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Items: 48

1.

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid.

Van den Bossche A, Varet H, Sury A, Sismeiro O, Legendre R, Coppee JY, Mathys V, Ceyssens PJ.

Tuberculosis (Edinb). 2019 Jul;117:18-23. doi: 10.1016/j.tube.2019.05.002. Epub 2019 May 15.

2.

In vitro activity of bedaquiline against slow-growing nontuberculous mycobacteria.

Martin A, Godino IT, Aguilar-Ayala DA, Mathys V, Lounis N, Villalobos HR.

J Med Microbiol. 2019 Aug;68(8):1137-1139. doi: 10.1099/jmm.0.001025. Epub 2019 Jun 18.

PMID:
31210631
3.

Strong increase of true and false positive mycobacterial cultures sent to the National Reference Centre in Belgium, 2007 to 2016.

Soetaert K, Subissi L, Ceyssens PJ, Vanfleteren B, Chantrenne M, Asikainen T, Duysburgh E, Mathys V.

Euro Surveill. 2019 Mar;24(11). doi: 10.2807/1560-7917.ES.2019.24.11.1800205.

4.

Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

Zeng S, Soetaert K, Ravon F, Vandeput M, Bald D, Kauffmann JM, Mathys V, Wattiez R, Fontaine V.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01841-18. doi: 10.1128/AAC.01841-18. Print 2019 Mar.

5.

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.

CRyPTIC Consortium and the 100,000 Genomes Project, Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I, Caulfield MJ, Chaiprasert A, Cirillo DM, Clifton DA, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R, Drobniewski FA, Faksri K, Farhat MR, Fleming J, Fowler P, Fowler TA, Gao Q, Gardy J, Gascoyne-Binzi D, Gibertoni-Cruz AL, Gil-Brusola A, Golubchik T, Gonzalo X, Grandjean L, He G, Guthrie JL, Hoosdally S, Hunt M, Iqbal Z, Ismail N, Johnston J, Khanzada FM, Khor CC, Kohl TA, Kong C, Lipworth S, Liu Q, Maphalala G, Martinez E, Mathys V, Merker M, Miotto P, Mistry N, Moore DAJ, Murray M, Niemann S, Omar SV, Ong RT, Peto TEA, Posey JE, Prammananan T, Pym A, Rodrigues C, Rodrigues M, Rodwell T, Rossolini GM, Sánchez Padilla E, Schito M, Shen X, Shendure J, Sintchenko V, Sloutsky A, Smith EG, Snyder M, Soetaert K, Starks AM, Supply P, Suriyapol P, Tahseen S, Tang P, Teo YY, Thuong TNT, Thwaites G, Tortoli E, van Soolingen D, Walker AS, Walker TM, Wilcox M, Wilson DJ, Wyllie D, Yang Y, Zhang H, Zhao Y, Zhu B.

N Engl J Med. 2018 Oct 11;379(15):1403-1415. doi: 10.1056/NEJMoa1800474. Epub 2018 Sep 26.

6.

Aloe Emodin Reduces Phthiodiolone Dimycocerosate Potentiating Vancomycin Susceptibility on Mycobacteria.

Rens C, Ceyssens PJ, Laval F, Lefèvre P, Mathys V, Daffé M, Fontaine V.

Indian J Microbiol. 2018 Sep;58(3):393-396. doi: 10.1007/s12088-018-0734-0. Epub 2018 May 4.

7.

The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis.

Whitfield MG, Warren RM, Mathys V, Scott L, De Vos E, Stevens W, Streicher EM, Groenen G, Sirgel FA, Van Rie A.

J Antimicrob Chemother. 2018 Oct 1;73(10):2667-2674. doi: 10.1093/jac/dky248.

8.

Time-and-motion tool for the assessment of working time in tuberculosis laboratories: a multicentre study.

Mathys V, Roycroft E, Raftery P, Groenheit R, Folkvardsen DB, Homorodean D, Vasiliauskiene E, Vasiliauskaite L, Kodmon C, van der Werf MJ, Drobniewski F, Nikolayevskyy V.

