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Nasal Glucagon as a Viable Alternative to Treat Insulin-induced Hypoglycemia in Japanese Patients with Type 1 and Type 2 Diabetes: A Phase 3 Randomized Crossover Study.

Matsuhisa M, Takita Y, Nasu R, Nagai Y, Ohwaki K, Nagashima H.

Diabetes Obes Metab. 2020 Mar 1. doi: 10.1111/dom.14019. [Epub ahead of print] No abstract available.


Assessing the oral health of in-patients with diabetes using a clinical version of the Diabetes Oral Health Assessment Tool© and its association with dental examinations.

Kuwamura Y, Sakamoto E, Sumikawa M, Matsuhisa M, Hinode D, Uemura H, Kishida S.

J Med Invest. 2019;66(3.4):328-336. doi: 10.2152/jmi.66.328.


Development and Validation of the Continuous Subcutaneous Insulin Infusion-Related Quality-of-Life (CSII-QOL) Scale.

Sakane N, Murata T, Tone A, Kato K, Kimura M, Kawashima S, Sawaki H, Hirota Y, Okada A, Kuroda A, Matsuhisa M, Watanabe T, Suganuma A, Nirengi S, Toyoda M.

Diabetes Technol Ther. 2020 Mar;22(3):216-221. doi: 10.1089/dia.2019.0216.


Predictive factors of posttransplant glucose intolerance in Japanese patients with type 1 diabetes after pancreas transplantation.

Takahi Y, Miyashita K, Takahara M, Katakami N, Kuroda A, Matsuoka TA, Matsuhisa M, Ito T, Shimomura I.

Endocr J. 2019 Dec 25;66(12):1101-1112. doi: 10.1507/endocrj.EJ19-0180. Epub 2019 Sep 7.


Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients.

Takashi Y, Wakino S, Minakuchi H, Ishizu M, Kuroda A, Shima H, Tashiro M, Miya K, Okada K, Minakuchi J, Kawashima S, Matsuhisa M, Matsumoto T, Fukumoto S.

J Bone Miner Metab. 2020 Jan;38(1):70-77. doi: 10.1007/s00774-019-01027-7. Epub 2019 Aug 16.


In vitro and in vivo effects of insulin-producing cells generated by xeno-antigen free 3D culture with RCP piece.

Ikemoto T, Feng R, Iwahashi SI, Yamada S, Saito Y, Morine Y, Imura S, Matsuhisa M, Shimada M.

Sci Rep. 2019 Jul 24;9(1):10759. doi: 10.1038/s41598-019-47257-7.


Clinical impact of sarcopenia and dynapenia on diabetes.

Mori H, Kuroda A, Matsuhisa M.

Diabetol Int. 2019 Jun 19;10(3):183-187. doi: 10.1007/s13340-019-00400-1. eCollection 2019 Jul.


Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation.

Takashi Y, Kosako H, Sawatsubashi S, Kinoshita Y, Ito N, Tsoumpra MK, Nangaku M, Abe M, Matsuhisa M, Kato S, Matsumoto T, Fukumoto S.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11418-11427. doi: 10.1073/pnas.1815166116. Epub 2019 May 16.


Remote Control of Electron Transfer Reaction by Microwave Irradiation: Kinetic Demonstration of Reduction of Bipyridine Derivatives on Surface of Nickel Particle.

Kishimoto F, Matsuhisa M, Imai T, Mochizuki D, Tsubaki S, Maitani MM, Suzuki E, Wada Y.

J Phys Chem Lett. 2019 Jun 20;10(12):3390-3394. doi: 10.1021/acs.jpclett.9b00629. Epub 2019 Jun 6.


Circulating osteocalcin as a bone-derived hormone is inversely correlated with body fat in patients with type 1 diabetes.

Takashi Y, Ishizu M, Mori H, Miyashita K, Sakamoto F, Katakami N, Matsuoka TA, Yasuda T, Hashida S, Matsuhisa M, Kuroda A.

PLoS One. 2019 May 3;14(5):e0216416. doi: 10.1371/journal.pone.0216416. eCollection 2019.


Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide.

Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukami H, Maruyama N, Watada H, Fujitani Y.

