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Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users.

Chanfreau-Coffinier C, Hull LE, Lynch JA, DuVall SL, Damrauer SM, Cunningham FE, Voight BF, Matheny ME, Oslin DW, Icardi MS, Tuteja S.

JAMA Netw Open. 2019 Jun 5;2(6):e195345. doi: 10.1001/jamanetworkopen.2019.5345.


Uptake of Video-Assisted Thoracoscopic Lung Resections Within the Veterans Affairs for Known or Suspected Lung Cancer.

Maiga AW, Deppen SA, Denton J, Matheny ME, Gillaspie EA, Nesbitt JC, Grogan EL.

JAMA Surg. 2019 Mar 13. doi: 10.1001/jamasurg.2019.0035. [Epub ahead of print]


Comparative Safety of Aspiration Thrombectomy Catheters Utilizing Prospective, Active Surveillance of the NCDR CathPCI Registry.

Majithia A, Matheny ME, Paulus JK, Marinac-Dabic D, Robbins S, Ssemaganda H, Hewitt K, Ponirakis A, Loyo-Berrios N, Moussa I, Drozda J, Normand SL, Resnic FS.

Circ Cardiovasc Qual Outcomes. 2019 Feb;12(2):e004666. doi: 10.1161/CIRCOUTCOMES.118.004666.


Comparison of automated and retrospectively calculated estimated glomerular filtration rate in electronic health record data.

Lynch KE, Chang JW, Matheny ME, Goldfarb A, Efimova O, Coronado G, DuVall SL.

BMC Nephrol. 2018 Dec 28;19(1):380. doi: 10.1186/s12882-018-1179-8.


Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL, Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA, Sargurupremraj M, Debette S, Boehnke M, Scott LJ, Luan J, Zhao JH, Willems SM, ThĂ©riault S, Shah N, Oldmeadow C, Almgren P, Li-Gao R, Verweij N, Boutin TS, Mangino M, Ntalla I, Feofanova E, Surendran P, Cook JP, Karthikeyan S, Lahrouchi N, Liu C, SepĂșlveda N, Richardson TG, Kraja A, Amouyel P, Farrall M, Poulter NR; Understanding Society Scientific Group; International Consortium for Blood Pressure; Blood Pressure-International Consortium of Exome Chip Studies, Laakso M, Zeggini E, Sever P, Scott RA, Langenberg C, Wareham NJ, Conen D, Palmer CNA, Attia J, Chasman DI, Ridker PM, Melander O, Mook-Kanamori DO, Harst PV, Cucca F, Schlessinger D, Hayward C, Spector TD, Jarvelin MR, Hennig BJ, Timpson NJ, Wei WQ, Smith JC, Xu Y, Matheny ME, Siew EE, Lindgren C, Herzig KH, Dedoussis G, Denny JC, Psaty BM, Howson JMM, Munroe PB, Newton-Cheh C, Caulfield MJ, Elliott P, Gaziano JM, Concato J, Wilson PWF, Tsao PS, Velez Edwards DR, Susztak K; Million Veteran Program, O'Donnell CJ, Hung AM, Edwards TL.

Nat Genet. 2019 Jan;51(1):51-62. doi: 10.1038/s41588-018-0303-9. Epub 2018 Dec 21.


Data and Information in the Sea of Electronic Health Records.

Shah RU, Matheny ME.

Circ Cardiovasc Qual Outcomes. 2018 Dec;11(12):e005247. doi: 10.1161/CIRCOUTCOMES.118.005247. No abstract available.


Automated mapping of laboratory tests to LOINC codes using noisy labels in a national electronic health record system database.

Parr SK, Shotwell MS, Jeffery AD, Lasko TA, Matheny ME.

J Am Med Inform Assoc. 2018 Oct 1;25(10):1292-1300. doi: 10.1093/jamia/ocy110.


Application of contextual design methods to inform targeted clinical decision support interventions in sub-specialty care environments.

Miller A, Koola JD, Matheny ME, Ducom JH, Slagle JM, Groessl EJ, Minter FF, Garvin JH, Weinger MB, Ho SB.

