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Items: 1 to 50 of 196

1.

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action.

Reis J, Massari M, Marchese S, Ceccon M, Aalbers FS, Corana F, Valente S, Mai A, Magnani F, Mattevi A.

Redox Biol. 2020 Feb 15;32:101466. doi: 10.1016/j.redox.2020.101466. [Epub ahead of print]

2.

Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.

Fioravanti R, Romanelli A, Mautone N, Di Bello E, Rovere A, Corinti D, Zwergel C, Valente S, Rotili D, Botrugno OA, Dessanti P, Vultaggio S, Vianello P, Cappa A, Binda C, Mattevi A, Minucci S, Mercurio C, Varasi M, Mai A.

ChemMedChem. 2020 Jan 31. doi: 10.1002/cmdc.201900730. [Epub ahead of print]

PMID:
32003940
3.

Publisher Correction: Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs.

Nicoll CR, Bailleul G, Fiorentini F, Mascotti ML, Fraaije MW, Mattevi A.

Nat Struct Mol Biol. 2020 Feb;27(2):222. doi: 10.1038/s41594-020-0378-8.

PMID:
31965080
4.

Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs.

Nicoll CR, Bailleul G, Fiorentini F, Mascotti ML, Fraaije MW, Mattevi A.

Nat Struct Mol Biol. 2020 Jan;27(1):14-24. doi: 10.1038/s41594-019-0347-2. Epub 2019 Dec 23. Erratum in: Nat Struct Mol Biol. 2020 Feb;27(2):222.

PMID:
31873300
5.

Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis.

Savino S, Borg AJE, Dennig A, Pfeiffer M, de Giorgi F, Weber H, Dubey KD, Rovira C, Mattevi A, Nidetzky B.

Nat Catal. 2019 Nov 25;2(12):1115-1123. doi: 10.1038/s41929-019-0382-8.

PMID:
31844840
6.

On the mechanism of calcium-dependent activation of NADPH oxidase 5 (NOX5).

Millana Fañanás E, Todesca S, Sicorello A, Masino L, Pompach P, Magnani F, Pastore A, Mattevi A.

FEBS J. 2019 Nov 30. doi: 10.1111/febs.15160. [Epub ahead of print]

PMID:
31785178
7.

Editorial overview: Biological catalysis at the cross-roads of signaling and metabolism.

Cole PA, Mattevi A.

Curr Opin Struct Biol. 2019 Dec;59:iii-v. doi: 10.1016/j.sbi.2019.09.006. Epub 2019 Oct 22. No abstract available.

8.

Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations.

Montefiori M, Pilotto S, Marabelli C, Moroni E, Ferraro M, Serapian SA, Mattevi A, Colombo G.

J Chem Inf Model. 2019 Sep 23;59(9):3927-3937. doi: 10.1021/acs.jcim.9b00588. Epub 2019 Aug 21.

PMID:
31408337
9.

Structure and mechanisms of ROS generation by NADPH oxidases.

Magnani F, Mattevi A.

Curr Opin Struct Biol. 2019 Dec;59:91-97. doi: 10.1016/j.sbi.2019.03.001. Epub 2019 Apr 30. Review.

PMID:
31051297
10.

Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer.

Stazi G, Fioravanti R, Mai A, Mattevi A, Valente S.

Curr Opin Chem Biol. 2019 Jun;50:89-100. doi: 10.1016/j.cbpa.2019.03.002. Epub 2019 Apr 12. Review.

PMID:
30986654
11.

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex.

Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A.

Cell Rep. 2019 Apr 9;27(2):387-399.e7. doi: 10.1016/j.celrep.2019.03.061.

12.

Side-Chain Pruning Has Limited Impact on Substrate Preference in a Promiscuous Enzyme.

Fürst MJLJ, Romero E, Gómez Castellanos JR, Fraaije MW, Mattevi A.

ACS Catal. 2018 Dec 7;8(12):11648-11656. doi: 10.1021/acscatal.8b03793. Epub 2018 Oct 30.

13.

Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO).

Lončar N, Fiorentini F, Bailleul G, Savino S, Romero E, Mattevi A, Fraaije MW.

