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Items: 1 to 50 of 121

1.

From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?

Cypryk W, Nyman TA, Matikainen S.

Front Immunol. 2018 Sep 25;9:2188. doi: 10.3389/fimmu.2018.02188. eCollection 2018. Review.

2.

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.

Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, Kakkola L, Nandania J, Turunen L, Ohman T, Ala-Hongisto H, Pesonen HM, Kuisma MS, Honkimaa A, Walton EL, Oksenych V, Lorey MB, Guschin D, Shim J, Kim J, Than TT, Chang SY, Hukkanen V, Kulesskiy E, Marjomaki VS, Julkunen I, Nyman TA, Matikainen S, Saarela JS, Sane F, Hober D, Gabriel G, De Brabander JK, Martikainen M, Windisch MP, Min JY, Bruzzone R, Aittokallio T, Vähä-Koskela M, Vapalahti O, Pulk A, Velagapudi V, Kainov DE.

Viruses. 2017 Sep 25;9(10). pii: E271. doi: 10.3390/v9100271.

3.

Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense.

Aittomäki S, Valanne S, Lehtinen T, Matikainen S, Nyman TA, Rämet M, Pesu M.

FASEB J. 2017 Nov;31(11):4770-4782. doi: 10.1096/fj.201700296R. Epub 2017 Jul 13.

PMID:
28705811
4.

Proteomics to study macrophage response to viral infection.

Nyman TA, Matikainen S.

J Proteomics. 2018 May 30;180:99-107. doi: 10.1016/j.jprot.2017.06.018. Epub 2017 Jun 21. Review.

PMID:
28647517
5.

Mass spectrometry-based proteomic exploration of the human immune system: focus on the inflammasome, global protein secretion, and T cells.

Nyman TA, Lorey MB, Cypryk W, Matikainen S.

Expert Rev Proteomics. 2017 May;14(5):395-407. doi: 10.1080/14789450.2017.1319768. Epub 2017 Apr 24. Review.

PMID:
28406322
6.

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation.

Lorey MB, Rossi K, Eklund KK, Nyman TA, Matikainen S.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S187-S199. doi: 10.1074/mcp.M116.064840. Epub 2017 Feb 14.

7.

Regulation of kynurenine biosynthesis during influenza virus infection.

Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE.

FEBS J. 2017 Jan;284(2):222-236. doi: 10.1111/febs.13966. Epub 2016 Dec 14.

8.

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, Ohman T, Tynell J, Kyttänen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE.

Biochim Biophys Acta. 2016 Nov;1859(11):1440-1448. doi: 10.1016/j.bbagrm.2016.09.005. Epub 2016 Sep 21.

PMID:
27664935
9.

Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection.

Cypryk W, Lorey M, Puustinen A, Nyman TA, Matikainen S.

J Proteome Res. 2017 Jan 6;16(1):217-227. doi: 10.1021/acs.jproteome.6b00596. Epub 2016 Nov 15.

PMID:
27723984
10.

Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.

Söderholm S, Fu Y, Gaelings L, Belanov S, Yetukuri L, Berlinkov M, Cheltsov AV, Anders S, Aittokallio T, Nyman TA, Matikainen S, Kainov DE.

Viruses. 2016 Sep 29;8(10). pii: E269. Review.

11.

Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation.

Nurmi K, Kareinen I, Virkanen J, Rajamäki K, Kouri VP, Vaali K, Levonen AL, Fyhrquist N, Matikainen S, Kovanen PT, Eklund KK.

J Innate Immun. 2017;9(1):65-82. doi: 10.1159/000448894. Epub 2016 Sep 22.

12.

Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages.

Välimäki E, Cypryk W, Virkanen J, Nurmi K, Turunen PM, Eklund KK, Åkerman KE, Nyman TA, Matikainen S.

J Immunol. 2016 Oct 15;197(8):3315-3325. Epub 2016 Sep 16.

13.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Söderholm S, Kainov DE, Öhman T, Denisova OV, Schepens B, Kulesskiy E, Imanishi SY, Corthals G, Hintsanen P, Aittokallio T, Saelens X, Matikainen S, Nyman TA.

Mol Cell Proteomics. 2016 Oct;15(10):3203-3219. Epub 2016 Aug 2.

14.

JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses.

