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A framework for extending trial design to facilitate missing data sensitivity analyses.

Mason AJ, Grieve RD, Richards-Belle A, Mouncey PR, Harrison DA, Carpenter JR.

BMC Med Res Methodol. 2020 Mar 17;20(1):66. doi: 10.1186/s12874-020-00930-2.


Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial.

Lamontagne F, Richards-Belle A, Thomas K, Harrison DA, Sadique MZ, Grieve RD, Camsooksai J, Darnell R, Gordon AC, Henry D, Hudson N, Mason AJ, Saull M, Whitman C, Young JD, Rowan KM, Mouncey PR; 65 trial investigators.

JAMA. 2020 Feb 12. doi: 10.1001/jama.2020.0930. [Epub ahead of print]


Trait differentiation and modular toxin expression in palm-pitvipers.

Mason AJ, Margres MJ, Strickland JL, Rokyta DR, Sasa M, Parkinson CL.

BMC Genomics. 2020 Feb 11;21(1):147. doi: 10.1186/s12864-020-6545-9.


Palaeoclimate evidence of vulnerable permafrost during times of low sea ice.

Vaks A, Mason AJ, Breitenbach SFM, Kononov AM, Osinzev AV, Rosensaft M, Borshevsky A, Gutareva OS, Henderson GM.

Nature. 2020 Jan;577(7789):221-225. doi: 10.1038/s41586-019-1880-1. Epub 2020 Jan 8.


Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial.

Antcliffe DB, Santhakumaran S, Orme RML, Ward JK, Al-Beidh F, O'Dea K, Perkins GD, Singer M, McAuley DF, Mason AJ, Cross M, Ashby D, Gordon AC.

Intensive Care Med. 2019 Oct;45(10):1392-1400. doi: 10.1007/s00134-019-05731-w. Epub 2019 Aug 19.


Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities.

Manzo G, Ferguson PM, Hind CK, Clifford M, Gustilo VB, Ali H, Bansal SS, Bui TT, Drake AF, Atkinson RA, Sutton JM, Lorenz CD, Phoenix DA, Mason AJ.

Sci Rep. 2019 Jul 29;9(1):10934. doi: 10.1038/s41598-019-47327-w.


Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling.

Gu W, Nowak WN, Xie Y, Le Bras A, Hu Y, Deng J, Issa Bhaloo S, Lu Y, Yuan H, Fidanis E, Saxena A, Kanno T, Mason AJ, Dulak J, Cai J, Xu Q.

Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2049-2066. doi: 10.1161/ATVBAHA.119.312732. Epub 2019 Jul 25.


Intraspecific sequence and gene expression variation contribute little to venom diversity in sidewinder rattlesnakes ( Crotalus cerastes).

Rautsaw RM, Hofmann EP, Margres MJ, Holding ML, Strickland JL, Mason AJ, Rokyta DR, Parkinson CL.

Proc Biol Sci. 2019 Jul 10;286(1906):20190810. doi: 10.1098/rspb.2019.0810. Epub 2019 Jul 3.


Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials.

Nagendran M, Russell JA, Walley KR, Brett SJ, Perkins GD, Hajjar L, Mason AJ, Ashby D, Gordon AC.

Intensive Care Med. 2019 Jun;45(6):844-855. doi: 10.1007/s00134-019-05620-2. Epub 2019 May 6.


CMOS Monolithic Electrochemical Gas Sensor Microsystem Using Room Temperature Ionic Liquid.

Yin H, Mu X, Li H, Liu X, Mason AJ.

IEEE Sens J. 2018 Oct;18(19):7899-7906. doi: 10.1109/JSEN.2018.2863644. Epub 2018 Aug 6.


Histidine-Rich Cationic Cell-Penetrating Peptides for Plasmid DNA and siRNA Delivery.

Kichler A, Mason AJ, Marquette A, Bechinger B.

Methods Mol Biol. 2019;1943:39-59. doi: 10.1007/978-1-4939-9092-4_3.


Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial.

Wade DM, Mouncey PR, Richards-Belle A, Wulff J, Harrison DA, Sadique MZ, Grieve RD, Emerson LM, Mason AJ, Aaronovitch D, Als N, Brewin CR, Harvey SE, Howell DCJ, Hudson N, Mythen MG, Smyth D, Weinman J, Welch J, Whitman C, Rowan KM; POPPI Trial Investigators.

