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Acute mesenteric ischemia (AMI): absence of renal insufficiency and performance of early bowel resection may indicate improved outcomes.

Matthaei H, Klein A, Branchi V, Kalff JC, Koscielny A.

Int J Colorectal Dis. 2019 Oct;34(10):1781-1790. doi: 10.1007/s00384-019-03388-x. Epub 2019 Sep 11.


Clinicopathological, immune and molecular correlates of PD-L2 methylation in gastric adenocarcinomas.

Lingohr P, Dohmen J, Semaan A, Branchi V, Dietrich J, Bootz F, Kalff JC, Matthaei H, Dietrich D.

Epigenomics. 2019 May;11(6):639-653. doi: 10.2217/epi-2018-0149. Epub 2019 Mar 1.


Visceral artery aneurysms: evolving interdisciplinary management and future role of the abdominal surgeon.

Branchi V, Meyer C, Verrel F, Kania A, Bölke E, Semaan A, Koscielny A, Kalff JC, Matthaei H.

Eur J Med Res. 2019 Feb 28;24(1):17. doi: 10.1186/s40001-019-0374-9.


Combined photodynamic therapy with systemic chemotherapy for unresectable cholangiocarcinoma.

Gonzalez-Carmona MA, Bolch M, Jansen C, Vogt A, Sampels M, Mohr RU, van Beekum K, Mahn R, Praktiknjo M, Nattermann J, Trebicka J, Branchi V, Matthaei H, Manekeller S, Kalff JC, Strassburg CP, Weismüller TJ.

Aliment Pharmacol Ther. 2019 Feb;49(4):437-447. doi: 10.1111/apt.15050. Epub 2019 Jan 13.


[Current and Future Role of Vascular Surgery Expertise for Visceral Surgeons - an Expert Survey].

Koscielny A, Schmidt V, Branchi V, Verrel F, Kalff JC, Matthaei H.

Zentralbl Chir. 2018 Oct;143(5):494-502. doi: 10.1055/a-0731-0499. Epub 2018 Oct 24. German.


Donor liver quality after hypovolemic shock and venous systemic oxygen persufflation in an experimental animal model.

Jafari A, Matthaei H, Branchi V, Bölke E, Tolba RH, Kalff JC, Manekeller S.

Eur J Med Res. 2018 Oct 23;23(1):51. doi: 10.1186/s40001-018-0346-5.


Bevacizumab exacerbates sinusoidal obstruction syndrome (SOS) in the animal model and increases MMP 9 production.

Jafari A, Matthaei H, Wehner S, Tonguc T, Kalff JC, Manekeller S.

Oncotarget. 2018 Apr 24;9(31):21797-21810. doi: 10.18632/oncotarget.25021. eCollection 2018 Apr 24.


Significance of PITX2 Promoter Methylation in Colorectal Carcinoma Prognosis.

Semaan A, Uhl B, Branchi V, Lingohr P, Bootz F, Kristiansen G, Kalff JC, Matthaei H, Pantelis D, Dietrich D.

Clin Colorectal Cancer. 2018 Jun;17(2):e385-e393. doi: 10.1016/j.clcc.2018.02.008. Epub 2018 Feb 23.


[Have Multimodal and Perioperative Therapeutic Strategies Changed the Survival after Oncological Oesophageal Surgery in the Last Two Decades? A Retrospective Cohort Analysis over 23 Years].

Lingohr P, Zender J, van Beekum C, Dohmen J, Matthaei H, Schaefer N, Kalff JC, Vilz TO.

Zentralbl Chir. 2018 Apr;143(2):171-180. doi: 10.1055/s-0043-119892. Epub 2017 Dec 7. German.


[Vascular Complications and Emergencies within Oncologic Abdominal Surgery - What Knowledge and Skills Are Essential for the Visceral Surgeon].

Matthaei H, Schmidt V, Branchi V, Verrel F, Kalff JC, Koscielny A.