Int J Tuberc Lung Dis. 2018 Apr 1;22(4):444-451. doi: 10.5588/ijtld.17.0564.

9.

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.

Walker TM, Merker M, Knoblauch AM, Helbling P, Schoch OD, van der Werf MJ, Kranzer K, Fiebig L, Kröger S, Haas W, Hoffmann H, Indra A, Egli A, Cirillo DM, Robert J, Rogers TR, Groenheit R, Mengshoel AT, Mathys V, Haanperä M, Soolingen DV, Niemann S, Böttger EC, Keller PM; MDR-TB Cluster Consortium.

Lancet Infect Dis. 2018 Apr;18(4):431-440. doi: 10.1016/S1473-3099(18)30004-5. Epub 2018 Jan 8. Erratum in: Lancet Infect Dis. 2018 Jan 10;:.

10.

Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.

Payen MC, Muylle I, Vandenberg O, Mathys V, Delforge M, Van den Wijngaert S, Clumeck N, De Wit S.

Int J Tuberc Lung Dis. 2018 Jan 1;22(1):34-39. doi: 10.5588/ijtld.17.0352.

PMID:
29297423
11.

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K, Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkönig A, Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P, Gitzinger M, Déprez B, Willand N, Baulard AR.

Science. 2017 Mar 17;355(6330):1206-1211. doi: 10.1126/science.aag1006. Epub 2017 Mar 16.

PMID:
28302858
12.

Trend analysis suggested a change in subspecies among Mycobacterium avium isolated from pigs in Belgium, 1967-2013.

Soetaert K, Vluggen C, Duytschaever L, Denoël J, Roupie V, Smeets F, Bruffaerts N, Huygen K, Fretin D, Diels M, Rigouts L, Saegerman C, Mathys V.

Vet Rec. 2017 May 6;180(18):449. doi: 10.1136/vr.103951. Epub 2017 Mar 10. No abstract available.

13.

Molecular epidemiology of Mycobacterium tuberculosis complex in Brussels, 2010-2013.

Vluggen C, Soetaert K, Groenen G, Wanlin M, Spitaels M, Arrazola de Oñate W, Fauville-Dufaux M, Saegerman C, Mathys V.

PLoS One. 2017 Feb 21;12(2):e0172554. doi: 10.1371/journal.pone.0172554. eCollection 2017.

14.

Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection.

Bruffaerts N, Vluggen C, Roupie V, Duytschaever L, Van den Poel C, Denoël J, Wattiez R, Letesson JJ, Fretin D, Rigouts L, Chapeira O, Mathys V, Saegerman C, Huygen K.

PLoS One. 2017 Feb 9;12(2):e0171895. doi: 10.1371/journal.pone.0171895. eCollection 2017.

15.

Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Combined Species Identification and Drug Sensitivity Testing in Mycobacteria.

Ceyssens PJ, Soetaert K, Timke M, Van den Bossche A, Sparbier K, De Cremer K, Kostrzewa M, Hendrickx M, Mathys V.

J Clin Microbiol. 2017 Feb;55(2):624-634. doi: 10.1128/JCM.02089-16. Epub 2016 Dec 21.

16.

Frequency of Mycobacterium chimaera among Belgian patients, 2015.

Soetaert K, Vluggen C, André E, Vanhoof R, Vanfleteren B, Mathys V.

J Med Microbiol. 2016 Nov;65(11):1307-1310. doi: 10.1099/jmm.0.000359.

PMID:
27902393
17.

Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria.

Andre E, Goeminne L, Cabibbe A, Beckert P, Kabamba Mukadi B, Mathys V, Gagneux S, Niemann S, Van Ingen J, Cambau E.

Clin Microbiol Infect. 2017 Mar;23(3):167-172. doi: 10.1016/j.cmi.2016.09.006. Epub 2016 Sep 21. Review.

18.

Nontuberculous mycobacteria among pulmonary tuberculosis patients: a retrospective Belgian multicenter study.

De Keukeleire S, Mathys V, Van den Wijngaert S, Van De Vyvere M, Jonckheere S, De Beenhouwer H, De Bel A, Arrazola de Onate W, Wanlin M, Piérard D, Nulens E, Saegeman V.

