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Items: 8


Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor-Positive Breast Cancer.

Matissek KJ, Onozato ML, Sun S, Zheng Z, Schultz A, Lee J, Patel K, Jerevall PL, Saladi SV, Macleay A, Tavallai M, Badovinac-Crnjevic T, Barrios C, Beşe N, Chan A, Chavarri-Guerra Y, Debiasi M, Demirdögen E, Egeli Ü, Gökgöz S, Gomez H, Liedke P, Tasdelen I, Tolunay S, Werutsky G, St Louis J, Horick N, Finkelstein DM, Le LP, Bardia A, Goss PE, Sgroi DC, Iafrate AJ, Ellisen LW.

Cancer Discov. 2018 Mar;8(3):336-353. doi: 10.1158/2159-8290.CD-17-0535. Epub 2017 Dec 14.


Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model.

Okal A, Matissek KJ, Matissek SJ, Price R, Salama ME, Janát-Amsbury MM, Lim CS.

Gene Ther. 2014 Oct;21(10):903-12. doi: 10.1038/gt.2014.70. Epub 2014 Jul 31.


Re-engineered p53 chimera with enhanced homo-oligomerization that maintains tumor suppressor activity.

Okal A, Cornillie S, Matissek SJ, Matissek KJ, Cheatham TE 3rd, Lim CS.

Mol Pharm. 2014 Jul 7;11(7):2442-52. doi: 10.1021/mp500202p. Epub 2014 May 29.


Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax.

Matissek KJ, Okal A, Mossalam M, Lim CS.

Pharm Res. 2014 Sep;31(9):2503-15. doi: 10.1007/s11095-014-1346-y. Epub 2014 Mar 15.


The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria.

Matissek KJ, Mossalam M, Okal A, Lim CS.

Mol Pharm. 2013 Oct 7;10(10):3592-602. doi: 10.1021/mp400380s. Epub 2013 Sep 6.


A chimeric p53 evades mutant p53 transdominant inhibition in cancer cells.

Okal A, Mossalam M, Matissek KJ, Dixon AS, Moos PJ, Lim CS.

Mol Pharm. 2013 Oct 7;10(10):3922-33. doi: 10.1021/mp400379c. Epub 2013 Sep 9.


Enhanced and selective killing of chronic myelogenous leukemia cells with an engineered BCR-ABL binding protein and imatinib.

Constance JE, Woessner DW, Matissek KJ, Mossalam M, Lim CS.

Mol Pharm. 2012 Nov 5;9(11):3318-29. doi: 10.1021/mp3003539. Epub 2012 Oct 12.


Direct induction of apoptosis using an optimal mitochondrially targeted p53.

Mossalam M, Matissek KJ, Okal A, Constance JE, Lim CS.

Mol Pharm. 2012 May 7;9(5):1449-58. doi: 10.1021/mp3000259. Epub 2012 Mar 28.

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