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Cerebral organoids and consciousness: how far are we willing to go?

Lavazza A, Massimini M.

J Med Ethics. 2018 Jun 28. pii: medethics-2018-104976. doi: 10.1136/medethics-2018-104976. [Epub ahead of print] No abstract available.


Genetic diversity of Coxiella burnetii in domestic ruminants in central Italy.

Di Domenico M, Curini V, Di Lollo V, Massimini M, Di Gialleonardo L, Franco A, Caprioli A, Battisti A, Cammà C.

BMC Vet Res. 2018 May 29;14(1):171. doi: 10.1186/s12917-018-1499-8.


Diffuse Pulmonary Adenocarcinoma with Micropapillary Growth Pattern in a Cat.

Romanucci M, Massimini M, Aste G, Defourny SVP, Crisi PE, Boari A, Della Salda L.

J Comp Pathol. 2018 Apr;160:34-38. doi: 10.1016/j.jcpa.2018.02.006. Epub 2018 Apr 4.


Human fronto-parietal response scattering subserves vigilance at night.

Gaggioni G, Ly JQM, Chellappa SL, Coppieters 't Wallant D, Rosanova M, Sarasso S, Luxen A, Salmon E, Middleton B, Massimini M, Schmidt C, Casali A, Phillips C, Vandewalle G.

Neuroimage. 2018 Jul 15;175:354-364. doi: 10.1016/j.neuroimage.2018.03.055. Epub 2018 Mar 28.


Cerebral organoids: ethical issues and consciousness assessment.

Lavazza A, Massimini M.

J Med Ethics. 2018 Feb 28. pii: medethics-2017-104555. doi: 10.1136/medethics-2017-104555. [Epub ahead of print]


Global structural integrity and effective connectivity in patients with disorders of consciousness.

Bodart O, Amico E, Gómez F, Casali AG, Wannez S, Heine L, Thibaut A, Annen J, Boly M, Casarotto S, Rosanova M, Massimini M, Laureys S, Gosseries O.

Brain Stimul. 2018 Mar - Apr;11(2):358-365. doi: 10.1016/j.brs.2017.11.006. Epub 2017 Nov 11.


Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses.

Storm JF, Boly M, Casali AG, Massimini M, Olcese U, Pennartz CMA, Wilke M.

J Neurosci. 2017 Nov 8;37(45):10882-10893. doi: 10.1523/JNEUROSCI.1838-17.2017. Review.


Are the Neural Correlates of Consciousness in the Front or in the Back of the Cerebral Cortex? Clinical and Neuroimaging Evidence.

Boly M, Massimini M, Tsuchiya N, Postle BR, Koch C, Tononi G.

J Neurosci. 2017 Oct 4;37(40):9603-9613. doi: 10.1523/JNEUROSCI.3218-16.2017. Review.


The spectral features of EEG responses to transcranial magnetic stimulation of the primary motor cortex depend on the amplitude of the motor evoked potentials.

Fecchio M, Pigorini A, Comanducci A, Sarasso S, Casarotto S, Premoli I, Derchi CC, Mazza A, Russo S, Resta F, Ferrarelli F, Mariotti M, Ziemann U, Massimini M, Rosanova M.

PLoS One. 2017 Sep 14;12(9):e0184910. doi: 10.1371/journal.pone.0184910. eCollection 2017.


Shaping the Default Activity Pattern of the Cortical Network.

Sanchez-Vives MV, Massimini M, Mattia M.

Neuron. 2017 Jun 7;94(5):993-1001. doi: 10.1016/j.neuron.2017.05.015. Review.


Bistability, Causality, and Complexity in Cortical Networks: An In Vitro Perturbational Study.

D'Andola M, Rebollo B, Casali AG, Weinert JF, Pigorini A, Villa R, Massimini M, Sanchez-Vives MV.

Cereb Cortex. 2018 Jul 1;28(7):2233-2242. doi: 10.1093/cercor/bhx122.


Pathology in Practice.

Romanucci M, Massimini M, Valerii V, Malatesta D, Bongiovanni L, Della Salda L.

J Am Vet Med Assoc. 2017 Jun 1;250(11):1251-1253. doi: 10.2460/javma.250.11.1251. No abstract available.


17-AAG and Apoptosis, Autophagy, and Mitophagy in Canine Osteosarcoma Cell Lines.

Massimini M, Palmieri C, De Maria R, Romanucci M, Malatesta D, De Martinis M, Maniscalco L, Ciccarelli A, Ginaldi L, Buracco P, Bongiovanni L, Della Salda L.

