wu X, Leclerc D, Watson ED, Bottiglieri T, Krupenko NI, Krupenko SA, Cross JC, Rozen R, Gravel RA, Matthews RG.

Mol Genet Metab. 2007 May;91(1):85-97. Epub 2007 Mar 21.

22.

Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL.

Chapman E, Farr GW, Usaite R, Furtak K, Fenton WA, Chaudhuri TK, Hondorp ER, Matthews RG, Wolf SG, Yates JR, Pypaert M, Horwich AL.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15800-5. Epub 2006 Oct 16.

23.

Human methionine synthase reductase is a molecular chaperone for human methionine synthase.

Yamada K, Gravel RA, Toraya T, Matthews RG.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9476-81. Epub 2006 Jun 12.

24.

Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase.

Taurog RE, Matthews RG.

Biochemistry. 2006 Apr 25;45(16):5092-102.

25.

Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase.

Taurog RE, Jakubowski H, Matthews RG.

Biochemistry. 2006 Apr 25;45(16):5083-91.

26.

Structural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation.

Pejchal R, Campbell E, Guenther BD, Lennon BW, Matthews RG, Ludwig ML.

Biochemistry. 2006 Apr 18;45(15):4808-18.

27.

Methionine.

Hondorp ER, Matthews RG.

EcoSal Plus. 2006 Jan;2(1). doi: 10.1128/ecosalplus.3.6.1.7.

PMID:
26443567
28.

Regulation of human methylenetetrahydrofolate reductase by phosphorylation.

Yamada K, Strahler JR, Andrews PC, Matthews RG.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10454-9. Epub 2005 Jul 15.

29.

Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli.

Hondorp ER, Matthews RG.

PLoS Biol. 2004 Nov;2(11):e336. Epub 2004 Oct 5.

30.

Measurement of energetics of conformational change in cobalamin-dependent methionine synthase.

Bandarian V, Matthews RG.

Methods Enzymol. 2004;380:152-69. No abstract available.

PMID:
15051336
31.

Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase.

Evans JC, Huddler DP, Hilgers MT, Romanchuk G, Matthews RG, Ludwig ML.

Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3729-36. Epub 2004 Jan 29.

32.

Catalysis and regulation - from structure to function.

Dijkstra BW, Matthews RG.

Curr Opin Struct Biol. 2003 Dec;13(6):706-8. Review. No abstract available.

PMID:
14675548
34.

Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans.

Kacprzak MM, Lewandowska I, Matthews RG, Paszewski A.

Biochem J. 2003 Dec 1;376(Pt 2):517-24.

35.

Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase.

Bandarian V, Ludwig ML, Matthews RG.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8156-63. Epub 2003 Jun 27.

37.

Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis.

Tani TH, Khodursky A, Blumenthal RM, Brown PO, Matthews RG.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13471-6. Epub 2002 Oct 8.

38.
39.

Effector regulation in a monomeric enzyme.

Ludwig ML, Matthews RG.

Nat Struct Biol. 2002 Apr;9(4):236-8. No abstract available.

PMID:
11914727
40.

Movies, metals, bonds and barriers.

Matthews RG, Dijkstra BW.

Curr Opin Struct Biol. 2001 Dec;11(6):655-6. No abstract available.

PMID:
11751044
41.

Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase.

Yamada K, Chen Z, Rozen R, Matthews RG.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14853-8. Epub 2001 Dec 11.

42.

Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.

Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.

Nat Struct Biol. 2002 Jan;9(1):53-6.

PMID:
11731805
43.

Cobalamin-dependent methyltransferases.

Matthews RG.

Acc Chem Res. 2001 Aug;34(8):681-9.

PMID:
11513576
44.

Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase.

Hall DA, Vander Kooi CW, Stasik CN, Stevens SY, Zuiderweg ER, Matthews RG.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9521-6. Epub 2001 Aug 7.

45.
46.

Folate activation and catalysis in methylenetetrahydrofolate reductase from Escherichia coli: roles for aspartate 120 and glutamate 28.

Trimmer EE, Ballou DP, Ludwig ML, Matthews RG.

Biochemistry. 2001 May 29;40(21):6216-26.

PMID:
11371182
47.
48.

Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase.

Bandarian V, Matthews RG.

Biochemistry. 2001 Apr 24;40(16):5056-64.

PMID:
11305922
49.
50.

L-Selenohomocysteine: one-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases.

Zhou ZS, Smith AE, Matthews RG.

Bioorg Med Chem Lett. 2000 Nov 6;10(21):2471-5.

PMID:
11078203

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