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Accuracy of a deep convolutional neural network in detection of retinitis pigmentosa on ultrawide-field images.

Masumoto H, Tabuchi H, Nakakura S, Ohsugi H, Enno H, Ishitobi N, Ohsugi E, Mitamura Y.

PeerJ. 2019 May 7;7:e6900. doi: 10.7717/peerj.6900. eCollection 2019.


Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues.

Dwenger M, Kowalski WJ, Ye F, Yuan F, Tinney JP, Setozaki S, Nakane T, Masumoto H, Campbell P, Guido W, Keller BB.

J Tissue Eng. 2019 Apr 17;10:2041731419841748. doi: 10.1177/2041731419841748. eCollection 2019 Jan-Dec.


Accuracy of ultrawide-field fundus ophthalmoscopy-assisted deep learning for detecting treatment-naïve proliferative diabetic retinopathy.

Nagasawa T, Tabuchi H, Masumoto H, Enno H, Niki M, Ohara Z, Yoshizumi Y, Ohsugi H, Mitamura Y.

Int Ophthalmol. 2019 Feb 23. doi: 10.1007/s10792-019-01074-z. [Epub ahead of print]


Whole genome characterisation of G11P[25] and G9P[19] rotavirus A strains from adult patients with diarrhoea in Nepal.

Takatsuki H, Agbemabiese CA, Nakagomi T, Pun SB, Gauchan P, Muto H, Masumoto H, Atarashi R, Nakagomi O, Pandey BD.

Infect Genet Evol. 2019 Apr;69:246-254. doi: 10.1016/j.meegid.2019.02.007. Epub 2019 Feb 11.


Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion.

Nagasato D, Tabuchi H, Ohsugi H, Masumoto H, Enno H, Ishitobi N, Sonobe T, Kameoka M, Niki M, Mitamura Y.

Int J Ophthalmol. 2019 Jan 18;12(1):94-99. doi: 10.18240/ijo.2019.01.15. eCollection 2019.


De novo formation and epigenetic maintenance of centromere chromatin.

Ohzeki J, Larionov V, Earnshaw WC, Masumoto H.

Curr Opin Cell Biol. 2019 Jan 14;58:15-25. doi: 10.1016/ [Epub ahead of print] Review.


Deep Neural Network-Based Method for Detecting Central Retinal Vein Occlusion Using Ultrawide-Field Fundus Ophthalmoscopy.

Nagasato D, Tabuchi H, Ohsugi H, Masumoto H, Enno H, Ishitobi N, Sonobe T, Kameoka M, Niki M, Hayashi K, Mitamura Y.

J Ophthalmol. 2018 Nov 1;2018:1875431. doi: 10.1155/2018/1875431. eCollection 2018.


MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model.

Nishio H, Masumoto H, Sakamoto K, Yamazaki K, Ikeda T, Minatoya K.

J Thorac Cardiovasc Surg. 2018 Oct 6. pii: S0022-5223(18)32515-7. doi: 10.1016/j.jtcvs.2018.08.115. [Epub ahead of print]


Accuracy of deep learning, a machine learning technology, using ultra-wide-field fundus ophthalmoscopy for detecting idiopathic macular holes.

Nagasawa T, Tabuchi H, Masumoto H, Enno H, Niki M, Ohsugi H, Mitamura Y.

PeerJ. 2018 Oct 22;6:e5696. doi: 10.7717/peerj.5696. eCollection 2018.


Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft.

Masumoto H, Yamashita JK.

Inflamm Regen. 2018 Oct 10;38:26. doi: 10.1186/s41232-018-0084-7. eCollection 2018. Review.


Comparison between support vector machine and deep learning, machine-learning technologies for detecting epiretinal membrane using 3D-OCT.

Sonobe T, Tabuchi H, Ohsugi H, Masumoto H, Ishitobi N, Morita S, Enno H, Nagasato D.

