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Sustained Gazing Causes Measurable Decline in Visual Function of Patients with Dry Eye.

Akpek EK, Karakus S, Ramulu PY, Mathews PM.

Am J Ophthalmol. 2019 Oct 10. pii: S0002-9394(19)30498-2. doi: 10.1016/j.ajo.2019.10.009. [Epub ahead of print]


Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor.

Saadipour K, Tiberi A, Lomardo S, Grajales E, Montroull L, Mañucat-Tan NB, LaFrancois J, Cammer M, Mathews PM, Scharfman HE, Liao FF, Friedman WJ, Zhou XF, Tesco G, Chao MV.

Mol Cell Neurosci. 2019 Sep;99:103395. doi: 10.1016/j.mcn.2019.103395. Epub 2019 Aug 15.


Prevalence and Risk Factors of Exposure Keratopathy Across Different Intensive Care Units.

Hartford JB, Bian Y, Mathews PM, De Rojas J, Garg A, Rasool N, Schroder SK, Trief D.

Cornea. 2019 Sep;38(9):1124-1130. doi: 10.1097/ICO.0000000000001961.


Apolipoprotein E4 genotype compromises brain exosome production.

Peng KY, Pérez-González R, Alldred MJ, Goulbourne CN, Morales-Corraliza J, Saito M, Saito M, Ginsberg SD, Mathews PM, Levy E.

Brain. 2019 Jan 1;142(1):163-175. doi: 10.1093/brain/awy289.


Impact of Dry Eye on Prolonged Reading.

Karakus S, Mathews PM, Agrawal D, Henrich C, Ramulu PY, Akpek EK.

Optom Vis Sci. 2018 Dec;95(12):1105-1113. doi: 10.1097/OPX.0000000000001303.


High resolution approaches for the identification of amyloid fragments in brain.

Ross JA, Mathews PM, Van Bockstaele EJ.

J Neurosci Methods. 2019 May 1;319:7-15. doi: 10.1016/j.jneumeth.2018.10.032. Epub 2018 Oct 24. Review.


Corneal collagen crosslinking in patients treated with dextran versus isotonic hydroxypropyl methylcellulose (HPMC) riboflavin solution: a retrospective analysis.

Rapuano PB, Mathews PM, Florakis GJ, Trokel SL, Suh LH.

Eye Vis (Lond). 2018 Sep 10;5:23. doi: 10.1186/s40662-018-0116-z. eCollection 2018.


Correlation of Scheimpflug densitometry changes with clinical outcomes after corneal crosslinking.

Mathews PM, De Rojas JO, Rapuano PB, Zemsky CJ, Florakis GJ, Trokel SL, Suh LH.

J Cataract Refract Surg. 2018 Aug;44(8):993-1002. doi: 10.1016/j.jcrs.2018.05.016.


Etiology of Global Corneal Blindness and Current Practices of Corneal Transplantation: A Focused Review.

Mathews PM, Lindsley K, Aldave AJ, Akpek EK.

Cornea. 2018 Sep;37(9):1198-1203. doi: 10.1097/ICO.0000000000001666. Review.


Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice.

East BS, Fleming G, Peng K, Olofsson JK, Levy E, Mathews PM, Wilson DA.

Neuroscience. 2018 Jun 1;380:103-110. doi: 10.1016/j.neuroscience.2018.04.009. Epub 2018 Apr 18.


The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo.

Nuriel T, Peng KY, Ashok A, Dillman AA, Figueroa HY, Apuzzo J, Ambat J, Levy E, Cookson MR, Mathews PM, Duff KE.

Front Neurosci. 2017 Dec 12;11:702. doi: 10.3389/fnins.2017.00702. eCollection 2017.


Tear Osmolarity and Correlation With Ocular Surface Parameters in Patients With Dry Eye.

Mathews PM, Karakus S, Agrawal D, Hindman HB, Ramulu PY, Akpek EK.

Cornea. 2017 Nov;36(11):1352-1357. doi: 10.1097/ICO.0000000000001364.


Evaluating Structural Progression of Retinitis Pigmentosa After Cataract Surgery.

De Rojas JO, Schuerch K, Mathews PM, Cabral T, Hazan A, Sparrow J, Tsang SH, Suh LH.

Am J Ophthalmol. 2017 Aug;180:117-123. doi: 10.1016/j.ajo.2017.05.026. Epub 2017 Jun 8.


Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments.

