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Items: 45

1.

Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase.

Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C.

Biochemistry. 2018 Oct 30;57(43):6201-6208. doi: 10.1021/acs.biochem.8b00886. Epub 2018 Oct 17.

PMID:
30289692
2.

Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.

Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C.

J Am Chem Soc. 2018 May 30;140(21):6518-6521. doi: 10.1021/jacs.8b02100. Epub 2018 May 18.

3.

The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.

Mathews II, Allison K, Robbins T, Lyubimov AY, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis M, Cohen AE.

Biochemistry. 2017 Sep 12;56(36):4751-4756. doi: 10.1021/acs.biochem.7b00711. Epub 2017 Aug 31.

4.

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.

Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS 2nd, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ.

J Clin Invest. 2017 Jan 3;127(1):183-198. doi: 10.1172/JCI85610. Epub 2016 Nov 28.

5.

Revealing an outward-facing open conformational state in a CLC Cl(-)/H(+) exchange transporter.

Khantwal CM, Abraham SJ, Han W, Jiang T, Chavan TS, Cheng RC, Elvington SM, Liu CW, Mathews II, Stein RA, Mchaourab HS, Tajkhorshid E, Maduke M.

Elife. 2016 Jan 22;5. pii: e11189. doi: 10.7554/eLife.11189.

6.

Goniometer-based femtosecond crystallography with X-ray free electron lasers.

Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17122-7. doi: 10.1073/pnas.1418733111. Epub 2014 Oct 31.

7.

Cell fate regulation governed by a repurposed bacterial histidine kinase.

Childers WS, Xu Q, Mann TH, Mathews II, Blair JA, Deacon AM, Shapiro L.

PLoS Biol. 2014 Oct 28;12(10):e1001979. doi: 10.1371/journal.pbio.1001979. eCollection 2014 Oct.

8.

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.

Kariolis MS, Miao YR, Jones DS 2nd, Kapur S, Mathews II, Giaccia AJ, Cochran JR.

Nat Chem Biol. 2014 Nov;10(11):977-83. doi: 10.1038/nchembio.1636. Epub 2014 Sep 21.

9.

Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.

Matsui T, Gu S, Lam KH, Carter LG, Rummel A, Mathews II, Jin R.

J Mol Biol. 2014 Nov 11;426(22):3773-3782. doi: 10.1016/j.jmb.2014.09.009. Epub 2014 Sep 18.

10.

Use of transmission electron microscopy to identify nanocrystals of challenging protein targets.

Stevenson HP, Makhov AM, Calero M, Edwards AL, Zeldin OB, Mathews II, Lin G, Barnes CO, Santamaria H, Ross TM, Soltis SM, Khosla C, Nagarajan V, Conway JF, Cohen AE, Calero G.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8470-5. doi: 10.1073/pnas.1400240111. Epub 2014 May 28.

12.

X-ray absorption spectroscopic investigation of the electronic structure differences in solution and crystalline oxyhemoglobin.

Wilson SA, Green E, Mathews II, Benfatto M, Hodgson KO, Hedman B, Sarangi R.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16333-8. doi: 10.1073/pnas.1315734110. Epub 2013 Sep 23.

13.

Branched signal wiring of an essential bacterial cell-cycle phosphotransfer protein.

Blair JA, Xu Q, Childers WS, Mathews II, Kern JW, Eckart M, Deacon AM, Shapiro L.

Structure. 2013 Sep 3;21(9):1590-601. doi: 10.1016/j.str.2013.06.024. Epub 2013 Aug 8.

14.

Folate binding site of flavin-dependent thymidylate synthase.

Koehn EM, Perissinotti LL, Moghram S, Prabhakar A, Lesley SA, Mathews II, Kohen A.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15722-7. Epub 2012 Sep 10.

15.

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Hotta K, Chen X, Paton RS, Minami A, Li H, Swaminathan K, Mathews II, Watanabe K, Oikawa H, Houk KN, Kim CY.

Nature. 2012 Mar 4;483(7389):355-8. doi: 10.1038/nature10865.

16.

Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.

Tollefsen S, Hotta K, Chen X, Simonsen B, Swaminathan K, Mathews II, Sollid LM, Kim CY.

J Biol Chem. 2012 Apr 20;287(17):13611-9. doi: 10.1074/jbc.M111.320374. Epub 2012 Feb 23.

17.

Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase.

Wong FT, Jin X, Mathews II, Cane DE, Khosla C.

Biochemistry. 2011 Aug 2;50(30):6539-48. doi: 10.1021/bi200632j. Epub 2011 Jul 5.

18.

Crystal structure of the glutamate receptor GluA1 N-terminal domain.

Yao G, Zong Y, Gu S, Zhou J, Xu H, Mathews II, Jin R.

Biochem J. 2011 Sep 1;438(2):255-63. doi: 10.1042/BJ20110801.

19.

Treponema denticola PurE Is a bacterial AIR carboxylase.

Tranchimand S, Starks CM, Mathews II, Hockings SC, Kappock TJ.

Biochemistry. 2011 May 31;50(21):4623-37. doi: 10.1021/bi102033a. Epub 2011 May 6.

PMID:
21548610
20.

Diffraction study of protein crystals grown in cryoloops and micromounts.

Berger MA, Decker JH, Mathews II.

J Appl Crystallogr. 2010 Dec 1;43(Pt 6):1513-1518. Epub 2010 Oct 20.

21.

Remote access to crystallography beamlines at SSRL: novel tools for training, education and collaboration.