Endocr J. 2019 May 28;66(5):459-468. doi: 10.1507/endocrj.EJ18-0441. Epub 2019 Mar 6.


Association of accumulated advanced glycation end-products with a high prevalence of sarcopenia and dynapenia in patients with type 2 diabetes.

Mori H, Kuroda A, Ishizu M, Ohishi M, Takashi Y, Otsuka Y, Taniguchi S, Tamaki M, Kurahashi K, Yoshida S, Endo I, Aihara KI, Funaki M, Akehi Y, Matsuhisa M.

J Diabetes Investig. 2019 Sep;10(5):1332-1340. doi: 10.1111/jdi.13014. Epub 2019 Feb 19.


The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: a report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society.

Namba M, Iwakura T, Nishimura R, Akazawa K, Matsuhisa M, Atsumi Y, Satoh J, Yamauchi T; Japan Diabetes Society (JDS) Committee for Surveys on Severe Hypoglycemia.

Diabetol Int. 2018 Mar 2;9(2):84-99. doi: 10.1007/s13340-018-0346-2. eCollection 2018 May.


New risk factors of severe hypoglycemia.

Matsuhisa M, Kuroda A.

J Diabetes Investig. 2019 Mar;10(2):219-220. doi: 10.1111/jdi.12925. Epub 2018 Oct 13. No abstract available.


Up-Titration Strategy After DPP-4 Inhibitor-Based Oral Therapy for Type 2 Diabetes: A Randomized Controlled Trial Shifting to a Single-Dose GLP-1 Enhancer Versus Adding a Variable Basal Insulin Algorithm.

Miyagi M, Uchino H, Kumashiro N, Higa M, Shin K, Sasamoto M, Kitazato H, Tamaki M, Matsuhisa M, Hirose T.

Diabetes Ther. 2018 Oct;9(5):1959-1968. doi: 10.1007/s13300-018-0486-1. Epub 2018 Aug 18.


The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: A report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society.

Namba M, Iwakura T, Nishimura R, Akazawa K, Matsuhisa M, Atsumi Y, Satoh J, Yamauchi T; Japan Diabetes Society (JDS) Committee for Surveys on Severe Hypoglycemia.

J Diabetes Investig. 2018 Mar 2. doi: 10.1111/jdi.12790. [Epub ahead of print]


Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus.

Yagi S, Aihara KI, Kondo T, Kurahashi K, Yoshida S, Endo I, Fukuda D, Nakaya Y, Suwaki KI, Takeji T, Wada T, Salim HM, Hama S, Matsuura T, Ise T, Kusunose K, Yamaguchi K, Tobiume T, Yamada H, Soeki T, Wakatsuki T, Matsuhisa M, Shimabukuro M, Akaike M, Sata M.

Adv Ther. 2018 Jan;35(1):124-134. doi: 10.1007/s12325-017-0639-z. Epub 2017 Nov 28.


Safety of the batteries and power units used in insulin pumps: A pilot cross-sectional study by the Association for the Study of Innovative Diabetes Treatment in Japan.

Murata T, Nirengi S, Sakane N, Kuroda A, Hirota Y, Matsuhisa M, Namba M, Kobayashi T; Association for the Study of Innovative Diabetes Treatment in Japan (ASINDTJ).

J Diabetes Investig. 2018 Jul;9(4):903-907. doi: 10.1111/jdi.12765. Epub 2017 Nov 28.


Accuracy and Time Delay of Glucose Measurements of Continuous Glucose Monitoring and Bedside Artificial Pancreas During Hyperglycemic and Euglycemic Hyperinsulinemic Glucose Clamp Study.

Kuroda A, Taniguchi S, Akehi Y, Mori H, Tamaki M, Suzuki R, Otsuka Y, Matsuhisa M.

J Diabetes Sci Technol. 2017 Nov;11(6):1096-1100. doi: 10.1177/1932296817735122. Epub 2017 Oct 9.


Remarkable Shrinkage of a Growth Hormone (GH)-secreting Macroadenoma Induced by Somatostatin Analogue Administration: A Case Report and Literature Review.

Kurahashi K, Endo I, Kondo T, Morimoto K, Yoshida S, Kuroda A, Aihara KI, Matsuhisa M, Nakajima K, Mizobuchi Y, Nagahiro S, Abe M, Fukumoto S.

