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Hepatitis virus (HCV) diagnosis and access to treatment in a UK cohort.

Adland E, Jesuthasan G, Downs L, Wharton V, Wilde G, McNaughton AL, Collier J, Barnes E, Klenerman P, Andersson M, Jeffery K, Matthews PC.

BMC Infect Dis. 2018 Sep 14;18(1):461. doi: 10.1186/s12879-018-3367-3.


A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.

Mokaya J, McNaughton AL, Hadley MJ, Beloukas A, Geretti AM, Goedhals D, Matthews PC.

PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006629. doi: 10.1371/journal.pntd.0006629. eCollection 2018 Aug.


Hepatitis B Virus Adaptation to the CD8+ T Cell Response: Consequences for Host and Pathogen.

Lumley SF, McNaughton AL, Klenerman P, Lythgoe KA, Matthews PC.

Front Immunol. 2018 Jul 16;9:1561. doi: 10.3389/fimmu.2018.01561. eCollection 2018. Review.


Multiplex PCR reveals high prevalence of enterovirus and HHV6 in acellular paediatric cerebrospinal fluid samples.

Lumley SF, Pritchard D, Dutta A, Matthews PC, Cann K.

J Infect. 2018 Sep;77(3):249-257. doi: 10.1016/j.jinf.2018.05.008. Epub 2018 May 29. No abstract available.


Oxford Screening CSF and Respiratory samples ('OSCAR'): results of a pilot study to screen clinical samples from a diagnostic microbiology laboratory for viruses using Illumina next generation sequencing.

Sharp C, Golubchik T, Gregory WF, McNaughton AL, Gow N, Selvaratnam M, Mirea A, Foster D, Andersson M, Klenerman P, Jeffery K, Matthews PC.

BMC Res Notes. 2018 Feb 9;11(1):120. doi: 10.1186/s13104-018-3234-8.


Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient.

Brener J, Gall A, Hurst J, Batorsky R, Lavandier N, Chen F, Edwards A, Bolton C, Dsouza R, Allen T, Pybus OG, Kellam P, Matthews PC, Goulder PJR.

Retrovirology. 2018 Jan 16;15(1):7. doi: 10.1186/s12977-018-0390-9.


Immunodominant cytomegalovirus-specific CD8+ T-cell responses in sub-Saharan African populations.

Malik A, Adland E, Laker L, Kløverpris H, Fardoos R, Roider J, Severinsen MC, Chen F, Riddell L, Edwards A, Buus S, Jooste P, Matthews PC, Goulder PJR.

PLoS One. 2017 Dec 12;12(12):e0189612. doi: 10.1371/journal.pone.0189612. eCollection 2017.


Hepatitis B vaccine shortage: another symptom of chronic neglect?

Matthews PC, Barnes E.

BMJ. 2017 Oct 19;359:j4686. doi: 10.1136/bmj.j4686. No abstract available.


Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.

Leitman EM, Palmer CD, Buus S, Chen F, Riddell L, Sims S, Klenerman P, Sáez-Cirión A, Walker BD, Hess PR, Altfeld M, Matthews PC, Goulder PJR.

PLoS One. 2017 Oct 11;12(10):e0184496. doi: 10.1371/journal.pone.0184496. eCollection 2017.


Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape.

Leitman EM, Thobakgale CF, Adland E, Ansari MA, Raghwani J, Prendergast AJ, Tudor-Williams G, Kiepiela P, Hemelaar J, Brener J, Tsai MH, Mori M, Riddell L, Luzzi G, Jooste P, Ndung'u T, Walker BD, Pybus OG, Kellam P, Naranbhai V, Matthews PC, Gall A, Goulder PJR.

J Exp Med. 2017 Nov 6;214(11):3239-3261. doi: 10.1084/jem.20162123. Epub 2017 Oct 5.


Hepatitis B virus infection as a neglected tropical disease.

O'Hara GA, McNaughton AL, Maponga T, Jooste P, Ocama P, Chilengi R, Mokaya J, Liyayi MI, Wachira T, Gikungi DM, Burbridge L, O'Donnell D, Akiror CS, Sloan D, Torimiro J, Yindom LM, Walton R, Andersson M, Marsh K, Newton R, Matthews PC.

PLoS Negl Trop Dis. 2017 Oct 5;11(10):e0005842. doi: 10.1371/journal.pntd.0005842. eCollection 2017 Oct. No abstract available.


Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.

Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM.

Lancet Glob Health. 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. Review. Erratum in: Lancet Glob Health. 2017 Nov;5(11):e1079.


HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.

Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR.

J Virol. 2017 Oct 27;91(22). pii: e00544-17. doi: 10.1128/JVI.00544-17. Print 2017 Nov 15.


Metalware-associated orthopaedic infections caused by Staphylococcus lugdunensis: An emerging pathogen.

Li A, Gow N, Atkins BL, Taylor A, Peto T, McNally MA, Matthews PC.

J Infect. 2017 Oct;75(4):368-370. doi: 10.1016/j.jinf.2017.05.013. Epub 2017 May 25. No abstract available.


PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort.

Sharp CP, Gregory WF, Hattingh L, Malik A, Adland E, Daniels S, van Zyl A, Carlson JM, Wareing S, Ogwu A, Shapiro R, Riddell L, Chen F, Ndung'u T, Goulder PJR, Klenerman P, Simmonds P, Jooste P, Matthews PC.

Wellcome Open Res. 2017 Apr 7;2:26. doi: 10.12688/wellcomeopenres.11135.1.


Human parvovirus 4 'PARV4' remains elusive despite a decade of study.

Matthews PC, Sharp C, Simmonds P, Klenerman P.

F1000Res. 2017 Jan 27;6:82. doi: 10.12688/f1000research.9828.1. eCollection 2017. Review.


Fairness in scientific publishing.

Matthews PC.

Version 2. F1000Res. 2016 Dec 5 [revised 2017 Jan 1];5:2816. doi: 10.12688/f1000research.10318.2. eCollection 2016.


Hepitopes: A live interactive database of HLA class I epitopes in hepatitis B virus.

Lumley S, Noble H, Hadley MJ, Callow L, Malik A, Chua YY, Duffey OJ, Grolmusova N, Kumar A, Ravenscroft S, Spencer JI, Neumann-Haefelin C, Thimme R, Andersson M, Klenerman P, Barnes E, Matthews PC.

Wellcome Open Res. 2016 Nov 15;1:9. doi: 10.12688/wellcomeopenres.9952.1.


Screening, characterisation and prevention of Hepatitis B virus (HBV) co-infection in HIV-positive children in South Africa.

Jooste P, van Zyl A, Adland E, Daniels S, Hattingh L, Brits A, Wareing S, Goedhals D, Jeffery K, Andersson M, Goulder P, Matthews PC.

J Clin Virol. 2016 Dec;85:71-74. doi: 10.1016/j.jcv.2016.10.017. Epub 2016 Oct 31.


Oral fosfomycin for treatment of urinary tract infection: a retrospective cohort study.

Matthews PC, Barrett LK, Warren S, Stoesser N, Snelling M, Scarborough M, Jones N.

BMC Infect Dis. 2016 Oct 11;16(1):556.


Subdominant Gag-specific anti-HIV efficacy in an HLA-B*57-positive elite controller.

Leitman EM, Willberg CB, De Burgh-Thomas A, Streeck H, Goulder PJ, Matthews PC.

AIDS. 2016 Mar 27;30(6):972-4. doi: 10.1097/QAD.0000000000001022. No abstract available.


Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.

Leitman EM, Hurst J, Mori M, Kublin J, Ndung'u T, Walker BD, Carlson J, Gray GE, Matthews PC, Frahm N, Goulder PJ.

J Infect Dis. 2016 Aug 1;214(3):379-89. doi: 10.1093/infdis/jiw093. Epub 2016 Mar 6.


HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.

Matthews PC, Carlson JM, Beloukas A, Malik A, Jooste P, Ogwu A, Shapiro R, Riddell L, Chen F, Luzzi G, Jesuthasan G, Jeffery K, Jojic N, Ndung'u T, Carrington M, Goulder PJ, Geretti AM, Klenerman P.

J Infect Dis. 2016 Apr 15;213(8):1248-52. doi: 10.1093/infdis/jiv592. Epub 2015 Dec 9.


Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era.

Adland E, Klenerman P, Goulder P, Matthews PC.

Front Microbiol. 2015 Sep 24;6:1016. doi: 10.3389/fmicb.2015.01016. eCollection 2015. Review.


Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana.

Matthews PC, Beloukas A, Malik A, Carlson JM, Jooste P, Ogwu A, Shapiro R, Riddell L, Chen F, Luzzi G, Jaggernath M, Jesuthasan G, Jeffery K, Ndung'u T, Goulder PJ, Geretti AM, Klenerman P.

PLoS One. 2015 Jul 28;10(7):e0134037. doi: 10.1371/journal.pone.0134037. eCollection 2015.


Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection.

Mori M, Adland E, Paioni P, Swordy A, Mori L, Laker L, Muenchhoff M, Matthews PC, Tudor-Williams G, Lavandier N, van Zyl A, Hurst J, Walker BD, Ndung'u T, Prendergast A, Goulder P, Jooste P.

PLoS One. 2015 Jul 7;10(7):e0131591. doi: 10.1371/journal.pone.0131591. eCollection 2015.


Disease progression despite protective HLA expression in an HIV-infected transmission pair.

Brener J, Gall A, Batorsky R, Riddell L, Buus S, Leitman E, Kellam P, Allen T, Goulder P, Matthews PC.

Retrovirology. 2015 Jun 30;12:55. doi: 10.1186/s12977-015-0179-z.


First-passage times in integrate-and-fire neurons with stochastic thresholds.

Braun W, Matthews PC, Thul R.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 May;91(5):052701. Epub 2015 May 7.


Rolling back malaria.

Matthews PC.

Elife. 2015 Mar 30;4. doi: 10.7554/eLife.07364. No abstract available.


Human parvovirus 4 infection among mothers and children in South Africa.

Matthews PC, Sharp CP, Malik A, Gregory WF, Adland E, Jooste P, Goulder PJ, Simmonds P, Klenerman P.

Emerg Infect Dis. 2015 Apr;21(4):713-5. doi: 10.3201/eid2104.141545. No abstract available.


Screening and treatment for hepatitis C: a balanced perspective.

Matthews PC, Jeffery K, Klenerman P, Barnes E, Cooke G.

BMJ. 2015 Feb 24;350:h644. doi: 10.1136/bmj.h644. No abstract available.


Epidemiology and impact of HIV coinfection with hepatitis B and hepatitis C viruses in Sub-Saharan Africa.

Matthews PC, Geretti AM, Goulder PJ, Klenerman P.

J Clin Virol. 2014 Sep;61(1):20-33. doi: 10.1016/j.jcv.2014.05.018. Epub 2014 Jun 5. Review.


PARV4: an emerging tetraparvovirus.

Matthews PC, Malik A, Simmons R, Sharp C, Simmonds P, Klenerman P.

PLoS Pathog. 2014 May 1;10(5):e1004036. doi: 10.1371/journal.ppat.1004036. eCollection 2014 May. Review. No abstract available.


Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints.

Payne RP, Branch S, Kløverpris H, Matthews PC, Koofhethile CK, Strong T, Adland E, Leitman E, Frater J, Ndung'u T, Hunter E, Haubrich R, Mothe B, Edwards A, Riddell L, Chen F, Harrigan PR, Brumme ZL, Mallal S, John M, Jooste JP, Shapiro R, Deeks SG, Walker BD, Brander C, Landis C, Carlson JM, Prado JG, Goulder PJ.

J Virol. 2014 May;88(9):4668-78. doi: 10.1128/JVI.03303-13. Epub 2014 Feb 5.


Electronic prescribing: Reducing delay to first dose of antibiotics for patients in intensive care.

Matthews PC, Wangrangsimakul T, Borthwick M, Williams C, Byren I, Wilkinson D.

BMJ Qual Improv Rep. 2013 Oct 28;2(2). pii: u202241.w1120. doi: 10.1136/bmjquality.u202241.w1120. eCollection 2014.


Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.

Adland E, Carlson JM, Paioni P, Kløverpris H, Shapiro R, Ogwu A, Riddell L, Luzzi G, Chen F, Balachandran T, Heckerman D, Stryhn A, Edwards A, Ndung'u T, Walker BD, Buus S, Goulder P, Matthews PC.

PLoS One. 2013 Sep 2;8(9):e73117. doi: 10.1371/journal.pone.0073117. eCollection 2013.


Increased teicoplanin doses are associated with improved serum levels but not drug toxicity.

Matthews PC, Chue AL, Wyllie D, Barnett A, Isinkaye T, Jefferies L, Lovering A, Scarborough M.

J Infect. 2014 Jan;68(1):43-9. doi: 10.1016/j.jinf.2013.08.018. Epub 2013 Sep 3.


HIV subtype influences HLA-B*07:02-associated HIV disease outcome.

Kløverpris HN, Adland E, Koyanagi M, Stryhn A, Harndahl M, Matthews PC, Shapiro R, Walker BD, Ndung'u T, Brander C, Takiguchi M, Buus S, Goulder P.

