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Structural and functional characterization of Solanum tuberosum VDAC36.

Lopes-Rodrigues M, Matagne A, Zanuy D, Alemán C, Perpète EA, Michaux C.

Proteins. 2019 Dec 12. doi: 10.1002/prot.25861. [Epub ahead of print]


Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models.

Leclercq K, Matagne A, Provins L, Klitgaard H, Kaminski RM.

J Pharmacol Exp Ther. 2020 Jan;372(1):11-20. doi: 10.1124/jpet.119.261222. Epub 2019 Oct 16.


Covalent Cross-Linking as an Enabler for Structural Mass Spectrometry.

Hanozin E, Grifnée E, Gattuso H, Matagne A, Morsa D, Pauw E.

Anal Chem. 2019 Oct 15;91(20):12808-12818. doi: 10.1021/acs.analchem.9b02491. Epub 2019 Sep 30.


An NMR and MD study of complexes of bacteriophage lambda lysozyme with tetra- and hexa-N-acetylchitohexaose.

Turupcu A, Bowen AM, Di Paolo A, Matagne A, Oostenbrink C, Redfield C, Smith LJ.

Proteins. 2020 Jan;88(1):82-93. doi: 10.1002/prot.25770. Epub 2019 Jul 26.


Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design.

De Franco S, Vandenameele J, Brans A, Verlaine O, Bendak K, Damblon C, Matagne A, Segal DJ, Galleni M, Mackay JP, Vandevenne M.

Sci Rep. 2019 Feb 21;9(1):2484. doi: 10.1038/s41598-019-38655-y.


Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem.

Azarkan M, Feller G, Vandenameele J, Herman R, El Mahyaoui R, Sauvage E, Vanden Broeck A, Matagne A, Charlier P, Kerff F.

Sci Rep. 2018 Jul 31;8(1):11508. doi: 10.1038/s41598-018-29439-x.


Peptidoglycan glycosyltransferase-ligand binding assay based on tryptophan fluorescence quenching.

Dahmane I, Montagner C, Matagne A, Dumbre S, Herdewijn P, Terrak M.

Biochimie. 2018 Sep;152:1-5. doi: 10.1016/j.biochi.2018.06.010. Epub 2018 Jun 15.


P174E Substitution in GES-1 and GES-5 β-Lactamases Improves Catalytic Efficiency toward Carbapenems.

Piccirilli A, Mercuri PS, Galleni M, Aschi M, Matagne A, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01851-17. doi: 10.1128/AAC.01851-17. Print 2018 May.


Biophysical Approaches to Protein Folding and Disease, a satellite meeting to the IUPAB-EBSA congress.

Dalla Serra M, Gilbert RJC, Matagne A, England P.

Eur Biophys J. 2018 Mar;47(2):95-96. doi: 10.1007/s00249-018-1288-0. No abstract available.


Peptide-surfactant interactions: A combined spectroscopic and molecular dynamics simulation approach.

Roussel G, Caudano Y, Matagne A, Sansom MS, Perpète EA, Michaux C.

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Feb 5;190:464-470. doi: 10.1016/j.saa.2017.09.056. Epub 2017 Sep 21.


Brivaracetam does not modulate ionotropic channels activated by glutamate, γ-aminobutyric acid, and glycine in hippocampal neurons.

Niespodziany I, Rigo JM, Moonen G, Matagne A, Klitgaard H, Wolff C.

Epilepsia. 2017 Nov;58(11):e157-e161. doi: 10.1111/epi.13890. Epub 2017 Aug 29.


Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus.

Niquet J, Suchomelova L, Thompson K, Klitgaard H, Matagne A, Wasterlain C.

Epilepsia. 2017 Jul;58(7):1199-1207. doi: 10.1111/epi.13787. Epub 2017 Jun 9.


The Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation.

Chevigné A, Campizi V, Szpakowska M, Bourry D, Dumez ME, Martins JC, Matagne A, Galleni M, Jacquet A.

Int J Mol Sci. 2017 May 20;18(5). pii: E1087. doi: 10.3390/ijms18051087.


The proteolytic system of pineapple stems revisited: Purification and characterization of multiple catalytically active forms.

