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CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction.

Kusuyama J, Bandow K, Ohnishi T, Amir MS, Shima K, Semba I, Matsuguchi T.

Biochem J. 2019 Nov 29;476(22):3533-3548. doi: 10.1042/BCJ20190709.


Self-Completion Method of Endoscopic Submucosal Dissection Using Endosaber without Any Other Device or Assistance: An ex vivo Porcine Model Study.

Esaki M, Minoda Y, Wada M, Sakisaka S, Tsuruta S, Hosokawa T, Matsuguchi T, Ichijima R, Suzuki S, Tamura Y, Iwao A, Yamakawa S, Irie A, Ihara E, Ogawa Y.

Digestion. 2019 Sep 27:1-8. doi: 10.1159/000502771. [Epub ahead of print]


BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction.

Kusuyama J, Seong C, Nakamura T, Ohnishi T, Amir MS, Shima K, Semba I, Noguchi K, Matsuguchi T.

Int J Biochem Cell Biol. 2019 Nov;116:105614. doi: 10.1016/j.biocel.2019.105614. Epub 2019 Sep 21.


BMP9 directly induces rapid GSK3-β phosphorylation in a Wnt-independent manner through class I PI3K-Akt axis in osteoblasts.

Eiraku N, Chiba N, Nakamura T, Amir MS, Seong CH, Ohnishi T, Kusuyama J, Noguchi K, Matsuguchi T.

FASEB J. 2019 Nov;33(11):12124-12134. doi: 10.1096/fj.201900733RR. Epub 2019 Jul 31.


Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation.

Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T.

Cell Signal. 2019 Oct;62:109345. doi: 10.1016/j.cellsig.2019.109345. Epub 2019 Jun 19.


Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts.

Kusuyama J, Nakamura T, Ohnishi T, Albertson BG, Ebe Y, Eiraku N, Noguchi K, Matsuguchi T.

J Cell Biochem. 2019 Sep;120(9):14657-14669. doi: 10.1002/jcb.28727. Epub 2019 Apr 21.


JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4).

Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T.

FASEB J. 2019 Jun;33(6):7331-7347. doi: 10.1096/fj.201802465R. Epub 2019 Mar 18.


Constitutive activation of p46JNK2 is indispensable for C/EBPδ induction in the initial stage of adipogenic differentiation.

Kusuyama J, Ohnishi T, Bandow K, Amir MS, Shima K, Semba I, Matsuguchi T.

Biochem J. 2017 Oct 5;474(20):3421-3437. doi: 10.1042/BCJ20170332.


Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.

Kusuyama J, Kamisono A, ChangHwan S, Amir MS, Bandow K, Eiraku N, Ohnishi T, Matsuguchi T.

J Cell Physiol. 2018 Mar;233(3):2549-2559. doi: 10.1002/jcp.26130. Epub 2017 Sep 28.


Low-Intensity Pulsed Ultrasound (LIPUS) Promotes BMP9-Induced Osteogenesis and Suppresses Inflammatory Responses in Human Periodontal Ligament-Derived Stem Cells.

Kusuyama J, Nakamura T, Ohnishi T, Eiraku N, Noguchi K, Matsuguchi T.

J Orthop Trauma. 2017 Jul;31(7):S4. doi: 10.1097/


Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low-molecular weight protein tyrosine phosphatase.

Kusuyama J, Bandow K, Ohnishi T, Hisadome M, Shima K, Semba I, Matsuguchi T.

Mol Biol Cell. 2017 May 15;28(10):1326-1336. doi: 10.1091/mbc.E16-10-0716. Epub 2017 Mar 22.


Hepatocyte growth factor reduces CXCL10 expression in keratinocytes.

Hisadome M, Ohnishi T, Kakimoto K, Kusuyama J, Bandow K, Kanekura T, Matsuguchi T.

FEBS Lett. 2016 Oct;590(20):3595-3605. doi: 10.1002/1873-3468.12452. Epub 2016 Oct 18.


Investigating the associations between adiposity, life course overweight trajectories, and telomere length.

Wulaningsih W, Watkins J, Matsuguchi T, Hardy R.

Aging (Albany NY). 2016 Sep 18;8(11):2689-2701. doi: 10.18632/aging.101036.


Circulating Prostate-Specific Antigen and Telomere Length in a Nationally Representative Sample of Men Without History of Prostate Cancer.

Wulaningsih W, Astuti Y, Matsuguchi T, Anggrandariyanny P, Watkins J; PILAR Research Network.

Prostate. 2017 Jan;77(1):22-32. doi: 10.1002/pros.23245. Epub 2016 Aug 27.


CXCL3 positively regulates adipogenic differentiation.

Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T.

J Lipid Res. 2016 Oct;57(10):1806-1820. Epub 2016 Aug 10.


Smoking, second-hand smoke exposure and smoking cessation in relation to leukocyte telomere length and mortality.