Int J Med Inform. 2018 Sep;117:55-65. doi: 10.1016/j.ijmedinf.2018.05.005. Epub 2018 May 30.


Perfectly Secure and Efficient Two-Party Electronic-Health-Record Linkage.

Chen F, Jiang X, Wang S, Schilling LM, Meeker D, Ong T, Matheny ME, Doctor JN, Ohno-Machado L, Vaidya J.

IEEE Internet Comput. 2018 Mar-Apr;22(2):32-41. doi: 10.1109/MIC.2018.112102542. Epub 2018 Jan 16.


Calibration Drift Among Regression and Machine Learning Models for Hospital Mortality.

Davis SE, Lasko TA, Chen G, Matheny ME.

AMIA Annu Symp Proc. 2018 Apr 16;2017:625-634. eCollection 2017.


Determining post-test risk in a national sample of stress nuclear myocardial perfusion imaging reports: Implications for natural language processing tools.

Levy AE, Shah NR, Matheny ME, Reeves RM, Gobbel GT, Bradley SM.

J Nucl Cardiol. 2018 Apr 25. doi: 10.1007/s12350-018-1275-y. [Epub ahead of print]


Development of an automated phenotyping algorithm for hepatorenal syndrome.

Koola JD, Davis SE, Al-Nimri O, Parr SK, Fabbri D, Malin BA, Ho SB, Matheny ME.

J Biomed Inform. 2018 Apr;80:87-95. doi: 10.1016/j.jbi.2018.03.001. Epub 2018 Mar 9.


Medical Devices in the Real World.

Resnic FS, Matheny ME.

N Engl J Med. 2018 Feb 15;378(7):595-597. doi: 10.1056/NEJMp1712001. No abstract available.


Automating Quality Measures for Heart Failure Using Natural Language Processing: A Descriptive Study in the Department of Veterans Affairs.

Garvin JH, Kim Y, Gobbel GT, Matheny ME, Redd A, Bray BE, Heidenreich P, Bolton D, Heavirland J, Kelly N, Reeves R, Kalsy M, Goldstein MK, Meystre SM.

JMIR Med Inform. 2018 Jan 15;6(1):e5. doi: 10.2196/medinform.9150.


Risk of Hypoglycemia Following Hospital Discharge in Patients With Diabetes and Acute Kidney Injury.

Hung AM, Siew ED, Wilson OD, Perkins AM, Greevy RA Jr, Horner J, Abdel-Kader K, Parr SK, Roumie CL, Griffin MR, Ikizler TA, Speroff T, Matheny ME.

Diabetes Care. 2018 Mar;41(3):503-512. doi: 10.2337/dc17-1237. Epub 2018 Jan 11.


Acute Kidney Injury and Risk of Incident Heart Failure Among US Veterans.

Bansal N, Matheny ME, Greevy RA Jr, Eden SK, Perkins AM, Parr SK, Fly J, Abdel-Kader K, Himmelfarb J, Hung AM, Speroff T, Ikizler TA, Siew ED.

Am J Kidney Dis. 2018 Feb;71(2):236-245. doi: 10.1053/j.ajkd.2017.08.027. Epub 2017 Nov 20.


Learning curve estimation in medical devices and procedures: hierarchical modeling.

Govindarajulu US, Stillo M, Goldfarb D, Matheny ME, Resnic FS.

Stat Med. 2017 Nov 30;36(27):4420. doi: 10.1002/sim.7487. Epub 2017 Sep 25. No abstract available.


Representing Knowledge Consistently Across Health Systems.

Rosenbloom ST, Carroll RJ, Warner JL, Matheny ME, Denny JC.

Yearb Med Inform. 2017 Aug;26(1):139-147. doi: 10.15265/IY-2017-018. Epub 2017 Sep 11. Review.


Acute kidney injury is a risk factor for subsequent proteinuria.

Parr SK, Matheny ME, Abdel-Kader K, Greevy RA Jr, Bian A, Fly J, Chen G, Speroff T, Hung AM, Ikizler TA, Siew ED.

