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Items: 1 to 50 of 74

1.

Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein.

Peschiera I, Giuliani M, Giusti F, Melero R, Paccagnini E, Donnarumma D, Pansegrau W, Carazo JM, Sorzano COS, Scarselli M, Masignani V, Liljeroos LJ, Ferlenghi I.

Commun Biol. 2019 Jun 26;2:241. doi: 10.1038/s42003-019-0493-4. eCollection 2019.

2.

The Development of a Vaccine Against Meningococcus B Using Reverse Vaccinology.

Masignani V, Pizza M, Moxon ER.

Front Immunol. 2019 Apr 16;10:751. doi: 10.3389/fimmu.2019.00751. eCollection 2019. Review.

3.

Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54.

Day CJ, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Jennings MP.

Biochem Biophys Res Commun. 2019 May 21;513(1):287-290. doi: 10.1016/j.bbrc.2019.03.092. Epub 2019 Apr 3.

PMID:
30954224
4.

Genome-Based Approach Delivers Vaccine Candidates Against Pseudomonas aeruginosa.

Bianconi I, Alcalá-Franco B, Scarselli M, Dalsass M, Buccato S, Colaprico A, Marchi S, Masignani V, Bragonzi A.

Front Immunol. 2019 Jan 9;9:3021. doi: 10.3389/fimmu.2018.03021. eCollection 2018.

5.

Meningococcal B vaccine (4CMenB): the journey from research to real world experience.

Rappuoli R, Pizza M, Masignani V, Vadivelu K.

Expert Rev Vaccines. 2018 Dec;17(12):1111-1121. doi: 10.1080/14760584.2018.1547637. Epub 2018 Dec 5. Review.

PMID:
30457407
6.

Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes.

Giuliani M, Bartolini E, Galli B, Santini L, Lo Surdo P, Buricchi F, Bruttini M, Benucci B, Pacchiani N, Alleri L, Donnarumma D, Pansegrau W, Peschiera I, Ferlenghi I, Cozzi R, Norais N, Giuliani MM, Maione D, Pizza M, Rappuoli R, Finco O, Masignani V.

Sci Rep. 2018 Feb 27;8(1):3700. doi: 10.1038/s41598-018-22057-7.

7.

Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.

8.

Emerging experience with meningococcal serogroup B protein vaccines.

Toneatto D, Pizza M, Masignani V, Rappuoli R.

Expert Rev Vaccines. 2017 May;16(5):433-451. doi: 10.1080/14760584.2017.1308828. Epub 2017 Apr 10. Review.

PMID:
28375029
9.

Corrigendum to "Preclinical studies on new proteins as carrier for glycoconjugate vaccines" [Vaccine 34 (2016) 4235-4242].

Tontini M, Romano MR, Proietti D, Balducci E, Micoli F, Balocchi C, Santini L, Masignani V, Berti F, Costantino P.

Vaccine. 2017 May 2;35(19):2612. doi: 10.1016/j.vaccine.2017.03.011. Epub 2017 Mar 30. No abstract available.

10.

Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.

Vacca I, Del Tordello E, Gasperini G, Pezzicoli A, Di Fede M, Rossi Paccani S, Marchi S, Mubaiwa TD, Hartley-Tassell LE, Jennings MP, Seib KL, Masignani V, Pizza M, Serruto D, Aricò B, Delany I.

PLoS One. 2016 Oct 25;11(10):e0162878. doi: 10.1371/journal.pone.0162878. eCollection 2016.

11.

Functional characterization of a monoclonal antibody epitope using a lambda phage display-deep sequencing platform.

Domina M, Lanza Cariccio V, Benfatto S, Venza M, Venza I, Borgogni E, Castellino F, Midiri A, Galbo R, Romeo L, Biondo C, Masignani V, Teti G, Felici F, Beninati C.

Sci Rep. 2016 Aug 17;6:31458. doi: 10.1038/srep31458.

12.

Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries.