Acta Clin Belg. 2017 Feb;72(1):45-48. doi: 10.1080/17843286.2016.1200823. Epub 2016 Jun 24.

PMID:
27345031
19.

Genome Sequences of Four Strains of Mycobacterium avium subsp. hominissuis, Isolated from Swine and Humans, Differing in Virulence in a Murine Intranasal Infection Model.

Bruffaerts N, Vluggen C, Duytschaever L, Mathys V, Saegerman C, Chapeira O, Huygen K.

Genome Announc. 2016 Jun 16;4(3). pii: e00533-16. doi: 10.1128/genomeA.00533-16.

20.

Genotyping and strain distribution of Mycobacterium avium subspecies hominissuis isolated from humans and pigs in Belgium, 2011-2013.

Vluggen C, Soetaert K, Duytschaever L, Denoël J, Fauville-Dufaux M, Smeets F, Bruffaerts N, Huygen K, Fretin D, Rigouts L, Saegerman C, Mathys V.

Euro Surveill. 2016;21(3):30111. doi: 10.2807/1560-7917.ES.2016.21.3.30111.

21.

Synthesis and anti-tubercular activity of N(2)-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides.

Rotthier G, Cappoen D, Nguyen QT, Dang Thi TA, Mathys V, Nguyen VT, Huygen K, Maes L, Cos P, Abbaspour Tehrani K.

Org Biomol Chem. 2016 Feb 14;14(6):2041-51. doi: 10.1039/c5ob02138c.

PMID:
26763748
22.

Case report of a false positive result of the Xpert® MTB/RIF assay for rifampicin resistance in Mycobacterium tuberculosis complex.

Claessens J, Mathys V, Derdelinckx I, Saegeman V.

Acta Clin Belg. 2017 Jun;72(3):195-197. doi: 10.1179/2295333715Y.0000000072. Epub 2016 Jun 10.

PMID:
26400761
23.

Efficacy of mechanical postconditioning following warm, global ischaemia depends on circulating fatty acid levels in an isolated, working rat heart model†.

Bartkevics M, Huber S, Mathys V, Sourdon J, Dornbierer M, Carmona Mendez N, Gahl B, Carrel TP, Tevaearai Stahel HT, Longnus SL.

Eur J Cardiothorac Surg. 2016 Jan;49(1):32-9. doi: 10.1093/ejcts/ezv008. Epub 2015 Feb 17.

PMID:
25694472
24.

Evaluation of the Speed-Oligo Mycobacteria assay for the identification of nontuberculous mycobacteria.

Ramis IB, Cnockaert M, Von Groll A, Mathys V, Simon A, Tortoli E, Palomino JC, Almeida da Silva PE, Vandamme P, Andre E, Martin A.

J Med Microbiol. 2015 Mar;64(Pt 3):283-7. doi: 10.1099/jmm.0.000025. Epub 2015 Jan 16.

PMID:
25596120
25.

False-positive rifampicin resistance on Xpert® MTB/RIF caused by a silent mutation in the rpoB gene.

Mathys V, van de Vyvere M, de Droogh E, Soetaert K, Groenen G.

Int J Tuberc Lung Dis. 2014 Oct;18(10):1255-7. doi: 10.5588/ijtld.14.0297.

PMID:
25216843
26.

Prolonged activity of the pestiviral RNase Erns as an interferon antagonist after uptake by clathrin-mediated endocytosis.

Zürcher C, Sauter KS, Mathys V, Wyss F, Schweizer M.

J Virol. 2014 Jul;88(13):7235-43. doi: 10.1128/JVI.00672-14. Epub 2014 Apr 16.

27.

Heart transplantation with donation after circulatory determination of death.

Longnus SL, Mathys V, Dornbierer M, Dick F, Carrel TP, Tevaearai HT.

Nat Rev Cardiol. 2014 Jun;11(6):354-63. doi: 10.1038/nrcardio.2014.45. Epub 2014 Apr 15. Review.

PMID:
24736758
28.

2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.