Appl Microbiol Biotechnol. 2019 Feb;103(4):1755-1764. doi: 10.1007/s00253-018-09579-w. Epub 2019 Jan 4.

PMID:
30607493
14.

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.

Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, Valente S.

Eur J Med Chem. 2019 Feb 1;163:722-735. doi: 10.1016/j.ejmech.2018.11.050. Epub 2018 Nov 28.

PMID:
30576903
15.

Structural and biochemical evaluation of Ceratitis capitata odorant-binding protein 22 affinity for odorants involved in intersex communication.

Falchetto M, Ciossani G, Scolari F, Di Cosimo A, Nenci S, Field LM, Mattevi A, Zhou JJ, Gasperi G, Forneris F.

Insect Mol Biol. 2019 Jun;28(3):431-443. doi: 10.1111/imb.12559. Epub 2019 Jan 17.

PMID:
30548711
16.

The Extreme Structural Plasticity in the CYP153 Subfamily of P450s Directs Development of Designer Hydroxylases.

Fiorentini F, Hatzl AM, Schmidt S, Savino S, Glieder A, Mattevi A.

Biochemistry. 2018 Dec 4;57(48):6701-6714. doi: 10.1021/acs.biochem.8b01052. Epub 2018 Nov 16.

PMID:
30398864
17.

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.

Oosterheert W, van Bezouwen LS, Rodenburg RNP, Granneman J, Förster F, Mattevi A, Gros P.

Nat Commun. 2018 Oct 18;9(1):4337. doi: 10.1038/s41467-018-06817-7.

18.

Engineering stability in NADPH oxidases: A common strategy for enzyme production.

Ceccon M, Millana Fananas E, Massari M, Mattevi A, Magnani F.

Mol Membr Biol. 2017 May - Dec;34(3-8):67-76. doi: 10.1080/09687688.2018.1535141. Epub 2019 Jan 10.

PMID:
30307338
19.

Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol.

Nguyen QT, Romero E, Dijkman WP, de Vasconcellos SP, Binda C, Mattevi A, Fraaije MW.

Biochemistry. 2018 Oct 30;57(43):6209-6218. doi: 10.1021/acs.biochem.8b00918. Epub 2018 Oct 16.

20.

Kinetic Resolution of sec-Thiols by Enantioselective Oxidation with Rationally Engineered 5-(Hydroxymethyl)furfural Oxidase.

Pickl M, Swoboda A, Romero E, Winkler CK, Binda C, Mattevi A, Faber K, Fraaije MW.

Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2864-2868. doi: 10.1002/anie.201713189. Epub 2018 Feb 15.

PMID:
29384246
21.

Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes.

Romero E, Gómez Castellanos JR, Gadda G, Fraaije MW, Mattevi A.

Chem Rev. 2018 Feb 28;118(4):1742-1769. doi: 10.1021/acs.chemrev.7b00650. Epub 2018 Jan 11.

PMID:
29323892
22.

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.

23.

Probing the interaction of the p53 C-terminal domain to the histone demethylase LSD1.

Speranzini V, Ciossani G, Marabelli C, Mattevi A.

Arch Biochem Biophys. 2017 Oct 15;632:202-208. doi: 10.1016/j.abb.2017.07.021. Epub 2017 Aug 4.

PMID:
28784588
24.

Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism.

Fiorentini F, Romero E, Fraaije MW, Faber K, Hall M, Mattevi A.

ACS Chem Biol. 2017 Sep 15;12(9):2379-2387. doi: 10.1021/acschembio.7b00470. Epub 2017 Aug 21.

PMID:
28783300
25.

Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase.

Ewing TA, Nguyen QT, Allan RC, Gygli G, Romero E, Binda C, Fraaije MW, Mattevi A, van Berkel WJH.

J Biol Chem. 2017 Sep 1;292(35):14668-14679. doi: 10.1074/jbc.M117.778449. Epub 2017 Jul 17.

26.

3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Contains a Phosphatidylinositol Cofactor.

Montersino S, Te Poele E, Orru R, Westphal AH, Barendregt A, Heck AJR, van der Geize R, Dijkhuizen L, Mattevi A, van Berkel WJH.