Domina M, Lanza Cariccio V, Benfatto S, Venza M, Venza I, Donnarumma D, Bartolini E, Borgogni E, Bruttini M, Santini L, Midiri A, Galbo R, Romeo L, Patanè F, Biondo C, Norais N, Masignani V, Teti G, Felici F, Beninati C.

PLoS One. 2016 Aug 10;11(8):e0160702. doi: 10.1371/journal.pone.0160702. eCollection 2016.

13.

Preclinical studies on new proteins as carrier for glycoconjugate vaccines.

Tontini M, Romano MR, Proietti D, Balducci E, Micoli F, Balocchi C, Santini L, Masignani V, Berti F, Costantino P.

Vaccine. 2016 Jul 29;34(35):4235-4242. doi: 10.1016/j.vaccine.2016.06.039. Epub 2016 Jun 24. Erratum in: Vaccine. 2017 May 2;35(19):2612.

14.

Exploring host-pathogen interactions through genome wide protein microarray analysis.

Scietti L, Sampieri K, Pinzuti I, Bartolini E, Benucci B, Liguori A, Haag AF, Lo Surdo P, Pansegrau W, Nardi-Dei V, Santini L, Arora S, Leber X, Rindi S, Savino S, Costantino P, Maione D, Merola M, Speziale P, Bottomley MJ, Bagnoli F, Masignani V, Pizza M, Scharenberg M, Schlaeppi JM, Nissum M, Liberatori S.

Sci Rep. 2016 Jun 15;6:27996. doi: 10.1038/srep27996.

15.

Phage display revisited: Epitope mapping of a monoclonal antibody directed against Neisseria meningitidis adhesin A using the PROFILER technology.

Cariccio VL, Domina M, Benfatto S, Venza M, Venza I, Faleri A, Bruttini M, Bartolini E, Giuliani MM, Santini L, Brunelli B, Norais N, Borgogni E, Midiri A, Galbo R, Romeo L, Biondo C, Masignani V, Teti G, Felici F, Beninati C.

MAbs. 2016 May-Jun;8(4):741-50. doi: 10.1080/19420862.2016.1158371. Epub 2016 Mar 10.

16.

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Biagini M, Spinsanti M, De Angelis G, Tomei S, Ferlenghi I, Scarselli M, Rigat F, Messuti N, Biolchi A, Muzzi A, Anderloni G, Brunelli B, Cartocci E, Buricchi F, Tani C, Stella M, Moschioni M, Del Tordello E, Colaprico A, Savino S, Giuliani MM, Delany I, Pizza M, Costantino P, Norais N, Rappuoli R, Masignani V.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2714-9. doi: 10.1073/pnas.1521142113. Epub 2016 Feb 17.

17.

Identification of a Monoclonal Antibody Against Pneumococcal Pilus 1 Ancillary Protein Impairing Bacterial Adhesion to Human Epithelial Cells.

Amerighi F, Valeri M, Donnarumma D, Maccari S, Moschioni M, Taddei A, Lapazio L, Pansegrau W, Buccato S, De Angelis G, Ruggiero P, Masignani V, Soriani M, Pezzicoli A.

J Infect Dis. 2016 Feb 15;213(4):516-22. doi: 10.1093/infdis/jiv461. Epub 2015 Sep 23.

PMID:
26401026
18.

Exploiting chimeric human antibodies to characterize a protective epitope of Neisseria adhesin A, one of the Bexsero vaccine components.

Bertoldi I, Faleri A, Galli B, Lo Surdo P, Liguori A, Norais N, Santini L, Masignani V, Pizza M, Giuliani MM.

FASEB J. 2016 Jan;30(1):93-101. doi: 10.1096/fj.15-273813. Epub 2015 Aug 24.

PMID:
26304221
19.

Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.

Seib KL, Scarselli M, Comanducci M, Toneatto D, Masignani V.

Expert Rev Vaccines. 2015 Jun;14(6):841-59. doi: 10.1586/14760584.2015.1016915. Epub 2015 Feb 23. Review.

PMID:
25704037
20.

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.