Int Ophthalmol. 2018 Sep 14. doi: 10.1007/s10792-018-1016-x. [Epub ahead of print]


Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy.

Lee HS, Carmena M, Liskovykh M, Peat E, Kim JH, Oshimura M, Masumoto H, Teulade-Fichou MP, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.

Cancer Res. 2018 Nov 1;78(21):6282-6296. doi: 10.1158/0008-5472.CAN-18-0894. Epub 2018 Aug 30.


Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies.

Kouprina N, Petrov N, Molina O, Liskovykh M, Pesenti E, Ohzeki JI, Masumoto H, Earnshaw WC, Larionov V.

ACS Synth Biol. 2018 Sep 21;7(9):1974-1989. doi: 10.1021/acssynbio.8b00230. Epub 2018 Aug 16.


Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts.

Ishigami M, Masumoto H, Ikuno T, Aoki T, Kawatou M, Minakata K, Ikeda T, Sakata R, Yamashita JK, Minatoya K.

PLoS One. 2018 Aug 2;13(8):e0201650. doi: 10.1371/journal.pone.0201650. eCollection 2018.


Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model.

Li Z, Masumoto H, Jo JI, Yamazaki K, Ikeda T, Tabata Y, Minatoya K.

Gen Thorac Cardiovasc Surg. 2018 Nov;66(11):641-647. doi: 10.1007/s11748-018-0969-z. Epub 2018 Jul 7.


Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes.

Keller BB, Ye F, Yuan F, Trada H, Tinney JP, Walsh KM, Masumoto H.

In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 46.
2016 Jun 25.


Deep-learning Classifier With an Ultrawide-field Scanning Laser Ophthalmoscope Detects Glaucoma Visual Field Severity.

Masumoto H, Tabuchi H, Nakakura S, Ishitobi N, Miki M, Enno H.

J Glaucoma. 2018 Jul;27(7):647-652. doi: 10.1097/IJG.0000000000000988.


A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model.

Kumagai M, Minakata K, Masumoto H, Yamamoto M, Yonezawa A, Ikeda T, Uehara K, Yamazaki K, Ikeda T, Matsubara K, Yokode M, Shimizu A, Tabata Y, Sakata R, Minatoya K.

Heart Vessels. 2018 Oct;33(10):1251-1257. doi: 10.1007/s00380-018-1185-6. Epub 2018 May 14.


Accuracy of ultra-wide-field fundus ophthalmoscopy-assisted deep learning, a machine-learning technology, for detecting age-related macular degeneration.

Matsuba S, Tabuchi H, Ohsugi H, Enno H, Ishitobi N, Masumoto H, Kiuchi Y.

Int Ophthalmol. 2019 Jun;39(6):1269-1275. doi: 10.1007/s10792-018-0940-0. Epub 2018 May 9.


A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats.

Hirao S, Masumoto H, Itonaga T, Minatoya K.

J Vis Exp. 2018 Mar 23;(133). doi: 10.3791/56986.


The combination of NAD+-dependent deacetylase gene deletion and the interruption of gluconeogenesis causes increased glucose metabolism in budding yeast.

Masumoto H, Matsuyama S.

PLoS One. 2018 Mar 26;13(3):e0194942. doi: 10.1371/journal.pone.0194942. eCollection 2018.


Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.

Pesenti E, Kouprina N, Liskovykh M, Aurich-Costa J, Larionov V, Masumoto H, Earnshaw WC, Molina O.

ACS Synth Biol. 2018 Apr 20;7(4):1116-1130. doi: 10.1021/acssynbio.8b00018. Epub 2018 Mar 29.


Giant Faraday Rotation in Metal-Fluoride Nanogranular Films.

Kobayashi N, Ikeda K, Gu B, Takahashi S, Masumoto H, Maekawa S.

Sci Rep. 2018 Mar 21;8(1):4978. doi: 10.1038/s41598-018-23128-5.



Masumoto H, Fujiwara S.

