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Items: 10

1.

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement.

La DS, Peterson EA, Bode C, Boezio AA, Bregman H, Chu-Moyer MY, Coats J, DiMauro EF, Dineen TA, Du B, Gao H, Graceffa R, Gunaydin H, Guzman-Perez A, Fremeau R Jr, Huang X, Ilch C, Kornecook TJ, Kreiman C, Ligutti J, Jasmine Lin MH, McDermott JS, Marx I, Matson DJ, McDonough SI, Moyer BD, Nho Nguyen H, Taborn K, Yu V, Weiss MM.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3477-3485. doi: 10.1016/j.bmcl.2017.05.070. Epub 2017 Jun 1.

PMID:
28629594
2.

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.

Huang X, Shaffer PL, Ayube S, Bregman H, Chen H, Lehto SG, Luther JA, Matson DJ, McDonough SI, Michelsen K, Plant MH, Schneider S, Simard JR, Teffera Y, Yi S, Zhang M, DiMauro EF, Gingras J.

Nat Struct Mol Biol. 2017 Feb;24(2):108-113. doi: 10.1038/nsmb.3329. Epub 2016 Dec 19.

PMID:
27991902
3.

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.

Matson DJ, Hamamoto DT, Bregman H, Cooke M, DiMauro EF, Huang L, Johnson D, Li X, McDermott J, Morgan C, Wilenkin B, Malmberg AB, McDonough SI, Simone DA.

PLoS One. 2015 Sep 17;10(9):e0138140. doi: 10.1371/journal.pone.0138140. eCollection 2015.

4.

Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.

Gingras J, Smith S, Matson DJ, Johnson D, Nye K, Couture L, Feric E, Yin R, Moyer BD, Peterson ML, Rottman JB, Beiler RJ, Malmberg AB, McDonough SI.

PLoS One. 2014 Sep 4;9(9):e105895. doi: 10.1371/journal.pone.0105895. eCollection 2014.

5.

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.

Nguyen HN, Bregman H, Buchanan JL, Du B, Feric E, Huang L, Li X, Ligutti J, Liu D, Malmberg AB, Matson DJ, McDermott JS, Patel VF, Wilenkin B, Zou A, McDonough SI, Dimauro EF.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1055-60. doi: 10.1016/j.bmcl.2011.11.111. Epub 2011 Dec 6.

PMID:
22209205
6.

Locomotor activity in a novel environment as a test of inflammatory pain in rats.

Matson DJ, Broom DC, Cortright DN.

Methods Mol Biol. 2010;617:67-78. doi: 10.1007/978-1-60327-323-7_6.

PMID:
20336414
7.

Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.

Broom DC, Matson DJ, Bradshaw E, Buck ME, Meade R, Coombs S, Matchett M, Ford KK, Yu W, Yuan J, Sun SH, Ochoa R, Krause JE, Wustrow DJ, Cortright DN.

J Pharmacol Exp Ther. 2008 Dec;327(3):620-33. doi: 10.1124/jpet.108.141853. Epub 2008 Sep 4.

PMID:
18772321
8.

New frontiers in assessing pain and analgesia in laboratory animals.

Cortright DN, Matson DJ, Broom DC.

Expert Opin Drug Discov. 2008 Sep;3(9):1099-108. doi: 10.1517/17460441.3.9.1099.

PMID:
23506182
9.

Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury.

Frederick J, Buck ME, Matson DJ, Cortright DN.

Biochem Biophys Res Commun. 2007 Jul 13;358(4):1058-64. Epub 2007 May 14.

PMID:
17517374
10.

Inflammation-induced reduction of spontaneous activity by adjuvant: A novel model to study the effect of analgesics in rats.

Matson DJ, Broom DC, Carson SR, Baldassari J, Kehne J, Cortright DN.

J Pharmacol Exp Ther. 2007 Jan;320(1):194-201. Epub 2006 Oct 18.

PMID:
17050782

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