Malito E, Biancucci M, Faleri A, Ferlenghi I, Scarselli M, Maruggi G, Lo Surdo P, Veggi D, Liguori A, Santini L, Bertoldi I, Petracca R, Marchi S, Romagnoli G, Cartocci E, Vercellino I, Savino S, Spraggon G, Norais N, Pizza M, Rappuoli R, Masignani V, Bottomley MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17128-33. doi: 10.1073/pnas.1419686111. Epub 2014 Nov 17.

21.

Neisseria adhesin A variation and revised nomenclature scheme.

Bambini S, De Chiara M, Muzzi A, Mora M, Lucidarme J, Brehony C, Borrow R, Masignani V, Comanducci M, Maiden MC, Rappuoli R, Pizza M, Jolley KA.

Clin Vaccine Immunol. 2014 Jul;21(7):966-71. doi: 10.1128/CVI.00825-13. Epub 2014 May 7.

22.

Immune responses to pneumococcal pilus RrgA and RrgB antigens and their relationship with pneumococcal carriage in humans.

Ahmed MS, Derbyshire S, Flanagan B, Loh C, McCormick M, Barocchi M, Masignani V, Finn A, Zhang Q.

J Infect. 2014 Jun;68(6):562-71. doi: 10.1016/j.jinf.2014.01.013. Epub 2014 Feb 6.

PMID:
24509142
23.

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].

Figueira M, Moschioni M, De Angelis G, Barocchi M, Sabharwal V, Masignani V, Pelton SI.

PLoS One. 2014 Jan 8;9(1):e83798. doi: 10.1371/journal.pone.0083798. eCollection 2014.

24.

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties.

Faleri A, Santini L, Brier S, Pansegrau W, Lo Surdo P, Scarselli M, Buricchi F, Volpini G, Genovese A, van der Veen S, Lea S, Tang CM, Savino S, Pizza M, Finco O, Norais N, Masignani V.

FASEB J. 2014 Apr;28(4):1644-53. doi: 10.1096/fj.13-239012. Epub 2013 Dec 26.

PMID:
24371123
25.

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

Malito E, Faleri A, Lo Surdo P, Veggi D, Maruggi G, Grassi E, Cartocci E, Bertoldi I, Genovese A, Santini L, Romagnoli G, Borgogni E, Brier S, Lo Passo C, Domina M, Castellino F, Felici F, van der Veen S, Johnson S, Lea SM, Tang CM, Pizza M, Savino S, Norais N, Rappuoli R, Bottomley MJ, Masignani V.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3304-9. doi: 10.1073/pnas.1222845110. Epub 2013 Feb 8.

26.

An extended multi-locus molecular typing schema for Streptococcus pneumoniae demonstrates that a limited number of capsular switch events is responsible for serotype heterogeneity of closely related strains from different countries.

Crisafulli G, Guidotti S, Muzzi A, Torricelli G, Moschioni M, Masignani V, Censini S, Donati C.

Infect Genet Evol. 2013 Jan;13:151-61. doi: 10.1016/j.meegid.2012.09.008. Epub 2012 Sep 27.

PMID:
23022733
27.

Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressing Streptococcus pneumoniae populations.

Moschioni M, De Angelis G, Harfouche C, Bizzarri E, Filippini S, Mori E, Mancuso G, Doro F, Barocchi MA, Ruggiero P, Masignani V.

Vaccine. 2012 Feb 8;30(7):1349-56. doi: 10.1016/j.vaccine.2011.12.080. Epub 2011 Dec 30.

PMID:
22210141
28.

RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies.

Harfouche C, Filippini S, Gianfaldoni C, Ruggiero P, Moschioni M, Maccari S, Pancotto L, Arcidiacono L, Galletti B, Censini S, Mori E, Giuliani M, Facciotti C, Cartocci E, Savino S, Doro F, Pallaoro M, Nocadello S, Mancuso G, Haston M, Goldblatt D, Barocchi MA, Pizza M, Rappuoli R, Masignani V.

