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Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Hurcombe JA, Hartley P, Lay AC, Ni L, Bedford JJ, Leader JP, Singh S, Murphy A, Scudamore CL, Marquez E, Barrington AF, Pinto V, Marchetti M, Wong LF, Uney J, Saleem MA, Mathieson PW, Patel S, Walker RJ, Woodgett JR, Quaggin SE, Welsh GI, Coward RJM.

Nat Commun. 2019 Jan 24;10(1):403. doi: 10.1038/s41467-018-08235-1.


Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1.

May O, Merle NS, Grunenwald A, Gnemmi V, Leon J, Payet C, Robe-Rybkine T, Paule R, Delguste F, Satchell SC, Mathieson PW, Hazzan M, Boulanger E, Dimitrov JD, Fremeaux-Bacchi V, Frimat M, Roumenina LT.

Front Immunol. 2018 Dec 20;9:3008. doi: 10.3389/fimmu.2018.03008. eCollection 2018.


VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy.

Onions KL, Gamez M, Buckner NR, Baker SL, Betteridge KB, Desideri S, Dallyn BP, Ramnath RD, Neal CR, Farmer LK, Mathieson PW, Gnudi L, Alitalo K, Bates DO, Salmon AHJ, Welsh GI, Satchell SC, Foster RR.

Diabetes. 2019 Jan;68(1):172-187. doi: 10.2337/db18-0045. Epub 2018 Nov 2.


Academic medicine should lead the way on gender equity: but it doesn't.

Mathieson PW.

Postgrad Med J. 2017 Dec;93(1106):717-718. doi: 10.1136/postgradmedj-2017-134931. Epub 2017 Aug 4. No abstract available.


RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways.

Jiang L, Hindmarch CC, Rogers M, Campbell C, Waterfall C, Coghill J, Mathieson PW, Welsh GI.

Sci Rep. 2016 Oct 24;6:35671. doi: 10.1038/srep35671.


MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

Yeung ML, Yao Y, Jia L, Chan JF, Chan KH, Cheung KF, Chen H, Poon VK, Tsang AK, To KK, Yiu MK, Teng JL, Chu H, Zhou J, Zhang Q, Deng W, Lau SK, Lau JY, Woo PC, Chan TM, Yung S, Zheng BJ, Jin DY, Mathieson PW, Qin C, Yuen KY.

Nat Microbiol. 2016 Feb 22;1:16004. doi: 10.1038/nmicrobiol.2016.4.


Nuclear translocation of IQGAP1 protein upon exposure to puromycin aminonucleoside in cultured human podocytes: ERK pathway involvement.

Rigothier C, Saleem MA, Bourget C, Mathieson PW, Combe C, Welsh GI.

Cell Signal. 2016 Oct;28(10):1470-8. doi: 10.1016/j.cellsig.2016.06.017. Epub 2016 Jul 1.


NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.

Narita I, Shimada M, Yamabe H, Kinjo T, Tanno T, Nishizaki K, Kawai M, Nakamura M, Murakami R, Nakamura N, Tomita H, Saleem MA, Mathieson PW, Okumura K.

Clin Exp Nephrol. 2016 Oct;20(5):679-688. Epub 2015 Dec 29.


Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells.

Leung JC, Chan LY, Saleem MA, Mathieson PW, Tang SC, Lai KN.

Apoptosis. 2015 Jul;20(7):907-20. doi: 10.1007/s10495-015-1117-1.


Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the kidney podocyte.

Jiang L, Dasgupta I, Hurcombe JA, Colyer HF, Mathieson PW, Welsh GI.

Clin Sci (Lond). 2015 Jun;128(12):883-93. doi: 10.1042/CS20140749.


Hyperglycemia enhances kidney cell injury in HIVAN through down-regulation of vitamin D receptors.

Rai P, Singh T, Lederman R, Chawla A, Kumar D, Cheng K, Valecha G, Mathieson PW, Saleem MA, Malhotra A, Singhal PC.

Cell Signal. 2015 Mar;27(3):460-9. doi: 10.1016/j.cellsig.2014.12.011. Epub 2014 Dec 24.


Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction.

Ramnath R, Foster RR, Qiu Y, Cope G, Butler MJ, Salmon AH, Mathieson PW, Coward RJ, Welsh GI, Satchell SC.

FASEB J. 2014 Nov;28(11):4686-99. doi: 10.1096/fj.14-252221. Epub 2014 Aug 13.


Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.

Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, Cheng D, Saleem MA, Satchell SC, Banas B, Mathieson PW, Kretzler M, Hemal AK, Rudel LL, Petrovic S, Weckerle A, Pollak MR, Ross MD, Parks JS, Freedman BI.

J Am Soc Nephrol. 2015 Feb;26(2):339-48. doi: 10.1681/ASN.2013091017. Epub 2014 Jul 10.


APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability.

Lan X, Jhaveri A, Cheng K, Wen H, Saleem MA, Mathieson PW, Mikulak J, Aviram S, Malhotra A, Skorecki K, Singhal PC.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F326-36. doi: 10.1152/ajprenal.00647.2013. Epub 2014 Jun 4.


Glomerular cell cross-talk influences composition and assembly of extracellular matrix.

Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R.

J Am Soc Nephrol. 2014 May;25(5):953-66. doi: 10.1681/ASN.2013070795. Epub 2014 Jan 16.


Immunosuppression for membranous nephropathy - Authors' reply.

Mathieson PW.

Lancet. 2013 Jun 22;381(9884):2163. doi: 10.1016/S0140-6736(13)61436-1. No abstract available.


Glycosaminoglycan regulation by VEGFA and VEGFC of the glomerular microvascular endothelial cell glycocalyx in vitro.

Foster RR, Armstrong L, Baker S, Wong DW, Wylie EC, Ramnath R, Jenkins R, Singh A, Steadman R, Welsh GI, Mathieson PW, Satchell SC.

Am J Pathol. 2013 Aug;183(2):604-16. doi: 10.1016/j.ajpath.2013.04.019. Epub 2013 Jun 12.


Insulin directly stimulates VEGF-A production in the glomerular podocyte.

Hale LJ, Hurcombe J, Lay A, Santamaría B, Valverde AM, Saleem MA, Mathieson PW, Welsh GI, Coward RJ.

Am J Physiol Renal Physiol. 2013 Jul 15;305(2):F182-8. doi: 10.1152/ajprenal.00548.2012. Epub 2013 May 22.


Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes.

Ishimoto T, Cara-Fuentes G, Wang H, Shimada M, Wasserfall CH, Winter WE, Rivard CJ, Araya CE, Saleem MA, Mathieson PW, Johnson RJ, Garin EH.

Pediatr Nephrol. 2013 Sep;28(9):1803-12. doi: 10.1007/s00467-013-2498-4. Epub 2013 May 21.


mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN.

Rai P, Plagov A, Lan X, Chandel N, Singh T, Lederman R, Ayasolla KR, Mathieson PW, Saleem MA, Husain M, Malhotra A, Chander PN, Singhal PC.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F343-54. doi: 10.1152/ajprenal.00135.2013. Epub 2013 May 15.


Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN).

Cheng K, Rai P, Plagov A, Lan X, Mathieson PW, Saleem MA, Husain M, Malhotra A, Singhal PC.

Exp Cell Res. 2013 Aug 1;319(13):2073-80. doi: 10.1016/j.yexcr.2013.04.011. Epub 2013 Apr 21.


Morphine induces albuminuria by compromising podocyte integrity.

Lan X, Rai P, Chandel N, Cheng K, Lederman R, Saleem MA, Mathieson PW, Husain M, Crosson JT, Gupta K, Malhotra A, Singhal PC.

PLoS One. 2013;8(3):e55748. doi: 10.1371/journal.pone.0055748. Epub 2013 Mar 29.


HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor.

Chandel N, Sharma B, Husain M, Salhan D, Singh T, Rai P, Mathieson PW, Saleem MA, Malhotra A, Singhal PC.

Am J Physiol Renal Physiol. 2013 Jun 1;304(11):F1347-57. doi: 10.1152/ajprenal.00717.2012. Epub 2013 Mar 6.


Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx.

Singh A, Ramnath RD, Foster RR, Wylie EC, Fridén V, Dasgupta I, Haraldsson B, Welsh GI, Mathieson PW, Satchell SC.

PLoS One. 2013;8(2):e55852. doi: 10.1371/journal.pone.0055852. Epub 2013 Feb 14.


Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy.

Coenen MJ, Hofstra JM, Debiec H, Stanescu HC, Medlar AJ, Stengel B, Boland-Augé A, Groothuismink JM, Bockenhauer D, Powis SH, Mathieson PW, Brenchley PE, Kleta R, Wetzels JF, Ronco P.

