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Phase II trial of biweekly cetuximab and irinotecan as third-line therapy for pretreated KRAS exon 2 wild-type colorectal cancer.

Osumi H, Shinozaki E, Mashima T, Wakatsuki T, Suenaga M, Ichimura T, Ogura M, Ota Y, Nakayama I, Takahari D, Chin K, Miki Y, Yamaguchi K.

Cancer Sci. 2018 Jun 16. doi: 10.1111/cas.13698. [Epub ahead of print]


Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Ning Y, Cremolini C, Antoniotti C, Borelli B, Mashima T, Okazaki S, Berger MD, Miyamoto Y, Gopez R Jr, Barzi A, Lonardi S, Yamaguchi T, Falcone A, Loupakis F, Lenz HJ.

Clin Colorectal Cancer. 2018 Jun;17(2):e395-e414. doi: 10.1016/j.clcc.2018.02.010. Epub 2018 Feb 27.


Plastic roles of phenylalanine and tyrosine residues of TLS/FUS in complex formation with the G-quadruplexes of telomeric DNA and TERRA.

Kondo K, Mashima T, Oyoshi T, Yagi R, Kurokawa R, Kobayashi N, Nagata T, Katahira M.

Sci Rep. 2018 Feb 12;8(1):2864. doi: 10.1038/s41598-018-21142-1.


DNA G-Wire Formation Using an Artificial Peptide is Controlled by Protease Activity.

Usui K, Okada A, Sakashita S, Shimooka M, Tsuruoka T, Nakano SI, Miyoshi D, Mashima T, Katahira M, Hamada Y.

Molecules. 2017 Nov 16;22(11). pii: E1991. doi: 10.3390/molecules22111991.


Successive energy transfer within multiple photosensitizers assembled in a hexameric hemoprotein scaffold.

Mashima T, Oohora K, Hayashi T.

Phys Chem Chem Phys. 2018 Jan 31;20(5):3200-3209. doi: 10.1039/c7cp05257j.


Development of an RNA aptamer that acquires binding capacity against HIV-1 Tat protein via G-quadruplex formation in response to potassium ions.

Yamaoki Y, Nagata T, Mashima T, Katahira M.

Chem Commun (Camb). 2017 Jul 4;53(52):7056-7059. doi: 10.1039/c7cc03312e. Epub 2017 Jun 16.


mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.

Mashima T, Taneda Y, Jang MK, Mizutani A, Muramatsu Y, Yoshida H, Sato A, Tanaka N, Sugimoto Y, Seimiya H.

Oncotarget. 2017 Jul 18;8(29):47902-47915. doi: 10.18632/oncotarget.18146.


A model curriculum for the study of animal welfare in colleges and schools of veterinary medicine.

AVMA Model Animal Welfare Curriculum Planning Group, Lord LK, Millman ST, Carbone L, Cook N, Fisher A, McKeegan D, Morton D, Pajor E, Peralta JM, Robertson SA, Siegford J; Stakeholder Representatives, Egrie PG, Mashima TY, Turner PV; Staff Consultants, Golab GC, Patterson-Kane E.

J Am Vet Med Assoc. 2017 Mar 15;250(6):632-640. doi: 10.2460/javma.250.6.632. No abstract available.


APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.

Tanaka N, Mashima T, Mizutani A, Sato A, Aoyama A, Gong B, Yoshida H, Muramatsu Y, Nakata K, Matsuura M, Katayama R, Nagayama S, Fujita N, Sugimoto Y, Seimiya H.

Mol Cancer Ther. 2017 Apr;16(4):752-762. doi: 10.1158/1535-7163.MCT-16-0578. Epub 2017 Feb 8.


Cancer Stem Cells (CSCs) as a Rational Therapeutic Cancer Target, and Screening for CSC-targeting Drugs.

Mashima T.

Yakugaku Zasshi. 2017;137(2):129-132. doi: 10.1248/yakushi.16-00229-1. Review. Japanese.


Pharmaceutical Sciences Advancing Molecular Cancer Therapeutics~To Improve Rationale and Effectiveness of Molecularly Targeted Drugs~.

Noguchi K, Mashima T.