Peng KY, Mathews PM, Levy E, Wilson DA.

Neuroscience. 2017 Feb 20;343:364-371. doi: 10.1016/j.neuroscience.2016.12.004. Epub 2016 Dec 18.


Functional impairment of reading in patients with dry eye.

Mathews PM, Ramulu PY, Swenor BS, Utine CA, Rubin GS, Akpek EK.

Br J Ophthalmol. 2017 Apr;101(4):481-486. doi: 10.1136/bjophthalmol-2015-308237. Epub 2016 Jul 22.


Cystatin C in aging and in Alzheimer's disease.

Mathews PM, Levy E.

Ageing Res Rev. 2016 Dec;32:38-50. doi: 10.1016/j.arr.2016.06.003. Epub 2016 Jun 19. Review.


Placental abnormalities in equine pregnancies generated by SCNT from one donor horse.

Pozor MA, Sheppard B, Hinrichs K, Kelleman AA, Macpherson ML, Runcan E, Choi YH, Diaw M, Mathews PM.

Theriogenology. 2016 Oct 1;86(6):1573-1582. doi: 10.1016/j.theriogenology.2016.05.017. Epub 2016 May 26.


Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes.

Morales-Corraliza J, Wong H, Mazzella MJ, Che S, Lee SH, Petkova E, Wagner JD, Hemby SE, Ginsberg SD, Mathews PM.

J Neurosci. 2016 Apr 13;36(15):4248-58. doi: 10.1523/JNEUROSCI.4640-14.2016.


Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA.

Neurobiol Aging. 2016 Mar;39:90-8. doi: 10.1016/j.neurobiolaging.2015.11.013. Epub 2015 Dec 2.


Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.

Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME.

Sci Rep. 2015 Nov 26;5:17042. doi: 10.1038/srep17042.


Boston Type 1 Keratoprosthesis versus Repeat Donor Keratoplasty for Corneal Graft Failure: A Systematic Review and Meta-analysis.

Ahmad S, Mathews PM, Lindsley K, Alkharashi M, Hwang FS, Ng SM, Aldave AJ, Akpek EK.

Ophthalmology. 2016 Jan;123(1):165-77. doi: 10.1016/j.ophtha.2015.09.028. Epub 2015 Nov 4. Review.


Outcomes of Repeat Boston Type 1 Keratoprosthesis Implantation.

Ahmad S, Mathews PM, Srikumaran D, Aldave AJ, Lenis T, Aquavella JV, Hannush SB, Belin M, Akpek EK.

Am J Ophthalmol. 2016 Jan;161:181-7.e1. doi: 10.1016/j.ajo.2015.10.012. Epub 2015 Oct 23.


Ocular complications of primary Sjögren syndrome in men.

Mathews PM, Hahn S, Hessen M, Kim J, Grader-Beck T, Birnbaum J, Baer AN, Akpek EK.

Am J Ophthalmol. 2015 Sep;160(3):447-452.e1. doi: 10.1016/j.ajo.2015.06.004. Epub 2015 Jun 17.


Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.

Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KPR, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM.

Neurobiol Aging. 2015 Jul;36(7):2241-2247. doi: 10.1016/j.neurobiolaging.2015.03.011. Epub 2015 Mar 25.


Severity of vision loss interacts with word-specific features to impact out-loud reading in glaucoma.

Mathews PM, Rubin GS, McCloskey M, Salek S, Ramulu PY.

Invest Ophthalmol Vis Sci. 2015 Mar 3;56(3):1537-45. doi: 10.1167/iovs.15-15462.


Severity of Vision Loss Interacts with Word-Specific Features to Impact Out-Loud Reading in Glaucoma.

Mathews PM, Rubin GS, McCloskey M, Salek S, Ramulu PY.

Invest Ophthalmol Vis Sci. 2015 Jan 27. pii: IOVS-14-15462. doi: 10.1167/iovs.14-15462. [Epub ahead of print]


Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice.

Schafer MJ, Alldred MJ, Lee SH, Calhoun ME, Petkova E, Mathews PM, Ginsberg SD.

Neurobiol Aging. 2015 Mar;36(3):1293-302. doi: 10.1016/j.neurobiolaging.2014.10.043. Epub 2014 Dec 4.


Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age.

Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE.

Neurobiol Aging. 2015 Jan;36(1):134-48. doi: 10.1016/j.neurobiolaging.2014.07.001. Epub 2014 Jul 11.


Evaluation of ocular surface disease in patients with glaucoma.

