Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 43

1.

A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea.

Van Dycke J, Arnoldi F, Papa G, Vandepoele J, Burrone OR, Mastrangelo E, Tarantino D, Heylen E, Neyts J, Rocha-Pereira J.

J Infect Dis. 2018 Oct 20;218(11):1753-1758. doi: 10.1093/infdis/jiy398.

PMID:
30085019
2.

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.

Corti A, Milani M, Lecis D, Seneci P, de Rosa M, Mastrangelo E, Cossu F.

FEBS J. 2018 Sep;285(17):3286-3298. doi: 10.1111/febs.14616. Epub 2018 Aug 16.

PMID:
30055105
3.

Role and inhibition of GLI1 protein in cancer.

Mastrangelo E, Milani M.

Lung Cancer (Auckl). 2018 Mar 27;9:35-43. doi: 10.2147/LCTT.S124483. eCollection 2018. Review.

4.

Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles.

Eichwald C, De Lorenzo G, Schraner EM, Papa G, Bollati M, Swuec P, de Rosa M, Milani M, Mastrangelo E, Ackermann M, Burrone OR, Arnoldi F.

J Virol. 2017 Nov 15. pii: JVI.01943-17. doi: 10.1128/JVI.01943-17. [Epub ahead of print]

5.

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.

Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V.

Eur J Med Chem. 2018 Jan 1;143:1667-1676. doi: 10.1016/j.ejmech.2017.10.064. Epub 2017 Nov 11.

PMID:
29137867
6.

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein.

Bonì F, Milani M, Barbiroli A, Diomede L, Mastrangelo E, de Rosa M.

Hum Mol Genet. 2018 Jan 1;27(1):53-65. doi: 10.1093/hmg/ddx383.

7.

Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor.

Sorrentino L, Cossu F, Milani M, Aliverti A, Mastrangelo E.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):1011-1017. doi: 10.1016/j.bbrc.2017.06.156. Epub 2017 Jun 27.

PMID:
28666871
8.

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.

Tarantino D, Cannalire R, Mastrangelo E, Croci R, Querat G, Barreca ML, Bolognesi M, Manfroni G, Cecchetti V, Milani M.

Antiviral Res. 2016 Oct;134:226-235. doi: 10.1016/j.antiviral.2016.09.007. Epub 2016 Sep 17.

9.

Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.

Croci R, Bottaro E, Chan KW, Watanabe S, Pezzullo M, Mastrangelo E, Nastruzzi C.

Int J Biomater. 2016;2016:8043983. doi: 10.1155/2016/8043983. Epub 2016 May 8.

10.

The activator of apoptosis Smac-DIABLO acts as a tetramer in solution.

Mastrangelo E, Vachette P, Cossu F, Malvezzi F, Bolognesi M, Milani M.

Biophys J. 2015 Feb 3;108(3):714-23. doi: 10.1016/j.bpj.2014.11.3471.

11.

NF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathway.

Cossu F, Milani M, Grassi S, Malvezzi F, Corti A, Bolognesi M, Mastrangelo E.

Proteins. 2015 Apr;83(4):612-20. doi: 10.1002/prot.24766. Epub 2015 Feb 5.

PMID:
25619915
12.

PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.

Croci R, Tarantino D, Milani M, Pezzullo M, Rohayem J, Bolognesi M, Mastrangelo E.

FEBS Lett. 2014 May 2;588(9):1720-5. doi: 10.1016/j.febslet.2014.03.021. Epub 2014 Mar 18.

13.

Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.

Croci R, Pezzullo M, Tarantino D, Milani M, Tsay SC, Sureshbabu R, Tsai YJ, Mastrangelo E, Rohayem J, Bolognesi M, Hwu JR.

PLoS One. 2014 Mar 12;9(3):e91765. doi: 10.1371/journal.pone.0091765. eCollection 2014.

14.

Delivery of suramin as an antiviral agent through liposomal systems.

Mastrangelo E, Mazzitelli S, Fabbri J, Rohayem J, Ruokolainen J, Nykänen A, Milani M, Pezzullo M, Nastruzzi C, Bolognesi M.

ChemMedChem. 2014 May;9(5):933-9. doi: 10.1002/cmdc.201300563. Epub 2014 Mar 11.

PMID:
24616282
15.

Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase.

Tarantino D, Pezzullo M, Mastrangelo E, Croci R, Rohayem J, Robel I, Bolognesi M, Milani M.

Antiviral Res. 2014 Feb;102:23-8. doi: 10.1016/j.antiviral.2013.11.016. Epub 2013 Dec 4.

16.

Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.

Cossu F, Milani M, Vachette P, Malvezzi F, Grassi S, Lecis D, Delia D, Drago C, Seneci P, Bolognesi M, Mastrangelo E.

PLoS One. 2012;7(11):e49527. doi: 10.1371/journal.pone.0049527. Epub 2012 Nov 15.

17.

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.

