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Items: 19


Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes.

Gomez L, Xu R, Sinko W, Selfridge B, Vernier W, Ly K, Truong R, Metz M, Marrone T, Sebring K, Yan Y, Appleton B, Aertgeerts K, Massari ME, Breitenbucher JG.

J Med Chem. 2018 Sep 13;61(17):7754-7766. doi: 10.1021/acs.jmedchem.8b00713. Epub 2018 Aug 20.


Dataset on Galanin Receptor 3 mutants that improve recombinant receptor expression and stability in an agonist and antagonist bound form.

Ho TT, Nguyen JT, Liu J, Stanczak P, Thompson AA, Yan YG, Chen J, Allerston CK, Dillard CL, Xu H, Shoger NJ, Cameron JS, Massari ME, Aertgeerts K.

Data Brief. 2017 May 4;12:603-607. doi: 10.1016/j.dib.2017.04.057. eCollection 2017 Jun.


Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.

Dyck B, Branstetter B, Gharbaoui T, Hudson AR, Breitenbucher JG, Gomez L, Botrous I, Marrone T, Barido R, Allerston CK, Cedervall EP, Xu R, Sridhar V, Barker R, Aertgeerts K, Schmelzer K, Neul D, Lee D, Massari ME, Andersen CB, Sebring K, Zhou X, Petroski R, Limberis J, Augustin M, Chun LE, Edwards TE, Peters M, Tabatabaei A.

J Med Chem. 2017 Apr 27;60(8):3472-3483. doi: 10.1021/acs.jmedchem.7b00302. Epub 2017 Apr 13.


Method for rapid optimization of recombinant GPCR protein expression and stability using virus-like particles.

Ho TT, Nguyen JT, Liu J, Stanczak P, Thompson AA, Yan YG, Chen J, Allerston CK, Dillard CL, Xu H, Shoger NJ, Cameron JS, Massari ME, Aertgeerts K.

Protein Expr Purif. 2017 May;133:41-49. doi: 10.1016/j.pep.2017.03.002. Epub 2017 Mar 3.


Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.

Gomez L, Massari ME, Vickers T, Freestone G, Vernier W, Ly K, Xu R, McCarrick M, Marrone T, Metz M, Yan YG, Yoder ZW, Lemus R, Broadbent NJ, Barido R, Warren N, Schmelzer K, Neul D, Lee D, Andersen CB, Sebring K, Aertgeerts K, Zhou X, Tabatabaei A, Peters M, Breitenbucher JG.

J Med Chem. 2017 Mar 9;60(5):2037-2051. doi: 10.1021/acs.jmedchem.6b01793. Epub 2017 Feb 21.


Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.

Rojas RJ, Edmondson DE, Almos T, Scott R, Massari ME.

Bioorg Med Chem. 2015 Feb 15;23(4):770-8. doi: 10.1016/j.bmc.2014.12.063. Epub 2015 Jan 3.


Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.

Gahman TC, Herbert MR, Lang H, Thayer A, Symons KT, Nguyen PM, Massari ME, Dozier S, Zhang Y, Sablad M, Rao TS, Noble SA, Shiau AK, Hassig CA.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6888-94. doi: 10.1016/j.bmcl.2011.08.112. Epub 2011 Sep 8.


Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.

Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS.

J Pharmacol Exp Ther. 2011 Feb;336(2):468-78. doi: 10.1124/jpet.110.172817. Epub 2010 Oct 29.


KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.

Symons KT, Massari ME, Nguyen PM, Lee TT, Roppe J, Bonnefous C, Payne JE, Smith ND, Noble SA, Sablad M, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.

Mol Pharmacol. 2009 Jul;76(1):153-62. doi: 10.1124/mol.109.055434. Epub 2009 Apr 13.


Back to basics: label-free technologies for small molecule screening.

Shiau AK, Massari ME, Ozbal CC.

Comb Chem High Throughput Screen. 2008 Mar;11(3):231-7. Review.


differential roles for the E2A activation domains in B lymphocytes and macrophages.

Bhalla S, Spaulding C, Brumbaugh RL, Zagort DE, Massari ME, Murre C, Kee BL.

J Immunol. 2008 Feb 1;180(3):1694-703.


Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response.

Symons KT, Massari ME, Dozier SJ, Nguyen PM, Jenkins D, Herbert M, Gahman TC, Noble SA, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.

Curr Chem Genomics. 2008 Sep 27;2:1-9. doi: 10.2174/1875397300802010001.


Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.

Massari ME, Murre C.

Mol Cell Biol. 2000 Jan;20(2):429-40. Review. No abstract available.


A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex.

Massari ME, Grant PA, Pray-Grant MG, Berger SL, Workman JL, Murre C.

Mol Cell. 1999 Jul;4(1):63-73.


Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes.

Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C.

Mol Cell Biol. 1998 Jun;18(6):3130-9.


c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products.

Robinson GL, Henderson E, Massari ME, Murre C, Stein R.

Mol Cell Biol. 1995 Mar;15(3):1398-404.


Structure and function of helix-loop-helix proteins.

Murre C, Bain G, van Dijk MA, Engel I, Furnari BA, Massari ME, Matthews JR, Quong MW, Rivera RR, Stuiver MH.

Biochim Biophys Acta. 1994 Jun 21;1218(2):129-35. Review. No abstract available.


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