Fu Y, Gaelings L, Söderholm S, Belanov S, Nandania J, Nyman TA, Matikainen S, Anders S, Velagapudi V, Kainov DE.

Antiviral Res. 2016 Sep;133:23-31. doi: 10.1016/j.antiviral.2016.07.008. Epub 2016 Jul 20.

PMID:
27451344
15.

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.

Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR.

EMBO J. 2016 Jul 1;35(13):1385-99. doi: 10.15252/embj.201593458. Epub 2016 May 27.

16.

[Role of cytokines and their blocking in immune-mediated inflammatory diseases].

Matikainen S, Jokiranta S, Eklund KK.

Duodecim. 2016;132(4):349-54. Review. Finnish.

PMID:
27017787
17.

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.

Söderholm S, Anastasina M, Islam MM, Tynell J, Poranen MM, Bamford DH, Stenman J, Julkunen I, Šaulienė I, De Brabander JK, Matikainen S, Nyman TA, Saelens X, Kainov D.

Antiviral Res. 2016 Feb;126:69-80. doi: 10.1016/j.antiviral.2015.12.011. Epub 2015 Dec 29.

18.

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

Anastasina M, Schepens B, Söderholm S, Nyman TA, Matikainen S, Saksela K, Saelens X, Kainov DE.

J Gen Virol. 2015 Aug;96(8):2086-91. doi: 10.1099/vir.0.000171. Epub 2015 May 1.

PMID:
25934792
19.

Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM-CSF: Results in vitro, in rodents and in humans.

Bramante S, Kaufmann JK, Veckman V, Liikanen I, Nettelbeck DM, Hemminki O, Vassilev L, Cerullo V, Oksanen M, Heiskanen R, Joensuu T, Kanerva A, Pesonen S, Matikainen S, Vähä-Koskela M, Koski A, Hemminki A.

Int J Cancer. 2015 Oct 1;137(7):1775-83. doi: 10.1002/ijc.29536. Epub 2015 Apr 11.

20.

Phosphoproteome characterization reveals that Sendai virus infection activates mTOR signaling in human epithelial cells.

Öhman T, Söderholm S, Paidikondala M, Lietzén N, Matikainen S, Nyman TA.

Proteomics. 2015 Jun;15(12):2087-97. doi: 10.1002/pmic.201400586. Epub 2015 Apr 27.

PMID:
25764225
21.

The peptide toxin amylosin of Bacillus amyloliquefaciens from moisture-damaged buildings is immunotoxic, induces potassium efflux from mammalian cells, and has antimicrobial activity.

Rasimus-Sahari S, Teplova VV, Andersson MA, Mikkola R, Kankkunen P, Matikainen S, Gahmberg CG, Andersson LC, Salkinoja-Salonen M.

Appl Environ Microbiol. 2015 Apr;81(8):2939-49. doi: 10.1128/AEM.03430-14. Epub 2015 Feb 13.

22.

Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy.

Vähä-Koskela M, Tähtinen S, Grönberg-Vähä-Koskela S, Taipale K, Saha D, Merisalo-Soikkeli M, Ahonen M, Rouvinen-Lagerström N, Hirvinen M, Veckman V, Matikainen S, Zhao F, Pakarinen P, Salo J, Kanerva A, Cerullo V, Hemminki A.

Mol Ther Oncolytics. 2015 Jan 7;1:14006. doi: 10.1038/mto.2014.6. eCollection 2015.

23.

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation.

Rydman EM, Ilves M, Koivisto AJ, Kinaret PA, Fortino V, Savinko TS, Lehto MT, Pulkkinen V, Vippola M, Hämeri KJ, Matikainen S, Wolff H, Savolainen KM, Greco D, Alenius H.

Part Fibre Toxicol. 2014 Oct 16;11:48. doi: 10.1186/s12989-014-0048-2.

24.

Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway.

Öhman T, Söderholm S, Hintsanen P, Välimäki E, Lietzén N, MacKintosh C, Aittokallio T, Matikainen S, Nyman TA.

Mol Cell Proteomics. 2014 Oct;13(10):2604-17. doi: 10.1074/mcp.M114.038968. Epub 2014 Jul 5.

25.

Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages.

Öhman T, Teirilä L, Lahesmaa-Korpinen AM, Cypryk W, Veckman V, Saijo S, Wolff H, Hautaniemi S, Nyman TA, Matikainen S.