Kidney Int. 2018 Feb;93(2):460-469. doi: 10.1016/j.kint.2017.07.007. Epub 2017 Sep 18.


Characteristics and Outcomes of Patients Discharged Home from an Emergency Department with AKI.

Acedillo RR, Wald R, McArthur E, Nash DM, Silver SA, James MT, Schull MJ, Siew ED, Matheny ME, House AA, Garg AX.

Clin J Am Soc Nephrol. 2017 Jul 20. pii: CJN.10431016. doi: 10.2215/CJN.10431016. [Epub ahead of print]


Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network.

Sperber NR, Carpenter JS, Cavallari LH, J Damschroder L, Cooper-DeHoff RM, Denny JC, Ginsburg GS, Guan Y, Horowitz CR, Levy KD, Levy MA, Madden EB, Matheny ME, Pollin TI, Pratt VM, Rosenman M, Voils CI, W Weitzel K, Wilke RA, Ryanne Wu R, Orlando LA.

BMC Med Genomics. 2017 May 22;10(1):35. doi: 10.1186/s12920-017-0273-2.


Learning curve estimation in medical devices and procedures: hierarchical modeling.

Govindarajulu US, Stillo M, Goldfarb D, Matheny ME, Resnic FS.

Stat Med. 2017 Jul 30;36(17):2764-2785. doi: 10.1002/sim.7309. Epub 2017 May 3. Erratum in: Stat Med. 2017 Nov 30;36(27):4420.


Calibration drift in regression and machine learning models for acute kidney injury.

Davis SE, Lasko TA, Chen G, Siew ED, Matheny ME.

J Am Med Inform Assoc. 2017 Nov 1;24(6):1052-1061. doi: 10.1093/jamia/ocx030.


Identification of adverse drug-drug interactions through causal association rule discovery from spontaneous adverse event reports.

Cai R, Liu M, Hu Y, Melton BL, Matheny ME, Xu H, Duan L, Waitman LR.

Artif Intell Med. 2017 Feb;76:7-15. doi: 10.1016/j.artmed.2017.01.004. Epub 2017 Feb 10.


Assessing the cost burden of United States FDA-mandated post-approval studies for medical devices.

Wimmer NJ, Robbins S, Ssemaganda H, Yang E, Normand SL, Matheny ME, Herz N, Rising J, Resnic FS.

J Health Care Finance. 2016 Summer;2016(Spec Features). pii:


Registry-Based Prospective, Active Surveillance of Medical-Device Safety.

Resnic FS, Majithia A, Marinac-Dabic D, Robbins S, Ssemaganda H, Hewitt K, Ponirakis A, Loyo-Berrios N, Moussa I, Drozda J, Normand SL, Matheny ME.

N Engl J Med. 2017 Feb 9;376(6):526-535. doi: 10.1056/NEJMoa1516333. Epub 2017 Jan 25.


Leveraging Electronic Health Care Record Information to Measure Pressure Ulcer Risk in Veterans With Spinal Cord Injury: A Longitudinal Study Protocol.

Luther SL, Thomason SS, Sabharwal S, Finch DK, McCart J, Toyinbo P, Bouayad L, Matheny ME, Gobbel GT, Powell-Cope G.

JMIR Res Protoc. 2017 Jan 19;6(1):e3. doi: 10.2196/resprot.5948.


High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study.

Lipworth L, Abdel-Kader K, Morse J, Stewart TG, Kabagambe EK, Parr SK, Birdwell KA, Matheny ME, Hung AM, Blot WJ, Ikizler TA, Siew ED.

BMC Nephrol. 2016 Nov 24;17(1):189.


Chronic Kidney Disease Progression and Cardiovascular Outcomes Following Cardiac Catheterization-A Population-Controlled Study.

Brown JR, Solomon RJ, Robey RB, Plomondon ME, Maddox TM, Marshall EJ, Nichols EL, Matheny ME, Tsai TT, Rumsfeld JS, Lee RE, Sarnak MJ.