Yakugaku Zasshi. 2017;137(2):127-128. doi: 10.1248/yakushi.16-00229-F. Japanese. No abstract available.


Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer.

Suenaga M, Mashima T, Kawata N, Wakatsuki T, Horiike Y, Matsusaka S, Dan S, Shinozaki E, Seimiya H, Mizunuma N, Yamaguchi K, Yamaguchi T.

Oncotarget. 2016 Jun 7;7(23):34811-23. doi: 10.18632/oncotarget.9187.


Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA.

Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M, Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T, Matsuura Y, Takeuchi O, Kishimoto T.

J Exp Med. 2016 Apr 4;213(4):605-19. doi: 10.1084/jem.20151289. Epub 2016 Mar 28.


The binding specificity of Translocated in LipoSarcoma/FUsed in Sarcoma with lncRNA transcribed from the promoter region of cyclin D1.

Yoneda R, Suzuki S, Mashima T, Kondo K, Nagata T, Katahira M, Kurokawa R.

Cell Biosci. 2016 Jan 25;6:4. doi: 10.1186/s13578-016-0068-8. eCollection 2016.


K(+)-Responsive off-to-on switching of hammerhead ribozyme through dual G-quadruplex formation requiring no heating and cooling treatment.

Yamaoki Y, Nagata T, Mashima T, Katahira M.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):27-31. doi: 10.1016/j.bbrc.2015.10.173. Epub 2015 Nov 10.


Bifacial Base-Pairing Behaviors of 5-Hydroxyuracil DNA Bases through Hydrogen Bonding and Metal Coordination.

Takezawa Y, Nishiyama K, Mashima T, Katahira M, Shionoya M.

Chemistry. 2015 Oct 12;21(42):14713-6. doi: 10.1002/chem.201502772. Epub 2015 Aug 31.


Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts.

Kusano S, Ishiyama S, Lam SL, Mashima T, Katahira M, Miyamoto K, Aida M, Nagatsugi F.

Nucleic Acids Res. 2015 Sep 18;43(16):7717-30. doi: 10.1093/nar/gkv797. Epub 2015 Aug 5.


Energy migration within hexameric hemoprotein reconstituted with Zn porphyrinoid molecules.

Oohora K, Mashima T, Ohkubo K, Fukuzumi S, Hayashi T.

Chem Commun (Camb). 2015 Jul 14;51(55):11138-40. doi: 10.1039/c5cc02680f.


Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation.

Mashima T, Ushijima M, Matsuura M, Tsukahara S, Kunimasa K, Furuno A, Saito S, Kitamura M, Soma-Nagae T, Seimiya H, Dan S, Yamori T, Tomida A.

Cancer Sci. 2015 Jul;106(7):909-20. doi: 10.1111/cas.12682. Epub 2015 May 25.


Boosting of activity enhancement of K(+)-responsive quadruplex hammerhead ribozyme.

Yamaoki Y, Mashima T, Nagata T, Katahira M.

Chem Commun (Camb). 2015 Apr 7;51(27):5898-901. doi: 10.1039/c5cc00961h. Epub 2015 Mar 2.


TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival by regulation of endoplasmic reticulum chaperone expression.

Mashima T, Soma-Nagae T, Migita T, Kinoshita R, Iwamoto A, Yuasa T, Yonese J, Ishikawa Y, Seimiya H.

Cancer Res. 2014 Sep 1;74(17):4888-97. doi: 10.1158/0008-5472.CAN-13-3718. Epub 2014 Jun 24.


Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition.

Hayashi T, Oshima H, Mashima T, Nagata T, Katahira M, Kinoshita M.

Nucleic Acids Res. 2014 Jun;42(11):6861-75. doi: 10.1093/nar/gku382. Epub 2014 May 6.


[The 15th result of screening for antineoplastic agents].

Yamori T, Uehara Y, Fukazawa H, Yoshida M, Imoto M, Kiyomiya H, Mashima T, Manakami T, Kawata M, Nagata H, Dan S, Matsuura M, Kakeya H, Tomita A.

Gan To Kagaku Ryoho. 2013 Apr;40 Suppl 1:116-47. No abstract available.