Front Microbiol. 2017 Jun 16;8:1110. doi: 10.3389/fmicb.2017.01110. eCollection 2017.

27.

The VAO/PCMH flavoprotein family.

Ewing TA, Fraaije MW, Mattevi A, van Berkel WJH.

Arch Biochem Biophys. 2017 Oct 15;632:104-117. doi: 10.1016/j.abb.2017.06.022. Epub 2017 Jun 30. Review.

PMID:
28669855
28.

Crystal structures and atomic model of NADPH oxidase.

Magnani F, Nenci S, Millana Fananas E, Ceccon M, Romero E, Fraaije MW, Mattevi A.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6764-6769. doi: 10.1073/pnas.1702293114. Epub 2017 Jun 12.

29.

Monoamine Oxidases, Oxidative Stress, and Altered Mitochondrial Dynamics in Cardiac Ageing.

Maggiorani D, Manzella N, Edmondson DE, Mattevi A, Parini A, Binda C, Mialet-Perez J.

Oxid Med Cell Longev. 2017;2017:3017947. doi: 10.1155/2017/3017947. Epub 2017 May 4. Review.

30.

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.

Esposito M, Szadocka S, Degiacomi G, Orena BS, Mori G, Piano V, Boldrin F, Zemanová J, Huszár S, Barros D, Ekins S, Lelièvre J, Manganelli R, Mattevi A, Pasca MR, Riccardi G, Ballell L, Mikušová K, Chiarelli LR.

ACS Infect Dis. 2017 Jun 9;3(6):428-437. doi: 10.1021/acsinfecdis.7b00006. Epub 2017 May 11.

PMID:
28475832
31.

Isolation and characterization of a thermostable F420:NADPH oxidoreductase from Thermobifida fusca.

Kumar H, Nguyen QT, Binda C, Mattevi A, Fraaije MW.

J Biol Chem. 2017 Jun 16;292(24):10123-10130. doi: 10.1074/jbc.M117.787754. Epub 2017 Apr 14.

32.

Flavins as Covalent Catalysts: New Mechanisms Emerge.

Piano V, Palfey BA, Mattevi A.

Trends Biochem Sci. 2017 Jun;42(6):457-469. doi: 10.1016/j.tibs.2017.02.005. Epub 2017 Mar 6. Review.

PMID:
28274732
33.

MCM5: a new actor in the link between DNA replication and Meier-Gorlin syndrome.

Vetro A, Savasta S, Russo Raucci A, Cerqua C, Sartori G, Limongelli I, Forlino A, Maruelli S, Perucca P, Vergani D, Mazzini G, Mattevi A, Stivala LA, Salviati L, Zuffardi O.

Eur J Hum Genet. 2017 May;25(5):646-650. doi: 10.1038/ejhg.2017.5. Epub 2017 Feb 15.

34.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

Vianello P, Sartori L, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Botrugno OA, Dessanti P, Minucci S, Vultaggio S, Zagarrí E, Varasi M, Mercurio C.

J Med Chem. 2017 Mar 9;60(5):1693-1715. doi: 10.1021/acs.jmedchem.6b01019. Epub 2017 Feb 27.

PMID:
28186757
35.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

Sartori L, Mercurio C, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Vultaggio S, Botrugno OA, Dessanti P, Minucci S, Zagarrí E, Carettoni D, Iuzzolino L, Varasi M, Vianello P.

J Med Chem. 2017 Mar 9;60(5):1673-1692. doi: 10.1021/acs.jmedchem.6b01018. Epub 2017 Feb 27.

PMID:
28186755
36.

Expanding the structural biology toolbox with single-molecule holography.

Forneris F, Mattevi A.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1448-1450. doi: 10.1073/pnas.1620897114. Epub 2017 Feb 2. No abstract available.

37.

Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates.

Fürst MJ, Savino S, Dudek HM, Gómez Castellanos JR, Gutiérrez de Souza C, Rovida S, Fraaije MW, Mattevi A.

J Am Chem Soc. 2017 Jan 18;139(2):627-630. doi: 10.1021/jacs.6b12246. Epub 2017 Jan 3.

PMID:
28010060
38.