Intern Med. 2017 Sep 15;56(18):2455-2461. doi: 10.2169/internalmedicine.8223-16. Epub 2017 Aug 21.


Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study.

Yamada H, Tanaka A, Kusunose K, Amano R, Matsuhisa M, Daida H, Ito M, Tsutsui H, Nanasato M, Kamiya H, Bando YK, Odawara M, Yoshida H, Murohara T, Sata M, Node K; PROLOGUE Study Investigators.

Cardiovasc Diabetol. 2017 May 11;16(1):63. doi: 10.1186/s12933-017-0546-2.


Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer.

Kondo T, Endo I, Ooguro Y, Morimoto K, Kurahashi K, Yoshida S, Kuroda A, Aihara KI, Matsuhisa M, Abe M, Fukumoto S.

Intern Med. 2016;55(24):3623-3626. Epub 2016 Dec 15.


Sustained glycaemic control and less nocturnal hypoglycaemia with insulin glargine 300U/mL compared with glargine 100U/mL in Japanese adults with type 1 diabetes (EDITION JP 1 randomised 12-month trial including 6-month extension).

Matsuhisa M, Koyama M, Cheng X, Sumi M, Riddle MC, Bolli GB, Hirose T; EDITION JP 1 study group.

Diabetes Res Clin Pract. 2016 Dec;122:133-140. doi: 10.1016/j.diabres.2016.10.002. Epub 2016 Oct 13.


Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study.

Tomiyama H, Miwa T, Kan K, Matsuhisa M, Kamiya H, Nanasato M, Kitano T, Sano H, Ohno J, Iida M, Sata M, Yamada H, Maemura K, Tanaka A, Murohara T, Node K.

Cardiovasc Diabetol. 2016 Nov 3;15(1):150.


Enhancement of anodic current attributed to oxygen evolution on α-Fe2O3 electrode by microwave oscillating electric field.

Kishimoto F, Matsuhisa M, Kawamura S, Fujii S, Tsubaki S, Maitani MM, Suzuki E, Wada Y.

Sci Rep. 2016 Oct 14;6:35554. doi: 10.1038/srep35554.


A pilot study comparing the CGM-assessed glycemic profiles of patients with type 1 diabetes on insulin degludec and insulin glargine.

Kuroda A, Tsuruo M, Aki N, Kondo T, Oguro Y, Tamaki M, Aihara KI, Endo I, Matsumoto T, Abe M, Matsuhisa M.

Diabetol Int. 2016 Oct 14;8(1):112-115. doi: 10.1007/s13340-016-0289-4. eCollection 2017 Mar.


Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes.

Mori H, Kuroda A, Araki M, Suzuki R, Taniguchi S, Tamaki M, Akehi Y, Matsuhisa M.

J Diabetes Investig. 2017 May;8(3):377-382. doi: 10.1111/jdi.12582. Epub 2016 Nov 23.


Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling.

Yuasa T, Amo-Shiinoki K, Ishikura S, Takahara M, Matsuoka T, Kaneto H, Kuroda A, Matsuhisa M, Hashida S.

Diabetologia. 2016 Dec;59(12):2711-2721. Epub 2016 Sep 30.


Somatic cell reprogramming-free generation of genetically modified pigs.

Tanihara F, Takemoto T, Kitagawa E, Rao S, Do LT, Onishi A, Yamashita Y, Kosugi C, Suzuki H, Sembon S, Suzuki S, Nakai M, Hashimoto M, Yasue A, Matsuhisa M, Noji S, Fujimura T, Fuchimoto D, Otoi T.

Sci Adv. 2016 Sep 14;2(9):e1600803. doi: 10.1126/sciadv.1600803. eCollection 2016 Sep.


Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study.

Tanaka A, Murohara T, Taguchi I, Eguchi K, Suzuki M, Kitakaze M, Sato Y, Ishizu T, Higashi Y, Yamada H, Nanasato M, Shimabukuro M, Teragawa H, Ueda S, Kodera S, Matsuhisa M, Kadokami T, Kario K, Nishio Y, Inoue T, Maemura K, Oyama J, Ohishi M, Sata M, Tomiyama H, Node K; PROTECT Study Investigators.