Matagne A, Bolle L, El Mahyaoui R, Baeyens-Volant D, Azarkan M.

Phytochemistry. 2017 Jun;138:29-51. doi: 10.1016/j.phytochem.2017.02.019. Epub 2017 Feb 23.


Infrared imaging of high density protein arrays.

De Meutter J, Vandenameele J, Matagne A, Goormaghtigh E.

Analyst. 2017 Apr 10;142(8):1371-1380. doi: 10.1039/c6an02048h.


Biophysical characterization data of the artificial protein Octarellin V.1 and binding test with its X-ray helpers.

Figueroa M, Vandenameele J, Goormaghtigh E, Valerio-Lepiniec M, Minard P, Matagne A, Van de Weerdt C.

Data Brief. 2016 Jul 26;8:1221-6. doi: 10.1016/j.dib.2016.07.036. eCollection 2016 Sep.


The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity.

Jourdan S, Francis IM, Kim MJ, Salazar JJ, Planckaert S, Frère JM, Matagne A, Kerff F, Devreese B, Loria R, Rigali S.

Sci Rep. 2016 Jun 2;6:27144. doi: 10.1038/srep27144.


The Role of Active Site Flexible Loops in Catalysis and of Zinc in Conformational Stability of Bacillus cereus 569/H/9 β-Lactamase.

Montagner C, Nigen M, Jacquin O, Willet N, Dumoulin M, Karsisiotis AI, Roberts GC, Damblon C, Redfield C, Matagne A.

J Biol Chem. 2016 Jul 29;291(31):16124-37. doi: 10.1074/jbc.M116.719005. Epub 2016 May 27.


Unravelling the mechanisms of a protein refolding process based on the association of detergents and co-solvents.

Michaux C, Roussel G, Lopes-Rodrigues M, Matagne A, Perpète EA.

J Pept Sci. 2016 Jul;22(7):485-91. doi: 10.1002/psc.2893. Epub 2016 May 19.


The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.

Figueroa M, Sleutel M, Vandevenne M, Parvizi G, Attout S, Jacquin O, Vandenameele J, Fischer AW, Damblon C, Goormaghtigh E, Valerio-Lepiniec M, Urvoas A, Durand D, Pardon E, Steyaert J, Minard P, Maes D, Meiler J, Matagne A, Martial JA, Van de Weerdt C.

J Struct Biol. 2016 Jul;195(1):19-30. doi: 10.1016/j.jsb.2016.05.004. Epub 2016 May 12.


Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment.

Klitgaard H, Matagne A, Nicolas JM, Gillard M, Lamberty Y, De Ryck M, Kaminski RM, Leclercq K, Niespodziany I, Wolff C, Wood M, Hannestad J, Kervyn S, Kenda B.

Epilepsia. 2016 Apr;57(4):538-48. doi: 10.1111/epi.13340. Epub 2016 Feb 26. Review.


Kinetic Study of Laboratory Mutants of NDM-1 Metallo-β-Lactamase and the Importance of an Isoleucine at Position 35.

Marcoccia F, Bottoni C, Sabatini A, Colapietro M, Mercuri PS, Galleni M, Kerff F, Matagne A, Celenza G, Amicosante G, Perilli M.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2366-72. doi: 10.1128/AAC.00531-15. Print 2016 Apr.


Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.

Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H.

Epilepsia. 2016 Feb;57(2):201-9. doi: 10.1111/epi.13267. Epub 2015 Dec 10.


A novel form of ficin from Ficus carica latex: Purification and characterization.

Baeyens-Volant D, Matagne A, El Mahyaoui R, Wattiez R, Azarkan M.

Phytochemistry. 2015 Sep;117:154-167. doi: 10.1016/j.phytochem.2015.05.019. Epub 2015 Jun 12.


Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats.

Dupuis N, Matagne A, Staelens L, Dournaud P, Desnous B, Gressens P, Auvin S.

Epilepsia. 2015 May;56(5):800-5. doi: 10.1111/epi.12973. Epub 2015 Mar 25.


Current understanding of the mechanism of action of the antiepileptic drug lacosamide.

Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C.