J Am Heart Assoc. 2016 Oct 14;5(10). pii: e003812.


Novel Developments in Acute Kidney Injury.

Brown JR, McCullough PA, Matheny ME.

Biomed Res Int. 2016;2016:2756204. doi: 10.1155/2016/2756204. Epub 2016 Aug 10. No abstract available.


Congestive heart failure information extraction framework for automated treatment performance measures assessment.

Meystre SM, Kim Y, Gobbel GT, Matheny ME, Redd A, Bray BE, Garvin JH.

J Am Med Inform Assoc. 2017 Apr 1;24(e1):e40-e46. doi: 10.1093/jamia/ocw097.


Hospital Mortality in the United States following Acute Kidney Injury.

Brown JR, Rezaee ME, Marshall EJ, Matheny ME.

Biomed Res Int. 2016;2016:4278579. doi: 10.1155/2016/4278579. Epub 2016 Jun 8. Review.


Characterizing treatment pathways at scale using the OHDSI network.

Hripcsak G, Ryan PB, Duke JD, Shah NH, Park RW, Huser V, Suchard MA, Schuemie MJ, DeFalco FJ, Perotte A, Banda JM, Reich CG, Schilling LM, Matheny ME, Meeker D, Pratt N, Madigan D.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7329-36. doi: 10.1073/pnas.1510502113. Epub 2016 Jun 6.


Reduced Mortality Associated with Acute Kidney Injury Requiring Dialysis in the United States.

Brown JR, Rezaee ME, Hisey WM, Cox KC, Matheny ME, Sarnak MJ.

Am J Nephrol. 2016;43(4):261-70. doi: 10.1159/000445846. Epub 2016 Apr 29.


Incidence and In-Hospital Mortality of Acute Kidney Injury (AKI) and Dialysis-Requiring AKI (AKI-D) After Cardiac Catheterization in the National Inpatient Sample.

Brown JR, Rezaee ME, Nichols EL, Marshall EJ, Siew ED, Matheny ME.

J Am Heart Assoc. 2016 Mar 15;5(3):e002739. doi: 10.1161/JAHA.115.002739.


Changes in Hospital Admissions and Mortality for Complications of Cirrhosis: Implications for Clinicians and Health Systems.

Ho SB, Matheny ME, Schnabl BE.

Gut Liver. 2016 Jan;10(1):8-9. doi: 10.5009/gnl15593. No abstract available.


Acute Kidney Injury Risk Prediction in Patients Undergoing Coronary Angiography in a National Veterans Health Administration Cohort With External Validation.

Brown JR, MacKenzie TA, Maddox TM, Fly J, Tsai TT, Plomondon ME, Nielson CD, Siew ED, Resnic FS, Baker CR, Rumsfeld JS, Matheny ME.

J Am Heart Assoc. 2015 Dec 11;4(12). pii: e002136. doi: 10.1161/JAHA.115.002136.


Creating a Common Data Model for Comparative Effectiveness with the Observational Medical Outcomes Partnership.

FitzHenry F, Resnic FS, Robbins SL, Denton J, Nookala L, Meeker D, Ohno-Machado L, Matheny ME.

Appl Clin Inform. 2015 Aug 26;6(3):536-47. doi: 10.4338/ACI-2014-12-CR-0121. eCollection 2015.


Choice of Reference Serum Creatinine in Defining Acute Kidney Injury.

Siew ED, Matheny ME.

Nephron. 2015;131(2):107-12. doi: 10.1159/000439144. Epub 2015 Sep 2. Review.


Predictors of Recurrent AKI.

Siew ED, Parr SK, Abdel-Kader K, Eden SK, Peterson JF, Bansal N, Hung AM, Fly J, Speroff T, Ikizler TA, Matheny ME.

J Am Soc Nephrol. 2016 Apr;27(4):1190-200. doi: 10.1681/ASN.2014121218. Epub 2015 Aug 11.


A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research.