Lecis D, Mastrangelo E, Belvisi L, Bolognesi M, Civera M, Cossu F, De Cesare M, Delia D, Drago C, Manenti G, Manzoni L, Milani M, Moroni E, Perego P, Potenza D, Rizzo V, Scavullo C, Scolastico C, Servida F, Vasile F, Seneci P.

Bioorg Med Chem. 2012 Nov 15;20(22):6709-23. doi: 10.1016/j.bmc.2012.09.041. Epub 2012 Sep 24.

PMID:
23062821
18.

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis.

Manzoni L, Belvisi L, Bianchi A, Conti A, Drago C, de Matteo M, Ferrante L, Mastrangelo E, Perego P, Potenza D, Scolastico C, Servida F, Timpano G, Vasile F, Rizzo V, Seneci P.

Bioorg Med Chem. 2012 Nov 15;20(22):6687-708. doi: 10.1016/j.bmc.2012.09.020. Epub 2012 Sep 21.

PMID:
23036335
19.

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug.

Mastrangelo E, Pezzullo M, De Burghgraeve T, Kaptein S, Pastorino B, Dallmeier K, de Lamballerie X, Neyts J, Hanson AM, Frick DN, Bolognesi M, Milani M.

J Antimicrob Chemother. 2012 Aug;67(8):1884-94. doi: 10.1093/jac/dks147. Epub 2012 Apr 25.

20.

Structure-based inhibition of Norovirus RNA-dependent RNA polymerases.

Mastrangelo E, Pezzullo M, Tarantino D, Petazzi R, Germani F, Kramer D, Robel I, Rohayem J, Bolognesi M, Milani M.

J Mol Biol. 2012 Jun 8;419(3-4):198-210. doi: 10.1016/j.jmb.2012.03.008. Epub 2012 Mar 21.

PMID:
22446684
21.

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.

Bianchi A, Ugazzi M, Ferrante L, Lecis D, Scavullo C, Mastrangelo E, Seneci P.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2204-8. doi: 10.1016/j.bmcl.2012.01.098. Epub 2012 Feb 2.

PMID:
22342627
22.

Flaviviral helicase: insights into the mechanism of action of a motor protein.

Mastrangelo E, Bolognesi M, Milani M.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):84-7. doi: 10.1016/j.bbrc.2011.11.060. Epub 2011 Nov 19.

23.

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1.

Cossu F, Malvezzi F, Canevari G, Mastrangelo E, Lecis D, Delia D, Seneci P, Scolastico C, Bolognesi M, Milani M.

Protein Sci. 2010 Dec;19(12):2418-29. doi: 10.1002/pro.523.

24.

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib.

Lecis D, Drago C, Manzoni L, Seneci P, Scolastico C, Mastrangelo E, Bolognesi M, Anichini A, Kashkar H, Walczak H, Delia D.

Br J Cancer. 2010 Jun 8;102(12):1707-16. doi: 10.1038/sj.bjc.6605687. Epub 2010 May 11.

25.

Structure and functionality in flavivirus NS-proteins: perspectives for drug design.

Bollati M, Alvarez K, Assenberg R, Baronti C, Canard B, Cook S, Coutard B, Decroly E, de Lamballerie X, Gould EA, Grard G, Grimes JM, Hilgenfeld R, Jansson AM, Malet H, Mancini EJ, Mastrangelo E, Mattevi A, Milani M, Moureau G, Neyts J, Owens RJ, Ren J, Selisko B, Speroni S, Steuber H, Stuart DI, Unge T, Bolognesi M.

Antiviral Res. 2010 Aug;87(2):125-48. doi: 10.1016/j.antiviral.2009.11.009. Epub 2009 Nov 27. Review.

26.

Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication.

Assenberg R, Mastrangelo E, Walter TS, Verma A, Milani M, Owens RJ, Stuart DI, Grimes JM, Mancini EJ.

J Virol. 2009 Dec;83(24):12895-906. doi: 10.1128/JVI.00942-09. Epub 2009 Sep 30.

27.

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Seneci P, Bianchi A, Battaglia C, Belvisi L, Bolognesi M, Caprini A, Cossu F, Franco Ed, Matteo Md, Delia D, Drago C, Khaled A, Lecis D, Manzoni L, Marizzoni M, Mastrangelo E, Milani M, Motto I, Moroni E, Potenza D, Rizzo V, Servida F, Turlizzi E, Varrone M, Vasile F, Scolastico C.

Bioorg Med Chem. 2009 Aug 15;17(16):5834-56. doi: 10.1016/j.bmc.2009.07.009. Epub 2009 Jul 10.

PMID:
19620011
28.

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition.

Milani M, Mastrangelo E, Bollati M, Selisko B, Decroly E, Bouvet M, Canard B, Bolognesi M.

Antiviral Res. 2009 Jul;83(1):28-34. doi: 10.1016/j.antiviral.2009.03.001. Epub 2009 Mar 14.

PMID:
19501254
29.

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.

Cossu F, Milani M, Mastrangelo E, Vachette P, Servida F, Lecis D, Canevari G, Delia D, Drago C, Rizzo V, Manzoni L, Seneci P, Scolastico C, Bolognesi M.

