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Timing is everything - impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on auto-induction.

Sloan TJ, Murray E, Yokoyama M, Massey RC, Chan WC, Bonev B, Williams P.

J Bacteriol. 2019 Jul 29. pii: JB.00409-19. doi: 10.1128/JB.00409-19. [Epub ahead of print]


Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.

Harrison EM, Ba X, Coll F, Blane B, Restif O, Carvell H, Köser CU, Jamrozy D, Reuter S, Lovering A, Gleadall N, Bellis KL, Uhlemann AC, Lowy FD, Massey RC, Grilo IR, Sobral R, Larsen J, Rhod Larsen A, Vingsbo Lundberg C, Parkhill J, Paterson GK, Holden MTG, Peacock SJ, Holmes MA.

Nat Microbiol. 2019 Jun 24. doi: 10.1038/s41564-019-0471-0. [Epub ahead of print]


Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia.

Giulieri SG, Baines SL, Guerillot R, Seemann T, Gonçalves da Silva A, Schultz M, Massey RC, Holmes NE, Stinear TP, Howden BP.

Genome Med. 2018 Aug 23;10(1):65. doi: 10.1186/s13073-018-0574-x.


Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA.

Yokoyama M, Stevens E, Laabei M, Bacon L, Heesom K, Bayliss S, Ooi N, O'Neill AJ, Murray E, Williams P, Lubben A, Reeksting S, Meric G, Pascoe B, Sheppard SK, Recker M, Hurst LD, Massey RC.

Genome Biol. 2018 Jul 18;19(1):94. doi: 10.1186/s13059-018-1469-2.


Severe infections emerge from commensal bacteria by adaptive evolution.

Young BC, Wu CH, Gordon NC, Cole K, Price JR, Liu E, Sheppard AE, Perera S, Charlesworth J, Golubchik T, Iqbal Z, Bowden R, Massey RC, Paul J, Crook DW, Peto TE, Walker AS, Llewelyn MJ, Wyllie DH, Wilson DJ.

Elife. 2017 Dec 19;6. pii: e30637. doi: 10.7554/eLife.30637.


Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase.

Stevens E, Laabei M, Gardner S, Somerville GA, Massey RC.

Sci Rep. 2017 Oct 23;7(1):13744. doi: 10.1038/s41598-017-14110-8.


Bacterial toxins: Offensive, defensive, or something else altogether?

Rudkin JK, McLoughlin RM, Preston A, Massey RC.

PLoS Pathog. 2017 Sep 21;13(9):e1006452. doi: 10.1371/journal.ppat.1006452. eCollection 2017 Sep. Review.


Promiscuous bacteria have staying power.

Massey RC, Wilson DJ.

Elife. 2017 Sep 8;6. pii: e30734. doi: 10.7554/eLife.30734.


Clonal differences in Staphylococcus aureus bacteraemia-associated mortality.

Recker M, Laabei M, Toleman MS, Reuter S, Saunderson RB, Blane B, Török ME, Ouadi K, Stevens E, Yokoyama M, Steventon J, Thompson L, Milne G, Bayliss S, Bacon L, Peacock SJ, Massey RC.

Nat Microbiol. 2017 Oct;2(10):1381-1388. doi: 10.1038/s41564-017-0001-x. Epub 2017 Aug 7.


Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus.

Laabei M, Uhlemann AC, Lowy FD, Austin ED, Yokoyama M, Ouadi K, Feil E, Thorpe HA, Williams B, Perkins M, Peacock SJ, Clarke SR, Dordel J, Holden M, Votintseva AA, Bowden R, Crook DW, Young BC, Wilson DJ, Recker M, Massey RC.

PLoS Biol. 2015 Sep 2;13(9):e1002229. doi: 10.1371/journal.pbio.1002229. eCollection 2015.


Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection.

O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM.

Infect Immun. 2015 Sep;83(9):3445-57. doi: 10.1128/IAI.00358-15. Epub 2015 Jun 22.


Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology.

Read TD, Massey RC.

Genome Med. 2014 Nov 22;6(11):109. doi: 10.1186/s13073-014-0109-z. eCollection 2014.


Predicting the virulence of MRSA from its genome sequence.

