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Items: 1 to 50 of 108

1.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit.

Tsai CJ, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G.

Elife. 2019 Jun 28;8. pii: e46041. doi: 10.7554/eLife.46041.

2.

Development of an antibody fragment that stabilizes GPCR/G-protein complexes.

Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK.

Nat Commun. 2018 Sep 13;9(1):3712. doi: 10.1038/s41467-018-06002-w.

3.

Structure of the µ-opioid receptor-Gi protein complex.

Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK.

Nature. 2018 Jun;558(7711):547-552. doi: 10.1038/s41586-018-0219-7. Epub 2018 Jun 13.

4.

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody.

Favuzza P, Guffart E, Tamborrini M, Scherer B, Dreyer AM, Rufer AC, Erny J, Hoernschemeyer J, Thoma R, Schmid G, Gsell B, Lamelas A, Benz J, Joseph C, Matile H, Pluschke G, Rudolph MG.

Elife. 2017 Feb 14;6. pii: e20383. doi: 10.7554/eLife.20383.

5.

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

Dong Y, Wang X, Kamaraj S, Bulbule VJ, Chiu FC, Chollet J, Dhanasekaran M, Hein CD, Papastogiannidis P, Morizzi J, Shackleford DM, Barker H, Ryan E, Scheurer C, Tang Y, Zhao Q, Zhou L, White KL, Urwyler H, Charman WN, Matile H, Wittlin S, Charman SA, Vennerstrom JL.

J Med Chem. 2017 Apr 13;60(7):2654-2668. doi: 10.1021/acs.jmedchem.6b01586. Epub 2017 Jan 18.

PMID:
28052200
6.

Generation of monoclonal antibodies against native viral proteins using antigen-expressing mammalian cells for mouse immunization.

Rose N, Pinho-Nascimento CA, Ruggieri A, Favuzza P, Tamborrini M, Roth H, Baroni de Moraes MT, Matile H, Jänisch T, Pluschke G, Röltgen K.

BMC Biotechnol. 2016 Nov 22;16(1):83.

7.

Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.

Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, Debulpaep M, Fry D, Huber W, Kremer T, Laeremans T, Matile H, Ross A, Rufer AC, Schoch G, Steinmetz MO, Steyaert J, Rudolph MG, Thoma R, Ruf A.

J Biol Chem. 2016 Jul 29;291(31):16292-306. doi: 10.1074/jbc.M116.726547. Epub 2016 May 10.

8.

Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA.

Favuzza P, Blaser S, Dreyer AM, Riccio G, Tamborrini M, Thoma R, Matile H, Pluschke G.

Malar J. 2016 Mar 15;15:161. doi: 10.1186/s12936-016-1213-x.

9.

Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP.

Lauer ME, Graff-Meyer A, Rufer AC, Maugeais C, von der Mark E, Matile H, D'Arcy B, Magg C, Ringler P, Müller SA, Scherer S, Dernick G, Thoma R, Hennig M, Niesor EJ, Stahlberg H.

J Struct Biol. 2016 May;194(2):191-8. doi: 10.1016/j.jsb.2016.02.016. Epub 2016 Feb 12.

10.

Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.

Raab S, Wang H, Uhles S, Cole N, Alvarez-Sanchez R, Künnecke B, Ullmer C, Matile H, Bedoucha M, Norcross RD, Ottaway-Parker N, Perez-Tilve D, Conde Knape K, Tschöp MH, Hoener MC, Sewing S.

Mol Metab. 2015 Nov 1;5(1):47-56. doi: 10.1016/j.molmet.2015.09.015. eCollection 2016 Jan.

11.

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).

Jourdan J, Matile H, Reift E, Biehlmaier O, Dong Y, Wang X, Mäser P, Vennerstrom JL, Wittlin S.

ACS Infect Dis. 2016 Jan 8;2(1):54-61. Epub 2015 Sep 28.

12.

Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.

