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Items: 29

1.

Structural Insights into the Process of GPCR-G Protein Complex Formation.

Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixà-González R, Mathiesen JM, Hildebrand PW, Kobilka BK.

Cell. 2019 May 16;177(5):1243-1251.e12. doi: 10.1016/j.cell.2019.04.021. Epub 2019 May 9.

PMID:
31080070
2.

Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Mar;567(7747):E10. doi: 10.1038/s41586-019-0983-z.

PMID:
30814739
3.

Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Erratum in: Nature. 2019 Mar;567(7747):E10.

PMID:
30675062
4.

A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors.

Vedel L, Bräuner-Osborne H, Mathiesen JM.

J Biomol Screen. 2015 Aug;20(7):849-57. doi: 10.1177/1087057115580019. Epub 2015 Apr 7.

PMID:
25851033
5.

mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery.

Mølck C, Harpsøe K, Gloriam DE, Mathiesen JM, Nielsen SM, Bräuner-Osborne H.

Neurochem Res. 2014 Oct;39(10):1862-75. doi: 10.1007/s11064-014-1248-8. Epub 2014 Feb 4.

PMID:
24493625
6.

Outcome of fetuses with short femur length detected at second-trimester anomaly scan: a national survey.

Mathiesen JM, Aksglaede L, Skibsted L, Petersen OB, Tabor A; Danish Fetal Medicine Study Group.

Ultrasound Obstet Gynecol. 2014 Aug;44(2):160-5. doi: 10.1002/uog.13286. Epub 2014 Jun 27.

7.

Real-time trafficking and signaling of the glucagon-like peptide-1 receptor.

Roed SN, Wismann P, Underwood CR, Kulahin N, Iversen H, Cappelen KA, Schäffer L, Lehtonen J, Hecksher-Soerensen J, Secher A, Mathiesen JM, Bräuner-Osborne H, Whistler JL, Knudsen SM, Waldhoer M.

Mol Cell Endocrinol. 2014 Feb 15;382(2):938-49. doi: 10.1016/j.mce.2013.11.010. Epub 2013 Nov 22.

8.

Diabetic nephropathy and microalbuminuria in pregnant women with type 1 and type 2 diabetes: prevalence, antihypertensive strategy, and pregnancy outcome.

Damm JA, Asbjörnsdóttir B, Callesen NF, Mathiesen JM, Ringholm L, Pedersen BW, Mathiesen ER.

Diabetes Care. 2013 Nov;36(11):3489-94. doi: 10.2337/dc13-1031. Epub 2013 Sep 5.

9.

Changes in basal rates and bolus calculator settings in insulin pumps during pregnancy in women with type 1 diabetes.

Mathiesen JM, Secher AL, Ringholm L, Nørgaard K, Hommel E, Andersen HU, Damm P, Mathiesen ER.

J Matern Fetal Neonatal Med. 2014 May;27(7):724-8. doi: 10.3109/14767058.2013.837444. Epub 2013 Sep 27.

PMID:
23981186
10.

cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors.

Mathiesen JM, Vedel L, Bräuner-Osborne H.

Methods Enzymol. 2013;522:191-207. doi: 10.1016/B978-0-12-407865-9.00011-X.

PMID:
23374187
11.

Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome.

Callesen NF, Damm J, Mathiesen JM, Ringholm L, Damm P, Mathiesen ER.

J Matern Fetal Neonatal Med. 2013 Apr;26(6):588-92. doi: 10.3109/14767058.2012.743523. Epub 2012 Dec 11.

PMID:
23211128
12.

Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.

Mølck C, Harpsøe K, Gloriam DE, Clausen RP, Madsen U, Pedersen LØ, Jimenez HN, Nielsen SM, Mathiesen JM, Bräuner-Osborne H.

Mol Pharmacol. 2012 Nov;82(5):929-37. doi: 10.1124/mol.112.078808. Epub 2012 Aug 16.

PMID:
22899869
13.

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.

Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S.