JAMA. 2019 Feb 19;321(7):665-675. doi: 10.1001/jama.2019.0073.


Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity.

Manzo G, Ferguson PM, Gustilo VB, Hind CK, Clifford M, Bui TT, Drake AF, Atkinson RA, Sutton JM, Batoni G, Lorenz CD, Phoenix DA, Mason AJ.

Sci Rep. 2019 Feb 4;9(1):1385. doi: 10.1038/s41598-018-37630-3.


A full Bayesian model to handle structural ones and missingness in economic evaluations from individual-level data.

Gabrio A, Mason AJ, Baio G.

Stat Med. 2019 Apr 15;38(8):1399-1420. doi: 10.1002/sim.8045. Epub 2018 Nov 22.


Evidence for divergent patterns of local selection driving venom variation in Mojave Rattlesnakes (Crotalus scutulatus).

Strickland JL, Smith CF, Mason AJ, Schield DR, Borja M, Castañeda-Gaytán G, Spencer CL, Smith LL, Trápaga A, Bouzid NM, Campillo-García G, Flores-Villela OA, Antonio-Rangel D, Mackessy SP, Castoe TA, Rokyta DR, Parkinson CL.

Sci Rep. 2018 Dec 4;8(1):17622. doi: 10.1038/s41598-018-35810-9.


Author Correction: Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes.

Amos STA, Vermeer LS, Ferguson PM, Kozlowska J, Davy M, Bui TT, Drake AF, Lorenz CD, Mason AJ.

Sci Rep. 2018 Nov 19;8(1):17073. doi: 10.1038/s41598-018-35519-9.


Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT.

Gordon AC, Santhakumaran S, Al-Beidh F, Orme RML, Perkins GD, Singer M, McAuley DF, Mason AJ, Ward JK, O’Dea KP, Felton T, Cross M, Best-Lane J, Lexow J, Campbell A, Ashby D.

Southampton (UK): NIHR Journals Library; 2018 Nov.


Opportunistic bacteria confer the ability to ferment prebiotic starch in the adult cystic fibrosis gut.

Wang Y, Leong LEX, Keating RL, Kanno T, Abell GCJ, Mobegi FM, Choo JM, Wesselingh SL, Mason AJ, Burr LD, Rogers GB.

Gut Microbes. 2019;10(3):367-381. doi: 10.1080/19490976.2018.1534512. Epub 2018 Oct 25.


Comparative venom-gland transcriptomics and venom proteomics of four Sidewinder Rattlesnake (Crotalus cerastes) lineages reveal little differential expression despite individual variation.

Hofmann EP, Rautsaw RM, Strickland JL, Holding ML, Hogan MP, Mason AJ, Rokyta DR, Parkinson CL.

Sci Rep. 2018 Oct 19;8(1):15534. doi: 10.1038/s41598-018-33943-5.


Rifampin- or Capreomycin-Induced Remodeling of the Mycobacterium smegmatis Mycolic Acid Layer Is Mitigated in Synergistic Combinations with Cationic Antimicrobial Peptides.

Man DK, Kanno T, Manzo G, Robertson BD, Lam JKW, Mason AJ.

mSphere. 2018 Jul 18;3(4). pii: e00218-18. doi: 10.1128/mSphere.00218-18.


A Bayesian framework for health economic evaluation in studies with missing data.

Mason AJ, Gomes M, Grieve R, Carpenter JR.

Health Econ. 2018 Nov;27(11):1670-1683. doi: 10.1002/hec.3793. Epub 2018 Jul 3.


Evaluating the Performance of De Novo Assembly Methods for Venom-Gland Transcriptomics.

Holding ML, Margres MJ, Mason AJ, Parkinson CL, Rokyta DR.

Toxins (Basel). 2018 Jun 19;10(6). pii: E249. doi: 10.3390/toxins10060249.


Characterization of the Ionic Liquid/Electrode Interfacial Relaxation Processes Under Potential Polarization for Ionic Liquid Amperometric Gas Sensor Method Development.

Lin L, Zhao P, Mason AJ, Zeng X.

ACS Sens. 2018 Jun 22;3(6):1126-1134. doi: 10.1021/acssensors.8b00155. Epub 2018 Jun 4.


Phenotypic Variation in Mojave Rattlesnake (Crotalus scutulatus) Venom Is Driven by Four Toxin Families.