Spontaneous middle cerebral artery dissection demonstrated by high-resolution T1-weighted 3D image.

Uemura M, Akaiwa Y, Toriyabe M, Mashima T, Terajima K, Shimohata T, Igarashi H, Nakada T, Nishizawa M.

Cerebrovasc Dis. 2013;36(3):243-4. doi: 10.1159/000353873. Epub 2013 Oct 12. No abstract available.


Structure of perosamine-containing polysaccharide, a component of the sheath of Thiothrix fructosivorans.

Kondo K, Umezu T, Shimura S, Narizuka R, Koizumi J, Mashima T, Katahira M, Takeda M.

Int J Biol Macromol. 2013 Aug;59:59-66. doi: 10.1016/j.ijbiomac.2013.04.013. Epub 2013 Apr 12.


Anti-prion activity of an RNA aptamer and its structural basis.

Mashima T, Nishikawa F, Kamatari YO, Fujiwara H, Saimura M, Nagata T, Kodaki T, Nishikawa S, Kuwata K, Katahira M.

Nucleic Acids Res. 2013 Jan;41(2):1355-62. doi: 10.1093/nar/gks1132. Epub 2012 Nov 24.


Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.

Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.

Cancer Sci. 2013 Mar;104(3):360-8. doi: 10.1111/cas.12071. Epub 2013 Jan 4.


Conformational analysis of an extracellular polysaccharide produced by Sphaerotilus natans.

Kondo K, Takeda M, Mashima T, Katahira M, Koizumi J, Ueda K.

Carbohydr Res. 2012 Oct 1;360:102-8. doi: 10.1016/j.carres.2012.07.023. Epub 2012 Aug 7.


Defining and measuring construct of interprofessional professionalism.

Hammer D, Anderson MB, Brunson WD, Grus C, Heun L, Holtman M, Mashima T, McGuinn K, Nunez L, Register S, Ross L, Ruffin A, Gandy Frost J.

J Allied Health. 2012 Summer;41(2):e49-53.


'Intelligent' ribozyme whose activity is altered in response to K+ as a result of quadruplex formation.

Nagata T, Sakurai Y, Hara Y, Mashima T, Kodaki T, Katahira M.

FEBS J. 2012 Apr;279(8):1456-63. doi: 10.1111/j.1742-4658.2012.08538.x. Epub 2012 Mar 16.


Presence of alternating glucosaminoglucan in the sheath of Thiothrix nivea.

Takeda M, Kondo K, Yamada M, Sumikawa M, Koizumi J, Mashima T, Katahira M.

Int J Biol Macromol. 2012 Jan 1;50(1):236-44. doi: 10.1016/j.ijbiomac.2011.10.024. Epub 2011 Nov 6.


A change in treatment from etanercept to infliximab was effective to control scleritis in a patient with rheumatoid arthritis.

Sassa Y, Kawano Y, Yamana T, Mashima T, Ishibashi T.

Acta Ophthalmol. 2012 Mar;90(2):e161-2. doi: 10.1111/j.1755-3768.2010.02090.x. Epub 2011 Apr 6. No abstract available.


Structural aspects for the recognition of ATP by ribonucleopeptide receptors.

Nakano S, Mashima T, Matsugami A, Inoue M, Katahira M, Morii T.

J Am Chem Soc. 2011 Mar 30;133(12):4567-79. doi: 10.1021/ja110725d. Epub 2011 Mar 3.


Study of a novel glycoconjugate, thiopeptidoglycan, and a novel polysaccharide lyase, thiopeptidoglycan lyase.

Kondo K, Takeda M, Ejima W, Kawasaki Y, Umezu T, Yamada M, Koizumi J, Mashima T, Katahira M.

Int J Biol Macromol. 2011 Mar 1;48(2):256-62. doi: 10.1016/j.ijbiomac.2010.11.009. Epub 2010 Nov 21.


Three-dimensional CT cavernosography: reconsidering venous ligation surgery on the basis of the modern technology.

Kawanishi Y, Izumi K, Muguruma H, Mashima T, Komori M, Yamanaka M, Yamamoto A, Numata A, Kishimoto T, Kanayama HO.