Mathews PM, Ramulu PY, Friedman DS, Utine CA, Akpek EK.

Ophthalmology. 2013 Nov;120(11):2241-8. doi: 10.1016/j.ophtha.2013.03.045. Epub 2013 May 25.


Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G.

J Biol Chem. 2013 May 24;288(21):15352-66. doi: 10.1074/jbc.M112.441840. Epub 2013 Apr 15.


Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice.

Choi JH, Kaur G, Mazzella MJ, Morales-Corraliza J, Levy E, Mathews PM.

J Alzheimers Dis. 2013;34(3):691-700. doi: 10.3233/JAD-122143.


Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model.

Wesson DW, Morales-Corraliza J, Mazzella MJ, Wilson DA, Mathews PM.

Behav Brain Res. 2013 Jan 15;237:96-102. doi: 10.1016/j.bbr.2012.09.019. Epub 2012 Sep 20.


Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice.

Papon MA, El Khoury NB, Marcouiller F, Julien C, Morin F, Bretteville A, Petry FR, Gaudreau S, Amrani A, Mathews PM, Hébert SS, Planel E.

Diabetes. 2013 Feb;62(2):609-17. doi: 10.2337/db12-0187. Epub 2012 Sep 6.


Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.

Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM.

Neurobiol Aging. 2013 Jan;34(1):137-45. doi: 10.1016/j.neurobiolaging.2012.04.007. Epub 2012 May 18.


Aβ measurement by enzyme-linked immunosorbent assay.

Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM.

Methods Mol Biol. 2012;849:507-27. doi: 10.1007/978-1-61779-551-0_34.


Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ.

Schmidt SD, Nixon RA, Mathews PM.

Methods Mol Biol. 2012;849:493-506. doi: 10.1007/978-1-61779-551-0_33.


FE65 as a link between VLDLR and APP to regulate their trafficking and processing.

Dumanis SB, Chamberlain KA, Jin Sohn Y, Jin Lee Y, Guénette SY, Suzuki T, Mathews PM, Pak DTs, Rebeck GW, Suh YH, Park HS, Hoe HS.

Mol Neurodegener. 2012 Mar 19;7:9. doi: 10.1186/1750-1326-7-9.


Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice.

Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM.

Neurobiol Aging. 2012 Jun;33(6):1125.e9-18. doi: 10.1016/j.neurobiolaging.2011.11.023. Epub 2011 Dec 27.


Synaptic autoregulation by metalloproteases and γ-secretase.

Restituito S, Khatri L, Ninan I, Mathews PM, Liu X, Weinberg RJ, Ziff EB.

J Neurosci. 2011 Aug 24;31(34):12083-93. doi: 10.1523/JNEUROSCI.2513-11.2011. Erratum in: J Neurosci. 2011 Sep 21;31(38):13695.


Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA.

Autophagy. 2011 Jul;7(7):788-9. Epub 2011 Jul 1.


Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J.

J Neurosci. 2011 Feb 2;31(5):1837-49. doi: 10.1523/JNEUROSCI.2954-10.2011.


Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA.

Brain. 2011 Jan;134(Pt 1):258-77. doi: 10.1093/brain/awq341.


Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.

Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7969-74. doi: 10.1073/pnas.1001056107. Epub 2010 Apr 12.


Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1630-5. doi: 10.1073/pnas.0908953107. Epub 2009 Dec 28.


Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.

Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M.

Nat Neurosci. 2009 Nov;12(11):1361-3. doi: 10.1038/nn.2432. Epub 2009 Oct 18.


In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice.

Morales-Corraliza J, Mazzella MJ, Berger JD, Diaz NS, Choi JH, Levy E, Matsuoka Y, Planel E, Mathews PM.

PLoS One. 2009 Sep 22;4(9):e7134. doi: 10.1371/journal.pone.0007134.


Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM.

J Neurochem. 2009 Sep;110(6):1818-27. doi: 10.1111/j.1471-4159.2009.06277.x. Epub 2009 Jul 10.


Complexes of amyloid-beta and cystatin C in the human central nervous system.

Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E.

J Alzheimers Dis. 2009;18(2):273-80. doi: 10.3233/JAD-2009-1147.


Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O.

J Clin Invest. 2008 Aug;118(8):2796-807. doi: 10.1172/JCI34254.


Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.

Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA.

Am J Pathol. 2008 Aug;173(2):370-84. doi: 10.2353/ajpath.2008.071053. Epub 2008 Jun 5.

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