Nihon Hinyokika Gakkai Zasshi. 2017;108(1):41-44. doi: 10.5980/jpnjurol.108.41. Japanese.


Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82.

Takeda M, Kanki Y, Masumoto H, Funakoshi S, Hatani T, Fukushima H, Izumi-Taguchi A, Matsui Y, Shimamura T, Yoshida Y, Yamashita JK.

Cell Rep. 2018 Jan 9;22(2):546-556. doi: 10.1016/j.celrep.2017.12.057.


Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia.

Tsumaru S, Masumoto H, Minakata K, Izuhara M, Yamazaki K, Ikeda T, Ono K, Sakata R, Minatoya K.

J Vasc Surg. 2018 Oct;68(4):1209-1215. doi: 10.1016/j.jvs.2017.08.097. Epub 2017 Dec 11.


Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue.

Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK.

Nat Commun. 2017 Oct 20;8(1):1078. doi: 10.1038/s41467-017-01125-y.


Rab3a-Bound CD63 Is Degraded and Rab3a-Free CD63 Is Incorporated into HIV-1 Particles.

Kubo Y, Masumoto H, Izumida M, Kakoki K, Hayashi H, Matsuyama T.

Front Microbiol. 2017 Aug 29;8:1653. doi: 10.3389/fmicb.2017.01653. eCollection 2017.


Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System.

Lee NCO, Kim JH, Petrov NS, Lee HS, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

ACS Synth Biol. 2018 Jan 19;7(1):63-74. doi: 10.1021/acssynbio.7b00209. Epub 2017 Aug 24.


Using human artificial chromosomes to study centromere assembly and function.

Molina O, Kouprina N, Masumoto H, Larionov V, Earnshaw WC.

Chromosoma. 2017 Oct;126(5):559-575. doi: 10.1007/s00412-017-0633-x. Epub 2017 Jul 7. Review.


Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model.

Hirao S, Minakata K, Masumoto H, Yamazaki K, Ikeda T, Minatoya K, Sakata R.

J Thorac Cardiovasc Surg. 2017 Dec;154(6):1973-1983.e1. doi: 10.1016/j.jtcvs.2017.05.051. Epub 2017 May 30.


Quantification of Cardiomyocyte Alignment from Three-Dimensional (3D) Confocal Microscopy of Engineered Tissue.

Kowalski WJ, Yuan F, Nakane T, Masumoto H, Dwenger M, Ye F, Tinney JP, Keller BB.

Microsc Microanal. 2017 Aug;23(4):826-842. doi: 10.1017/S1431927617000666. Epub 2017 Jun 19.


Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity.

Shimamoto Y, Tamura S, Masumoto H, Maeshima K.

Mol Biol Cell. 2017 Jun 1;28(11):1580-1589. doi: 10.1091/mbc.E16-11-0783. Epub 2017 Apr 20.


Correction: Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP.

Ikuno T, Masumoto H, Yamamizu K, Yoshioka M, Minakata K, Ikeda T, Sakata R, Yamashita JK.

PLoS One. 2017 Apr 17;12(4):e0176238. doi: 10.1371/journal.pone.0176238. eCollection 2017.


Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue.

Nakane T, Masumoto H, Tinney JP, Yuan F, Kowalski WJ, Ye F, LeBlanc AJ, Sakata R, Yamashita JK, Keller BB.

Sci Rep. 2017 Apr 3;7:45641. doi: 10.1038/srep45641.


Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP.

Ikuno T, Masumoto H, Yamamizu K, Yoshioka M, Minakata K, Ikeda T, Sakata R, Yamashita JK.

PLoS One. 2017 Mar 13;12(3):e0173271. doi: 10.1371/journal.pone.0173271. eCollection 2017. Erratum in: PLoS One. 2017 Apr 17;12 (4):e0176238.


Untiring steps toward the maturation of human stem cell-engineered heart tissue.

Masumoto H, Yamashita JK.

Ann Transl Med. 2017 Feb;5(4):87. doi: 10.21037/atm.2017.01.60. No abstract available.


Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.

Molina O, Vargiu G, Abad MA, Zhiteneva A, Jeyaprakash AA, Masumoto H, Kouprina N, Larionov V, Earnshaw WC.

Nat Commun. 2016 Nov 14;7:13334. doi: 10.1038/ncomms13334.


3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin.

Booth DG, Beckett AJ, Molina O, Samejima I, Masumoto H, Kouprina N, Larionov V, Prior IA, Earnshaw WC.

Mol Cell. 2016 Nov 17;64(4):790-802. doi: 10.1016/j.molcel.2016.10.009. Epub 2016 Nov 10.


Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model.

Taki T, Masumoto H, Funamoto M, Minakata K, Yamazaki K, Ikeda T, Sakata R.

J Thorac Cardiovasc Surg. 2017 Mar;153(3):726-734. doi: 10.1016/j.jtcvs.2016.10.014. Epub 2016 Oct 24.


Optically Transparent Ferromagnetic Nanogranular Films with Tunable Transmittance.

Kobayashi N, Masumoto H, Takahashi S, Maekawa S.

Sci Rep. 2016 Sep 28;6:34227. doi: 10.1038/srep34227.


Human iPS Cell-Derived Cardiac Tissue Sheets: a Platform for Cardiac Regeneration.

Masumoto H, Yamashita JK.

Curr Treat Options Cardiovasc Med. 2016 Nov;18(11):65. doi: 10.1007/s11936-016-0489-z. Review.


Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model.

Setozaki S, Minakata K, Masumoto H, Hirao S, Yamazaki K, Kuwahara K, Ikeda T, Sakata R.

J Vasc Surg. 2017 Jun;65(6):1803-1812.e2. doi: 10.1016/j.jvs.2016.06.003. Epub 2016 Jul 26.


Rate Constant Change of Photo Reaction of Bacteriorhodopsin Observed in Trimeric Molecular System.

Tsujiuchi Y, Masumoto H, Goto T.

J Nanosci Nanotechnol. 2016 Apr;16(4):3431-5.


The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages.

Masumoto H, Nakane T, Tinney JP, Yuan F, Ye F, Kowalski WJ, Minakata K, Sakata R, Yamashita JK, Keller BB.

Sci Rep. 2016 Jul 20;6:29933. doi: 10.1038/srep29933.


Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation.

Ota Y, Chinen T, Yoshida K, Kudo S, Nagumo Y, Shiwa Y, Yamada R, Umihara H, Iwasaki K, Masumoto H, Yokoshima S, Yoshikawa H, Fukuyama T, Kobayashi J, Usui T.

Chembiochem. 2016 Sep 2;17(17):1616-20. doi: 10.1002/cbic.201600075. Epub 2016 Jul 22.


Formation of functional CENP-B boxes at diverse locations in repeat units of centromeric DNA in New World monkeys.

Kugou K, Hirai H, Masumoto H, Koga A.

Sci Rep. 2016 Jun 13;6:27833. doi: 10.1038/srep27833.


KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

Ohzeki J, Shono N, Otake K, Martins NM, Kugou K, Kimura H, Nagase T, Larionov V, Earnshaw WC, Masumoto H.

Dev Cell. 2016 Jun 6;37(5):413-27. doi: 10.1016/j.devcel.2016.05.006.


CENP-B box, a nucleotide motif involved in centromere formation, occurs in a New World monkey.

Suntronpong A, Kugou K, Masumoto H, Srikulnath K, Ohshima K, Hirai H, Koga A.

Biol Lett. 2016 Mar;12(3):20150817. doi: 10.1098/rsbl.2015.0817.


Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells.

Kim JH, Lee HS, Lee NC, Goncharov NV, Kumeiko V, Masumoto H, Earnshaw WC, Kouprina N, Larionov V.

Oncotarget. 2016 Mar 22;7(12):14841-56. doi: 10.18632/oncotarget.7854.

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