Wulaningsih W, Serrano FE, Utarini A, Matsuguchi T, Watkins J; PILAR Research Network.

Oncotarget. 2016 Sep 13;7(37):60419-60431. doi: 10.18632/oncotarget.11051.


10. Low-Intensity Pulsed Ultrasound (LIPUS) Stimulation Helps to Maintain the Differentiation Potency of Mesenchymal Stem Cells by Induction in Nanog Protein Transcript Levels and Phosphorylation.

Kusuyama J, Hwan Seong C, Ohnishi T, Bandow K, Matsuguchi T.

J Orthop Trauma. 2016 Aug;30(8):S4-5. doi: 10.1097/


The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo.

Matsuguchi T, Blackburn E.

PeerJ. 2016 Jan 4;4:e1534. doi: 10.7717/peerj.1534. eCollection 2016.


A High Through-put Platform for Recombinant Antibodies to Folded Proteins.

Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Gräslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells J.

Mol Cell Proteomics. 2015 Oct;14(10):2833-47. doi: 10.1074/mcp.O115.052209. Epub 2015 Aug 19.


Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH.

Genetics. 2015 Aug;200(4):1061-72. doi: 10.1534/genetics.115.178624. Epub 2015 Jun 19.


Scalable high throughput selection from phage-displayed synthetic antibody libraries.

Miersch S, Li Z, Hanna R, McLaughlin ME, Hornsby M, Matsuguchi T, Paduch M, Sääf A, Wells J, Koide S, Kossiakoff A, Sidhu SS.

J Vis Exp. 2015 Jan 17;(95):51492. doi: 10.3791/51492.


Induction of CXCL2 and CCL2 by pressure force requires IL-1β-MyD88 axis in osteoblasts.

Maeda A, Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Miyawaki S, Matsuguchi T.

Bone. 2015 May;74:76-82. doi: 10.1016/j.bone.2015.01.007. Epub 2015 Jan 17.


AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.

Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T.

Bone. 2015 May;74:125-33. doi: 10.1016/j.bone.2014.12.001. Epub 2014 Dec 10.


Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: the Strong Heart Family Study.

Chen S, Lin J, Matsuguchi T, Blackburn E, Yeh F, Best LG, Devereux RB, Lee ET, Howard BV, Roman MJ, Zhao J.

Aging (Albany NY). 2014 May;6(5):414-27.


Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo.

Sukup-Jackson MR, Kiraly O, Kay JE, Na L, Rowland EA, Winther KE, Chow DN, Kimoto T, Matsuguchi T, Jonnalagadda VS, Maklakova VI, Singh VR, Wadduwage DN, Rajapakse J, So PT, Collier LS, Engelward BP.

PLoS Genet. 2014 Jun 5;10(6):e1004299. doi: 10.1371/journal.pgen.1004299. eCollection 2014 Jun.


Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study.

Chen S, Yeh F, Lin J, Matsuguchi T, Blackburn E, Lee ET, Howard BV, Zhao J.

Aging (Albany NY). 2014 May;6(5):380-9.


Metabolic profiles of biological aging in American Indians: the Strong Heart Family Study.

Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV.

Aging (Albany NY). 2014 Mar;6(3):176-86.


MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.

PLoS One. 2014 Feb 24;9(2):e89615. doi: 10.1371/journal.pone.0089615. eCollection 2014.


Low intensity pulsed ultrasound (LIPUS) influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathway.

Kusuyama J, Bandow K, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T.

J Biol Chem. 2014 Apr 11;289(15):10330-44. doi: 10.1074/jbc.M113.546382. Epub 2014 Feb 18.


Long-time treatment by low-dose N-acetyl-L-cysteine enhances proinflammatory cytokine expressions in LPS-stimulated macrophages.

Ohnishi T, Bandow K, Kakimoto K, Kusuyama J, Matsuguchi T.

PLoS One. 2014 Feb 4;9(2):e87229. doi: 10.1371/journal.pone.0087229. eCollection 2014.


Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4-MyD88 dissociation.

Nakao J, Fujii Y, Kusuyama J, Bandow K, Kakimoto K, Ohnishi T, Matsuguchi T.

Bone. 2014 Jan;58:17-25. doi: 10.1016/j.bone.2013.09.018. Epub 2013 Sep 30.


QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study.

Zhu Y, Voruganti VS, Lin J, Matsuguchi T, Blackburn E, Best LG, Lee ET, MacCluer JW, Cole SA, Zhao J.

Aging (Albany NY). 2013 Sep;5(9):704-16.


Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study.

Zhao J, Zhu Y, Lin J, Matsuguchi T, Blackburn E, Zhang Y, Cole SA, Best LG, Lee ET, Howard BV.

Diabetes. 2014 Jan;63(1):354-62. doi: 10.2337/db13-0744. Epub 2013 Aug 15.


LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages.

Bandow K, Kusuyama J, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T.

