Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 61

1.

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP.

Shen Y, Kapfhamer D, Minnella AM, Kim JE, Won SJ, Chen Y, Huang Y, Low LH, Massa SM, Swanson RA.

Nat Commun. 2017 Sep 22;8(1):624. doi: 10.1038/s41467-017-00707-0.

2.

A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.

Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM.

Sci Rep. 2017 Feb 16;7:42474. doi: 10.1038/srep42474.

3.

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM.

Hum Mol Genet. 2016 Nov 15;25(22):4920-4938. doi: 10.1093/hmg/ddw316.

4.

Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease.

Simmons DA, Longo FM, Massa SM.

CNS Neurol Disord Drug Targets. 2017;16(3):291-302. doi: 10.2174/1871527315666161107093047. Review.

PMID:
27823570
5.

The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.

Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D.

J Neurosci. 2016 Sep 28;36(39):10116-27. doi: 10.1523/JNEUROSCI.4597-14.2016. Epub 2016 Sep 28.

6.

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.

Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM.

Neuropharmacology. 2016 Nov;110(Pt A):343-361. doi: 10.1016/j.neuropharm.2016.06.015. Epub 2016 Jun 19.

7.

The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.

Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D.

Biol Psychiatry. 2016 Mar 15;79(6):463-73. doi: 10.1016/j.biopsych.2015.06.007. Epub 2015 Jun 12.

8.

Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.

Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q.

Neurotoxicology. 2014 Dec;45:81-90. doi: 10.1016/j.neuro.2014.09.005. Epub 2014 Sep 30.

9.

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM.

PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014.

10.

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.

Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM.

J Alzheimers Dis. 2014;42(2):459-83. doi: 10.3233/JAD-140036.

11.

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM.

J Neurosci. 2013 Nov 27;33(48):18712-27. doi: 10.1523/JNEUROSCI.1310-13.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

12.

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.

Longo FM, Massa SM.

Nat Rev Drug Discov. 2013 Jul;12(7):507-25. Review.

PMID:
23977697
13.

A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.

Shi J, Longo FM, Massa SM.

Stem Cells. 2013 Nov;31(11):2561-74. doi: 10.1002/stem.1516.

14.

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.

Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.

15.

Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO.

J Neurosci. 2013 Jan 9;33(2):397-410. doi: 10.1523/JNEUROSCI.0399-12.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

16.

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.

Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS.

Stroke. 2012 Jul;43(7):1918-24. doi: 10.1161/STROKEAHA.111.641878. Epub 2012 Apr 24.

17.

A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.

Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM.

J Neurosci. 2012 Feb 1;32(5):1803-10. doi: 10.1523/JNEUROSCI.0865-11.2012. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

18.

PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.

Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM.

J Huntingtons Dis. 2012;1(2):211-9. doi: 10.3233/JHD-120029.

PMID:
25063332
19.

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.

Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM.

J Clin Invest. 2010 May;120(5):1774-85. doi: 10.1172/JCI41356. Epub 2010 Apr 19.

20.

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM.

J Neurosci. 2009 Aug 26;29(34):10627-37. doi: 10.1523/JNEUROSCI.0620-09.2009.

21.

Signaling through Rho GTPase pathway as viable drug target.

Lu Q, Longo FM, Zhou H, Massa SM, Chen YH.

Curr Med Chem. 2009;16(11):1355-65.

22.

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.

PLoS One. 2008;3(11):e3604. doi: 10.1371/journal.pone.0003604. Epub 2008 Nov 3.

23.

Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.

James SE, Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q.

Neurotoxicology. 2008 Jul;29(4):605-12. doi: 10.1016/j.neuro.2008.04.008. Epub 2008 Apr 26.

24.

Small molecule modulation of p75 neurotrophin receptor functions.

Longo FM, Massa SM.

CNS Neurol Disord Drug Targets. 2008 Feb;7(1):63-70. Review.

PMID:
18289033
25.

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.

Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM.

Curr Alzheimer Res. 2007 Dec;4(5):503-6. Review.

PMID:
18220511
26.

Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels.

Shi J, Miles DK, Orr BA, Massa SM, Kernie SG.

Eur J Neurosci. 2007 Jun;25(12):3499-512.

PMID:
17610570
27.
28.

Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain.

Pehar M, Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L.

