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Hsp70-nucleotide exchange factor (NEF) Fes1 has non-NEF roles in degradation of gluconeogenic enzymes and cell wall integrity.

Kumar S, Masison DC.

PLoS Genet. 2019 Jun 26;15(6):e1008219. doi: 10.1371/journal.pgen.1008219. eCollection 2019 Jun.


Human DnaJB6 Antiamyloid Chaperone Protects Yeast from Polyglutamine Toxicity Separately from Spatial Segregation of Aggregates.

Kumar J, Kline NL, Masison DC.

Mol Cell Biol. 2018 Nov 13;38(23). pii: e00437-18. doi: 10.1128/MCB.00437-18. Print 2018 Dec 1.


Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle.

Reidy M, Kumar S, Anderson DE, Masison DC.

Genetics. 2018 Aug;209(4):1139-1154. doi: 10.1534/genetics.118.301178. Epub 2018 Jun 21.


Functional and physical interaction between yeast Hsp90 and Hsp70.

Kravats AN, Hoskins JR, Reidy M, Johnson JL, Doyle SM, Genest O, Masison DC, Wickner S.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2210-E2219. doi: 10.1073/pnas.1719969115. Epub 2018 Feb 20.


Real-time imaging of yeast cells reveals several distinct mechanisms of curing of the [URE3] prion.

Zhao X, Lanz J, Steinberg D, Pease T, Ahearn JM, Bezsonov EE, Staguhn ED, Eisenberg E, Masison DC, Greene LE.

J Biol Chem. 2018 Mar 2;293(9):3104-3117. doi: 10.1074/jbc.M117.809079. Epub 2018 Jan 12.


Molecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3].

Xue YL, Wang H, Riedy M, Roberts BL, Sun Y, Song YB, Jones GW, Masison DC, Song Y.

J Biomol Struct Dyn. 2018 May;36(7):1764-1775. doi: 10.1080/07391102.2017.1334594. Epub 2017 Aug 2.


Hsp104 disaggregase at normal levels cures many [PSI+] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p.

Gorkovskiy A, Reidy M, Masison DC, Wickner RB.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4193-E4202. doi: 10.1073/pnas.1704016114. Epub 2017 May 8.


Human J-protein DnaJB6b Cures a Subset of Saccharomyces cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids.

Reidy M, Sharma R, Roberts BL, Masison DC.

J Biol Chem. 2016 Feb 19;291(8):4035-47. doi: 10.1074/jbc.M115.700393. Epub 2015 Dec 23.


Yeast prions are useful for studying protein chaperones and protein quality control.

Masison DC, Reidy M.

Prion. 2015;9(3):174-83. doi: 10.1080/19336896.2015.1027856. Review.


Yeast prions help identify and define chaperone interaction networks.

Reidy M, Masison DC.

Curr Pharm Biotechnol. 2014;15(11):1008-18. Review.


Hsp40s specify functions of Hsp104 and Hsp90 protein chaperone machines.

Reidy M, Sharma R, Shastry S, Roberts BL, Albino-Flores I, Wickner S, Masison DC.

PLoS Genet. 2014 Oct 16;10(10):e1004720. doi: 10.1371/journal.pgen.1004720. eCollection 2014 Oct.


Hsp104 overexpression cures Saccharomyces cerevisiae [PSI+] by causing dissolution of the prion seeds.

Park YN, Zhao X, Yim YI, Todor H, Ellerbrock R, Reidy M, Eisenberg E, Masison DC, Greene LE.

Eukaryot Cell. 2014 May;13(5):635-47. doi: 10.1128/EC.00300-13. Epub 2014 Mar 14.


The BAG homology domain of Snl1 cures yeast prion [URE3] through regulation of Hsp70 chaperones.

Kumar N, Gaur D, Masison DC, Sharma D.

G3 (Bethesda). 2014 Mar 20;4(3):461-70. doi: 10.1534/g3.113.009993.


Schizosaccharomyces pombe disaggregation machinery chaperones support Saccharomyces cerevisiae growth and prion propagation.

Reidy M, Sharma R, Masison DC.

Eukaryot Cell. 2013 May;12(5):739-45. doi: 10.1128/EC.00301-12. Epub 2013 Mar 15.


Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.

Genest O, Reidy M, Street TO, Hoskins JR, Camberg JL, Agard DA, Masison DC, Wickner S.

Mol Cell. 2013 Feb 7;49(3):464-73. doi: 10.1016/j.molcel.2012.11.017. Epub 2012 Dec 20.


Prokaryotic chaperones support yeast prions and thermotolerance and define disaggregation machinery interactions.

Reidy M, Miot M, Masison DC.

Genetics. 2012 Sep;192(1):185-93. doi: 10.1534/genetics.112.142307. Epub 2012 Jun 25.


Perfecting precision of predicting prion propensity.

Masison DC.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6362-3. doi: 10.1073/pnas.1203767109. Epub 2012 Apr 12. No abstract available.


Modulation and elimination of yeast prions by protein chaperones and co-chaperones.

Reidy M, Masison DC.

Prion. 2011 Oct-Dec;5(4):245-9. doi: 10.4161/pri.17749. Epub 2011 Oct 1. Review.


Single methyl group determines prion propagation and protein degradation activities of yeast heat shock protein (Hsp)-70 chaperones Ssa1p and Ssa2p.