Zentralbl Chir. 2017 Aug;142(4):411-420. doi: 10.1055/s-0043-114735. Epub 2017 Aug 24. German.


[Prognostic Factors of Open Abdomen Treatment in Visceral Surgery].

von Websky MW, Jedig A, Willms A, Jafari A, Matthaei H, Kalff JC, Manekeller S.

Zentralbl Chir. 2017 Jun;142(3):259-266. doi: 10.1055/s-0042-119303. Epub 2017 Apr 24. German.


Delayed gastric emptying following pancreatoduodenectomy with alimentary reconstruction according to Roux-en-Y or Billroth-II.

Glowka TR, Webler M, Matthaei H, Schäfer N, Schmitz V, Kalff JC, Standop J, Manekeller S.

BMC Surg. 2017 Mar 20;17(1):24. doi: 10.1186/s12893-017-0226-x.


Promoter hypermethylation of SHOX2 and SEPT9 is a potential biomarker for minimally invasive diagnosis in adenocarcinomas of the biliary tract.

Branchi V, Schaefer P, Semaan A, Kania A, Lingohr P, Kalff JC, Schäfer N, Kristiansen G, Dietrich D, Matthaei H.

Clin Epigenetics. 2016 Dec 12;8:133. doi: 10.1186/s13148-016-0299-x. eCollection 2016.


CXCL12 expression and PD-L1 expression serve as prognostic biomarkers in HCC and are induced by hypoxia.

Semaan A, Dietrich D, Bergheim D, Dietrich J, Kalff JC, Branchi V, Matthaei H, Kristiansen G, Fischer HP, Goltz D.

Virchows Arch. 2017 Feb;470(2):185-196. doi: 10.1007/s00428-016-2051-5. Epub 2016 Dec 2.


DNA Methylation of PITX2 and PANCR Is Prognostic for Overall Survival in Patients with Resected Adenocarcinomas of the Biliary Tract.

Uhl B, Dietrich D, Branchi V, Semaan A, Schaefer P, Gevensleben H, Rostamzadeh B, Lingohr P, Schäfer N, Kalff JC, Kristiansen G, Matthaei H.

PLoS One. 2016 Oct 31;11(10):e0165769. doi: 10.1371/journal.pone.0165769. eCollection 2016.


Advantages of laparoscopic compared to conventional surgery are not related to an innate immune response of peritoneal immune activation: an animal study in rats.

Lingohr P, Dohmen J, Matthaei H, Schwandt T, Stein K, Hong GS, Steitz J, Longerich T, Bölke E, Wehner S, Kalff JC.

Langenbecks Arch Surg. 2017 Jun;402(4):625-636. doi: 10.1007/s00423-016-1521-1. Epub 2016 Oct 19.


SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas.

Semaan A, van Ellen A, Meller S, Bergheim D, Branchi V, Lingohr P, Goltz D, Kalff JC, Kristiansen G, Matthaei H, Pantelis D, Dietrich D.

Clin Epigenetics. 2016 Sep 20;8:100. doi: 10.1186/s13148-016-0267-5. eCollection 2016.


Incidentally Detected Focal Liver Lesions - A Common Clinical Management Dilemma Revisited.

Semaan A, Branchi V, Marowsky AL, VON Websky M, Kupczyk P, Enkirch SJ, Kukuk G, Bölke E, Stoffels B, Kalff JC, Schäfer N, Lingohr P, Matthaei H.

Anticancer Res. 2016 Jun;36(6):2923-32.


Comprehensive epidemiological and genotype-phenotype analyses in a large European sample with idiopathic achalasia.

Becker J, Niebisch S, Ricchiuto A, Schaich EJ, Lehmann G, Waltgenbach T, Schafft A, Hess T, Lenze F, Venerito M, Hüneburg R, Lingohr P, Matthaei H, Seewald S, Scheuermann U, Kreuser N, Veits L, Wouters MM, Gockel HR, Lang H, Vieth M, Müller M, Eckardt AJ, von Rahden BH, Knapp M, Boeckxstaens GE, Fimmers R, Nöthen MM, Schulz HG, Gockel I, Schumacher J.