Infect Immun. 2012 Jan;80(1):451-60. doi: 10.1128/IAI.05780-11. Epub 2011 Nov 14.

29.

The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern.

De Angelis G, Moschioni M, Muzzi A, Pezzicoli A, Censini S, Delany I, Lo Sapio M, Sinisi A, Donati C, Masignani V, Barocchi MA.

PLoS One. 2011;6(6):e21269. doi: 10.1371/journal.pone.0021269. Epub 2011 Jun 22.

30.

Structural and functional characterization of the Streptococcus pneumoniae RrgB pilus backbone D1 domain.

Gentile MA, Melchiorre S, Emolo C, Moschioni M, Gianfaldoni C, Pancotto L, Ferlenghi I, Scarselli M, Pansegrau W, Veggi D, Merola M, Cantini F, Ruggiero P, Banci L, Masignani V.

J Biol Chem. 2011 Apr 22;286(16):14588-97. doi: 10.1074/jbc.M110.202739. Epub 2011 Mar 2.

31.

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species.

Donati C, Hiller NL, Tettelin H, Muzzi A, Croucher NJ, Angiuoli SV, Oggioni M, Dunning Hotopp JC, Hu FZ, Riley DR, Covacci A, Mitchell TJ, Bentley SD, Kilian M, Ehrlich GD, Rappuoli R, Moxon ER, Masignani V.

Genome Biol. 2010;11(10):R107. doi: 10.1186/gb-2010-11-10-r107. Epub 2010 Oct 29. Erratum in: Genome Biol. 2011;12(10):140.

32.

The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo.

Moschioni M, Emolo C, Biagini M, Maccari S, Pansegrau W, Donati C, Hilleringmann M, Ferlenghi I, Ruggiero P, Sinisi A, Pizza M, Norais N, Barocchi MA, Masignani V.

Infect Immun. 2010 Dec;78(12):5033-42. doi: 10.1128/IAI.00601-10. Epub 2010 Sep 7.

33.

Genome-based vaccine development: a short cut for the future.

Moriel DG, Scarselli M, Serino L, Mora M, Rappuoli R, Masignani V.

Hum Vaccin. 2008 May-Jun;4(3):184-8. Epub 2010 May 15. Review.

PMID:
20686357
34.

Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus.

Spraggon G, Koesema E, Scarselli M, Malito E, Biagini M, Norais N, Emolo C, Barocchi MA, Giusti F, Hilleringmann M, Rappuoli R, Lesley S, Covacci A, Masignani V, Ferlenghi I.

PLoS One. 2010 Jun 15;5(6):e10919. doi: 10.1371/journal.pone.0010919.

35.

Simple sequence repeats and genome plasticity in Streptococcus agalactiae.

Janulczyk R, Masignani V, Maione D, Tettelin H, Grandi G, Telford JL.

J Bacteriol. 2010 Aug;192(15):3990-4000. doi: 10.1128/JB.01465-09. Epub 2010 May 21.

36.

Genome-based vaccine development: a short cut for the future.

Moriel DG, Scarselli M, Serino L, Mora M, Rappuoli R, Masignani V.

Adv Exp Med Biol. 2009;655:81-9. doi: 10.1007/978-1-4419-1132-2_8. Review.

PMID:
20047037
37.

Prevalence of pilus-encoding islets among acute otitis media Streptococcus pneumoniae isolates from Israel.

Moschioni M, De Angelis G, Melchiorre S, Masignani V, Leibovitz E, Barocchi MA, Dagan R.

Clin Microbiol Infect. 2010 Sep;16(9):1501-4. doi: 10.1111/j.1469-0691.2009.03105.x.

38.

Sortase A confers protection against Streptococcus pneumoniae in mice.

Gianfaldoni C, Maccari S, Pancotto L, Rossi G, Hilleringmann M, Pansegrau W, Sinisi A, Moschioni M, Masignani V, Rappuoli R, Del Giudice G, Ruggiero P.

Infect Immun. 2009 Jul;77(7):2957-61. doi: 10.1128/IAI.01516-08. Epub 2009 May 11.