J Am Soc Nephrol. 2013 Mar;24(4):677-83. doi: 10.1681/ASN.2012070730. Epub 2013 Feb 21.


Immunosuppression for progressive membranous nephropathy: a UK randomised controlled trial.

Howman A, Chapman TL, Langdon MM, Ferguson C, Adu D, Feehally J, Gaskin GJ, Jayne DR, O'Donoghue D, Boulton-Jones M, Mathieson PW.

Lancet. 2013 Mar 2;381(9868):744-51. doi: 10.1016/S0140-6736(12)61566-9. Epub 2013 Jan 9.


Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse.

Hale LJ, Welsh GI, Perks CM, Hurcombe JA, Moore S, Hers I, Saleem MA, Mathieson PW, Murphy AJ, Jeansson M, Holly JM, Hardouin SN, Coward RJ.

J Pathol. 2013 May;230(1):95-106. doi: 10.1002/path.4165. Epub 2013 Mar 21.


The podocyte cytoskeleton in health and in disease.

Mathieson PW.

Clin Kidney J. 2012 Dec;5(6):498-501. doi: 10.1093/ckj/sfs153.


Membranous nephropathy.

Mathieson PW.

Clin Med (Lond). 2012 Oct;12(5):461-6. No abstract available.


Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN.

Rai P, Plagov A, Kumar D, Pathak S, Ayasolla KR, Chawla AK, Mathieson PW, Saleem MA, Husain M, Malhotra A, Singhal PC.

Exp Mol Pathol. 2013 Feb;94(1):255-61. doi: 10.1016/j.yexmp.2012.09.009. Epub 2012 Sep 23.


Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy.

Hofstra JM, Debiec H, Short CD, Pellé T, Kleta R, Mathieson PW, Ronco P, Brenchley PE, Wetzels JF.

J Am Soc Nephrol. 2012 Oct;23(10):1735-43. Epub 2012 Sep 6.


Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells.

Prabakaran T, Nielsen R, Satchell SC, Mathieson PW, Feldt-Rasmussen U, Sørensen SS, Christensen EI.

PLoS One. 2012;7(6):e39975. doi: 10.1371/journal.pone.0039975. Epub 2012 Jun 29.


Nef interaction with actin compromises human podocyte actin cytoskeletal integrity.

Tan R, Patni H, Tandon P, Luan L, Sharma B, Salhan D, Saleem MA, Mathieson PW, Malhotra A, Husain M, Upadhya P, Singhal PC.

Exp Mol Pathol. 2013 Feb;94(1):51-7. doi: 10.1016/j.yexmp.2012.06.001. Epub 2012 Jun 18.


Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes.

Slater SC, Ramnath RD, Uttridge K, Saleem MA, Cahill PA, Mathieson PW, Welsh GI, Satchell SC.

Int J Biochem Cell Biol. 2012 Sep;44(9):1482-90. doi: 10.1016/j.biocel.2012.05.020. Epub 2012 Jun 6.


IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro.

Rigothier C, Auguste P, Welsh GI, Lepreux S, Deminière C, Mathieson PW, Saleem MA, Ripoche J, Combe C.

PLoS One. 2012;7(5):e37695. doi: 10.1371/journal.pone.0037695. Epub 2012 May 25.


Podocyte culture: tricks of the trade.

Ni L, Saleem M, Mathieson PW.

Nephrology (Carlton). 2012 Aug;17(6):525-31. doi: 10.1111/j.1440-1797.2012.01619.x. Review.


MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation.

Asgeirsdóttir SA, van Solingen C, Kurniati NF, Zwiers PJ, Heeringa P, van Meurs M, Satchell SC, Saleem MA, Mathieson PW, Banas B, Kamps JA, Rabelink TJ, van Zonneveld AJ, Molema G.

Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1630-9. doi: 10.1152/ajprenal.00400.2011. Epub 2012 Mar 14.


Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.

Khurana S, Chakraborty S, Lam M, Liu Y, Su YT, Zhao X, Saleem MA, Mathieson PW, Bruggeman LA, Kao HY.

J Biol Chem. 2012 Apr 6;287(15):12027-35. doi: 10.1074/jbc.M112.345421. Epub 2012 Feb 17.


Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse.

Tanabe K, Lanaspa MA, Kitagawa W, Rivard CJ, Miyazaki M, Klawitter J, Schreiner GF, Saleem MA, Mathieson PW, Makino H, Johnson RJ, Nakagawa T.