Eur J Gastroenterol Hepatol. 2016 Jun;28(6):689-95. doi: 10.1097/MEG.0000000000000602.


Cytokine expression in the visceral adipose tissue after laparoscopic and conventional surgery in a rodent model.

Lingohr P, Dohmen J, Matthaei H, Konieczny N, Hoffmann J, Bölke E, Wehner S, Kalff JC.

Eur J Med Res. 2016 Feb 5;21:4. doi: 10.1186/s40001-016-0199-8.


A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.

Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting.

Am J Surg Pathol. 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533.


Erratum to: Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified?

Branchi V, Lingohr P, Willinek WA, Bölke E, Semaan A, Zhou H, Kristiansen G, Klöppel G, Kalff JC, Schäfer N, Matthaei H.

Eur J Med Res. 2015 May 20;20:53. doi: 10.1186/s40001-015-0143-3. No abstract available.


Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified?

Branchi V, Lingohr P, Willinek WA, Bölke E, Semaan A, Zhou H, Kristiansen G, Klöppel G, Kalff JC, Schäfer N, Matthaei H.

Eur J Med Res. 2015 Mar 19;20:26. doi: 10.1186/s40001-015-0117-5. Erratum in: Eur J Med Res. 2015;20:53. Bölke, Edwin [added].


Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract: Recommendations of Verona Consensus Meeting.

Adsay V, Mino-Kenudson M, Furukawa T, Basturk O, Zamboni G, Marchegiani G, Bassi C, Salvia R, Malleo G, Paiella S, Wolfgang CL, Matthaei H, Offerhaus GJ, Adham M, Bruno MJ, Reid MD, Krasinskas A, Klöppel G, Ohike N, Tajiri T, Jang KT, Roa JC, Allen P, Fernández-del Castillo C, Jang JY, Klimstra DS, Hruban RH; Members of Verona Consensus Meeting, 2013.

Ann Surg. 2016 Jan;263(1):162-77. doi: 10.1097/SLA.0000000000001173.


The genetic classification of pancreatic neoplasia.

Matthaei H, Semaan A, Hruban RH.

J Gastroenterol. 2015 May;50(5):520-32. doi: 10.1007/s00535-015-1037-4. Epub 2015 Jan 21. Review.


Biliary intraepithelial neoplasia (BilIN) is frequently found in surgical margins of biliary tract cancer resection specimens but has no clinical implications.

Matthaei H, Lingohr P, Strässer A, Dietrich D, Rostamzadeh B, Glees S, Roering M, Möhring P, Scheerbaum M, Stoffels B, Kalff JC, Schäfer N, Kristiansen G.

Virchows Arch. 2015 Feb;466(2):133-41. doi: 10.1007/s00428-014-1689-0. Epub 2014 Nov 26.


Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats.

Lingohr P, Dohmen J, Matthaei H, Schwandt T, Hong GS, Konieczny N, Bölke E, Wehner S, Kalff JC.

Eur J Med Res. 2014 Jun 17;19:33. doi: 10.1186/2047-783X-19-33.


Value and risk of laparoscopic surgery in hemophiliacs-experiences from a tertiary referral center for hemorrhagic diatheses.

Lingohr P, Bensoukehal S, Matthaei H, Dohmen J, Nadal J, Vilz TO, Koscielny A, Oldenburg J, Kalff JC, Goldmann G.

Langenbecks Arch Surg. 2014 Jun;399(5):609-18. doi: 10.1007/s00423-014-1185-7. Epub 2014 Apr 2.


Conventional mesh repair of a giant iatrogenic bilateral diaphragmatic hernia with an enterothorax.

Lingohr P, Galetin T, Vestweber B, Matthaei H, Kalff JC, Vestweber KH.