J Immunol. 2014 Jun 15;192(12):5952-62. doi: 10.4049/jimmunol.1303213. Epub 2014 May 7.

26.

Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

Denisova OV, Söderholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, Desloovere J, Tynell J, Ikonen N, Theisen LL, Nyman TA, Matikainen S, Kallioniemi O, Julkunen I, Muller CP, Saelens X, Verkhusha VV, Kainov DE.

Antimicrob Agents Chemother. 2014 Jul;58(7):3689-96. doi: 10.1128/AAC.02798-13. Epub 2014 Apr 21.

27.

Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation.

Cypryk W, Ohman T, Eskelinen EL, Matikainen S, Nyman TA.

J Proteome Res. 2014 May 2;13(5):2468-77. doi: 10.1021/pr4012552. Epub 2014 Apr 16.

PMID:
24670152
28.

Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway.

Kankkunen P, Välimäki E, Rintahaka J, Palomäki J, Nyman T, Alenius H, Wolff H, Matikainen S.

Hum Immunol. 2014 Feb;75(2):134-40. doi: 10.1016/j.humimm.2013.11.010. Epub 2013 Nov 20.

PMID:
24269698
29.

Partial sleep restriction activates immune response-related gene expression pathways: experimental and epidemiological studies in humans.

Aho V, Ollila HM, Rantanen V, Kronholm E, Surakka I, van Leeuwen WM, Lehto M, Matikainen S, Ripatti S, Härmä M, Sallinen M, Salomaa V, Jauhiainen M, Alenius H, Paunio T, Porkka-Heiskanen T.

PLoS One. 2013 Oct 23;8(10):e77184. doi: 10.1371/journal.pone.0077184. eCollection 2013.

30.

Intracellular RNA recognition pathway activates strong anti-viral response in human mast cells.

Lappalainen J, Rintahaka J, Kovanen PT, Matikainen S, Eklund KK.

Clin Exp Immunol. 2013 Apr;172(1):121-8. doi: 10.1111/cei.12042.

31.

Normal inflammasome activation and low production of IL-23 by monocyte-derived macrophages from subjects with a history of reactive arthritis.

Välimäki E, Aittomäki S, Karenko L, Kantonen J, Pettersson T, Turunen U, Matikainen S, Leirisalo-Repo M, Repo H.

Scand J Rheumatol. 2013;42(4):294-8. doi: 10.3109/03009742.2012.754940. Epub 2013 Feb 20.

PMID:
23425136
32.

Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages.

Välimäki E, Miettinen JJ, Lietzén N, Matikainen S, Nyman TA.

Mol Cell Proteomics. 2013 Mar;12(3):749-63. doi: 10.1074/mcp.M112.024661. Epub 2013 Jan 4.

33.

Global secretome characterization of herpes simplex virus 1-infected human primary macrophages.

Miettinen JJ, Matikainen S, Nyman TA.

J Virol. 2012 Dec;86(23):12770-8. doi: 10.1128/JVI.01545-12. Epub 2012 Sep 12.

34.

IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors.

Savinko T, Matikainen S, Saarialho-Kere U, Lehto M, Wang G, Lehtimäki S, Karisola P, Reunala T, Wolff H, Lauerma A, Alenius H.

J Invest Dermatol. 2012 May;132(5):1392-400. doi: 10.1038/jid.2011.446. Epub 2012 Jan 26.

35.

Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA.

Berg RK, Melchjorsen J, Rintahaka J, Diget E, Søby S, Horan KA, Gorelick RJ, Matikainen S, Larsen CS, Ostergaard L, Paludan SR, Mogensen TH.

PLoS One. 2012;7(1):e29291. doi: 10.1371/journal.pone.0029291. Epub 2012 Jan 3.

36.

Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism.

Palomäki J, Välimäki E, Sund J, Vippola M, Clausen PA, Jensen KA, Savolainen K, Matikainen S, Alenius H.

ACS Nano. 2011 Sep 27;5(9):6861-70. doi: 10.1021/nn200595c. Epub 2011 Aug 3.

PMID:
21800904
37.

Quantitative subcellular proteome and secretome profiling of influenza A virus-infected human primary macrophages.