FEBS Lett. 2012 May 21;586(10):1540-6. doi: 10.1016/j.febslet.2012.04.018. Epub 2012 Apr 21.


Mast cells as critical effectors of host immune defense against Gram-negative bacteria.

Matsuguchi T.

Curr Med Chem. 2012;19(10):1432-42. Review.


Bleomycin-induced lung injury in mice investigated by MRI: model assessment for target analysis.

Babin AL, Cannet C, Gérard C, Saint-Mezard P, Page CP, Sparrer H, Matsuguchi T, Beckmann N.

Magn Reson Med. 2012 Feb;67(2):499-509. doi: 10.1002/mrm.23009. Epub 2011 Jun 7.


Functional involvement of dual specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, in the regulation of T helper cell differentiation.

Musikacharoen T, Bandow K, Kakimoto K, Kusuyama J, Onishi T, Yoshikai Y, Matsuguchi T.

J Biol Chem. 2011 Jul 15;286(28):24896-905. doi: 10.1074/jbc.M111.245019. Epub 2011 May 25.


Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation.

Bandow K, Maeda A, Kakimoto K, Kusuyama J, Shamoto M, Ohnishi T, Matsuguchi T.

Biochem Biophys Res Commun. 2010 Nov 26;402(4):755-61. doi: 10.1016/j.bbrc.2010.10.103. Epub 2010 Oct 29.


Functional roles of Cot/Tpl2 in mast cell responses to lipopolysaccharide and FcεRI-clustering.

Chiba N, Kakimoto K, Masuda A, Matsuguchi T.

Biochem Biophys Res Commun. 2010 Nov 5;402(1):1-6. doi: 10.1016/j.bbrc.2010.08.075. Epub 2010 Aug 21.


Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.

Kakimoto K, Musikacharoen T, Chiba N, Bandow K, Ohnishi T, Matsuguchi T.

J Physiol Biochem. 2010 Mar;66(1):47-53. doi: 10.1007/s13105-010-0007-9. Epub 2010 Apr 20.


Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells.

Kumabe S, Itsumi M, Yamada H, Yajima T, Matsuguchi T, Yoshikai Y.

Microbiol Immunol. 2010 Feb;54(2):105-11. doi: 10.1111/j.1348-0421.2009.00188.x.


Involvement of Cot/Tp12 in bone loss during periodontitis.

Ohnishi T, Okamoto A, Kakimoto K, Bandow K, Chiba N, Matsuguchi T.

J Dent Res. 2010 Feb;89(2):192-7. doi: 10.1177/0022034509353405.


[JNK signaling in osteoblast differentiation].

Matsuguchi T.

Seikagaku. 2009 Aug;81(8):703-7. Review. Japanese. No abstract available.


Osteoblast differentiation is functionally associated with decreased AMP kinase activity.

Kasai T, Bandow K, Suzuki H, Chiba N, Kakimoto K, Ohnishi T, Kawamoto S, Nagaoka E, Matsuguchi T.

J Cell Physiol. 2009 Dec;221(3):740-9. doi: 10.1002/jcp.21917.


Dehydroepiandrosterone increased oxidative stress in a human cell line during differentiation.

Izumo K, Horiuchi M, Komatsu M, Aoyama K, Bandow K, Matsuguchi T, Takeuchi M, Takeuchi T.

Free Radic Res. 2009 Oct;43(10):922-31. doi: 10.1080/10715760903137093. Epub 2009 Aug 12.


Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice.

Okamoto A, Ohnishi T, Bandow K, Kakimoto K, Chiba N, Maeda A, Fukunaga T, Miyawaki S, Matsuguchi T.

Eur J Oral Sci. 2009 Jun;117(3):238-47. doi: 10.1111/j.1600-0722.2009.00625.x.


Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.

Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH.

Cell. 2009 Jan 9;136(1):50-61. doi: 10.1016/j.cell.2008.11.027.


JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation.

Matsuguchi T, Chiba N, Bandow K, Kakimoto K, Masuda A, Ohnishi T.

J Bone Miner Res. 2009 Mar;24(3):398-410. doi: 10.1359/jbmr.081107.


Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes.

Ohnishi T, Bandow K, Kakimoto K, Machigashira M, Matsuyama T, Matsuguchi T.

J Periodontal Res. 2009 Feb;44(1):43-51. doi: 10.1111/j.1600-0765.2007.01060.x. Epub 2008 Oct 7.


Serine/threonine kinase, Cot/Tpl2, regulates renal cell apoptosis in ischaemia/reperfusion injury.

Yaomura T, Tsuboi N, Urahama Y, Hobo A, Sugimoto K, Miyoshi J, Matsuguchi T, Reiji K, Matsuo S, Yuzawa Y.

Nephrology (Carlton). 2008 Oct;13(5):397-404. doi: 10.1111/j.1440-1797.2008.00959.x. Epub 2008 May 29.


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