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Analysis of the EPR spectra of transferrin: the importance of a zero-field-splitting distribution and 4th-order terms.

Azarkh M, Gast P, Mason AB, Groenen EJJ, Mathies G.

Phys Chem Chem Phys. 2019 Aug 21;21(31):16937-16948. doi: 10.1039/c9cp02626f. Epub 2019 Jul 24.


Mathematical modeling of mutant transferrin-CRM107 molecular conjugates for cancer therapy.

Yoon DJ, Chen KY, Lopes AM, Pan AA, Shiloach J, Mason AB, Kamei DT.

J Theor Biol. 2017 Mar 7;416:88-98. doi: 10.1016/j.jtbi.2017.01.008. Epub 2017 Jan 6.


Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.

Hamdi A, Roshan TM, Kahawita TM, Mason AB, Sheftel AD, Ponka P.

Biochim Biophys Acta. 2016 Dec;1863(12):2859-2867. doi: 10.1016/j.bbamcr.2016.09.008. Epub 2016 Sep 11.


Endosome-mitochondria interactions are modulated by iron release from transferrin.

Das A, Nag S, Mason AB, Barroso MM.

J Cell Biol. 2016 Sep 26;214(7):831-45. doi: 10.1083/jcb.201602069. Epub 2016 Sep 19.


Exploring the Fe(III) binding sites of human serum transferrin with EPR at 275 GHz.

Mathies G, Gast P, Chasteen ND, Luck AN, Mason AB, Groenen EJ.

J Biol Inorg Chem. 2015 Apr;20(3):487-96. doi: 10.1007/s00775-014-1229-z. Epub 2014 Dec 24.


The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles.

Klaus JP, Eisenhauer P, Russo J, Mason AB, Do D, King B, Taatjes D, Cornillez-Ty C, Boyson JE, Thali M, Zheng C, Liao L, Yates JR 3rd, Zhang B, Ballif BA, Botten JW.

Cell Host Microbe. 2013 Nov 13;14(5):522-34. doi: 10.1016/j.chom.2013.10.010.


C-terminal truncations of the Saccharomyces cerevisiae PMA1 H+-ATPase have major impacts on protein conformation, trafficking, quality control, and function.

Mason AB, Allen KE, Slayman CW.

Eukaryot Cell. 2014 Jan;13(1):43-52. doi: 10.1128/EC.00201-13. Epub 2013 Nov 1.


Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia?

Luck AN, Bobst CE, Kaltashov IA, Mason AB.

Biochemistry. 2013 Nov 19;52(46):8333-41. doi: 10.1021/bi401190m. Epub 2013 Nov 8.


Receptor recognition of transferrin bound to lanthanides and actinides: a discriminating step in cellular acquisition of f-block metals.

Deblonde GJ, Sturzbecher-Hoehne M, Mason AB, Abergel RJ.

Metallomics. 2013 Jun;5(6):619-26. doi: 10.1039/c3mt20237b.


Sensitizing curium luminescence through an antenna protein to investigate biological actinide transport mechanisms.

Sturzbecher-Hoehne M, Goujon C, Deblonde GJ, Mason AB, Abergel RJ.

J Am Chem Soc. 2013 Feb 20;135(7):2676-83. doi: 10.1021/ja310957f. Epub 2013 Feb 11.


Structure and dynamics of drug carriers and their interaction with cellular receptors: focus on serum transferrin.

Luck AN, Mason AB.

Adv Drug Deliv Rev. 2013 Jul;65(8):1012-9. doi: 10.1016/j.addr.2012.11.001. Epub 2012 Nov 23. Review.


Transferrin-mediated cellular iron delivery.

Luck AN, Mason AB.

Curr Top Membr. 2012;69:3-35. doi: 10.1016/B978-0-12-394390-3.00001-X. Review.


Biochemical and structural characterization of recombinant human serum transferrin from rice (Oryza sativa L.).

Steere AN, Bobst CE, Zhang D, Pettit SC, Kaltashov IA, Huang N, Mason AB.

J Inorg Biochem. 2012 Nov;116:37-44. doi: 10.1016/j.jinorgbio.2012.07.005. Epub 2012 Jul 11.


Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin.

Steere AN, Chasteen ND, Miller BF, Smith VC, MacGillivray RT, Mason AB.

Biochemistry. 2012 Mar 13;51(10):2113-21. doi: 10.1021/bi3001038. Epub 2012 Mar 1.


Structural basis for iron piracy by pathogenic Neisseria.

Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK.

Nature. 2012 Feb 12;483(7387):53-8. doi: 10.1038/nature10823.


Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release.

Steere AN, Miller BF, Roberts SE, Byrne SL, Chasteen ND, Smith VC, MacGillivray RT, Mason AB.