Lietzén N, Ohman T, Rintahaka J, Julkunen I, Aittokallio T, Matikainen S, Nyman TA.

PLoS Pathog. 2011 May;7(5):e1001340. doi: 10.1371/journal.ppat.1001340. Epub 2011 May 12.

38.

Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.

Niemi K, Teirilä L, Lappalainen J, Rajamäki K, Baumann MH, Öörni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK.

J Immunol. 2011 Jun 1;186(11):6119-28. doi: 10.4049/jimmunol.1002843. Epub 2011 Apr 20.

39.

Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders.

Rechardt M, Shiri R, Matikainen S, Viikari-Juntura E, Karppinen J, Alenius H.

Cytokine. 2011 May;54(2):149-53. doi: 10.1016/j.cyto.2011.02.003. Epub 2011 Mar 2.

PMID:
21371906
40.

Setting up TRAPS.

Pettersson T, Kantonen J, Matikainen S, Repo H.

Ann Med. 2012 Mar;44(2):109-18. doi: 10.3109/07853890.2010.548399. Epub 2011 Feb 1. Review.

PMID:
21284532
41.

Recognition of cytoplasmic RNA results in cathepsin-dependent inflammasome activation and apoptosis in human macrophages.

Rintahaka J, Lietzén N, Öhman T, Nyman TA, Matikainen S.

J Immunol. 2011 Mar 1;186(5):3085-92. doi: 10.4049/jimmunol.1002051. Epub 2011 Jan 21.

42.

Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways.

Melchjorsen J, Rintahaka J, Søby S, Horan KA, Poltajainen A, Østergaard L, Paludan SR, Matikainen S.

J Virol. 2010 Nov;84(21):11350-8. doi: 10.1128/JVI.01106-10. Epub 2010 Aug 25.

43.

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.

Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT, Eklund KK.

PLoS One. 2010 Jul 23;5(7):e11765. doi: 10.1371/journal.pone.0011765.

44.

Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model.

Lehtimäki S, Tillander S, Puustinen A, Matikainen S, Nyman T, Fyhrquist N, Savinko T, Majuri ML, Wolff H, Alenius H, Lauerma A.

J Invest Dermatol. 2010 Dec;130(12):2743-51. doi: 10.1038/jid.2010.208. Epub 2010 Jul 15.

45.

(1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages.

Kankkunen P, Teirilä L, Rintahaka J, Alenius H, Wolff H, Matikainen S.

J Immunol. 2010 Jun 1;184(11):6335-42. doi: 10.4049/jimmunol.0903019. Epub 2010 Apr 26.

46.

MK2 signaling: lessons on tissue specificity in modulation of inflammation.

Fyhrquist N, Matikainen S, Lauerma A.

J Invest Dermatol. 2010 Feb;130(2):342-4. doi: 10.1038/jid.2009.372.

47.

Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes.

Ohman T, Lietzén N, Välimäki E, Melchjorsen J, Matikainen S, Nyman TA.

J Proteome Res. 2010 Mar 5;9(3):1549-64. doi: 10.1021/pr901040u.

PMID:
20070120
48.

ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses.

Pulkkinen V, Bruce S, Rintahaka J, Hodgson U, Laitinen T, Alenius H, Kinnula VL, Myllärniemi M, Matikainen S, Kere J.

FASEB J. 2010 Apr;24(4):1167-77. doi: 10.1096/fj.09-138545. Epub 2009 Dec 4.

PMID:
19966137
49.

Activation and evasion of innate antiviral immunity by herpes simplex virus.

Melchjorsen J, Matikainen S, Paludan SR.

Viruses. 2009 Dec;1(3):737-59. doi: 10.3390/v1030737. Epub 2009 Nov 5.

50.

Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice.

Rossi EM, Pylkkänen L, Koivisto AJ, Vippola M, Jensen KA, Miettinen M, Sirola K, Nykäsenoja H, Karisola P, Stjernvall T, Vanhala E, Kiilunen M, Pasanen P, Mäkinen M, Hämeri K, Joutsensaari J, Tuomi T, Jokiniemi J, Wolff H, Savolainen K, Matikainen S, Alenius H.

Toxicol Sci. 2010 Feb;113(2):422-33. doi: 10.1093/toxsci/kfp254. Epub 2009 Oct 29.

PMID:
19875681

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