BJU Int. 2011 May;107(9):1442-6. doi: 10.1111/j.1464-410X.2010.09644.x. Epub 2010 Sep 24.


Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth.

Mashima T, Okabe S, Seimiya H.

Mol Pharmacol. 2010 Nov;78(5):846-54. doi: 10.1124/mol.110.064790. Epub 2010 Aug 13.


Fulbright scholar international teaching and research opportunities for veterinary faculty.

Memon MA, Garrison G, Mashima TY, Chaddock M.

J Vet Med Educ. 2010 Summer;37(2):207-8. doi: 10.3138/jvme.37.2.207.


Solubilization and structural determination of a glycoconjugate which is assembled into the sheath of Leptothrix cholodnii.

Takeda M, Kondo K, Yamada M, Koizumi J, Mashima T, Matsugami A, Katahira M.

Int J Biol Macromol. 2010 Mar 1;46(2):206-11. doi: 10.1016/j.ijbiomac.2009.12.006. Epub 2009 Dec 22.


Structural analysis of ribonucleopeptide aptamer against ATP.

Mashima T, Matsugami A, Nakano S, Inoue M, Fukuda M, Morii T, Katahira M.

Nucleic Acids Symp Ser (Oxf). 2009;(53):267-8. doi: 10.1093/nass/nrp134.


Structural aspects for the function of ATP-binding ribonucleopeptide receptors.

Nakano S, Fukuda M, Mashima T, Katahira M, Morii T.

Nucleic Acids Symp Ser (Oxf). 2009;(53):259-60. doi: 10.1093/nass/nrp130.


Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein.

Mashima T, Matsugami A, Nishikawa F, Nishikawa S, Katahira M.

Nucleic Acids Res. 2009 Oct;37(18):6249-58. doi: 10.1093/nar/gkp647. Epub 2009 Aug 7.


Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.

Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, Tsuruo T, Seimiya H.

Cancer Sci. 2009 Aug;100(8):1556-62. doi: 10.1111/j.1349-7006.2009.01203.x. Epub 2009 May 13.


De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.

Mashima T, Seimiya H, Tsuruo T.

Br J Cancer. 2009 May 5;100(9):1369-72. doi: 10.1038/sj.bjc.6605007. Epub 2009 Apr 7. Review.


Involvement of Fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells.

Schulz R, Vogel T, Mashima T, Tsuruo T, Krieglstein K.

Glia. 2009 Nov 15;57(15):1619-29. doi: 10.1002/glia.20875.


Apoptosis resistance in tumor cells.

Mashima T, Seimiya H, Chen Z, Kataoka S, Tsuruo T.

Cytotechnology. 1998 Sep;27(1-3):293-308. doi: 10.1023/A:1008058031511.


ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, Matsuura M, Ushijima M, Mashima T, Seimiya H, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y.

Cancer Res. 2008 Oct 15;68(20):8547-54. doi: 10.1158/0008-5472.CAN-08-1235.


Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.

Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H.

Oncogene. 2009 Jan 8;28(1):9-19. doi: 10.1038/onc.2008.355. Epub 2008 Sep 22.


Interactions between antitumor drugs and vault RNA.

Mashima T, Kudo M, Takada Y, Matsugami A, Gopinath SC, Kumar PK, Katahira M.

Nucleic Acids Symp Ser (Oxf). 2008;(52):217-8. doi: 10.1093/nass/nrn110.


Structural analysis of Musashi-RNA complex on the basis of long-range structural information.

Ohyama T, Furukawa A, Mashima T, Sugiyama T, Ohgara S, Yamazaki T, Imai T, Okano H, Nagata T, Katahira M.

Nucleic Acids Symp Ser (Oxf). 2008;(52):193-4. doi: 10.1093/nass/nrn098.


Structural analysis of r(GGA)4 found in RNA aptamer for bovine prion protein.

Matsugami A, Mashima T, Nishikawa F, Murakami K, Nishikawa S, Noda K, Yokoyama T, Katahira M.

Nucleic Acids Symp Ser (Oxf). 2008;(52):179-80. doi: 10.1093/nass/nrn091.


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