Claes P, Cappoen D, Uythethofken C, Jacobs J, Mertens B, Mathys V, Verschaeve L, Huygen K, De Kimpe N.

Eur J Med Chem. 2014 Apr 22;77:409-21. doi: 10.1016/j.ejmech.2014.03.024. Epub 2014 Mar 12.

PMID:
24681334
29.

Anti-mycobacterial activity of 1,3-diaryltriazenes.

Cappoen D, Vajs J, Uythethofken C, Virag A, Mathys V, Kočevar M, Verschaeve L, Gazvoda M, Polanc S, Huygen K, Košmrlj J.

Eur J Med Chem. 2014 Apr 22;77:193-203. doi: 10.1016/j.ejmech.2014.02.065. Epub 2014 Mar 1.

PMID:
24631899
30.

1,2,3,4,8,9,10,11-octahydrobenzo[j]phenanthridine-7,12-diones as new leads against Mycobacterium tuberculosis.

Cappoen D, Claes P, Jacobs J, Anthonissen R, Mathys V, Verschaeve L, Huygen K, De Kimpe N.

J Med Chem. 2014 Apr 10;57(7):2895-907. doi: 10.1021/jm401735w. Epub 2014 Mar 21.

PMID:
24611928
31.

Biological evaluation of diazene derivatives as anti-tubercular compounds.

Cappoen D, Majce V, Uythethofken C, Urankar D, Mathys V, Kočevar M, Verschaeve L, Polanc S, Huygen K, Košmrlj J.

Eur J Med Chem. 2014 Mar 3;74:85-94. doi: 10.1016/j.ejmech.2013.12.057. Epub 2014 Jan 8.

PMID:
24448419
32.

Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine.

Claes P, Cappoen D, Mbala BM, Jacobs J, Mertens B, Mathys V, Verschaeve L, Huygen K, De Kimpe N.

Eur J Med Chem. 2013 Sep;67:98-110. doi: 10.1016/j.ejmech.2013.06.010. Epub 2013 Jun 18.

PMID:
23850570
33.

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.

Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR.

J Biol Chem. 2013 Aug 9;288(32):23447-56. doi: 10.1074/jbc.M113.475798. Epub 2013 Jun 18. Erratum in: J Biol Chem. 2013 Oct 4;288(40):28951.

34.

From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study.

Stoffels K, Allix-Béguec C, Groenen G, Wanlin M, Berkvens D, Mathys V, Supply P, Fauville-Dufaux M.

PLoS One. 2013 May 9;8(5):e63128. doi: 10.1371/journal.pone.0063128. Print 2013.

35.

Biological evaluation of bisbenzaldehydes against four Mycobacterium species.

Cappoen D, Forge D, Vercammen F, Mathys V, Kiass M, Roupie V, Anthonissen R, Verschaeve L, Vanden Eynde JJ, Huygen K.

Eur J Med Chem. 2013 May;63:731-8. doi: 10.1016/j.ejmech.2013.03.023. Epub 2013 Mar 18.

PMID:
23567963
36.

Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.

Stoffels K, Mathys V, Fauville-Dufaux M, Wintjens R, Bifani P.

Antimicrob Agents Chemother. 2012 Oct;56(10):5186-93. doi: 10.1128/AAC.05385-11. Epub 2012 Jul 23.

37.

Urease activity represents an alternative pathway for Mycobacterium tuberculosis nitrogen metabolism.

Lin W, Mathys V, Ang EL, Koh VH, Martínez Gómez JM, Ang ML, Zainul Rahim SZ, Tan MP, Pethe K, Alonso S.

Infect Immun. 2012 Aug;80(8):2771-9. doi: 10.1128/IAI.06195-11. Epub 2012 May 29.

38.

Evolutionary changes in antimicrobial resistance of invasive Neisseria meningitidis isolates in Belgium from 2000 to 2010: increasing prevalence of penicillin nonsusceptibility.

Bertrand S, Carion F, Wintjens R, Mathys V, Vanhoof R.

Antimicrob Agents Chemother. 2012 May;56(5):2268-72. doi: 10.1128/AAC.06310-11. Epub 2012 Jan 30.

39.