Epilepsy Res. 2015 Feb;110:189-205. doi: 10.1016/j.eplepsyres.2014.11.021. Epub 2014 Dec 3. Review.


Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.

Bury D, Dahmane I, Derouaux A, Dumbre S, Herdewijn P, Matagne A, Breukink E, Mueller-Seitz E, Petz M, Terrak M.

Biochem Pharmacol. 2015 Jan 15;93(2):141-50. doi: 10.1016/j.bcp.2014.11.003. Epub 2014 Nov 14.


Determination of kinetics and the crystal structure of a novel type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase from Streptococcus pneumoniae.

de Ruyck J, Janczak MW, Neti SS, Rothman SC, Schubert HL, Cornish RM, Matagne A, Wouters J, Poulter CD.

Chembiochem. 2014 Jul 7;15(10):1452-8. doi: 10.1002/cbic.201402046. Epub 2014 Jun 6.


Low potency and limited efficacy of antiepileptic drugs in the mouse 6 Hz corneal kindling model.

Leclercq K, Matagne A, Kaminski RM.

Epilepsy Res. 2014 May;108(4):675-83. doi: 10.1016/j.eplepsyres.2014.02.013. Epub 2014 Mar 5.


The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction.

Dumez ME, Herman J, Campisi V, Bouaziz A, Rosu F, Luxen A, Vandenberghe I, de Pauw E, Frère JM, Matagne A, Chevigné A, Galleni M.

PLoS One. 2013 Sep 20;8(9):e68014. doi: 10.1371/journal.pone.0068014. eCollection 2013.


Influence of sample and mobile phase composition on peptide retention behaviour and sensitivity in reversed-phase liquid chromatography/mass spectrometry.

Houbart V, Rozet E, Matagne A, Crommen J, Servais AC, Fillet M.

J Chromatogr A. 2013 Nov 1;1314:199-207. doi: 10.1016/j.chroma.2013.09.036. Epub 2013 Sep 13.


Class A β-lactamases as versatile scaffolds to create hybrid enzymes: applications from basic research to medicine.

Huynen C, Filée P, Matagne A, Galleni M, Dumoulin M.

Biomed Res Int. 2013;2013:827621. doi: 10.1155/2013/827621. Epub 2013 Aug 28. Review.


Octarellin VI: using rosetta to design a putative artificial (β/α)8 protein.

Figueroa M, Oliveira N, Lejeune A, Kaufmann KW, Dorr BM, Matagne A, Martial JA, Meiler J, Van de Weerdt C.

PLoS One. 2013 Aug 19;8(8):e71858. doi: 10.1371/journal.pone.0071858. eCollection 2013.


A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.

De Genst E, Chan PH, Pardon E, Hsu SD, Kumita JR, Christodoulou J, Menzer L, Chirgadze DY, Robinson CV, Muyldermans S, Matagne A, Wyns L, Dobson CM, Dumoulin M.

J Phys Chem B. 2013 Oct 24;117(42):13245-13258. doi: 10.1021/jp403425z. Epub 2013 Sep 24.


The dynamics of lysozyme from bacteriophage lambda in solution probed by NMR and MD simulations.

Smith LJ, Bowen AM, Di Paolo A, Matagne A, Redfield C.

Chembiochem. 2013 Sep 23;14(14):1780-8. doi: 10.1002/cbic.201300193. Epub 2013 Jun 25.


Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice.

Shandra A, Shandra P, Kaschenko O, Matagne A, Stöhr T.

Epilepsia. 2013 Jul;54(7):1167-75. doi: 10.1111/epi.12237. Epub 2013 Jun 10.


Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase.

Delvaux D, Kerff F, Murty MR, Lakaye B, Czerniecki J, Kohn G, Wins P, Herman R, Gabelica V, Heuze F, Tordoir X, Marée R, Matagne A, Charlier P, De Pauw E, Bettendorff L.

Biochim Biophys Acta. 2013 Oct;1830(10):4513-23. doi: 10.1016/j.bbagen.2013.05.014. Epub 2013 May 22.


Lacosamide treatment following status epilepticus attenuates neuronal cell loss and alterations in hippocampal neurogenesis in a rat electrical status epilepticus model.