Int Med Case Rep J. 2014 Feb 12;7:23-5. doi: 10.2147/IMCRJ.S54361. eCollection 2014.


GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".

Matthaei H, Wu J, Dal Molin M, Shi C, Perner S, Kristiansen G, Lingohr P, Kalff JC, Wolfgang CL, Kinzler KW, Vogelstein B, Maitra A, Hruban RH.

Am J Surg Pathol. 2014 Mar;38(3):360-3. doi: 10.1097/PAS.0000000000000117.


Malignant melanoma of the ileo-anal pouch anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case.

Lingohr P, Galetin T, Matthaei H, Straub E, Jafari A, Bölke E, Kalff JC, Vestweber KH.

Eur J Med Res. 2013 Nov 4;18:39. doi: 10.1186/2047-783X-18-39.


Molecular diagnostics of pancreatic cysts.

Matthaei H, Feldmann G, Lingohr P, Kalff JC.

Langenbecks Arch Surg. 2013 Dec;398(8):1021-7. doi: 10.1007/s00423-013-1116-z. Epub 2013 Sep 26. Review.


Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas.

Molin MD, Matthaei H, Wu J, Blackford A, Debeljak M, Rezaee N, Wolfgang CL, Butturini G, Salvia R, Bassi C, Goggins MG, Kinzler KW, Vogelstein B, Eshleman JR, Hruban RH, Maitra A.

Ann Surg Oncol. 2013 Nov;20(12):3802-8. doi: 10.1245/s10434-013-3096-1. Epub 2013 Jul 12.


Identification and analysis of precursors to invasive pancreatic cancer.

Matthaei H, Dal Molin M, Maitra A.

Methods Mol Biol. 2013;980:1-12. doi: 10.1007/978-1-62703-287-2_1. Review.


GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.

Matthaei H, Wu J, Dal Molin M, Debeljak M, Lingohr P, Katabi N, Klimstra DS, Adsay NV, Eshleman JR, Schulick RD, Kinzler KW, Vogelstein B, Hruban RH, Maitra A.

HPB (Oxford). 2012 Oct;14(10):677-83. doi: 10.1111/j.1477-2574.2012.00504.x. Epub 2012 Jun 18.


miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts.

Matthaei H, Wylie D, Lloyd MB, Dal Molin M, Kemppainen J, Mayo SC, Wolfgang CL, Schulick RD, Langfield L, Andruss BF, Adai AT, Hruban RH, Szafranska-Schwarzbach AE, Maitra A.

Clin Cancer Res. 2012 Sep 1;18(17):4713-24. doi: 10.1158/1078-0432.CCR-12-0035. Epub 2012 Jun 21.


Losses at chromosome 4q are associated with poor survival in operable ductal pancreatic adenocarcinoma.

Luebke AM, Baudis M, Matthaei H, Vashist YK, Verde PE, Hosch SB, Erbersdobler A, Klein CA, Izbicki JR, Knoefel WT, Stoecklein NH.

Pancreatology. 2012 Jan-Feb;12(1):16-22. doi: 10.1016/j.pan.2011.11.001. Epub 2011 Nov 20.


Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.

Kanda M, Matthaei H, Wu J, Hong SM, Yu J, Borges M, Hruban RH, Maitra A, Kinzler K, Vogelstein B, Goggins M.

Gastroenterology. 2012 Apr;142(4):730-733.e9. doi: 10.1053/j.gastro.2011.12.042. Epub 2012 Jan 5.


Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas.

Matthaei H, Norris AL, Tsiatis AC, Olino K, Hong SM, dal Molin M, Goggins MG, Canto M, Horton KM, Jackson KD, Capelli P, Zamboni G, Bortesi L, Furukawa T, Egawa S, Ishida M, Ottomo S, Unno M, Motoi F, Wolfgang CL, Edil BH, Cameron JL, Eshleman JR, Schulick RD, Maitra A, Hruban RH.

