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Items: 18

1.

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S.

Cell Rep. 2019 Jun 4;27(10):3049-3061.e6. doi: 10.1016/j.celrep.2019.05.017.

2.

HECT E3 Ligases: A Tale With Multiple Facets.

Weber J, Polo S, Maspero E.

Front Physiol. 2019 Apr 3;10:370. doi: 10.3389/fphys.2019.00370. eCollection 2019. Review.

3.

Detection of ubiquitinated targets in mammalian and Drosophila models.

Maspero E, Fajner V, Weber J, Polo S.

Methods Enzymol. 2019;619:293-318. doi: 10.1016/bs.mie.2018.12.030. Epub 2019 Feb 11.

PMID:
30910026
4.

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

Jäckl M, Stollmaier C, Strohäker T, Hyz K, Maspero E, Polo S, Wiesner S.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3218-3233. doi: 10.1016/j.jmb.2018.06.044. Epub 2018 Jun 28.

PMID:
29964046
5.

Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.

Fajner V, Maspero E, Polo S.

FEBS Lett. 2017 Sep;591(17):2636-2647. doi: 10.1002/1873-3468.12775. Epub 2017 Aug 20. Review.

6.

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ.

EMBO Mol Med. 2017 Feb;9(2):181-197. doi: 10.15252/emmm.201606684.

7.

In Vitro Ubiquitination: Self-Ubiquitination, Chain Formation, and Substrate Ubiquitination Assays.

Maspero E, Polo S.

Methods Mol Biol. 2016;1449:153-60. doi: 10.1007/978-1-4939-3756-1_7.

PMID:
27613033
8.

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.

Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S.

Curr Biol. 2016 Jan 25;26(2):173-183. doi: 10.1016/j.cub.2015.11.050. Epub 2015 Dec 31.

9.

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S, Wiesner S.

Structure. 2014 Nov 4;22(11):1639-49. doi: 10.1016/j.str.2014.09.006. Epub 2014 Oct 30.

10.

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D.

Sci Signal. 2014 Oct 7;7(346):ra95. doi: 10.1126/scisignal.2005290.

PMID:
25292214
11.

Threshold-controlled ubiquitination of the EGFR directs receptor fate.

Sigismund S, Algisi V, Nappo G, Conte A, Pascolutti R, Cuomo A, Bonaldi T, Argenzio E, Verhoef LG, Maspero E, Bianchi F, Capuani F, Ciliberto A, Polo S, Di Fiore PP.

EMBO J. 2013 Jul 31;32(15):2140-57. doi: 10.1038/emboj.2013.149. Epub 2013 Jun 25.

12.

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.

Sorrentino V, Nelson JK, Maspero E, Marques AR, Scheer L, Polo S, Zelcer N.

J Lipid Res. 2013 Aug;54(8):2174-84. doi: 10.1194/jlr.M037713. Epub 2013 Jun 3.

13.

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

Maspero E, Valentini E, Mari S, Cecatiello V, Soffientini P, Pasqualato S, Polo S.

Nat Struct Mol Biol. 2013 Jun;20(6):696-701. doi: 10.1038/nsmb.2566. Epub 2013 May 5.

PMID:
23644597
14.

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

Gatti M, Pinato S, Maspero E, Soffientini P, Polo S, Penengo L.

Cell Cycle. 2012 Jul 1;11(13):2538-44. doi: 10.4161/cc.20919. Epub 2012 Jul 1.

15.

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation.

Maspero E, Mari S, Valentini E, Musacchio A, Fish A, Pasqualato S, Polo S.

EMBO Rep. 2011 Apr;12(4):342-9. doi: 10.1038/embor.2011.21. Epub 2011 Mar 11.

16.

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.

Frosi Y, Anastasi S, Ballarò C, Varsano G, Castellani L, Maspero E, Polo S, Alemà S, Segatto O.

J Cell Biol. 2010 May 3;189(3):557-71. doi: 10.1083/jcb.201002032. Epub 2010 Apr 26.

17.

Molecular mechanisms of coupled monoubiquitination.

Woelk T, Oldrini B, Maspero E, Confalonieri S, Cavallaro E, Di Fiore PP, Polo S.

Nat Cell Biol. 2006 Nov;8(11):1246-54. Epub 2006 Oct 1.

PMID:
17013377
18.

Clathrin-independent endocytosis of ubiquitinated cargos.

Sigismund S, Woelk T, Puri C, Maspero E, Tacchetti C, Transidico P, Di Fiore PP, Polo S.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2760-5. Epub 2005 Feb 8.

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