Sharma D, Masison DC.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13665-70. doi: 10.1073/pnas.1107421108. Epub 2011 Aug 1.


Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity.

Kirkland PA, Reidy M, Masison DC.

Genetics. 2011 Jul;188(3):565-77. doi: 10.1534/genetics.111.129460. Epub 2011 May 9.


Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation.

Miot M, Reidy M, Doyle SM, Hoskins JR, Johnston DM, Genest O, Vitery MC, Masison DC, Wickner S.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6915-20. doi: 10.1073/pnas.1102828108. Epub 2011 Apr 7.


Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex.

Chattopadhyay MK, Fernandez C, Sharma D, McPhie P, Masison DC.

Biochem Biophys Res Commun. 2011 Mar 11;406(2):177-82. doi: 10.1016/j.bbrc.2011.01.113. Epub 2011 Feb 3.


Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis.

Madala SK, Dolan MA, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM, Masison DC, Wynn TA.

Proteins. 2011 Jan;79(1):282-93. doi: 10.1002/prot.22881.


Sti1 regulation of Hsp70 and Hsp90 is critical for curing of Saccharomyces cerevisiae [PSI+] prions by Hsp104.

Reidy M, Masison DC.

Mol Cell Biol. 2010 Jul;30(14):3542-52. doi: 10.1128/MCB.01292-09. Epub 2010 May 17.


Function of SSA subfamily of Hsp70 within and across species varies widely in complementing Saccharomyces cerevisiae cell growth and prion propagation.

Sharma D, Martineau CN, Le Dall MT, Reidy M, Masison DC, Kabani M.

PLoS One. 2009 Aug 14;4(8):e6644. doi: 10.1371/journal.pone.0006644.


Influence of Hsp70s and their regulators on yeast prion propagation.

Masison DC, Kirkland PA, Sharma D.

Prion. 2009 Apr-Jun;3(2):65-73. Epub 2009 Apr 29. Review.


Application of GFP-labeling to study prions in yeast.

Greene LE, Park YN, Masison DC, Eisenberg E.

Protein Pept Lett. 2009;16(6):635-41. Review.


Hsp70 structure, function, regulation and influence on yeast prions.

Sharma D, Masison DC.

Protein Pept Lett. 2009;16(6):571-81. Review.


Curing of yeast [URE3] prion by the Hsp40 cochaperone Ydj1p is mediated by Hsp70.

Sharma D, Stanley RF, Masison DC.

Genetics. 2009 Jan;181(1):129-37. doi: 10.1534/genetics.108.098699. Epub 2008 Nov 17.


Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities.

Needham PG, Masison DC.

Arch Biochem Biophys. 2008 Oct 15;478(2):167-74. doi: 10.1016/ Epub 2008 Aug 6.


Functionally redundant isoforms of a yeast Hsp70 chaperone subfamily have different antiprion effects.

Sharma D, Masison DC.

Genetics. 2008 Jul;179(3):1301-11. doi: 10.1534/genetics.108.089458. Epub 2008 Jun 18.


Ure2p function is enhanced by its prion domain in Saccharomyces cerevisiae.

Shewmaker F, Mull L, Nakayashiki T, Masison DC, Wickner RB.

Genetics. 2007 Jul;176(3):1557-65. Epub 2007 May 16.


Unique classes of mutations in the Saccharomyces cerevisiae G-protein translation elongation factor 1A suppress the requirement for guanine nucleotide exchange.

Ozturk SB, Vishnu MR, Olarewaju O, Starita LM, Masison DC, Kinzy TG.

Genetics. 2006 Oct;174(2):651-63. Epub 2006 Sep 1.


Application of photobleaching for measuring diffusion of prion proteins in cytosol of yeast cells.

Wu YX, Masison DC, Eisenberg E, Greene LE.

Methods. 2006 May;39(1):43-9.


Curing of yeast [PSI+] prion by guanidine inactivation of Hsp104 does not require cell division.

Wu YX, Greene LE, Masison DC, Eisenberg E.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12789-94. Epub 2005 Aug 25.


Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1).

Song Y, Masison DC.

J Biol Chem. 2005 Oct 7;280(40):34178-85. Epub 2005 Aug 12.


Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication.

Song Y, Wu YX, Jung G, Tutar Y, Eisenberg E, Greene LE, Masison DC.

Eukaryot Cell. 2005 Feb;4(2):289-97.


Cell biology: designer prions.

Masison DC.

Nature. 2004 May 6;429(6987):37-8. No abstract available.


Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance.

Jung G, Jones G, Masison DC.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9936-41. Epub 2002 Jul 8.


Protein synthesis assayed by electroporation of mRNA in Saccharomyces cerevisiae.

Searfoss AM, Masison DC, Wickner RB.

Methods Enzymol. 2002;351:631-9. Review. No abstract available.


[URE3] and [PSI] are prions of yeast and evidence for new fungal prions.

Masison DC, Edskes HK, Maddelein ML, Taylor KL, Wickner RB.

Curr Issues Mol Biol. 2000 Apr;2(2):51-9. Review.


A role for cytosolic hsp70 in yeast [PSI(+)] prion propagation and [PSI(+)] as a cellular stress.

Jung G, Jones G, Wegrzyn RD, Masison DC.

Genetics. 2000 Oct;156(2):559-70.


Expanding the prion model for the yeast [PSI+] element.

Masison DC.

Trends Microbiol. 2000 Jan;8(1):1-3. Review. No abstract available.


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