NeuroLSD1: Splicing-Generated Epigenetic Enhancer of Neuroplasticity.

Rusconi F, Grillo B, Toffolo E, Mattevi A, Battaglioli E.

Trends Neurosci. 2017 Jan;40(1):28-38. doi: 10.1016/j.tins.2016.11.002. Epub 2016 Dec 13. Review.

PMID:
27986293
39.

Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1.

Nguyen QT, Trinco G, Binda C, Mattevi A, Fraaije MW.

Appl Microbiol Biotechnol. 2017 Apr;101(7):2831-2842. doi: 10.1007/s00253-016-8038-y. Epub 2016 Dec 13.

40.

Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase.

Romero E, Castellanos JR, Mattevi A, Fraaije MW.

Angew Chem Int Ed Engl. 2016 Dec 19;55(51):15852-15855. doi: 10.1002/anie.201608951. Epub 2016 Nov 22.

41.

Recombinant human dihydroxyacetonephosphate acyl-transferase characterization as an integral monotopic membrane protein.

Piano V, Nenci S, Magnani F, Aliverti A, Mattevi A.

Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):51-58. doi: 10.1016/j.bbrc.2016.11.019. Epub 2016 Nov 9.

42.

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.

Speranzini V, Rotili D, Ciossani G, Pilotto S, Marrocco B, Forgione M, Lucidi A, Forneris F, Mehdipour P, Velankar S, Mai A, Mattevi A.

Sci Adv. 2016 Sep 9;2(9):e1601017. doi: 10.1126/sciadv.1601017. eCollection 2016 Sep.

43.

The growing structural and functional complexity of the LSD1/KDM1A histone demethylase.

Marabelli C, Marrocco B, Mattevi A.

Curr Opin Struct Biol. 2016 Dec;41:135-144. doi: 10.1016/j.sbi.2016.07.011. Epub 2016 Jul 26. Review.

PMID:
27470128
44.

At Long Last Potent and Selective KDM5 Inhibitors.

Rotili D, Mattevi A.

Cell Chem Biol. 2016 Jul 21;23(7):749-751. doi: 10.1016/j.chembiol.2016.07.003.

45.

Biocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus jostii RHA1: A Versatile Oxidative Biocatalyst.

Nguyen QT, de Gonzalo G, Binda C, Rioz-Martínez A, Mattevi A, Fraaije MW.

Chembiochem. 2016 Jul 15;17(14):1359-66. doi: 10.1002/cbic.201600148. Epub 2016 Jun 7.

46.

LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.

Pilotto S, Speranzini V, Marabelli C, Rusconi F, Toffolo E, Grillo B, Battaglioli E, Mattevi A.

Hum Mol Genet. 2016 Jun 15;25(12):2578-2587. Epub 2016 Apr 19.

PMID:
27094131
47.

Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity.

Savino S, Ferrandi EE, Forneris F, Rovida S, Riva S, Monti D, Mattevi A.

Proteins. 2016 Jun;84(6):859-65. doi: 10.1002/prot.25036. Epub 2016 Apr 6.

PMID:
27006087
48.

Touch, act and go: landing and operating on nucleosomes.

Speranzini V, Pilotto S, Sixma TK, Mattevi A.

EMBO J. 2016 Feb 15;35(4):376-88. doi: 10.15252/embj.201593377. Epub 2016 Jan 19. Review.

49.

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans.

Fiorentini F, Geier M, Binda C, Winkler M, Faber K, Hall M, Mattevi A.

ACS Chem Biol. 2016 Apr 15;11(4):1039-48. doi: 10.1021/acschembio.5b01016. Epub 2016 Feb 1.

PMID:
26771671
50.

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

Vianello P, Botrugno OA, Cappa A, Dal Zuffo R, Dessanti P, Mai A, Marrocco B, Mattevi A, Meroni G, Minucci S, Stazi G, Thaler F, Trifiró P, Valente S, Villa M, Varasi M, Mercurio C.

J Med Chem. 2016 Feb 25;59(4):1501-17. doi: 10.1021/acs.jmedchem.5b01209. Epub 2016 Jan 7.

PMID:
26702542

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