Licko T, Seeger N, Zellinger C, Russmann V, Matagne A, Potschka H.

Epilepsia. 2013 Jul;54(7):1176-85. doi: 10.1111/epi.12196. Epub 2013 Apr 24.


Energetics of protein stability at extreme environmental temperatures in bacterial trigger factors.

Struvay C, Negro S, Matagne A, Feller G.

Biochemistry. 2013 Apr 30;52(17):2982-90. doi: 10.1021/bi4002387. Epub 2013 Apr 17.


Use of red autofluorescence for monitoring prodiginine biosynthesis.

Tenconi E, Guichard P, Motte P, Matagne A, Rigali S.

J Microbiol Methods. 2013 May;93(2):138-43. doi: 10.1016/j.mimet.2013.02.012. Epub 2013 Mar 18.


Efficient refolding of a recombinant abzyme : structural and catalytic characterizations.

Ben Naya R, Matti K, Guellier A, Matagne A, Boquet D, Thomas D, Friboulet A, Avalle B, Padiolleau-Lefèvre S.

Appl Microbiol Biotechnol. 2013 Sep;97(17):7721-31. doi: 10.1007/s00253-012-4600-4. Epub 2012 Dec 19.


Towards a universal method for protein refolding: the trimeric beta barrel membrane Omp2a as a test case.

Roussel G, Perpète EA, Matagne A, Tinti E, Michaux C.

Biotechnol Bioeng. 2013 Feb;110(2):417-23. doi: 10.1002/bit.24722. Epub 2012 Sep 18.


Purification, refolding and characterization of the trimeric Omp2a outer membrane porin from Brucella melitensis.

Roussel G, Matagne A, De Bolle X, Perpète EA, Michaux C.

Protein Expr Purif. 2012 Jun;83(2):198-204. doi: 10.1016/j.pep.2012.04.003. Epub 2012 Apr 17.


Amyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host protein.

Scarafone N, Pain C, Fratamico A, Gaspard G, Yilmaz N, Filée P, Galleni M, Matagne A, Dumoulin M.

PLoS One. 2012;7(3):e31253. doi: 10.1371/journal.pone.0031253. Epub 2012 Mar 9.


Stepwise adaptations to low temperature as revealed by multiple mutants of psychrophilic α-amylase from Antarctic Bacterium.

Cipolla A, D'Amico S, Barumandzadeh R, Matagne A, Feller G.

J Biol Chem. 2011 Nov 4;286(44):38348-55. doi: 10.1074/jbc.M111.274423. Epub 2011 Sep 7.


Selective and reversible thiol-pegylation, an effective approach for purification and characterization of five fully active ficin (iso)forms from Ficus carica latex.

Azarkan M, Matagne A, Wattiez R, Bolle L, Vandenameele J, Baeyens-Volant D.

Phytochemistry. 2011 Oct;72(14-15):1718-31. doi: 10.1016/j.phytochem.2011.05.009. Epub 2011 Jun 12.


Effects of monopropanediamino-β-cyclodextrin on the denaturation process of the hybrid protein BlaPChBD.

Vandevenne M, Gaspard G, Belgsir el M, Ramnath M, Cenatiempo Y, Marechal D, Dumoulin M, Frere JM, Matagne A, Galleni M, Filee P.

Biochim Biophys Acta. 2011 Sep;1814(9):1146-53. doi: 10.1016/j.bbapap.2011.05.007. Epub 2011 May 15.


Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties.

Gillard M, Fuks B, Leclercq K, Matagne A.

Eur J Pharmacol. 2011 Aug 16;664(1-3):36-44. doi: 10.1016/j.ejphar.2011.04.064. Epub 2011 May 8.


The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus.

Wasterlain CG, Stöhr T, Matagne A.

Epilepsy Res. 2011 Mar;94(1-2):10-7. doi: 10.1016/j.eplepsyres.2010.12.014. Epub 2011 Jan 28.


Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70.

Vercheval L, Bauvois C, di Paolo A, Borel F, Ferrer JL, Sauvage E, Matagne A, Frère JM, Charlier P, Galleni M, Kerff F.

Biochem J. 2010 Dec 15;432(3):495-504. doi: 10.1042/BJ20101122.


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