Cardiovasc Diabetol. 2016 Sep 13;15(1):133. doi: 10.1186/s12933-016-0449-7.


Skin Autofluorescence is Associated with Early-stage Atherosclerosis in Patients with Type 1 Diabetes.

Osawa S, Katakami N, Kuroda A, Takahara M, Sakamoto F, Kawamori D, Matsuoka T, Matsuhisa M, Shimomura I.

J Atheroscler Thromb. 2017 Mar 1;24(3):312-326. doi: 10.5551/jat.35592. Epub 2016 Sep 2.


Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury.

Mita N, Kawahito S, Soga T, Takaishi K, Kitahata H, Matsuhisa M, Shimada M, Kinoshita H, Tsutsumi YM, Tanaka K.

J Artif Organs. 2017 Mar;20(1):76-83. doi: 10.1007/s10047-016-0925-6. Epub 2016 Aug 24.


A Review of Insulin-Dosing Formulas for Continuous Subcutaneous Insulin Infusion (CSII) for Adults with Type 1 Diabetes.

King AB, Kuroda A, Matsuhisa M, Hobbs T.

Curr Diab Rep. 2016 Sep;16(9):83. doi: 10.1007/s11892-016-0772-0. Review.


The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial.

Oyama J, Murohara T, Kitakaze M, Ishizu T, Sato Y, Kitagawa K, Kamiya H, Ajioka M, Ishihara M, Dai K, Nanasato M, Sata M, Maemura K, Tomiyama H, Higashi Y, Kaku K, Yamada H, Matsuhisa M, Yamashita K, Bando YK, Kashihara N, Ueda S, Inoue T, Tanaka A, Node K; PROLOGUE Study Investigators.

PLoS Med. 2016 Jun 28;13(6):e1002051. doi: 10.1371/journal.pmed.1002051. eCollection 2016 Jun.


[Prevention of hypoglycemia].

Matsuhisa M.

Nihon Rinsho. 2016 Apr;74 Suppl 2:643-7. Japanese. No abstract available.


Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors.

Kondo T, Endo I, Aihara K, Onishi Y, Dong B, Ohguro Y, Kurahashi K, Yoshida S, Fujinaka Y, Kuroda A, Matsuhisa M, Fukumoto S, Matsumoto T, Abe M.

Endocr J. 2016 Apr 25;63(4):397-404. doi: 10.1507/endocrj.EJ15-0589. Epub 2016 Feb 13.


Significant elevation of serum dipeptidyl peptidase-4 activity in young-adult type 1 diabetes.

Osawa S, Kawamori D, Katakami N, Takahara M, Sakamoto F, Katsura T, Yasuda T, Kaneto H, Matsuhisa M, Matsuoka TA, Shimomura I.

Diabetes Res Clin Pract. 2016 Mar;113:135-42. doi: 10.1016/j.diabres.2015.12.022. Epub 2016 Jan 14.


New insulin glargine 300 U/ml versus glargine 100 U/ml in Japanese adults with type 1 diabetes using basal and mealtime insulin: glucose control and hypoglycaemia in a randomized controlled trial (EDITION JP 1).

Matsuhisa M, Koyama M, Cheng X, Takahashi Y, Riddle MC, Bolli GB, Hirose T; EDITION JP 1 study group.

Diabetes Obes Metab. 2016 Apr;18(4):375-83. doi: 10.1111/dom.12619. Epub 2016 Feb 1.


Non-invasive Measurement of Skin Autofluorescence as a Beneficial Surrogate Marker for Atherosclerosis in Patients with Type 2 Diabetes.

Temma J, Matsuhisa M, Horie T, Kuroda A, Mori H, Tamaki M, Endo I, Aihara K, Abe M, Matsumoto T.

J Med Invest. 2015;62(3-4):126-9. doi: 10.2152/jmi.62.126.


Acute effect of fast walking on postprandial blood glucose control in type 2 diabetes.

Deguchi K, Enishi T, Sato N, Miura H, Fujinaka Y, Matsuhisa M, Katoh S.

Diabetol Int. 2015 Jun 27;7(2):119-123. doi: 10.1007/s13340-015-0217-z. eCollection 2016 Jun.