Laabei M, Recker M, Rudkin JK, Aldeljawi M, Gulay Z, Sloan TJ, Williams P, Endres JL, Bayles KW, Fey PD, Yajjala VK, Widhelm T, Hawkins E, Lewis K, Parfett S, Scowen L, Peacock SJ, Holden M, Wilson D, Read TD, van den Elsen J, Priest NK, Feil EJ, Hurst LD, Josefsson E, Massey RC.

Genome Res. 2014 May;24(5):839-49. doi: 10.1101/gr.165415.113. Epub 2014 Apr 9.


Evidence for steric regulation of fibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA).

Stemberk V, Jones RP, Moroz O, Atkin KE, Edwards AM, Turkenburg JP, Leech AP, Massey RC, Potts JR.

J Biol Chem. 2014 May 2;289(18):12842-51. doi: 10.1074/jbc.M113.543546. Epub 2014 Mar 13.


Staphylococcus aureus interaction with phospholipid vesicles--a new method to accurately determine accessory gene regulator (agr) activity.

Laabei M, Jamieson WD, Massey RC, Jenkins AT.

PLoS One. 2014 Jan 30;9(1):e87270. doi: 10.1371/journal.pone.0087270. eCollection 2014.


Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus.

Rudkin JK, Laabei M, Edwards AM, Joo HS, Otto M, Lennon KL, O'Gara JP, Waterfield NR, Massey RC.

Antimicrob Agents Chemother. 2014;58(2):1100-7. doi: 10.1128/AAC.01618-13. Epub 2013 Dec 2.


From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

Priest NK, Rudkin JK, Feil EJ, van den Elsen JM, Cheung A, Peacock SJ, Laabei M, Lucks DA, Recker M, Massey RC.

Nat Rev Microbiol. 2012 Nov;10(11):791-7. doi: 10.1038/nrmicro2880. Review.


Staphylococcus aureus extracellular adherence protein triggers TNFα release, promoting attachment to endothelial cells via protein A.

Edwards AM, Bowden MG, Brown EL, Laabei M, Massey RC.

PLoS One. 2012;7(8):e43046. doi: 10.1371/journal.pone.0043046. Epub 2012 Aug 15.


Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections.

Pozzi C, Waters EM, Rudkin JK, Schaeffer CR, Lohan AJ, Tong P, Loftus BJ, Pier GB, Fey PD, Massey RC, O'Gara JP.

PLoS Pathog. 2012;8(4):e1002626. doi: 10.1371/journal.ppat.1002626. Epub 2012 Apr 5.


Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system.

Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters EM, Chan WC, Williams P, O'Gara JP, Massey RC.

J Infect Dis. 2012 Mar 1;205(5):798-806. doi: 10.1093/infdis/jir845. Epub 2012 Feb 1.


Molecular mechanisms of Staphylococcus aureus nasopharyngeal colonization.

Edwards AM, Massey RC, Clarke SR.

Mol Oral Microbiol. 2012 Feb;27(1):1-10. doi: 10.1111/j.2041-1014.2011.00628.x. Epub 2011 Nov 4. Review.


Staphylococcus aureus keratinocyte invasion is dependent upon multiple high-affinity fibronectin-binding repeats within FnBPA.

Edwards AM, Potter U, Meenan NA, Potts JR, Massey RC.

PLoS One. 2011 Apr 22;6(4):e18899. doi: 10.1371/journal.pone.0018899.


Invasion of human cells by a bacterial pathogen.

Edwards AM, Massey RC.

J Vis Exp. 2011 Mar 21;(49). pii: 2693. doi: 10.3791/2693.


How does Staphylococcus aureus escape the bloodstream?

Edwards AM, Massey RC.

Trends Microbiol. 2011 Apr;19(4):184-90. doi: 10.1016/j.tim.2010.12.005. Epub 2011 Jan 10. Review.


Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA.

Edwards AM, Potts JR, Josefsson E, Massey RC.

PLoS Pathog. 2010 Jun 24;6(6):e1000964. doi: 10.1371/journal.ppat.1000964.


Offsetting virulence and antibiotic resistance costs by MRSA.

Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, Massey RC.

ISME J. 2010 Apr;4(4):577-84. doi: 10.1038/ismej.2009.151. Epub 2010 Jan 14.


Identification of factors contributing to T-cell toxicity of Staphylococcus aureus clinical isolates.

Collins J, Buckling A, Massey RC.