Biochemistry. 2012 Jan 17;51(2):686-94. doi: 10.1021/bi201661g. Epub 2012 Jan 6.


The long history of iron in the Universe and in health and disease.

Sheftel AD, Mason AB, Ponka P.

Biochim Biophys Acta. 2012 Mar;1820(3):161-87. doi: 10.1016/j.bbagen.2011.08.002. Epub 2011 Aug 9. Review.


How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH.

Eckenroth BE, Steere AN, Chasteen ND, Everse SJ, Mason AB.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13089-94. doi: 10.1073/pnas.1105786108. Epub 2011 Jul 25.


Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.

Steere AN, Byrne SL, Chasteen ND, Mason AB.

Biochim Biophys Acta. 2012 Mar;1820(3):326-33. doi: 10.1016/j.bbagen.2011.06.003. Epub 2011 Jun 15. Review.


Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin.

Steere AN, Byrne SL, Chasteen ND, Smith VC, MacGillivray RT, Mason AB.

J Biol Inorg Chem. 2010 Nov;15(8):1341-52. doi: 10.1007/s00775-010-0694-2. Epub 2010 Aug 14.


Human transferrin confers serum resistance against Bacillus anthracis.

Rooijakkers SH, Rasmussen SL, McGillivray SM, Bartnikas TB, Mason AB, Friedlander AM, Nizet V.

J Biol Chem. 2010 Sep 3;285(36):27609-13. doi: 10.1074/jbc.M110.154930. Epub 2010 Jul 8.


The structure and evolution of the murine inhibitor of carbonic anhydrase: a member of the transferrin superfamily.

Eckenroth BE, Mason AB, McDevitt ME, Lambert LA, Everse SJ.

Protein Sci. 2010 Sep;19(9):1616-26. doi: 10.1002/pro.439.


Intratumoral therapy of glioblastoma multiforme using genetically engineered transferrin for drug delivery.

Yoon DJ, Kwan BH, Chao FC, Nicolaides TP, Phillips JJ, Lam GY, Mason AB, Weiss WA, Kamei DT.

Cancer Res. 2010 Jun 1;70(11):4520-7. doi: 10.1158/0008-5472.CAN-09-4311. Epub 2010 May 11.


Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry.

Leverence R, Mason AB, Kaltashov IA.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8123-8. doi: 10.1073/pnas.0914898107. Epub 2010 Apr 19.


Identification of a kinetically significant anion binding (KISAB) site in the N-lobe of human serum transferrin.

Byrne SL, Steere AN, Chasteen ND, Mason AB.

Biochemistry. 2010 May 18;49(19):4200-7. doi: 10.1021/bi1003519.


Properties of a homogeneous C-lobe prepared by introduction of a TEV cleavage site between the lobes of human transferrin.

Steere AN, Roberts SE, Byrne SL, Dennis Chasteen N, Bobst CE, Kaltashov IA, Smith VC, MacGillivray RT, Mason AB.

Protein Expr Purif. 2010 Jul;72(1):32-41. doi: 10.1016/j.pep.2010.01.008. Epub 2010 Jan 11.


The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pH.

Byrne SL, Chasteen ND, Steere AN, Mason AB.

J Mol Biol. 2010 Feb 12;396(1):130-40. doi: 10.1016/j.jmb.2009.11.023. Epub 2009 Nov 13.


Excited-state lifetime studies of the three tryptophan residues in the N-lobe of human serum transferrin.

James NG, Ross JA, Mason AB, Jameson DM.

Protein Sci. 2010 Jan;19(1):99-110. doi: 10.1002/pro.287.


A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping.

Mason AB, Byrne SL, Everse SJ, Roberts SE, Chasteen ND, Smith VC, MacGillivray RT, Kandemir B, Bou-Abdallah F.

J Mol Recognit. 2009 Nov-Dec;22(6):521-9. doi: 10.1002/jmr.979.


CCR3: Shedding new light on a dark problem?

Mason AB, Hoh J.

J Mol Cell Biol. 2009 Oct;1(1):17-9. doi: 10.1093/jmcb/mjp011. Epub 2009 Aug 14.


Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro.

Kovac S, Ferrand A, Estève JP, Mason AB, Baldwin GS.

FEBS J. 2009 Sep;276(17):4866-74. doi: 10.1111/j.1742-4658.2009.07186.x. Epub 2009 Jul 31.


Inequivalent contribution of the five tryptophan residues in the C-lobe of human serum transferrin to the fluorescence increase when iron is released.

James NG, Byrne SL, Steere AN, Smith VC, MacGillivray RT, Mason AB.

Biochemistry. 2009 Apr 7;48(13):2858-67. doi: 10.1021/bi8022834.


Structural and functional consequences of the substitution of glycine 65 with arginine in the N-lobe of human transferrin.