Nature. 2012 Mar 21;485(7398):321-6. doi: 10.1038/nature10954.

14.

Structure-activity relationships for negative allosteric mGluR5 modulators.

Kaae BH, Harpsøe K, Kvist T, Mathiesen JM, Mølck C, Gloriam D, Jimenez HN, Uberti MA, Nielsen SM, Nielsen B, Bräuner-Osborne H, Sauerberg P, Clausen RP, Madsen U.

ChemMedChem. 2012 Mar 5;7(3):440-51. doi: 10.1002/cmdc.201100578. Epub 2012 Jan 20.

PMID:
22267204
15.

Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK.

Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361.

16.

1,2,3-triazolyl amino acids as AMPA receptor ligands.

Stanley NJ, Pedersen DS, Nielsen B, Kvist T, Mathiesen JM, Bräuner-Osborne H, Taylor DK, Abell AD.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7512-5. doi: 10.1016/j.bmcl.2010.09.139. Epub 2010 Oct 14.

PMID:
21036612
17.

A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity.

Stanley NJ, Hutchinson MR, Kvist T, Nielsen B, Mathiesen JM, Bräuner-Osborne H, Avery TD, Tiekink ER, Pedersen DS, Irvine RJ, Abell AD, Taylor DK.

Bioorg Med Chem. 2010 Aug 15;18(16):6089-98. doi: 10.1016/j.bmc.2010.06.051. Epub 2010 Jun 25.

PMID:
20638290
18.

Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists.

Grimstrup M, Receveur JM, Rist Ø, Frimurer TM, Nielsen PA, Mathiesen JM, Högberg T.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1638-41. doi: 10.1016/j.bmcl.2010.01.092. Epub 2010 Jan 22.

PMID:
20137942
19.

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2.

Grimstrup M, Rist Ø, Receveur JM, Frimurer TM, Ulven T, Mathiesen JM, Kostenis E, Högberg T.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1181-5. doi: 10.1016/j.bmcl.2009.12.015. Epub 2009 Dec 6.

PMID:
20022749
20.

The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.

Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E.

J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14.

21.

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.

Uller L, Mathiesen JM, Alenmyr L, Korsgren M, Ulven T, Högberg T, Andersson G, Persson CG, Kostenis E.

Respir Res. 2007 Feb 28;8:16.

22.

Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits.

Ulven T, Receveur JM, Grimstrup M, Rist Ø, Frimurer TM, Gerlach LO, Mathiesen JM, Kostenis E, Uller L, Högberg T.

J Med Chem. 2006 Nov 16;49(23):6638-41.

PMID:
17154491
23.
24.

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.

Mathiesen JM, Christopoulos A, Ulven T, Royer JF, Campillo M, Heinemann A, Pardo L, Kostenis E.

Mol Pharmacol. 2006 Apr;69(4):1441-53. Epub 2006 Jan 17.

PMID:
16418339
25.

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.

Ritzén A, Mathiesen JM, Thomsen C.

Basic Clin Pharmacol Toxicol. 2005 Oct;97(4):202-13. Review.

26.

Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.

Mathiesen JM, Ulven T, Martini L, Gerlach LO, Heinemann A, Kostenis E.

Mol Pharmacol. 2005 Aug;68(2):393-402. Epub 2005 May 3.

PMID:
15870392
27.

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.

Mathiesen JM, Svendsen N, Bräuner-Osborne H, Thomsen C, Ramirez MT.

Br J Pharmacol. 2003 Mar;138(6):1026-30.

28.

Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways.

Klein JB, Rane MJ, Scherzer JA, Coxon PY, Kettritz R, Mathiesen JM, Buridi A, McLeish KR.

J Immunol. 2000 Apr 15;164(8):4286-91.

29.

Regulation of expression of type II sodium-phosphate cotransporters by protein kinases A and C.

Lederer ED, Sohi SS, Mathiesen JM, Klein JB.

Am J Physiol. 1998 Aug;275(2):F270-7. doi: 10.1152/ajprenal.1998.275.2.F270.

PMID:
9691018

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