J Clin Microbiol. 2008 Jun;46(6):2112-4. doi: 10.1128/JCM.00156-08. Epub 2008 Apr 16.


The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines.

Scriba TJ, Sierro S, Brown EL, Phillips RE, Sewell AK, Massey RC.

Infect Immun. 2008 May;76(5):2164-8. doi: 10.1128/IAI.01699-07. Epub 2008 Mar 10.


Interspecific competition and siderophore-mediated cooperation in Pseudomonas aeruginosa.

Harrison F, Paul J, Massey RC, Buckling A.

ISME J. 2008 Jan;2(1):49-55. doi: 10.1038/ismej.2007.96. Epub 2007 Nov 1.


Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells.

Massey RC, Scriba TJ, Brown EL, Phillips RE, Sewell AK.

Infect Immun. 2007 Dec;75(12):5711-5. Epub 2007 Oct 15.


The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?

Massey RC, Horsburgh MJ, Lina G, Höök M, Recker M.

Nat Rev Microbiol. 2006 Dec;4(12):953-8. Review.


Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence.

Fleming V, Feil E, Sewell AK, Day N, Buckling A, Massey RC.

J Bacteriol. 2006 Nov;188(21):7686-8. Epub 2006 Aug 25.


Antagonistic coevolution with parasites increases the cost of host deleterious mutations.

Buckling A, Wei Y, Massey RC, Brockhurst MA, Hochberg ME.

Proc Biol Sci. 2006 Jan 7;273(1582):45-9.


Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus.

Buckling A, Neilson J, Lindsay J, ffrench-Constant R, Enright M, Day N, Massey RC.

J Bacteriol. 2005 Apr;187(8):2917-9.


Interference competition and parasite virulence.

Massey RC, Buckling A, ffrench-Constant R.

Proc Biol Sci. 2004 Apr 22;271(1541):785-8.


Genes encoding a cellulosic polymer contribute toward the ecological success of Pseudomonas fluorescens SBW25 on plant surfaces.

Gal M, Preston GM, Massey RC, Spiers AJ, Rainey PB.

Mol Ecol. 2003 Nov;12(11):3109-21.


Environmental regulation of mutation rates at specific sites.

Massey RC, Buckling A.

Trends Microbiol. 2002 Dec;10(12):580-4. Review.


Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization.

O'Brien LM, Walsh EJ, Massey RC, Peacock SJ, Foster TJ.

Cell Microbiol. 2002 Nov;4(11):759-70.


Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media.

Massey RC, Dissanayeke SR, Cameron B, Ferguson D, Foster TJ, Peacock SJ.

Infect Immun. 2002 Oct;70(10):5339-45.


The ica operon and biofilm production in coagulase-negative Staphylococci associated with carriage and disease in a neonatal intensive care unit.

de Silva GD, Kantzanou M, Justice A, Massey RC, Wilkinson AR, Day NP, Peacock SJ.

J Clin Microbiol. 2002 Feb;40(2):382-8.


A biomarker approach to measuring human dietary exposure to certain phthalate diesters.

Anderson WA, Castle L, Scotter MJ, Massey RC, Springall C.

Food Addit Contam. 2001 Dec;18(12):1068-74.


Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cells.

Massey RC, Kantzanou MN, Fowler T, Day NP, Schofield K, Wann ER, Berendt AR, Höök M, Peacock SJ.

Cell Microbiol. 2001 Dec;3(12):839-51.


Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus.

Massey RC, Buckling A, Peacock SJ.

Curr Biol. 2001 Nov 13;11(22):1810-4.


Environmentally constrained mutation and adaptive evolution in Salmonella.

Massey RC, Rainey PB, Sheehan BJ, Keane OM, Dorman CJ.

Curr Biol. 1999 Dec 16-30;9(24):1477-80.


The contribution of azodicarbonamide to ethyl carbamate formation in bread and beer.

Dennis MJ, Massey RC, Ginn R, Willetts P, Crews C, Parker I.

Food Addit Contam. 1997 Jan;14(1):101-8.


The effect of azodicarbonamide concentrations on ethyl carbamate concentrations in bread and toast.

Dennis MJ, Massey RC, Ginn R, Parker I, Crews C, Zimmerli B, Zoller O, Rhyn P, Osborne B.

Food Addit Contam. 1997 Jan;14(1):95-100.


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