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Items: 27

1.

Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface.

Biggi S, Pancher M, Stincardini C, Luotti S, Massignan T, Dalle Vedove A, Astolfi A, Gatto P, Lolli G, Barreca ML, Bonetto V, Adami V, Biasini E.

J Neurochem. 2020 Jan;152(1):136-150. doi: 10.1111/jnc.14805. Epub 2019 Jul 18.

PMID:
31264722
2.

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Aiello FB, Guszczynski T, Li W, Hixon JA, Jiang Q, Hodge DL, Massignan T, Di Lisio C, Merchant A, Procopio AD, Bonetto V, Durum SK.

Cell Signal. 2018 Jul;47:131-141. doi: 10.1016/j.cellsig.2018.03.008. Epub 2018 Mar 24.

PMID:
29581031
3.

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E.

PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017.

4.

A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity.

Massignan T, Sangiovanni V, Biggi S, Stincardini C, Elezgarai SR, Maietta G, Andreev IA, Ratmanova NK, Belov DS, Lukyanenko ER, Belov GM, Barreca ML, Altieri A, Kurkin AV, Biasini E.

ChemMedChem. 2017 Aug 22;12(16):1286-1292. doi: 10.1002/cmdc.201700302. Epub 2017 Aug 1.

PMID:
28722340
5.

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

Massignan T, Cimini S, Stincardini C, Cerovic M, Vanni I, Elezgarai SR, Moreno J, Stravalaci M, Negro A, Sangiovanni V, Restelli E, Riccardi G, Gobbi M, Castilla J, Borsello T, Nonno R, Biasini E.

Sci Rep. 2016 Mar 15;6:23180. doi: 10.1038/srep23180.

6.

Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

Lauranzano E, Pozzi S, Pasetto L, Stucchi R, Massignan T, Paolella K, Mombrini M, Nardo G, Lunetta C, Corbo M, Mora G, Bendotti C, Bonetto V.

Brain. 2015 Apr;138(Pt 4):974-91. doi: 10.1093/brain/awv005. Epub 2015 Feb 12.

PMID:
25678563
7.

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.

Biasini E, Unterberger U, Solomon IH, Massignan T, Senatore A, Bian H, Voigtlaender T, Bowman FP, Bonetto V, Chiesa R, Luebke J, Toselli P, Harris DA.

J Neurosci. 2013 Feb 6;33(6):2408-18. doi: 10.1523/JNEUROSCI.3406-12.2013.

8.

The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).

Turnbaugh JA, Unterberger U, SaĆ” P, Massignan T, Fluharty BR, Bowman FP, Miller MB, Supattapone S, Biasini E, Harris DA.

J Neurosci. 2012 Jun 27;32(26):8817-30. doi: 10.1523/JNEUROSCI.1103-12.2012.

9.

The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells.

Biasini E, Turnbaugh JA, Massignan T, Veglianese P, Forloni G, Bonetto V, Chiesa R, Harris DA.

PLoS One. 2012;7(3):e33472. doi: 10.1371/journal.pone.0033472. Epub 2012 Mar 12.

10.

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.

Russo L, Marsella C, Nardo G, Massignan T, Alessio M, Piermarini E, La Rosa S, Finzi G, Bonetto V, Bertuzzi F, Maechler P, Massa O.

Acta Diabetol. 2013 Feb;50(1):61-72. doi: 10.1007/s00592-012-0381-6. Epub 2012 Mar 3.

PMID:
22382775
11.

An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity.

Solomon IH, Khatri N, Biasini E, Massignan T, Huettner JE, Harris DA.

J Biol Chem. 2011 Apr 22;286(16):14724-36. doi: 10.1074/jbc.M110.214973. Epub 2011 Mar 8.

12.

A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide.

Massignan T, Biasini E, Harris DA.

Methods. 2011 Mar;53(3):214-9. doi: 10.1016/j.ymeth.2010.11.005. Epub 2010 Nov 27.

13.

The hydrophobic core region governs mutant prion protein aggregation and intracellular retention.

Biasini E, Tapella L, Restelli E, Pozzoli M, Massignan T, Chiesa R.

Biochem J. 2010 Sep 15;430(3):477-86. doi: 10.1042/BJ20100615.