Smith CA, Card GL, Cohen AE, Doukov TI, Eriksson T, Gonzalez AM, McPhillips SE, Dunten PW, Mathews II, Song J, Soltis SM.

J Appl Crystallogr. 2010 Oct 1;43(Pt 5):1261-1270. Epub 2010 Aug 3.

22.

Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.

Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA.

J Mol Biol. 2010 Dec 3;404(3):403-17. doi: 10.1016/j.jmb.2010.09.032. Epub 2010 Oct 1.

23.

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.

Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A.

Nature. 2009 Apr 16;458(7240):919-23. doi: 10.1038/nature07973.

24.

Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.

Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, Bokoch GM, Tainer JA, Weckbecker G, Kuhn P.

J Mol Biol. 2008 Jul 25;380(5):828-43. doi: 10.1016/j.jmb.2008.05.024. Epub 2008 May 17.

25.

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution.

Mathews II, McMullan D, Miller MD, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, McPhillips TM, Morse AT, Quijano K, Rife CL, Schwarzenbacher R, Spraggon G, Stevens RC, van den Bedem H, Weekes D, Wolf G, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA.

Proteins. 2008 Feb 1;70(2):603-8. No abstract available.

PMID:
18004772
26.

N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis.

Hoskins AA, Morar M, Kappock TJ, Mathews II, Zaugg JB, Barder TE, Peng P, Okamoto A, Ealick SE, Stubbe J.

Biochemistry. 2007 Mar 13;46(10):2842-55. Epub 2007 Feb 14.

27.

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution.

Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller MD, Abdubek P, Agarwalla S, Ambing E, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Elsliger MA, Grzechnik SK, Hale J, Hampton E, Haugen J, Jin KK, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, Levin I, Morse AT, Nigoghossian E, Okach L, Oommachen S, Paulsen J, Quijano K, Reyes R, Rife CL, Spraggon G, Stevens RC, van den Bedem H, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA.

Proteins. 2006 Oct 1;65(1):249-54. No abstract available.

PMID:
16865708
28.

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

Tang Y, Kim CY, Mathews II, Cane DE, Khosla C.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11124-9. Epub 2006 Jul 14.

29.

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution.

Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, Hampton E, Han GW, Haugen J, Jaroszewski L, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, Levin I, Miller MD, Moy K, Nigoghossian E, Paulsen J, Quijano K, Reyes R, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA.

Proteins. 2006 Jun 1;63(4):1106-11. No abstract available.

PMID:
16544324
30.

Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity.

Shan L, Mathews II, Khosla C.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3599-604. Epub 2005 Feb 28.

31.

Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein.

Mathews II, Deacon AM, Canaves JM, McMullan D, Lesley SA, Agarwalla S, Kuhn P.

Structure. 2003 Jun;11(6):677-90.

32.

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution.

Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JM, Kreusch AT, McMullan D, McPhillips TM, Miller MA, Miller M, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, Taylor SS, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Wooley J, Wilson IA.

Proteins. 2002 Oct 1;49(1):142-5. No abstract available.

PMID:
12211025
33.

The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.

Tolbert WD, Ekstrom JL, Mathews II, Secrist JA 3rd, Kapoor P, Pegg AE, Ealick SE.

Biochemistry. 2001 Aug 14;40(32):9484-94. Erratum in: Biochemistry 2001 Oct 30;40(43):13124.

PMID:
11583147
34.

Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.

Appleby TC, Mathews II, Porcelli M, Cacciapuoti G, Ealick SE.

J Biol Chem. 2001 Oct 19;276(42):39232-42. Epub 2001 Aug 6.

35.

Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.

Campobasso N, Mathews II, Begley TP, Ealick SE.

Biochemistry. 2000 Jul 11;39(27):7868-77.

PMID:
10891066
36.

Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.

Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG.

J Mol Biol. 2000 May 19;298(5):875-93.

PMID:
10801355
37.

Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.

Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG.

J Mol Biol. 2000 Feb 18;296(2):549-67.

PMID:
10669608
38.

Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.

Mathews II, Kappock TJ, Stubbe J, Ealick SE.

Structure. 1999 Nov 15;7(11):1395-406.

39.

Characterization of the active site of ADP-ribosyl cyclase.

Munshi C, Thiel DJ, Mathews II, Aarhus R, Walseth TF, Lee HC.

J Biol Chem. 1999 Oct 22;274(43):30770-7.

40.

The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold.

Ekstrom JL, Mathews II, Stanley BA, Pegg AE, Ealick SE.

Structure. 1999 May;7(5):583-95.

41.

Structure of human adenosine kinase at 1.5 A resolution.

Mathews II, Erion MD, Ealick SE.

Biochemistry. 1998 Nov 10;37(45):15607-20.

PMID:
9843365
42.
43.

Active-site mimetic inhibition of thrombin.

Mathews II, Tulinsky A.

Acta Crystallogr D Biol Crystallogr. 1995 Jul 1;51(Pt 4):550-9.

PMID:
15299843
44.

Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.

Mathews II, Padmanabhan KP, Tulinksy A, Sadler JE.

Biochemistry. 1994 Nov 22;33(46):13547-52.

PMID:
7947765
45.

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.

Mathews II, Padmanabhan KP, Ganesh V, Tulinsky A, Ishii M, Chen J, Turck CW, Coughlin SR, Fenton JW 2nd.

Biochemistry. 1994 Mar 22;33(11):3266-79.

PMID:
8136362

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