Vet Pathol. 2017 May;54(3):405-412. doi: 10.1177/0300985816681409. Epub 2016 Dec 14.


Measures of metabolism and complexity in the brain of patients with disorders of consciousness.

Bodart O, Gosseries O, Wannez S, Thibaut A, Annen J, Boly M, Rosanova M, Casali AG, Casarotto S, Tononi G, Massimini M, Laureys S.

Neuroimage Clin. 2017 Feb 6;14:354-362. doi: 10.1016/j.nicl.2017.02.002. eCollection 2017.


Tracking Dynamic Interactions Between Structural and Functional Connectivity: A TMS/EEG-dMRI Study.

Amico E, Bodart O, Rosanova M, Gosseries O, Heine L, Van Mierlo P, Martial C, Massimini M, Marinazzo D, Laureys S.

Brain Connect. 2017 Mar;7(2):84-97. doi: 10.1089/brain.2016.0462. Epub 2017 Mar 3.


Abnormal brain oscillations persist after recovery from bipolar depression.

Canali P, Casarotto S, Rosanova M, Sferrazza-Papa G, Casali AG, Gosseries O, Massimini M, Smeraldi E, Colombo C, Benedetti F.

Eur Psychiatry. 2017 Mar;41:10-15. doi: 10.1016/j.eurpsy.2016.10.005. Epub 2017 Feb 3.


Unexpected Cardiac Death During Anaesthesia of a Young Rabbit Associated with Fibro-fatty Replacement of the Right Ventricular Myocardium.

Romanucci M, Defourny SV, Massimini M, Valerii V, Arbuatti A, Giordano V, Bongiovanni L, Perrone C, Della Salda L.

J Comp Pathol. 2017 Jan;156(1):33-36. doi: 10.1016/j.jcpa.2016.10.008. Epub 2016 Nov 25.


Stratification of unresponsive patients by an independently validated index of brain complexity.

Casarotto S, Comanducci A, Rosanova M, Sarasso S, Fecchio M, Napolitani M, Pigorini A, G Casali A, Trimarchi PD, Boly M, Gosseries O, Bodart O, Curto F, Landi C, Mariotti M, Devalle G, Laureys S, Tononi G, Massimini M.

Ann Neurol. 2016 Nov;80(5):718-729. doi: 10.1002/ana.24779. Epub 2016 Nov 2.


Circadian dynamics in measures of cortical excitation and inhibition balance.

Chellappa SL, Gaggioni G, Ly JQ, Papachilleos S, Borsu C, Brzozowski A, Rosanova M, Sarasso S, Luxen A, Middleton B, Archer SN, Dijk DJ, Massimini M, Maquet P, Phillips C, Moran RJ, Vandewalle G.

Sci Rep. 2016 Sep 21;6:33661. doi: 10.1038/srep33661.


HSP32 and HSP90 Immunoexpression, in Relation to Kit Pattern, Grading, and Mitotic Count in Canine Cutaneous Mast Cell Tumors.

Romanucci M, Massimini M, Ciccarelli A, Malatesta D, Bongiovanni L, Gasbarre A, Della Salda L.

Vet Pathol. 2017 Mar;54(2):222-225. doi: 10.1177/0300985816669405. Epub 2016 Sep 29.


Ovarian teratoma in an adult female Zoogoneticus tequila (Webb & Miller 1998): histological and immunohistochemical features.

Romanucci M, Arbuatti A, Massimini M, Defourny SVP, Della Salda L.

J Fish Dis. 2017 Jun;40(6):859-862. doi: 10.1111/jfd.12553. Epub 2016 Sep 5. No abstract available.


Consciousness and cortical responsiveness: a within-state study during non-rapid eye movement sleep.

Nieminen JO, Gosseries O, Massimini M, Saad E, Sheldon AD, Boly M, Siclari F, Postle BR, Tononi G.

Sci Rep. 2016 Aug 5;6:30932. doi: 10.1038/srep30932.


Posterior and anterior cortex - where is the difference that makes the difference?

Koch C, Massimini M, Boly M, Tononi G.

Nat Rev Neurosci. 2016 Jul 28. doi: 10.1038/nrn.2016.105. [Epub ahead of print] No abstract available.


Circadian regulation of human cortical excitability.

Ly JQ, Gaggioni G, Chellappa SL, Papachilleos S, Brzozowski A, Borsu C, Rosanova M, Sarasso S, Middleton B, Luxen A, Archer SN, Phillips C, Dijk DJ, Maquet P, Massimini M, Vandewalle G.

Nat Commun. 2016 Jun 24;7:11828. doi: 10.1038/ncomms11828.


Integrated information theory: from consciousness to its physical substrate.