Mason AB, Halbrooks PJ, James NG, Byrne SL, Grady JK, Chasteen ND, Bobst CE, Kaltashov IA, Smith VC, MacGillivray RT, Everse SJ.

Biochemistry. 2009 Mar 10;48(9):1945-53. doi: 10.1021/bi802254x.


Incorporation of 5-hydroxytryptophan into transferrin and its receptor allows assignment of the pH induced changes in intrinsic fluorescence when iron is released.

James NG, Byrne SL, Mason AB.

Biochim Biophys Acta. 2009 Mar;1794(3):532-40. doi: 10.1016/j.bbapap.2008.11.017. Epub 2008 Dec 6.


Genetically engineering transferrin to improve its in vitro ability to deliver cytotoxins.

Yoon DJ, Chu DS, Ng CW, Pham EA, Mason AB, Hudson DM, Smith VC, MacGillivray RT, Kamei DT.

J Control Release. 2009 Feb 10;133(3):178-84. doi: 10.1016/j.jconrel.2008.10.006. Epub 2008 Oct 21.


Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis.

Mason AB, Judson GL, Bravo MC, Edelstein A, Byrne SL, James NG, Roush ED, Fierke CA, Bobst CE, Kaltashov IA, Daughtery MA.

Biochemistry. 2008 Sep 16;47(37):9847-55. doi: 10.1021/bi801133d. Epub 2008 Aug 20.


Protocol to determine accurate absorption coefficients for iron-containing transferrins.

James NG, Mason AB.

Anal Biochem. 2008 Jul 15;378(2):202-7. doi: 10.1016/j.ab.2008.04.012. Epub 2008 Apr 10. Erratum in: Anal Biochem. 2008 Nov 15;382(2):150.


Intrinsic fluorescence reports a global conformational change in the N-lobe of human serum transferrin following iron release.

James NG, Berger CL, Byrne SL, Smith VC, MacGillivray RT, Mason AB.

Biochemistry. 2007 Sep 18;46(37):10603-11. Epub 2007 Aug 21.


A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase.

Wang F, Lothrop AP, James NG, Griffiths TA, Lambert LA, Leverence R, Kaltashov IA, Andrews NC, MacGillivray RT, Mason AB.

Biochem J. 2007 Aug 15;406(1):85-95.


Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin.

Baker HM, Nurizzo D, Mason AB, Baker EN.

Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):408-14. Epub 2007 Feb 21.


Inhibition of transferrin iron release increases in vitro drug carrier efficacy.

Lao BJ, Tsai WL, Mashayekhi F, Pham EA, Mason AB, Kamei DT.

J Control Release. 2007 Feb 26;117(3):403-12. Epub 2006 Dec 8.


The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding.

Wally J, Halbrooks PJ, Vonrhein C, Rould MA, Everse SJ, Mason AB, Buchanan SK.

J Biol Chem. 2006 Aug 25;281(34):24934-44. Epub 2006 Jun 22.


Effects of C-terminal truncations on trafficking of the yeast plasma membrane H+-ATPase.

Mason AB, Allen KE, Slayman CW.

J Biol Chem. 2006 Aug 18;281(33):23887-98. Epub 2006 Jun 2.


Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor.

Byrne SL, Leverence R, Klein JS, Giannetti AM, Smith VC, MacGillivray RT, Kaltashov IA, Mason AB.

Biochemistry. 2006 May 30;45(21):6663-73.


Conformational changes of yeast plasma membrane H(+)-ATPase during activation by glucose: role of threonine-912 in the carboxy-terminal tail.

Lecchi S, Allen KE, Pardo JP, Mason AB, Slayman CW.

Biochemistry. 2005 Dec 20;44(50):16624-32.


Identification of the epitope of a monoclonal antibody that disrupts binding of human transferrin to the human transferrin receptor.

Teh EM, Hewitt J, Ung KC, Griffiths TA, Nguyen V, Briggs SK, Mason AB, MacGillivray RT.

FEBS J. 2005 Dec;272(24):6344-53.


Composition of pH-sensitive triad in C-lobe of human serum transferrin. Comparison to sequences of ovotransferrin and lactoferrin provides insight into functional differences in iron release.

Halbrooks PJ, Giannetti AM, Klein JS, Björkman PJ, Larouche JR, Smith VC, MacGillivray RT, Everse SJ, Mason AB.

Biochemistry. 2005 Nov 29;44(47):15451-60.


The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.

Giannetti AM, Halbrooks PJ, Mason AB, Vogt TM, Enns CA, Björkman PJ.

Structure. 2005 Nov;13(11):1613-23.


Evolution of the transferrin family: conservation of residues associated with iron and anion binding.

Lambert LA, Perri H, Halbrooks PJ, Mason AB.

Comp Biochem Physiol B Biochem Mol Biol. 2005 Oct;142(2):129-41. Review.


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