Banner DW, Gsell B, Benz J, Bertschinger J, Burger D, Brack S, Cuppuleri S, Debulpaep M, Gast A, Grabulovski D, Hennig M, Hilpert H, Huber W, Kuglstatter A, Kusznir E, Laeremans T, Matile H, Miscenic C, Rufer AC, Schlatter D, Steyaert J, Stihle M, Thoma R, Weber M, Ruf A.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1124-37. doi: 10.1107/S0907444913006574. Epub 2013 May 15.

PMID:
23695257
13.

Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain.

Kremer T, Jagasia R, Herrmann A, Matile H, Borroni E, Francis F, Kuhn HG, Czech C.

PLoS One. 2013 May 14;8(5):e59269. doi: 10.1371/journal.pone.0059269. Print 2013.

14.

Generation of an antibody toolbox to characterize hERG.

Hausammann GJ, Heitkamp T, Matile H, Gsell B, Thoma R, Schmid G, Frasson D, Sievers M, Hennig M, Grütter MG.

Biochem Biophys Res Commun. 2013 Feb 1;431(1):70-5. doi: 10.1016/j.bbrc.2012.12.089. Epub 2012 Dec 28.

PMID:
23277102
15.

Apolipoprotein M can discriminate HNF1A-MODY from Type 1 diabetes.

Mughal SA, Park R, Nowak N, Gloyn AL, Karpe F, Matile H, Malecki MT, McCarthy MI, Stoffel M, Owen KR.

Diabet Med. 2013 Feb;30(2):246-50. doi: 10.1111/dme.12066.

16.

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).

Vats D, Wang H, Esterhazy D, Dikaiou K, Danzer C, Honer M, Stuker F, Matile H, Migliorini C, Fischer E, Ripoll J, Keist R, Krek W, Schibli R, Stoffel M, Rudin M.

Diabetologia. 2012 Sep;55(9):2407-16. doi: 10.1007/s00125-012-2605-2. Epub 2012 Jul 13.

17.

Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7.

Ullmer C, Zoffmann S, Bohrmann B, Matile H, Lindemann L, Flor P, Malherbe P.

Br J Pharmacol. 2012 Dec;167(7):1448-66. doi: 10.1111/j.1476-5381.2012.02090.x.

18.

Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen.

Dreyer AM, Matile H, Papastogiannidis P, Kamber J, Favuzza P, Voss TS, Wittlin S, Pluschke G.

J Immunol. 2012 Jun 15;188(12):6225-37. doi: 10.4049/jimmunol.1103177. Epub 2012 May 16.

19.

Multidimensional profiling of plasma lipoproteins by size exclusion chromatography followed by reverse-phase protein arrays.

Dernick G, Obermüller S, Mangold C, Magg C, Matile H, Gutmann O, von der Mark E, Handschin C, Maugeais C, Niesor EJ.

J Lipid Res. 2011 Dec;52(12):2323-31. doi: 10.1194/jlr.D016824. Epub 2011 Oct 4.

20.

Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism.

Karuna R, Park R, Othman A, Holleboom AG, Motazacker MM, Sutter I, Kuivenhoven JA, Rohrer L, Matile H, Hornemann T, Stoffel M, Rentsch KM, von Eckardstein A.

Atherosclerosis. 2011 Dec;219(2):855-63. doi: 10.1016/j.atherosclerosis.2011.08.049. Epub 2011 Sep 6.

PMID:
21944699
21.

Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.

Esterházy D, Stützer I, Wang H, Rechsteiner MP, Beauchamp J, Döbeli H, Hilpert H, Matile H, Prummer M, Schmidt A, Lieske N, Boehm B, Marselli L, Bosco D, Kerr-Conte J, Aebersold R, Spinas GA, Moch H, Migliorini C, Stoffel M.

Cell Metab. 2011 Sep 7;14(3):365-77. doi: 10.1016/j.cmet.2011.06.018.

22.

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.

Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FC, Chollet J, Craft JC, Creek DJ, Dong Y, Matile H, Maurer M, Morizzi J, Nguyen T, Papastogiannidis P, Scheurer C, Shackleford DM, Sriraghavan K, Stingelin L, Tang Y, Urwyler H, Wang X, White KL, Wittlin S, Zhou L, Vennerstrom JL.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5. doi: 10.1073/pnas.1015762108. Epub 2011 Feb 7.

23.

An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells.

Dreyer AM, Beauchamp J, Matile H, Pluschke G.

BMC Biotechnol. 2010 Dec 15;10:87. doi: 10.1186/1472-6750-10-87.

24.

Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport.

Niesor EJ, Magg C, Ogawa N, Okamoto H, von der Mark E, Matile H, Schmid G, Clerc RG, Chaput E, Blum-Kaelin D, Huber W, Thoma R, Pflieger P, Kakutani M, Takahashi D, Dernick G, Maugeais C.

J Lipid Res. 2010 Dec;51(12):3443-54. doi: 10.1194/jlr.M008706. Epub 2010 Sep 22.

25.

The comparative antimalarial properties of weak base and neutral synthetic ozonides.

Tang Y, Wittlin S, Charman SA, Chollet J, Chiu FC, Morizzi J, Johnson LM, Tomas JS, Scheurer C, Snyder C, Zhou L, Dong Y, Charman WN, Matile H, Urwyler H, Dorn A, Vennerstrom JL.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):563-6. doi: 10.1016/j.bmcl.2009.11.088. Epub 2009 Nov 22.

PMID:
19962893
26.

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL.

J Med Chem. 2010 Jan 14;53(1):481-91. doi: 10.1021/jm901473s.

PMID:
19924861
27.

A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity.

Tritten L, Matile H, Brun R, Wittlin S.

Malar J. 2009 Oct 12;8:226. doi: 10.1186/1475-2875-8-226.

28.

In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.

Hofer S, Brun R, Maerki S, Matile H, Scheurer C, Wittlin S.

J Antimicrob Chemother. 2008 Nov;62(5):1061-4. doi: 10.1093/jac/dkn315. Epub 2008 Jul 30.

PMID:
18669520
29.

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Kaiser M, Wittlin S, Nehrbass-Stuedli A, Dong Y, Wang X, Hemphill A, Matile H, Brun R, Vennerstrom JL.

Antimicrob Agents Chemother. 2007 Aug;51(8):2991-3. Epub 2007 Jun 11.

30.

In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277).

Osorio L, Murillo C, Aponte S, Mayagaya V, Scheurer C, Brun R, Matile H, Wittlin S.

Am J Trop Med Hyg. 2007 Jun;76(6):1024-6.

PMID:
17556605
31.

Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation.

Okitsu SL, Kienzl U, Moehle K, Silvie O, Peduzzi E, Mueller MS, Sauerwein RW, Matile H, Zurbriggen R, Mazier D, Robinson JA, Pluschke G.

Chem Biol. 2007 May;14(5):577-87.

32.

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

Dong Y, Creek D, Chollet J, Matile H, Charman SA, Wittlin S, Wood JK, Vennerstrom JL.

Antimicrob Agents Chemother. 2007 Aug;51(8):3033-5. Epub 2007 May 7.

33.

Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.

Tang Y, Dong Y, Wittlin S, Charman SA, Chollet J, Chiu FC, Charman WN, Matile H, Urwyler H, Dorn A, Bajpai S, Wang X, Padmanilayam M, Karle JM, Brun R, Vennerstrom JL.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1260-5. Epub 2006 Dec 15.

PMID:
17189686
34.

Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).

Uhlemann AC, Wittlin S, Matile H, Bustamante LY, Krishna S.

Antimicrob Agents Chemother. 2007 Feb;51(2):667-72. Epub 2006 Dec 4.

35.

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.

Padmanilayam M, Scorneaux B, Dong Y, Chollet J, Matile H, Charman SA, Creek DJ, Charman WN, Tomas JS, Scheurer C, Wittlin S, Brun R, Vennerstrom JL.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5542-5. Epub 2006 Aug 22.

PMID:
16931006
36.