BCG induces protection against Mycobacterium tuberculosis infection in the Wistar rat model.

Singhal A, Mathys V, Kiass M, Creusy C, Delaire B, Aliouat el M, Dartois V, Kaplan G, Bifani P.

PLoS One. 2011;6(12):e28082. doi: 10.1371/journal.pone.0028082. Epub 2011 Dec 5.

40.

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors.

Flipo M, Desroses M, Lecat-Guillet N, Villemagne B, Blondiaux N, Leroux F, Piveteau C, Mathys V, Flament MP, Siepmann J, Villeret V, Wohlkönig A, Wintjens R, Soror SH, Christophe T, Jeon HK, Locht C, Brodin P, Déprez B, Baulard AR, Willand N.

J Med Chem. 2012 Jan 12;55(1):68-83. doi: 10.1021/jm200825u. Epub 2011 Dec 6.

PMID:
22098589
41.

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.

Heng Y, Seah PG, Siew JY, Tay HC, Singhal A, Mathys V, Kiass M, Bifani P, Dartois V, Hervé M.

Tuberculosis (Edinb). 2011 Jul;91(4):339-41. doi: 10.1016/j.tube.2011.05.003. Epub 2011 Jun 1.

PMID:
21636324
42.

Experimental tuberculosis in the Wistar rat: a model for protective immunity and control of infection.

Singhal A, Aliouat el M, Hervé M, Mathys V, Kiass M, Creusy C, Delaire B, Tsenova L, Fleurisse L, Bertout J, Camacho L, Foo D, Tay HC, Siew JY, Boukhouchi W, Romano M, Mathema B, Dartois V, Kaplan G, Bifani P.

PLoS One. 2011 Apr 12;6(4):e18632. doi: 10.1371/journal.pone.0018632.

43.

Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study.

Mäkinen J, Marjamäki M, Haanperä-Heikkinen M, Marttila H, Endourova LB, Presnova SE, Mathys V, Bifani P, Ruohonen R, Viljanen MK, Soini H.

Eur J Clin Microbiol Infect Dis. 2011 Sep;30(9):1119-26. doi: 10.1007/s10096-011-1200-7. Epub 2011 Mar 11.

PMID:
21394425
44.

Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.

Vanzembergh F, Peirs P, Lefevre P, Celio N, Mathys V, Content J, Kalai M.

Tuberculosis (Edinb). 2010 Nov;90(6):338-45. doi: 10.1016/j.tube.2010.09.004. Epub 2010 Oct 8.

PMID:
20933472
45.

Synthetic EthR inhibitors boost antituberculous activity of ethionamide.

Willand N, Dirié B, Carette X, Bifani P, Singhal A, Desroses M, Leroux F, Willery E, Mathys V, Déprez-Poulain R, Delcroix G, Frénois F, Aumercier M, Locht C, Villeret V, Déprez B, Baulard AR.

Nat Med. 2009 May;15(5):537-44. doi: 10.1038/nm.1950. Epub 2009 May 3.

PMID:
19412174
46.

Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.

Mathys V, Wintjens R, Lefevre P, Bertout J, Singhal A, Kiass M, Kurepina N, Wang XM, Mathema B, Baulard A, Kreiswirth BN, Bifani P.

Antimicrob Agents Chemother. 2009 May;53(5):2100-9. doi: 10.1128/AAC.01197-08. Epub 2009 Feb 23.

47.

Salmonella enterica serovar typhi: molecular analysis of strains with decreased susceptibility and resistant to ciprofloxacin in India from 2001-2003.

Capoor MR, Nair D, Aggarwal P, Mathys V, Dehem M, Bifani PJ.

Braz J Infect Dis. 2007 Aug;11(4):423-5.

PMID:
17873998
48.

Detection of human papillomavirus types 45 and 51 by type-specific polymerase chain reaction.

Weyn C, Boulenouar S, Mathys V, Vanhoolandt J, Bernis A, Fontaine V; RIIP and INCTR Workshop Study Group.

J Virol Methods. 2007 Dec;146(1-2):405-8. Epub 2007 Sep 14.

PMID:
17868914

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