AIDS Res Hum Retroviruses. 2014 May;30(5):468-75. doi: 10.1089/AID.2013.0197. Epub 2013 Oct 4.


Co-operative additive effects between HLA alleles in control of HIV-1.

Matthews PC, Listgarten J, Carlson JM, Payne R, Huang KH, Frater J, Goedhals D, Steyn D, van Vuuren C, Paioni P, Jooste P, Ogwu A, Shapiro R, Mncube Z, Ndung'u T, Walker BD, Heckerman D, Goulder PJ.

PLoS One. 2012;7(10):e47799. doi: 10.1371/journal.pone.0047799. Epub 2012 Oct 19.


Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.

Matthews PC, Koyanagi M, Kløverpris HN, Harndahl M, Stryhn A, Akahoshi T, Gatanaga H, Oka S, Juarez Molina C, Valenzuela Ponce H, Avila Rios S, Cole D, Carlson J, Payne RP, Ogwu A, Bere A, Ndung'u T, Gounder K, Chen F, Riddell L, Luzzi G, Shapiro R, Brander C, Walker B, Sewell AK, Reyes Teran G, Heckerman D, Hunter E, Buus S, Takiguchi M, Goulder PJ.

J Virol. 2012 Dec;86(23):12643-54. doi: 10.1128/JVI.01381-12. Epub 2012 Sep 12.


Variational approximations to homoclinic snaking in continuous and discrete systems.

Matthews PC, Susanto H.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Dec;84(6 Pt 2):066207. Epub 2011 Dec 19.


HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.

Kloverpris HN, Stryhn A, Harndahl M, van der Stok M, Payne RP, Matthews PC, Chen F, Riddell L, Walker BD, Ndung'u T, Buus S, Goulder P.

J Virol. 2012 Jan;86(2):919-29. doi: 10.1128/JVI.06150-11. Epub 2011 Nov 16.


A continuum model of cell proliferation and nutrient transport in a perfusion bioreactor.

Shakeel M, Matthews PC, Graham RS, Waters SL.

Math Med Biol. 2013 Mar;30(1):21-44. doi: 10.1093/imammb/dqr022. Epub 2011 Oct 11.


Acute necrotizing sinusitis caused by Staphylococcus lugdunensis.

Matthews PC, Lazarus R, Protheroe A, Milford C, Bowler IC.

J Clin Microbiol. 2011 Jul;49(7):2740-2. doi: 10.1128/JCM.00722-11. Epub 2011 May 18.


Variational approximations to homoclinic snaking.

Susanto H, Matthews PC.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Mar;83(3 Pt 2):035201. Epub 2011 Mar 31.


HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703.

Matthews PC, Adland E, Listgarten J, Leslie A, Mkhwanazi N, Carlson JM, Harndahl M, Stryhn A, Payne RP, Ogwu A, Huang KH, Frater J, Paioni P, Kloverpris H, Jooste P, Goedhals D, van Vuuren C, Steyn D, Riddell L, Chen F, Luzzi G, Balachandran T, Ndung'u T, Buus S, Carrington M, Shapiro R, Heckerman D, Goulder PJ.

J Immunol. 2011 May 15;186(10):5675-86. doi: 10.4049/jimmunol.1003711. Epub 2011 Apr 15.


Banting Memorial Lecture: reply from Matthews and Matthews. Type2 diabetes as an 'infectious'disease: is this the Black Death of the 21st century?

Matthews DR, Matthews PC.

Diabet Med. 2011 Jul;28(7):880. doi: 10.1111/j.1464-5491.2011.03289.x. No abstract available.


Banting Memorial Lecture 2010^. Type 2 diabetes as an 'infectious' disease: is this the Black Death of the 21st century?

Matthews DR, Matthews PC.

Diabet Med. 2011 Jan;28(1):2-9. doi: 10.1111/j.1464-5491.2010.03167.x. Review.


The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms.

Crawford H, Matthews PC, Schaefer M, Carlson JM, Leslie A, Kilembe W, Allen S, Ndung'u T, Heckerman D, Hunter E, Goulder PJ.

J Virol. 2011 Feb;85(3):1384-90. doi: 10.1128/JVI.01879-10. Epub 2010 Nov 24.


Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.

Leslie A, Matthews PC, Listgarten J, Carlson JM, Kadie C, Ndung'u T, Brander C, Coovadia H, Walker BD, Heckerman D, Goulder PJ.

J Virol. 2010 Oct;84(19):9879-88. doi: 10.1128/JVI.00320-10. Epub 2010 Jul 21.

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