Eur J Neurosci. 2006 Sep;24(6):1575-80.

PMID:
17004921
29.

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM.

J Neurosci. 2006 May 17;26(20):5288-300. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

30.

Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function.

Xie Y, Massa SM, Ensslen-Craig SE, Major DL, Yang T, Tisi MA, Derevyanny VD, Runge WO, Mehta BP, Moore LA, Brady-Kalnay SM, Longo FM.

J Biol Chem. 2006 Jun 16;281(24):16482-92. Epub 2006 Apr 12.

31.

Small molecule approaches for promoting neurogenesis.

Longo FM, Yang T, Xie Y, Massa SM.

Curr Alzheimer Res. 2006 Feb;3(1):5-10. Review.

PMID:
16472196
32.

Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.

Nguyen T, Hamby A, Massa SM.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11840-5. Epub 2005 Aug 8.

33.

Neurotrophin receptor-based strategies for Alzheimer's disease.

Longo FM, Massa SM.

Curr Alzheimer Res. 2005 Apr;2(2):167-9. Review.

PMID:
15974914
34.

Neuroprotective strategies in Alzheimer's disease.

Longo FM, Massa SM.

NeuroRx. 2004 Jan;1(1):117-27. Review.

35.

Neurotrophin-based strategies for neuroprotection.

Longo FM, Massa SM.

J Alzheimers Dis. 2004 Dec;6(6 Suppl):S13-7.

PMID:
15665408
36.

Alzheimer's therapeutics: neurotrophin domain small molecule mimetics.

Massa SM, Xie Y, Longo FM.

J Mol Neurosci. 2003;20(3):323-6.

PMID:
14501015
37.

A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs.

Zhang C, Xie Y, Martignetti JA, Yeo TT, Massa SM, Longo FM.

DNA Cell Biol. 2003 May;22(5):303-15.

PMID:
12941158
38.
39.

Adaptable modification of adenoviral tropism using a bifunctional ligand protein.

Li Y, Yao XM, Hong-Brown L, Massa SM.

Virus Res. 2003 Feb;91(2):223-30.

PMID:
12573501
40.

Alzheimer's therapeutics: neurotrophin small molecule mimetics.

Massa SM, Xie Y, Longo FM.

J Mol Neurosci. 2002 Aug-Oct;19(1-2):107-11.

PMID:
12212765
41.

The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo.

Xie Y, Yeo TT, Zhang C, Yang T, Tisi MA, Massa SM, Longo FM.

J Neurosci. 2001 Jul 15;21(14):5130-8.

43.
44.

Heat-shock protein protection.

Sharp FR, Massa SM, Swanson RA.

Trends Neurosci. 1999 Mar;22(3):97-9. Review. No abstract available.

PMID:
10199631
45.

Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation.

Yeo TT, Yang T, Massa SM, Zhang JS, Honkaniemi J, Butcher LL, Longo FM.

J Neurosci Res. 1997 Feb 1;47(3):348-60.

PMID:
9039657
46.

Global ischemia induces apoptosis-associated genes in hippocampus.

Honkaniemi J, Massa SM, Breckinridge M, Sharp FR.

Brain Res Mol Brain Res. 1996 Nov;42(1):79-88.

PMID:
8915583
47.

Focal hyperexpression of hemeoxygenase-1 protein and messenger RNA in rat brain caused by cellular stress following subarachnoid injections of lysed blood.

Matz PG, Massa SM, Weinstein PR, Turner C, Panter SS, Sharp FR.

J Neurosurg. 1996 Nov;85(5):892-900.

PMID:
8893729
48.

Patterns of cognitive recovery in sudden cardiac arrest survivors: the pilot study.

Sauvé MJ, Walker JA, Massa SM, Winkle RA, Scheinman MM.

Heart Lung. 1996 May-Jun;25(3):172-81.

PMID:
8635918
49.

Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia.

Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR.

Brain Res Mol Brain Res. 1996 Apr;37(1-2):201-8.

PMID:
8738152
50.

Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage.

Matz P, Turner C, Weinstein PR, Massa SM, Panter SS, Sharp FR.

Brain Res. 1996 Mar 25;713(1-2):211-22.

PMID:
8724993

Supplemental Content

Loading ...
Support Center