39.

HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells.

Serruto D, Spadafina T, Scarselli M, Bambini S, Comanducci M, Höhle S, Kilian M, Veiga E, Cossart P, Oggioni MR, Savino S, Ferlenghi I, Taddei AR, Rappuoli R, Pizza M, Masignani V, Aricò B.

Cell Microbiol. 2009 Jul;11(7):1044-63. doi: 10.1111/j.1462-5822.2009.01306.x. Epub 2009 Mar 12.

PMID:
19290916
40.

Genome-based approaches to develop vaccines against bacterial pathogens.

Serruto D, Serino L, Masignani V, Pizza M.

Vaccine. 2009 May 26;27(25-26):3245-50. doi: 10.1016/j.vaccine.2009.01.072. Epub 2009 Feb 5. Review.

PMID:
19200820
41.

A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells.

Bagnoli F, Moschioni M, Donati C, Dimitrovska V, Ferlenghi I, Facciotti C, Muzzi A, Giusti F, Emolo C, Sinisi A, Hilleringmann M, Pansegrau W, Censini S, Rappuoli R, Covacci A, Masignani V, Barocchi MA.

J Bacteriol. 2008 Aug;190(15):5480-92. doi: 10.1128/JB.00384-08. Epub 2008 May 30.

42.

Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A.

Hilleringmann M, Giusti F, Baudner BC, Masignani V, Covacci A, Rappuoli R, Barocchi MA, Ferlenghi I.

PLoS Pathog. 2008 Mar 21;4(3):e1000026. doi: 10.1371/journal.ppat.1000026.

43.

Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related.

Moschioni M, Donati C, Muzzi A, Masignani V, Censini S, Hanage WP, Bishop CJ, Reis JN, Normark S, Henriques-Normark B, Covacci A, Rappuoli R, Barocchi MA.

J Infect Dis. 2008 Mar 15;197(6):888-96. doi: 10.1086/528375.

PMID:
18269316
44.

Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization.

Serino L, Nesta B, Leuzzi R, Fontana MR, Monaci E, Mocca BT, Cartocci E, Masignani V, Jerse AE, Rappuoli R, Pizza M.

Mol Microbiol. 2007 Jun;64(5):1391-403.

45.

The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials.

Muzzi A, Masignani V, Rappuoli R.

Drug Discov Today. 2007 Jun;12(11-12):429-39. Epub 2007 May 7. Review.

PMID:
17532526
46.

BibA: a novel immunogenic bacterial adhesin contributing to group B Streptococcus survival in human blood.

Santi I, Scarselli M, Mariani M, Pezzicoli A, Masignani V, Taddei A, Grandi G, Telford JL, Soriani M.

Mol Microbiol. 2007 Feb;63(3):754-67. Epub 2007 Jan 8.

47.

Towards a universal group B Streptococcus vaccine using multistrain genome analysis.

Tettelin H, Medini D, Donati C, Masignani V.

Expert Rev Vaccines. 2006 Oct;5(5):687-94. Review.

PMID:
17181441
48.

Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.

Gianfaldoni C, Censini S, Hilleringmann M, Moschioni M, Facciotti C, Pansegrau W, Masignani V, Covacci A, Rappuoli R, Barocchi MA, Ruggiero P.

Infect Immun. 2007 Feb;75(2):1059-62. Epub 2006 Dec 4.

49.

A universal vaccine for serogroup B meningococcus.

Giuliani MM, Adu-Bobie J, Comanducci M, Aricò B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10834-9. Epub 2006 Jul 6.

50.

A pneumococcal pilus influences virulence and host inflammatory responses.

Barocchi MA, Ries J, Zogaj X, Hemsley C, Albiger B, Kanth A, Dahlberg S, Fernebro J, Moschioni M, Masignani V, Hultenby K, Taddei AR, Beiter K, Wartha F, von Euler A, Covacci A, Holden DW, Normark S, Rappuoli R, Henriques-Normark B.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2857-62. Epub 2006 Feb 15.

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