Tononi G, Boly M, Massimini M, Koch C.

Nat Rev Neurosci. 2016 Jul;17(7):450-61. doi: 10.1038/nrn.2016.44. Epub 2016 May 26. Review.


Neural correlates of consciousness: progress and problems.

Koch C, Massimini M, Boly M, Tononi G.

Nat Rev Neurosci. 2016 May;17(5):307-21. doi: 10.1038/nrn.2016.22. Review.


Consciousness and Complexity during Unresponsiveness Induced by Propofol, Xenon, and Ketamine.

Sarasso S, Boly M, Napolitani M, Gosseries O, Charland-Verville V, Casarotto S, Rosanova M, Casali AG, Brichant JF, Boveroux P, Rex S, Tononi G, Laureys S, Massimini M.

Curr Biol. 2015 Dec 7;25(23):3099-105. doi: 10.1016/j.cub.2015.10.014. Epub 2015 Nov 19.


Consensus Paper: Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation.

Karabanov A, Ziemann U, Hamada M, George MS, Quartarone A, Classen J, Massimini M, Rothwell J, Siebner HR.

Brain Stimul. 2015 Sep-Oct;8(5):993-1006. Review.


Shared reduction of oscillatory natural frequencies in bipolar disorder, major depressive disorder and schizophrenia.

Canali P, Sarasso S, Rosanova M, Casarotto S, Sferrazza-Papa G, Gosseries O, Fecchio M, Massimini M, Mariotti M, Cavallaro R, Smeraldi E, Colombo C, Benedetti F.

J Affect Disord. 2015 Sep 15;184:111-5. doi: 10.1016/j.jad.2015.05.043. Epub 2015 Jun 3.


Consensus Paper: Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation.

Karabanov A, Ziemann U, Hamada M, George MS, Quartarone A, Classen J, Massimini M, Rothwell J, Siebner HR.

Brain Stimul. 2015 May-Jun;8(3):442-54. doi: 10.1016/j.brs.2015.01.404. Epub 2015 Apr 1. Review. Corrected and republished in: Brain Stimul. 2015 Sep-Oct;8(5):993-1006.


Stimulus set meaningfulness and neurophysiological differentiation: a functional magnetic resonance imaging study.

Boly M, Sasai S, Gosseries O, Oizumi M, Casali A, Massimini M, Tononi G.

PLoS One. 2015 May 13;10(5):e0125337. doi: 10.1371/journal.pone.0125337. eCollection 2015.


Effect of dietary supplementation on lipid photooxidation in beef meat, during storage under commercial retail conditions.

Cardenia V, Massimini M, Poerio A, Venturini MC, Rodriguez-Estrada MT, Vecchia P, Lercker G.

Meat Sci. 2015 Jul;105:126-35. doi: 10.1016/j.meatsci.2015.02.010. Epub 2015 Feb 28.


Fluid boundaries between wake and sleep: experimental evidence from Stereo-EEG recordings.

Sarasso S, Pigorini A, Proserpio P, Gibbs SA, Massimini M, Nobili L.

Arch Ital Biol. 2014 Jun-Sep;152(2-3):169-77. doi: 10.12871/0002982920142311. Review.


Bistability breaks-off deterministic responses to intracortical stimulation during non-REM sleep.

Pigorini A, Sarasso S, Proserpio P, Szymanski C, Arnulfo G, Casarotto S, Fecchio M, Rosanova M, Mariotti M, Lo Russo G, Palva JM, Nobili L, Massimini M.

Neuroimage. 2015 May 15;112:105-113. doi: 10.1016/j.neuroimage.2015.02.056. Epub 2015 Mar 4.


On the cerebral origin of EEG responses to TMS: insights from severe cortical lesions.

Gosseries O, Sarasso S, Casarotto S, Boly M, Schnakers C, Napolitani M, Bruno MA, Ledoux D, Tshibanda JF, Massimini M, Laureys S, Rosanova M.

Brain Stimul. 2015 Jan-Feb;8(1):142-9. doi: 10.1016/j.brs.2014.10.008. Epub 2014 Oct 18.


Defensive response of European sea bass (Dicentrarchus labrax) against Listonella anguillarum or Photobacterium damselae subsp. piscicida experimental infection.

Mosca F, Ciulli S, Volpatti D, Romano N, Volpe E, Bulfon C, Massimini M, Caccia E, Galeotti M, Tiscar PG.

Vet Immunol Immunopathol. 2014 Dec 15;162(3-4):83-95. doi: 10.1016/j.vetimm.2014.10.002. Epub 2014 Oct 15.