Impact of newly developed, next-generation artificial endocrine pancreas.

Kambe N, Kawahito S, Mita N, Takaishi K, Katayama T, Sakai Y, Soga T, Kawano H, Matsuhisa M, Shimada M, Kitagawa T, Kitahata H.

J Med Invest. 2015;62(1-2):41-4. doi: 10.2152/jmi.62.41.


Short- and long-term effect of sitagliptin after near normalization of glycemic control with insulin in poorly controlled Japanese type 2 diabetic patients.

Fujisawa K, Yasuda T, Kaneto H, Katakami N, Tsuji M, Kubo F, Sasaki S, Miyashita K, Naka T, Kasami R, Kuroda A, Matsuhisa M, Shimomura I.

J Diabetes Investig. 2014 Sep;5(5):548-53. doi: 10.1111/jdi.12176. Epub 2013 Nov 28.


Vitamin D deficiency is significantly associated with retinopathy in young Japanese type 1 diabetic patients.

Shimo N, Yasuda T, Kaneto H, Katakami N, Kuroda A, Sakamoto F, Takahara M, Irie Y, Horikawa K, Miyashita K, Miyatsuka T, Yoshiuchi K, Kawamori D, Sakamoto K, Matsuoka TA, Kosugi K, Shimomura I, Matsuhisa M.

Diabetes Res Clin Pract. 2014 Nov;106(2):e41-3. doi: 10.1016/j.diabres.2014.08.005. Epub 2014 Aug 12.


Usefulness of artificial endocrine pancreas during resection of insulinoma.

Hirose K, Kawahito S, Mita N, Takaishi K, Kawahara T, Soga T, Katayama T, Imura S, Morine Y, Ikemoto T, Shimada M, Matsuhisa M, Kitahata H.

J Med Invest. 2014;61(3-4):421-5.


Usefulness of a novel system for measuring glucose area under the curve while screening for glucose intolerance in outpatients.

Sakamoto K, Kubo F, Yoshiuchi K, Ono A, Sato T, Tomita K, Sakaguchi K, Matsuhisa M, Kaneto H, Maegawa H, Nakajima H, Kashiwagi A, Kosugi K.

J Diabetes Investig. 2013 Nov 27;4(6):552-9. doi: 10.1111/jdi.12096. Epub 2013 May 8.


Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease.

Kato K, Takamura T, Takeshita Y, Ryu Y, Misu H, Ota T, Tokuyama K, Nagasaka S, Matsuhisa M, Matsui O, Kaneko S.

PLoS One. 2014 Mar 20;9(3):e92170. doi: 10.1371/journal.pone.0092170. eCollection 2014.


Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: the PROFIT-J study.

Yoshii H, Onuma T, Yamazaki T, Watada H, Matsuhisa M, Matsumoto M, Kitagawa K, Kitakaze M, Yamasaki Y, Kawamori R; PROFIT-J Study Group.

J Atheroscler Thromb. 2014;21(6):563-73. Epub 2014 Jan 29.


Diabetic conditions differentially affect the endothelial function, arterial stiffness and carotid atherosclerosis.

Kinouchi M, Aihara K, Fujinaka Y, Yoshida S, Ooguro Y, Kurahashi K, Kondo T, Aki N, Kuroda A, Endo I, Matsuhisa M, Matsumoto T.

J Atheroscler Thromb. 2014;21(5):486-500. Epub 2014 Jan 8.


Usefulness of continuous blood glucose monitoring and control for patients undergoing liver transplantation.

Okada T, Kawahito S, Mita N, Matsuhisa M, Kitahata H, Shimada M, Oshita S.

J Med Invest. 2013;60(3-4):205-12.


Evaluation of a minimally invasive system for measuring glucose area under the curve during oral glucose tolerance tests: usefulness of sweat monitoring for precise measurement.

Sakaguchi K, Hirota Y, Hashimoto N, Ogawa W, Hamaguchi T, Matsuo T, Miyagawa J, Namba M, Sato T, Okada S, Tomita K, Matsuhisa M, Kaneto H, Kosugi K, Maegawa H, Nakajima H, Kashiwagi A.

J Diabetes Sci Technol. 2013 May 1;7(3):678-88.

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