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.

Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN, Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X, Padmanilayam M, Cheruku SR, Brun R, Vennerstrom JL.

Bioorg Med Chem. 2006 Sep 15;14(18):6368-82. Epub 2006 Jun 8.

PMID:
16759871
37.

In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.

Maerki S, Brun R, Charman SA, Dorn A, Matile H, Wittlin S.

J Antimicrob Chemother. 2006 Jul;58(1):52-8. Epub 2006 May 30.

PMID:
16735432
38.

Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.

Kocken CH, van der Wel A, Arbe-Barnes S, Brun R, Matile H, Scheurer C, Wittlin S, Thomas AW.

Exp Parasitol. 2006 Jul;113(3):197-200. Epub 2006 Feb 3.

PMID:
16458301
39.

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL.

J Med Chem. 2005 Jul 28;48(15):4953-61.

PMID:
16033274
40.

Identification of an antimalarial synthetic trioxolane drug development candidate.

Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN.

Nature. 2004 Aug 19;430(7002):900-4.

41.

The N'-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes.

Daubenberger CA, Tisdale EJ, Curcic M, Diaz D, Silvie O, Mazier D, Eling W, Bohrmann B, Matile H, Pluschke G.

Biol Chem. 2003 Aug;384(8):1227-37.

PMID:
12974391
42.

Immobilized amyloid precursor protein constructs: a tool for the in vitro screening of glial cell reactivity.

von Bernhardi R, Ramírez G, Matile H, Döbeli H.

Eur J Neurosci. 2001 Sep;14(6):946-56.

PMID:
11595033
43.

Short report: floxacrine analog WR 243251 inhibits hematin polymerization.

Dorn A, Scovill JP, Ellis WY, Matile H, Ridley RG, Vennerstrom JL.

Am J Trop Med Hyg. 2001 Jul;65(1):19-20.

PMID:
11504401
44.

Artemether administered together with haemin damages schistosomes in vitro.

Xiao S, Chollet J, Utzinger J, Matile H, Mei J, Tanner M.

Trans R Soc Trop Med Hyg. 2001 Jan-Feb;95(1):67-71.

PMID:
11280070
45.

Rhoptry-associated protein 1-binding monoclonal antibody raised against a heterologous peptide sequence inhibits Plasmodium falciparum growth in vitro.

Moreno R, Pöltl-Frank F, Stüber D, Matile H, Mutz M, Weiss NA, Pluschke G.

Infect Immun. 2001 Apr;69(4):2558-68.

46.

The synthetic, oxidized C-terminal fragment of the Plasmodium berghei circumsporozoite protein elicits a high protective response.

Roggero MA, Meraldi V, López JA, Eberl G, Romero JC, Matile H, Betschart B, Corradin G, Renggli J.

Eur J Immunol. 2000 Sep;30(9):2679-85.

47.

Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores.

Kurosawa Y, Dorn A, Kitsuji-Shirane M, Shimada H, Satoh T, Matile H, Hofheinz W, Masciadri R, Kansy M, Ridley RG.

Antimicrob Agents Chemother. 2000 Oct;44(10):2638-44.

48.

Phenyl beta-methoxyacrylates: a new antimalarial pharmacophore.

Alzeer J, Chollet J, Heinze-Krauss I, Hubschwerlen C, Matile H, Ridley RG.

J Med Chem. 2000 Feb 24;43(4):560-8.

PMID:
10691682
49.

Sequence diversity of the merozoite surface protein 1 of Plasmodium falciparum in clinical isolates from the Kilombero District, Tanzania.

Jiang G, Daubenberger C, Huber W, Matile H, Tanner M, Pluschke G.

Acta Trop. 2000 Jan 5;74(1):51-61.

PMID:
10643908
50.

Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.

Vippagunta SR, Dorn A, Matile H, Bhattacharjee AK, Karle JM, Ellis WY, Ridley RG, Vennerstrom JL.

J Med Chem. 1999 Nov 4;42(22):4630-9.

PMID:
10579825

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