Strickland JL, Mason AJ, Rokyta DR, Parkinson CL.

Toxins (Basel). 2018 Mar 23;10(4). pii: E135. doi: 10.3390/toxins10040135.


Epoxy Chip-in-Carrier Integration and Screen-Printed Metalization for Multichannel Microfluidic Lab-on-CMOS Microsystems.

Li L, Yin H, Mason AJ.

IEEE Trans Biomed Circuits Syst. 2018 Apr;12(2):416-425. doi: 10.1109/TBCAS.2018.2797063.


Cationic antimicrobial peptides do not change recombination frequency in Escherichia coli.

Rodríguez-Rojas A, Moreno-Morales J, Mason AJ, Rolff J.

Biol Lett. 2018 Mar;14(3). pii: 20180006. doi: 10.1098/rsbl.2018.0006.


Erratum to: Handling Missing Data in Within-Trial Cost-Effectiveness Analysis: A Review with Future Recommendations.

Gabrio A, Mason AJ, Baio G.

Pharmacoecon Open. 2017 Jun;1(2):143. doi: 10.1007/s41669-017-0029-0. No abstract available.


Handling Missing Data in Within-Trial Cost-Effectiveness Analysis: A Review with Future Recommendations.

Gabrio A, Mason AJ, Baio G.

Pharmacoecon Open. 2017 Jun;1(2):79-97. doi: 10.1007/s41669-017-0015-6. Review. Erratum in: Pharmacoecon Open. 2017 Jun;1(2):143.


A Single Mutation Unlocks Cascading Exaptations in the Origin of a Potent Pitviper Neurotoxin.

Whittington AC, Mason AJ, Rokyta DR.

Mol Biol Evol. 2018 Apr 1;35(4):887-898. doi: 10.1093/molbev/msx334. Erratum in: Mol Biol Evol. 2018 Jul 1;35(7):1821.


Miniaturized Planar Room Temperature Ionic Liquid Electrochemical Gas Sensor for Rapid Multiple Gas Pollutants Monitoring.

Wan H, Yin H, Lin L, Zeng X, Mason AJ.

Sens Actuators B Chem. 2018 Feb;255(Pt 1):638-646. doi: 10.1016/j.snb.2017.08.109. Epub 2017 Aug 18.


Ultracompact Microwatt CMOS Current Readout With Picoampere Noise and Kilohertz Bandwidth for Biosensor Arrays.

Li H, Parsnejad S, Ashoori E, Thompson C, Purcell EK, Mason AJ.

IEEE Trans Biomed Circuits Syst. 2018 Feb;12(1):35-46. doi: 10.1109/TBCAS.2017.2752742. Epub 2017 Oct 5.



Mason AJ, Gomes M, Grieve R, Carpenter J.

Clin Trials. 2017 Aug;14(4):370-371. doi: 10.1177/1740774517711444. Epub 2017 May 18. No abstract available.


Development of a practical approach to expert elicitation for randomised controlled trials with missing health outcomes: Application to the IMPROVE trial.

Mason AJ, Gomes M, Grieve R, Ulug P, Powell JT, Carpenter J.

Clin Trials. 2017 Aug;14(4):357-367. doi: 10.1177/1740774517711442. Epub 2017 Jul 4.


Rapid Measurement of Room Temperature Ionic Liquid Electrochemical Gas Sensor using Transient Double Potential Amperometry.

Wan H, Yin H, Mason AJ.

Sens Actuators B Chem. 2017 Apr;242:658-666. doi: 10.1016/j.snb.2016.11.103.


A Hardware-Efficient Scalable Spike Sorting Neural Signal Processor Module for Implantable High-Channel-Count Brain Machine Interfaces.

Yang Y, Boling S, Mason AJ.

IEEE Trans Biomed Circuits Syst. 2017 Aug;11(4):743-754. doi: 10.1109/TBCAS.2017.2679032. Epub 2017 May 24.


Divergent Relationships between Fecal Microbiota and Metabolome following Distinct Antibiotic-Induced Disruptions.

Choo JM, Kanno T, Zain NM, Leong LE, Abell GC, Keeble JE, Bruce KD, Mason AJ, Rogers GB.

mSphere. 2017 Feb 8;2(1). pii: e00005-17. doi: 10.1128/mSphere.00005-17. eCollection 2017 Jan-Feb.


Histidine-rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo.