Meeker D, Jiang X, Matheny ME, Farcas C, D'Arcy M, Pearlman L, Nookala L, Day ME, Kim KK, Kim H, Boxwala A, El-Kareh R, Kuo GM, Resnic FS, Kesselman C, Ohno-Machado L.

J Am Med Inform Assoc. 2015 Nov;22(6):1187-95. doi: 10.1093/jamia/ocv017. Epub 2015 Jul 3.


National Veterans Health Administration inpatient risk stratification models for hospital-acquired acute kidney injury.

Cronin RM, VanHouten JP, Siew ED, Eden SK, Fihn SD, Nielson CD, Peterson JF, Baker CR, Ikizler TA, Speroff T, Matheny ME.

J Am Med Inform Assoc. 2015 Sep;22(5):1054-71. doi: 10.1093/jamia/ocv051. Epub 2015 Jun 23.


Validated contemporary risk model of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the National Cardiovascular Data Registry Cath-PCI Registry.

Tsai TT, Patel UD, Chang TI, Kennedy KF, Masoudi FA, Matheny ME, Kosiborod M, Amin AP, Weintraub WS, Curtis JP, Messenger JC, Rumsfeld JS, Spertus JA.

J Am Heart Assoc. 2014 Dec;3(6):e001380.


The data extraction and longitudinal trend analysis network study of distributed automated postmarket cardiovascular device safety surveillance.

Kumar A, Matheny ME, Ho KK, Yeh RW, Piemonte TC, Waldman H, Shah PB, Cope R, Normand SL, Donnelly S, Robbins S, Resnic FS.

Circ Cardiovasc Qual Outcomes. 2015 Jan;8(1):38-46. doi: 10.1161/CIRCOUTCOMES.114.001123. Epub 2014 Dec 9.


Laboratory test surveillance following acute kidney injury.

Matheny ME, Peterson JF, Eden SK, Hung AM, Speroff T, Abdel-Kader K, Parr SK, Ikizler TA, Siew ED.

PLoS One. 2014 Aug 12;9(8):e103746. doi: 10.1371/journal.pone.0103746. eCollection 2014.


pSCANNER: patient-centered Scalable National Network for Effectiveness Research.

Ohno-Machado L, Agha Z, Bell DS, Dahm L, Day ME, Doctor JN, Gabriel D, Kahlon MK, Kim KK, Hogarth M, Matheny ME, Meeker D, Nebeker JR; pSCANNER team.

J Am Med Inform Assoc. 2014 Jul-Aug;21(4):621-6. doi: 10.1136/amiajnl-2014-002751. Epub 2014 Apr 29.


Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the NCDR Cath-PCI registry.

Tsai TT, Patel UD, Chang TI, Kennedy KF, Masoudi FA, Matheny ME, Kosiborod M, Amin AP, Messenger JC, Rumsfeld JS, Spertus JA.

JACC Cardiovasc Interv. 2014 Jan;7(1):1-9. doi: 10.1016/j.jcin.2013.06.016.


Assisted annotation of medical free text using RapTAT.

Gobbel GT, Garvin J, Reeves R, Cronin RM, Heavirland J, Williams J, Weaver A, Jayaramaraja S, Giuse D, Speroff T, Brown SH, Xu H, Matheny ME.

J Am Med Inform Assoc. 2014 Sep-Oct;21(5):833-41. doi: 10.1136/amiajnl-2013-002255. Epub 2014 Jan 15.


Determining molecular predictors of adverse drug reactions with causality analysis based on structure learning.

Liu M, Cai R, Hu Y, Matheny ME, Sun J, Hu J, Xu H.

J Am Med Inform Assoc. 2014 Mar-Apr;21(2):245-51. doi: 10.1136/amiajnl-2013-002051. Epub 2013 Dec 11.


Development and evaluation of RapTAT: a machine learning system for concept mapping of phrases from medical narratives.

Gobbel GT, Reeves R, Jayaramaraja S, Giuse D, Speroff T, Brown SH, Elkin PL, Matheny ME.

J Biomed Inform. 2014 Apr;48:54-65. doi: 10.1016/j.jbi.2013.11.008. Epub 2013 Dec 4.

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