PMID:
20626348
14.

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.

Massignan T, Biasini E, Lauranzano E, Veglianese P, Pignataro M, Fioriti L, Harris DA, Salmona M, Chiesa R, Bonetto V.

Mol Cell Proteomics. 2010 Apr;9(4):611-22. doi: 10.1074/mcp.M900271-MCP200. Epub 2009 Dec 7.

15.

Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.

Basso M, Samengo G, Nardo G, Massignan T, D'Alessandro G, Tartari S, Cantoni L, Marino M, Cheroni C, De Biasi S, Giordana MT, Strong MJ, Estevez AG, Salmona M, Bendotti C, Bonetto V.

PLoS One. 2009 Dec 2;4(12):e8130. doi: 10.1371/journal.pone.0008130.

16.

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

Massignan T, Stewart RS, Biasini E, Solomon IH, Bonetto V, Chiesa R, Harris DA.

J Biol Chem. 2010 Mar 5;285(10):7752-65. doi: 10.1074/jbc.M109.064949. Epub 2009 Nov 24.

17.

Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse.

Massignan T, Casoni F, Basso M, Stefanazzi P, Biasini E, Tortarolo M, Salmona M, Gianazza E, Bendotti C, Bonetto V.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):719-25. Epub 2006 Dec 20.

PMID:
17196550
18.

Regulation of redox-sensitive exofacial protein thiols in CHO cells.

Laragione T, Gianazza E, Tonelli R, Bigini P, Mennini T, Casoni F, Massignan T, Bonetto V, Ghezzi P.

Biol Chem. 2006 Oct-Nov;387(10-11):1371-6. Review.

PMID:
17081109
19.

Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice.

Basso M, Massignan T, Samengo G, Cheroni C, De Biasi S, Salmona M, Bendotti C, Bonetto V.

J Biol Chem. 2006 Nov 3;281(44):33325-35. Epub 2006 Aug 30.

20.

Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity.

Biasini E, Massignan T, Fioriti L, Rossi V, Dossena S, Salmona M, Forloni G, Bonetto V, Chiesa R.

Proteomics. 2006 May;6(9):2823-34.

PMID:
16572473
21.

Redox regulation of cyclophilin A by glutathionylation.

Ghezzi P, Casagrande S, Massignan T, Basso M, Bellacchio E, Mollica L, Biasini E, Tonelli R, Eberini I, Gianazza E, Dai WW, Fratelli M, Salmona M, Sherry B, Bonetto V.

Proteomics. 2006 Feb;6(3):817-25.

PMID:
16372262
22.

Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis.

Casoni F, Basso M, Massignan T, Gianazza E, Cheroni C, Salmona M, Bendotti C, Bonetto V.

J Biol Chem. 2005 Apr 22;280(16):16295-304. Epub 2005 Feb 7.

23.

The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.

Fioriti L, Quaglio E, Massignan T, Colombo L, Stewart RS, Salmona M, Harris DA, Forloni G, Chiesa R.

Mol Cell Neurosci. 2005 Jan;28(1):165-76.

PMID:
15607951
24.

Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics.

Laragione T, Bonetto V, Casoni F, Massignan T, Bianchi G, Gianazza E, Ghezzi P.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14737-41. Epub 2003 Dec 1. Erratum in: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4718.

25.

Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein.

Salmona M, Morbin M, Massignan T, Colombo L, Mazzoleni G, Capobianco R, Diomede L, Thaler F, Mollica L, Musco G, Kourie JJ, Bugiani O, Sharma D, Inouye H, Kirschner DA, Forloni G, Tagliavini F.

J Biol Chem. 2003 Nov 28;278(48):48146-53. Epub 2003 Sep 11.

26.

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems.

Casagrande S, Bonetto V, Fratelli M, Gianazza E, Eberini I, Massignan T, Salmona M, Chang G, Holmgren A, Ghezzi P.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9745-9. Epub 2002 Jul 15.

27.

Synthetic miniprion PrP106.

Bonetto V, Massignan T, Chiesa R, Morbin M, Mazzoleni G, Diomede L, Angeretti N, Colombo L, Forloni G, Tagliavini F, Salmona M.

J Biol Chem. 2002 Aug 30;277(35):31327-34. Epub 2002 Jun 10.

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