Moulay G, Leborgne C, Mason AJ, Aisenbrey C, Kichler A, Bechinger B.

J Pept Sci. 2017 Apr;23(4):320-328. doi: 10.1002/psc.2955. Epub 2017 Jan 9.


CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review.

Li H, Liu X, Li L, Mu X, Genov R, Mason AJ.

Sensors (Basel). 2016 Dec 31;17(1). pii: E74. doi: 10.3390/s17010074. Review.


Developing a Bayesian adaptive design for a phase I clinical trial: a case study for a novel HIV treatment.

Mason AJ, Gonzalez-Maffe J, Quinn K, Doyle N, Legg K, Norsworthy P, Trevelion R, Winston A, Ashby D.

Stat Med. 2017 Feb 28;36(5):754-771. doi: 10.1002/sim.7169. Epub 2016 Nov 27.


Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes.

Amos ST, Vermeer LS, Ferguson PM, Kozlowska J, Davy M, Bui TT, Drake AF, Lorenz CD, Mason AJ.

Sci Rep. 2016 Nov 22;6:37639. doi: 10.1038/srep37639. Erratum in: Sci Rep. 2018 Nov 19;8(1):17073.


Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis.

Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RM, Santhakumaran S, Mason AJ, Cross M, Al-Beidh F, Best-Lane J, Brealey D, Nutt CL, McNamee JJ, Reschreiter H, Breen A, Liu KD, Ashby D.

N Engl J Med. 2016 Oct 27;375(17):1638-1648. doi: 10.1056/NEJMoa1609409. Epub 2016 Oct 5.


Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial.

Gordon AC, Mason AJ, Thirunavukkarasu N, Perkins GD, Cecconi M, Cepkova M, Pogson DG, Aya HD, Anjum A, Frazier GJ, Santhakumaran S, Ashby D, Brett SJ; VANISH Investigators.

JAMA. 2016 Aug 2;316(5):509-18. doi: 10.1001/jama.2016.10485.


A cryptic palm-pitviper species (Squamata: Viperidae: Bothriechis) from the Costa Rican highlands, with notes on the variation within B. nigroviridis.

Doan TM, Mason AJ, Castoe TA, Sasa M, Parkinson CL.

Zootaxa. 2016 Jul 15;4138(2):271-90. doi: 10.11646/zootaxa.4138.2.3.


Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA.

Xu Y, Liang W, Qiu Y, Cespi M, Palmieri GF, Mason AJ, Lam JK.

Mol Pharm. 2016 Sep 6;13(9):3141-52. doi: 10.1021/acs.molpharmaceut.6b00338. Epub 2016 Aug 9.


Frequency Band Separability Feature Extraction Method With Weighted Haar Wavelet Implementation for Implantable Spike Sorting.

Yang Y, Mason AJ.

IEEE Trans Neural Syst Rehabil Eng. 2017 Jun;25(6):530-538. doi: 10.1109/TNSRE.2016.2590560. Epub 2016 Jul 12.


CMOS Amperometric ADC With High Sensitivity, Dynamic Range and Power Efficiency for Air Quality Monitoring.

Li H, Boling CS, Mason AJ.

IEEE Trans Biomed Circuits Syst. 2016 Aug;10(4):817-27. doi: 10.1109/TBCAS.2016.2571306. Epub 2016 Jun 23.


Hardware Efficient Automatic Thresholding for NEO-Based Neural Spike Detection.

Yang Y, Mason AJ.

IEEE Trans Biomed Eng. 2017 Apr;64(4):826-833. doi: 10.1109/TBME.2016.2580319. Epub 2016 Jun 13.


Highly Sensitive Capacitive Gas Sensing at Ionic Liquid-Electrode Interfaces.

Wang Z, Guo M, Mu X, Sen S, Insley T, Mason AJ, Král P, Zeng X.

Anal Chem. 2016 Feb 2;88(3):1959-64. doi: 10.1021/acs.analchem.5b04677. Epub 2016 Jan 12.


The influence of rough lipopolysaccharide structure on molecular interactions with mammalian antimicrobial peptides.

Bello G, Bodin A, Lawrence MJ, Barlow D, Mason AJ, Barker RD, Harvey RD.

Biochim Biophys Acta. 2016 Feb;1858(2):197-209. doi: 10.1016/j.bbamem.2015.11.007. Epub 2015 Nov 17.

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