Ann Surg. 2012 Feb;255(2):326-33. doi: 10.1097/SLA.0b013e3182378a18.


Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas.

Dal Molin M, Hong SM, Hebbar S, Sharma R, Scrimieri F, de Wilde RF, Mayo SC, Goggins M, Wolfgang CL, Schulick RD, Lin MT, Eshleman JR, Hruban RH, Maitra A, Matthaei H.

Hum Pathol. 2012 Apr;43(4):585-91. doi: 10.1016/j.humpath.2011.06.009. Epub 2011 Sep 21.


Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.

Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, Goggins M, Canto MI, Schulick RD, Edil BH, Wolfgang CL, Klein AP, Diaz LA Jr, Allen PJ, Schmidt CM, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B.

Sci Transl Med. 2011 Jul 20;3(92):92ra66. doi: 10.1126/scitranslmed.3002543.


Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma.

Ryu JK, Matthaei H, Dal Molin M, Hong SM, Canto MI, Schulick RD, Wolfgang C, Goggins MG, Hruban RH, Cope L, Maitra A.

Pancreatology. 2011;11(3):343-50. doi: 10.1159/000329183. Epub 2011 Jul 12.


Compartmental resection for subfascial extremity soft tissue sarcoma and quality of life in long-term survivors.

Peiper M, Matthaei H, Bölke E, Zurakowski D, Orth K, Heinecke A, Knoefel WT.

Wien Klin Wochenschr. 2011 Aug;123(15-16):488-95. doi: 10.1007/s00508-011-1592-5. Epub 2011 Jul 12.


Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer.

Matthaei H, Hong SM, Mayo SC, dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH.

Ann Surg Oncol. 2011 Nov;18(12):3493-9. doi: 10.1245/s10434-011-1745-9. Epub 2011 May 3.


Cystic precursors to invasive pancreatic cancer.

Matthaei H, Schulick RD, Hruban RH, Maitra A.

Nat Rev Gastroenterol Hepatol. 2011 Mar;8(3):141-50. doi: 10.1038/nrgastro.2011.2. Review.


Pancreatic incidentalomas: a growing clinical challenge exemplified by an intrapancreatic accessory spleen.

Matthaei H, Schmelzle M, Braunstein S, Bölke E, Peiper M.

Wien Klin Wochenschr. 2011 Mar;123(5-6):186-8. doi: 10.1007/s00508-011-1543-1. Epub 2011 Mar 3.


Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer.

Matthaei H, Hong SM, Mayo SC, Dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH.

Indian J Surg Oncol. 2011 Mar;2(1):9-15. doi: 10.1007/s13193-011-0073-7. Epub 2011 Jun 30.


[Necrotising inflammations of the lower extremities due to gastrointestinal perforations].

Schmelzle M, Peterschulte G, Matthaei H, Schulte Am Esch J 2nd, Peiper M, Rehders A, Eisenberger CF, Knoefel WT.

Zentralbl Chir. 2011 Feb;136(1):82-3. doi: 10.1055/s-0030-1262685. Epub 2011 Jan 24. German. No abstract available.


Mutant proteins as cancer-specific biomarkers.

Wang Q, Chaerkady R, Wu J, Hwang HJ, Papadopoulos N, Kopelovich L, Maitra A, Matthaei H, Eshleman JR, Hruban RH, Kinzler KW, Pandey A, Vogelstein B.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2444-9. doi: 10.1073/pnas.1019203108. Epub 2011 Jan 19.


Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9).

Schmelzle M, Dizdar L, Matthaei H, Baldus SE, Wolters J, Lindenlauf N, Bruns I, Cadeddu RP, Kröpil F, Topp SA, Schulte am Esch J 2nd, Eisenberger CF, Knoefel WT, Stoecklein NH.

Prostaglandins Other Lipid Mediat. 2011 Feb;94(1-2):25-33. doi: 10.1016/j.prostaglandins.2010.12.001. Epub 2010 Dec 15.


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