Am J Physiol Renal Physiol. 2012 May 1;302(9):F1151-60. doi: 10.1152/ajprenal.00596.2011. Epub 2012 Feb 15.


A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.

Roumenina LT, Frimat M, Miller EC, Provot F, Dragon-Durey MA, Bordereau P, Bigot S, Hue C, Satchell SC, Mathieson PW, Mousson C, Noel C, Sautes-Fridman C, Halbwachs-Mecarelli L, Atkinson JP, Lionet A, Fremeaux-Bacchi V.

Blood. 2012 May 3;119(18):4182-91. doi: 10.1182/blood-2011-10-383281. Epub 2012 Jan 13.


Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration.

Hu N, Westra J, Rutgers A, Doornbos-Van der Meer B, Huitema MG, Stegeman CA, Abdulahad WH, Satchell SC, Mathieson PW, Heeringa P, Kallenberg CG.

Arthritis Res Ther. 2011;13(6):R201. doi: 10.1186/ar3534. Epub 2011 Dec 8.


The podocyte as a target for therapies--new and old.

Mathieson PW.

Nat Rev Nephrol. 2011 Nov 1;8(1):52-6. doi: 10.1038/nrneph.2011.171. Review.


HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II.

Sanchez-Niño MD, Sanz AB, Sanchez-Lopez E, Ruiz-Ortega M, Benito-Martin A, Saleem MA, Mathieson PW, Mezzano S, Egido J, Ortiz A.

Lab Invest. 2012 Jan;92(1):32-45. doi: 10.1038/labinvest.2011.138. Epub 2011 Sep 19.


Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation.

O'Flynn J, Flierman R, van der Pol P, Rops A, Satchell SC, Mathieson PW, van Kooten C, van der Vlag J, Berden JH, Daha MR.

Mol Immunol. 2011 Oct;49(1-2):75-83. doi: 10.1016/j.molimm.2011.07.020. Epub 2011 Aug 19.


Monocyte- and endothelial-derived microparticles induce an inflammatory phenotype in human podocytes.

Eyre J, Burton JO, Saleem MA, Mathieson PW, Topham PS, Brunskill NJ.

Nephron Exp Nephrol. 2011;119(3):e58-66. doi: 10.1159/000329575. Epub 2011 Aug 18.


Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase.

Bevan HS, Slater SC, Clarke H, Cahill PA, Mathieson PW, Welsh GI, Satchell SC.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F733-42. doi: 10.1152/ajprenal.00458.2010. Epub 2011 Jul 20.


An in vitro model of the glomerular capillary wall using electrospun collagen nanofibres in a bioartificial composite basement membrane.

Slater SC, Beachley V, Hayes T, Zhang D, Welsh GI, Saleem MA, Mathieson PW, Wen X, Su B, Satchell SC.

PLoS One. 2011;6(6):e20802. doi: 10.1371/journal.pone.0020802. Epub 2011 Jun 24.


Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-κB-dependent pathway.

Shimada M, Ishimoto T, Lee PY, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Wymer DT, Yamabe H, Mathieson PW, Saleem MA, Garin EH, Johnson RJ.

Nephrol Dial Transplant. 2012 Jan;27(1):81-9. doi: 10.1093/ndt/gfr271. Epub 2011 May 26.


Altered nephrin and podoplanin distribution is associated with disturbed polarity protein PARD-3 and PARD-6 expressions in podocytes from preeclampsia.

Zhao S, Gu Y, Coates G, Groome LJ, Saleem MA, Mathieson PW, Wang Y.

Reprod Sci. 2011 Aug;18(8):772-80. doi: 10.1177/1933719111398145. Epub 2011 Mar 21.


Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

Stanescu HC, Arcos-Burgos M, Medlar A, Bockenhauer D, Kottgen A, Dragomirescu L, Voinescu C, Patel N, Pearce K, Hubank M, Stephens HA, Laundy V, Padmanabhan S, Zawadzka A, Hofstra JM, Coenen MJ, den Heijer M, Kiemeney LA, Bacq-Daian D, Stengel B, Powis SH, Brenchley P, Feehally J, Rees AJ, Debiec H, Wetzels JF, Ronco P, Mathieson PW, Kleta R.

N Engl J Med. 2011 Feb 17;364(7):616-26. doi: 10.1056/NEJMoa1009742.

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