J Mol Biol. 2009 Sep 25;392(3):630-44. doi: 10.1016/j.jmb.2009.04.033. Epub 2009 Apr 22.

PMID:
19393243
30.

Crystal structure of a methyltransferase from a no-known-vector Flavivirus.

Bollati M, Milani M, Mastrangelo E, de Lamballerie X, Canard B, Bolognesi M.

Biochem Biophys Res Commun. 2009 Apr 24;382(1):200-4. doi: 10.1016/j.bbrc.2009.03.008. Epub 2009 Mar 9.

PMID:
19275894
31.

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.

Cossu F, Mastrangelo E, Milani M, Sorrentino G, Lecis D, Delia D, Manzoni L, Seneci P, Scolastico C, Bolognesi M.

Biochem Biophys Res Commun. 2009 Jan 9;378(2):162-7. doi: 10.1016/j.bbrc.2008.10.139. Epub 2008 Nov 4.

PMID:
18992220
32.

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus.

Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M.

J Mol Biol. 2009 Jan 9;385(1):140-52. doi: 10.1016/j.jmb.2008.10.028. Epub 2008 Oct 19.

PMID:
18976670
33.

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.

Mastrangelo E, Cossu F, Milani M, Sorrentino G, Lecis D, Delia D, Manzoni L, Drago C, Seneci P, Scolastico C, Rizzo V, Bolognesi M.

J Mol Biol. 2008 Dec 19;384(3):673-89. doi: 10.1016/j.jmb.2008.09.064. Epub 2008 Oct 7.

PMID:
18851976
34.

Hemoprotein time-resolved X-ray crystallography.

Milani M, Nardini M, Pesce A, Mastrangelo E, Bolognesi M.

IUBMB Life. 2008 Mar;60(3):154-8. doi: 10.1002/iub.23. Review.

35.

Ebolavirus and Marburgvirus: insight the Filoviridae family.

Ascenzi P, Bocedi A, Heptonstall J, Capobianchi MR, Di Caro A, Mastrangelo E, Bolognesi M, Ippolito G.

Mol Aspects Med. 2008 Jun;29(3):151-85. Epub 2007 Oct 22. Review.

PMID:
18063023
36.

Structure and biochemical analysis of Kokobera virus helicase.

Speroni S, De Colibus L, Mastrangelo E, Gould E, Coutard B, Forrester NL, Blanc S, Canard B, Mattevi A.

Proteins. 2008 Feb 15;70(3):1120-3. No abstract available.

PMID:
18004778
37.

Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein.

Mastrangelo E, Milani M, Bollati M, Selisko B, Peyrane F, Pandini V, Sorrentino G, Canard B, Konarev PV, Svergun DI, de Lamballerie X, Coutard B, Khromykh AA, Bolognesi M.

J Mol Biol. 2007 Sep 14;372(2):444-55. Epub 2007 Jun 27.

PMID:
17658551
38.

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase.

Mastrangelo E, Bollati M, Milani M, Selisko B, Peyrane F, Canard B, Grard G, de Lamballerie X, Bolognesi M.

Protein Sci. 2007 Jun;16(6):1133-45. Epub 2007 May 1.

39.

Ferredoxin-NADP+ reductase from Plasmodium falciparum undergoes NADP+-dependent dimerization and inactivation: functional and crystallographic analysis.

Milani M, Balconi E, Aliverti A, Mastrangelo E, Seeber F, Bolognesi M, Zanetti G.

J Mol Biol. 2007 Mar 23;367(2):501-13. Epub 2007 Jan 9.

PMID:
17258767
40.

Preliminary crystallographic characterization of an RNA helicase from Kunjin virus.

Mastrangelo E, Bollati M, Milani M, Brisbarre N, de Lamballerie X, Coutard B, Canard B, Khromykh A, Bolognesi M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):876-9. Epub 2006 Aug 11.

41.

Preliminary characterization of (nucleoside-2'-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses.

Mastrangelo E, Bollati M, Milani M, de Lamballerie X, Brisbarre N, Dalle K, Lantez V, Egloff MP, Coutard B, Canard B, Gould E, Forrester N, Bolognesi M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):768-70. Epub 2006 Jul 24. Erratum in: Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):252. de Lamballeire, Xavier [corrected de Lamballerie, Xavier]; Brisbare, Nadège [corrected to Brisbarre, Nadège].

42.

Identification of a novel HLA-A*02 allele, A*027401*.

Piancatelli D, Beato TD, Papola F, Aureli A, Fioroni A, Canossi A, Mastrangelo E, Liberatore G, Tessitore A, Adorno D.

Tissue Antigens. 2005 Aug;66(2):138-40.

PMID:
16029435
43.

Efficacy and tolerance of acetate free biofiltration: a central Italian multicenter trial.

Albertazzi A, Palmieri PF, Mastrangelo E.

Kidney Int Suppl. 1993 Jun;41:S188-94.

PMID:
8320918

Supplemental Content

Loading ...
Support Center