Reduced mediodorsal thalamic volume and prefrontal cortical spindle activity in schizophrenia.

Buchmann A, Dentico D, Peterson MJ, Riedner BA, Sarasso S, Massimini M, Tononi G, Ferrarelli F.

Neuroimage. 2014 Nov 15;102 Pt 2:540-7. doi: 10.1016/j.neuroimage.2014.08.017. Epub 2014 Aug 17.


Transcranial magnetic stimulation combined with high-density EEG in altered states of consciousness.

Napolitani M, Bodart O, Canali P, Seregni F, Casali A, Laureys S, Rosanova M, Massimini M, Gosseries O.

Brain Inj. 2014;28(9):1180-9. doi: 10.3109/02699052.2014.920524. Review.


The PredictAD project: development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease.

Antila K, Lötjönen J, Thurfjell L, Laine J, Massimini M, Rueckert D, Zubarev RA, Orešič M, van Gils M, Mattila J, Hviid Simonsen A, Waldemar G, Soininen H.

Interface Focus. 2013 Apr 6;3(2):20120072. doi: 10.1098/rsfs.2012.0072.


Directed information transfer in scalp electroencephalographic recordings: insights on disorders of consciousness.

Marinazzo D, Gosseries O, Boly M, Ledoux D, Rosanova M, Massimini M, Noirhomme Q, Laureys S.

Clin EEG Neurosci. 2014 Jan;45(1):33-9. doi: 10.1177/1550059413510703. Epub 2014 Jan 8.


Quantifying cortical EEG responses to TMS in (un)consciousness.

Sarasso S, Rosanova M, Casali AG, Casarotto S, Fecchio M, Boly M, Gosseries O, Tononi G, Laureys S, Massimini M.

Clin EEG Neurosci. 2014 Jan;45(1):40-9. doi: 10.1177/1550059413513723. Epub 2014 Jan 8.


Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography.

Gosseries O, Thibaut A, Boly M, Rosanova M, Massimini M, Laureys S.

Ann Fr Anesth Reanim. 2014 Feb;33(2):65-71. doi: 10.1016/j.annfar.2013.11.002. Epub 2014 Jan 6. Review.


Hippocampal sleep spindles preceding neocortical sleep onset in humans.

Sarasso S, Proserpio P, Pigorini A, Moroni F, Ferrara M, De Gennaro L, De Carli F, Lo Russo G, Massimini M, Nobili L.

Neuroimage. 2014 Feb 1;86:425-32. doi: 10.1016/j.neuroimage.2013.10.031. Epub 2013 Oct 28.


A theoretically based index of consciousness independent of sensory processing and behavior.

Casali AG, Gosseries O, Rosanova M, Boly M, Sarasso S, Casali KR, Casarotto S, Bruno MA, Laureys S, Tononi G, Massimini M.

Sci Transl Med. 2013 Aug 14;5(198):198ra105. doi: 10.1126/scitranslmed.3006294.


Multivariate autoregressive models with exogenous inputs for intracerebral responses to direct electrical stimulation of the human brain.

Chang JY, Pigorini A, Massimini M, Tononi G, Nobili L, Van Veen BD.

Front Hum Neurosci. 2012 Nov 30;6:317. doi: 10.3389/fnhum.2012.00317. eCollection 2012.


Cortical mechanisms of loss of consciousness: insight from TMS/EEG studies.

Massimini M, Ferrarelli F, Sarasso S, Tononi G.

Arch Ital Biol. 2012 Jun-Sep;150(2-3):44-55. doi: 10.4449/aib.v150i2.1361. Review.


Assessing the effects of electroconvulsive therapy on cortical excitability by means of transcranial magnetic stimulation and electroencephalography.

Casarotto S, Canali P, Rosanova M, Pigorini A, Fecchio M, Mariotti M, Lucca A, Colombo C, Benedetti F, Massimini M.

Brain Topogr. 2013 Apr;26(2):326-37. doi: 10.1007/s10548-012-0256-8. Epub 2012 Oct 9.


Brain connectivity in disorders of consciousness.

Boly M, Massimini M, Garrido MI, Gosseries O, Noirhomme Q, Laureys S, Soddu A.

Brain Connect. 2012;2(1):1-10. doi: 10.1089/brain.2011.0049. Epub 2012 Apr 18. Review.


Reduced natural oscillatory frequency of frontal thalamocortical circuits in schizophrenia.

Ferrarelli F, Sarasso S, Guller Y, Riedner BA, Peterson MJ, Bellesi M, Massimini M, Postle BR, Tononi G.

Arch Gen Psychiatry. 2012 Aug;69(8):766-74.

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